Scopus Publication Detail
The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in Scopus. This abstract is what is used to create the fingerprint of the publication.
H3K4 demethylation by Jarid1a and Jarid1b contributes to retinoblastoma-mediated gene silencing during cellular senescence
Agustin Chicas; Avnish Kapoor; Xiaowo Wang; Ozlem Aksoy; Adam G. Evertts; Michael Q. Zhang; Benjamin A. Garcia; Emily Bernstein; Scott W. Lowe (Profiled Author: Scott Lowe)
Proceedings of the National Academy of Sciences of the United States of America. 2012;109(23):8971-8976.Abstract
Cellular senescence is a tumor-suppressive program that involves chromatin reorganization and specific changes in gene expression that trigger an irreversible cell-cycle arrest. Here we combine quantitative mass spectrometry, ChIP deep-sequencing, and functional studies to determine the role of histone modifications on chromatin structure and gene-expression alterations associated with senescence in primary human cells. We uncover distinct senescence- associated changes in histone-modification patterns consistent with a repressive chromatin environment and link the establishment of one of these patterns - loss of H3K4 methylation - to the retinoblastoma tumor suppressor and the H3K4 demethylases Jarid1a and Jarid1b. Our results show that Jarid1a/b-mediated H3K4 demethylation contributes to silencing of retinoblastoma target genes in senescent cells, suggesting a mechanism by which retinoblastoma triggers gene silencing. Therefore, we link the Jarid1a and Jarid1b demethylases to a tumor-suppressor network controlling cellular senescence.
PMID: 22615382 PMCID: PMC3384172
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
Patrick Trojer; Alina R. Cao; Zhonghua Gao; Yan Li; Jin Zhang; Xiaoqin Xu; Guohong Li; Regine Losson; Hediye Erdjument-Bromage; Paul Tempst; et al.Molecular Cell. 2011;42(4):438-450.
Aaron Arvey; Phaedra Agius; William Stafford Noble; Christina LeslieGenome Research. 2012;22(9):1723-1734.
Robert J. Klose; Qin Yan; Zuzana Tothova; Kenichi Yamane; Hediye Erdjument-Bromage; Paul Tempst; D. Gary Gilliland; Yi Zhang; William G. Kaelin Jr.Cell. 2007;128(5):889-900.
Appears in this Document