The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
Neuroprotective effects of acetyl-L-carnitine after stroke in rats.
Department of Emergency Medicine, Ronald Reagan Institute of Emergency Medicine, Washington, DC, USA.
Annals of emergency medicine 1997;29(6):758-65.
STUDY OBJECTIVE: To test the hypothesis that acetyl-L-carnitine (ALCAR) promotes neurologic recovery from experimental focal cerebral ischemia (stroke) in rats. METHODS: We conducted a prospective, randomized, blinded study in which adult male Sprague-Dawley rats were subjected to coagulative occlusion of the distal right middle cerebral artery (MCA) and temporary occlusion of both common carotid arteries (CCAs) for 60 minutes. After the onset of ischemia each rat was given ALCAR (200 mg/kg) or a similar volume of drug vehicle. Neurologic evaluation was performed on postoperative days 1, 2, 3, and 7. Postoperative weight loss was measured at day 7. Infarct volume was measured in separate groups of rats at 24 hours. RESULTS: Neurologic outcomes, as assessed with an 11-point neurologic deficit scoring system, were significantly improved in ALCAR-treated rats on days 1, 2, and 3 (P < .05). Improvement approached significance on day 7. Rats treated with ALCAR also demonstrated significantly less weight loss on day 7 compared with the vehicle-treated controls. We detected no differences, however, in infarct volumes measured between treatment groups. CONCLUSION: Although we noted no differences in infarct volume, postischemic treatment with ALCAR did improve early clinical recovery and prevented significant weight loss in this rat model of focal cerebral ischemia.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts and related grants with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
Robert E Rosenthal; Yolanda E Bogaert; Gary FiskumNeuroscience letters 2005;378(2):82-7.
Santina A Zanelli; Nina J Solenski; Robert E Rosenthal; Gary FiskumAnnals of the New York Academy of Sciences 2005;1053():153-61.
Susanna Scafidi; Jennifer Racz; Julie Hazelton; Mary C McKenna; Gary FiskumDevelopmental neuroscience 2010;32(5-6):480-7.
Appears in this Publication
Author of this Publication