Scopus Publication Detail
The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in Scopus. This abstract is what is used to create the fingerprint of the publication.
A single-nucleotide polymorphism in tumor suppressor gene SEL1L as a predictive and prognostic marker for pancreatic ductal adenocarcinoma in caucasians
Qian Liu; Jinyun Chen; Billy Mai; Christopher Amos; Ann M. Killary; Subrata Sen; Chongjuan Wei; Marsha L. Frazier (Profiled Authors: Jinyun Chen; Marsha L Frazier; Ann M Killary; Subrata Sen; Chongjuan Wei)
Molecular Carcinogenesis. 2012;51(5):433-438.Abstract
SEL1L is a putative tumor suppressor gene that is frequently down-regulated in pancreatic ductal adenocarcinoma (PDA). A single-nucleotide polymorphism (SNP) rs12435998 in intron3 of SEL1L has previously been reported to be associated with susceptibility to Alzheimer's disease. We hypothesized that this SNP may influence clinical outcomes of patients with PDA. We analyzed DNA samples from 497 Caucasian patients with pathologically confirmed primary PDA. Of these, 98 had been enrolled in a clinical trial of neoadjuvant chemo-radiotherapy and 77 of the 98 had subsequently undergone pancreaticoduodenectomy (PD). We performed Kaplan-Meier analysis to evaluate the correlation between different SNP genotypes and age at diagnosis, survival time after diagnosis, and survival time after PD. In nonsmokers, we found a significant difference in median age at diagnosis between variant genotypes (AG/GG) carriers and wild-type genotype (AA) carriers (58 vs. 62 yr; log-rank test, P=0.017). Patients with variant genotypes also showed an increased hazard ratio (HR) of 1.45 [95% confidence interval (CI), 1.07-1.97] relative to wild-type genotype. Among the patients in the clinical trial, the variant genotypes carriers had a median post-PD survival time that was 34.7 months shorter than wild-type genotype carriers (log-rank test, P=0.019; HR, 1.91; 95% CI, 1.09-3.34). Our results suggest that the rs12435998 SNP in SEL1L gene plays a role in modifying age at diagnosis of PDA in Caucasian nonsmokers. In addition, this SNP may serve as a prognostic marker in PDA patients who undergo the same or similar treatment as the clinical trials. © 2011 Wiley Periodicals, Inc.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
Xiaoqun Dong; Li Jiao; Yanan Li; Douglas B. Evans; Huamin Wang; Kenneth R. Hess; James L. Abbruzzese; Donghui LiJournal of Clinical Oncology. 2009;27(10):1592-1599.
Donghui Li; Motofumi Tanaka; F. Charles Brunicardi; William E. Fisher; Richard A Gibbs; Marie-Claude GingrasCancer. 2011;117(13):2863-2872.
Li Jiao; Manal M. Hassan; Melissa L. Bondy; Robert A. Wolff; Douglas B. Evans; James L. Abbruzzese; Donghui LiAmerican Journal of Gastroenterology. 2008;103(2):360-367.
Appears in this Document