Scopus Publication Detail
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David A. Prober; Bruce A. Edgar (Profiled Author: Bruce Edgar)
The Ras GTPase links extracellular mitogens to intracellular mechanisms that control cell proliferation. To understand how Ras regulates proliferation in vivo, we activated or inactivated Ras in cell clones in the developing Drosophila wing. Cells lacking Ras were smaller, had reduced growth rates, accumulated in G1, and underwent apoptosis due to cell competition. Conversely, activation of Ras increased cell size and growth rates and promoted G1/S transitions. Ras upregulated the growth driver dMyc, and both Ras and dMyc increased levels of cyclin E posttranscriptionally. We propose that Ras primarily promotes growth and that growth is coupled to G1/S progression via cyclin E. Interestingly, upregulation of growth by Ras did not deregulate G2/M progression or a developmentally regulated cell cycle exit.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
Thomas P. Neufeld; Aida Flor A. De La Cruz; Laura A. Johnston; Bruce A. EdgarCell. 1998;93(7):1183-1193.
David A. Prober; Bruce A. EdgarGenes and Development. 2002;16(17):2286-2299.
Jan Emmerich; Claas A. Meyer; Aida Flor A. De La Cruz; Bruce A. Edgar; Christian F. LehnerGenetics. 2004;168(2):867-875.
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