Scopus Publication Detail
The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in Scopus. This abstract is what is used to create the fingerprint of the publication.
Multi-color palette of fluorescent proteins for imaging the tumor microenvironment of orthotopic tumorgraft mouse models of clinical pancreatic cancer specimens
Journal of Cellular Biochemistry. 2012;113(7):2290-2295.Abstract
Pancreatic-cancer-patient tumor specimens were initially established subcutaneously in NOD/SCID mice immediately after surgery. The patient tumors were then harvested from NOD/SCID mice and passaged orthotopically in transgenic nude mice ubiquitously expressing red fluorescent protein (RFP). The primary patient tumors acquired RFP-expressing stroma. The RFP-expressing stroma included cancer-associated fibroblasts (CAFs) and tumor-associated macrophages (TAMs). Further passage to transgenic nude mice ubiquitously expressing green fluorescent protein (GFP) resulted in tumors that acquired GFP stroma in addition to their RFP stroma, including CAFs and TAMs as well as blood vessels. The RFP stroma persisted in the tumors growing in the GFP mice. Further passage to transgenic nude mice ubiquitously expressing cyan fluorescent protein (CFP) resulted in tumors acquiring CFP stroma in addition to persisting RFP and GFP stroma, including RFP- and GFP-expressing CAFs, TAMs and blood vessels. This model can be used to image progression of patient pancreatic tumors and to visually target stroma as well as cancer cells and to individualize patient therapy. © 2012 Wiley Periodicals, Inc.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
Atsushi Suetsugu; Matthew Katz; Jason Fleming; Mark Truty; Ryan Thomas; Shigetoyo Saji; Hisataka Moriwaki; Michael Bouvet; Robert M. HoffmanAnticancer Research. 2012;32(8):3063-3067.
Qiang Li; Daoyan Wei; Li Wang; Liwei Wang; Zhiliang Jia; Xiangdong Le; Yong Gao; Suyun Huang; Keping XieClinical and Experimental Metastasis. 2010;27(1):11-18.
Michael Bouvet; Joseph Spernyak; Matthew H. Katz; Richard V. Mazurchuk; Shinako Takimoto; Ralph Bernacki; Youcef M. Rustum; Abdool R. Moossa; Robert M. HoffmanCancer Research. 2005;65(21):9829-9833.
Appears in this Document