Scopus Publication Detail
The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in Scopus. This abstract is what is used to create the fingerprint of the publication.
Jiyong Liang; Joyce M Slingerland (Profiled Author: Jiyong Liang)
Cell cycle (Georgetown, Tex.). 2003;2(4):339-345.Abstract
As its role in tumor progression emerges, the PI3K/PKB (Akt) pathway presents an appealing cancer therapeutic target. Recent studies have investigated the mechanisms underlying the tumor-promoting effects of this pathway. PKB triggers a network that positively regulates G1/S cell cycle progression through inactivation of GSK3-beta, leading to increased cyclin D1, and inhibition of Forkhead family transcription factors and the tumor suppressor tuberin (TSC2), leading to reduction of p27Kip1. The identification of p21Waf1/Cip1 and p27Kip1 as novel substrates of PKB provided new insights into mechanisms whereby hyperactivation of this lipid signaling pathway may lead to cell cycle deregulation in human cancers. The PI3K pathway may also play a key role in the G2/M transition and its constitutive activation may lead to defects in DNA damage checkpoint control.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
Shira Yaari; Jasmine Jacob-Hirsch; Ninette Amariglio; Ronit Haklai; Gideon Rechavi; Yoel KloogClinical Cancer Research. 2005;11(12):4321-4330.
Soheil Naderf; Kristine B. Gützkow; Jon Christoffersen; Erlend B. Smeland; Heidi K. BlomhoffEuropean Journal of Immunology. 2000;30(6):1757-1768.
Ho-Young Lee; Young-Ah Suh; Jerome W. Kosmeder; John M. Pezzuto; Waun Ki Hong; Jonathan M. KurieClinical Cancer Research. 2004;10(3):1074-1079.
Appears in this Document