The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
Cytochrome c release from brain mitochondria is independent of the mitochondrial permeability transition.
A Y Andreyev; B Fahy; G Fiskum (Profiled Author: Gary M Fiskum)
Department of Anesthesiology, University of Maryland, School of Medicine, Baltimore 21201, USA.
FEBS letters 1998;439(3):373-6.
Ca2+ uptake by brain mitochondria induces the release of up to 40% of total cytochrome c in a cyclosporin A-insensitive manner. In the presence of ATP and Mg2+, this process is not accompanied by mitochondrial swelling. There is a moderate decrease in membrane potential under these conditions, but it is completely reversible upon removal of accumulated Ca2+ by addition of EGTA+A23187 but not by EGTA alone. These observations provide evidence that cytochrome c release from brain mitochondria does not require the membrane permeability transition. However, brain mitochondria can undergo the permeability transition in the absence of ATP and Mg2+, which results in cyclosporin A-sensitive large amplitude swelling, loss of Ca2+ uptake capacity and release of matrix solutes.
1 Originating Grant
1 May 1995 - 31 December 2008
NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
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