Internal Medicine - Research

Scopus Publication Detail

The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in Scopus. This abstract is what is used to create the fingerprint of the publication.

A NaYbF ₄: Tm ³⁺ nanoprobe for CT and NIR-to-NIR fluorescent bimodal imaging

Huaiyong Xing; Wenbo Bu; Qingguo Ren; Xiangpeng Zheng; Ming Li; Shengjian Zhang; Haiyun Qu; Zheng Wang; Yanqing Hua; Kuaile Zhao; et al. (Profiled Author: Weijun Peng)

Biomaterials. 2012;33(21):5384-5393.

Early diagnosis that combines the high-resolutional CT and sensitive NIR-fluorescence bioimaging could provide more accurate information for cancerous tissues, which, however, remain a big challenge. Here we report a simple bimodal imaging platform based on PEGylated NaYbF 4: Tm ³⁺ nanopaticles (NPs) of less than 20 nm in diameter for both CT and NIR-fluorescence bioimaging. The as-designed nanoprobes showed excellent in vitro and in vivo performances in the dual-bioimaging, very low cytotoxicity and no detectable tissue damge in one month. Remarkably, the Yb ³⁺ in the lattice of NaYbF 4: Tm ³⁺ NPs functions not only as a promising CT contrast medium due to its high X-ray absorption coefficiency, but also an excellent sensitizer contributing to the strong NIR-fluorescent emissions for its large NIR absorption cross-section. In addition, these NPs could be easily excreted mainly via feces without detectable remnant in the animal bodies. © 2012 Elsevier Ltd.

PMID: 22538199    

Scientific Context

This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.