Scopus Publication Detail
The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in Scopus. This abstract is what is used to create the fingerprint of the publication.
A T cell-independent antitumor response in mice with bone marrow cells retrovirally transduced with an antibody/Fc-γ chain chimetic receptor gene recognizing a human ovarian cancer antigen
Nature Medicine. 1998;4(2):168-172.Abstract
In order to treat common cancers with immunotherapy, chimeric receptors have been developed that combine the tumor specificity of antibodies with T- cell effector functions. Previously, we demonstrated that T cells transduced with a chimeric receptor gene against human ovarian cancer were able to recognize ovarian cancer cells in vitro and in vivo. We now report that recipients of bone marrow cells transduced with these genes exhibited significant antitumor activity in vivo. Moreover, in vivo depletion of T cells in reconstituted mice did not affect antitumor activity, suggesting that other immune cells expressing the chimeric receptor gene may play an important role in tumor rejection.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
P. Hwu; J.C. Yang; R. Cowherd; J. Treisman; G.E. Shafer; Z. Eshhar; S.A. RosenbergCancer Research. 1995;55(15):3369-3373.
Tom Daly; Richard E. Royal; Michael H. Kershaw; Jonathan Treisman; Gang Wang; Weiping Li; Dorothee Herlyn; Zelig Eshhar; Patrick HwuCancer Gene Therapy. 2000;7(2):284-291.
C.A. Chambers; M.S. Kuhns; J.G. Egen; J.P. AllisonAnnual Review of Immunology. 2001;19:565-594.
Appears in this Document