Scopus Publication Detail
The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in Scopus. This abstract is what is used to create the fingerprint of the publication.
Gary Davidson; Wei Wu; Jinlong Shen; Josipa Bilic; Ursula Fenger; Peter Stannek; Andrei Glinka; Christof Niehrs (Profiled Author: Christof Niehrs)
Signalling by Wnt proteins (Wingless in Drosophila) has diverse roles during embryonic development and in adults, and is implicated in human diseases, including cancer 1,2. LDL-receptor-related proteins 5 and 6 (LRP5 and LRP6; Arrow in Drosophila) are key receptors required for transmission of Wnt/β-catenin signalling in metazoa 3. Although the role of these receptors in Wnt signalling is well established, their coupling with the cytoplasmic signalling apparatus remains poorly defined. Using a protein modification screen for regulators of LRP6, we describe the identification of Xenopus Casein kinase 1 γ (CK1γ), a membrane-bound member of the CK1 family. Gain-of-function and loss-of-function experiments show that CK1γ is both necessary and sufficient to transduce LRP6 signalling in vertebrates and Drosophila cells. In Xenopus embryos, CK1γ is required during anterio-posterior patterning to promote posteriorizing Wnt/β-catenin signalling. CK1γ is associated with LRP6, which has multiple, modular CK1 phosphorylation sites. Wnt treatment induces the rapid CK1γ-mediated phosphorylation of these sites within LRP6, which, in turn, promotes the recruitment of the scaffold protein Axin. Our results reveal an evolutionarily conserved mechanism that couples Wnt receptor activation to the cytoplasmic signal transduction apparatus. © 2005 Nature Publishing Group.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
Jiangong Niu; Zhe Chang; Bailu Peng; Qianghua Xia; Weiqin Lu; Peng Huang; Ming-Sound Tsao; Paul J. ChiaoJournal of Biological Chemistry. 2007;282(9):6001-6011.
Katrin I. Willig; Silvio O. Rizzoli; Volker Westphal; Reinhard Jahn; Stefan W. HellNature. 2006;440(7086):935-939.
R. Voit; A. Kuhn; E.E. Sander; I. GrummtNucleic Acids Research. 1995;23(14):2593-2599.
Appears in this Document