Scopus Publication Detail
The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in Scopus. This abstract is what is used to create the fingerprint of the publication.
A. Orian; S.S. Grewal; P.S. Knoepfler; B.A. Edgar; S.M. Parkhurst; R.N. Eisenman (Profiled Author: Bruce Edgar)
Cold Spring Harbor Symposia on Quantitative Biology. 2005;70:299-307.Abstract
Deregulated expression of members of the myc oncogene family has been linked to the genesis of a wide range of cancers, whereas their normal expression is associated with growth, proliferation, differentiation, and apoptosis. Myc proteins are transcription factors that function within a network of transcriptional activators (Myc) and repressors (Mxd/Mad and Mnt), all of which heterodimerize with the bHLHZ protein Mad and bind E-box sequences in DNA. These transcription factors recruit coactivator or corepressor complexes that in turn modify histones. Myc, Mxd/Max, and Mnt proteins have been thought to act on a specific subset of genes. However, expression array studies and, most recently, genomic binding studies suggest that these proteins exhibit widespread binding across the genome. Here we demonstrate by immunostaining of Drosophila polytene chromosome that Drosophila Myc (dMyc) is associated with multiple euchromatic chromosomal regions. Furthermore, many dMyc-binding regions overlap with regions containing active RNA polymerase II, although dMyc can also be found in regions lacking active polymerase. We also demonstrate that the pattern of dMyc expression in nuclei overlaps with histone markers of active chromatin but not pericentric heterochromatin. dMyc binding is not detected on the X chromosome rDNA cluster (bobbed locus). This is consistent with recent evidence that in Drosophila cells dMyc regulates rRNA transcription indirectly, in contrast to mammalian cells where direct binding of c-Myc to rDNA has been observed. We further show that the dMyc antagonist dMnt inhibits rRNA transcription in the wing disc. Our results support the view that the Myc/Max/Mad network influences transcription on a global scale. © 2005 Cold Spring Harbor Laboratory Press.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
E. Nili; G.S. Cojocaru; Y. Kalma; D. Ginsberg; N.G. Copeland; D.J. Gilbert; N.A. Jenkins; R. Berger; S. Shaklai; N. Amariglio; et al.Journal of Cell Science. 2001;114(18):3297-3307.
Kathleen Gajewski; Qian Zhang; Cheol Yong Choi; Nancy Fossett; Anh Dang; Young Ho Kim; Yongsok Kim; Robert A. SchulzDevelopmental Biology. 2001;233(2):425-436.
Amir Orian; Bas Van Steensel; Jeffrey Delrow; Harmen J. Bussemaker; Ling Li; Tomoyuki Sawado; Eleanor Williams; Lenora W.M. Loo; Shaun M. Cowley; Cynthia Yost; et al.Genes and Development. 2003;17(9):1101-1114.
Appears in this Document