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Targeting PI3K/AKT effector signaling in KRAS mutant colorectal tumors
Rona YaegerPF-12-190-01-TBE 7/1/2012 - 6/30/2014 TDC: $ 98,000
Sponsor: American Cancer Society
Rona Yaeger (PD/PI)
We hypothesize that KRAS activates different downstream pathways in different tumors and that the genetic determinants of these differences can be identified and used to guide the rational selection of patients for treatment with inhibitors in the clinic.