David E Gannon

University of Nebraska Medical Center, Internal Medicine Pulmonary

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Translocation (2;11)(q31;q12) is recurrent in collagenous fibroma (desmoplastic fibroblastoma)

Kerry Bernal; Marilu Nelson; James R. Neff; Stephen M. Nielsen; Julia A. Bridge (Profiled Author: Julia Ann Bridge)

Cancer Genetics and Cytogenetics 2004;149(2):161-163.

Collagenous fibroma (desmoplastic fibroblastoma) is a rare, benign tumor composed of spindle and stellate-shaped fibroblasts and myofibroblasts in a densely collagenous background. A t(2;11)(q31;q12) has been reported in one case of collagenous fibroma and a rearrangement of the 11q12 breakpoint in a second case. In the present study, we detected a t(2;11) identical to that previously described in a collagenous fibroma arising in the supraclavicular fossa of a 55-year-old man. This finding confirms the nonrandom association of t(2;11)(q31;q12) with collagenous fibroma. © 2004 Elsevier Inc. All rights reserved.

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