The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in Scopus. This abstract is what is used to create the fingerprint of the publication.
Journal of Periodontology 2008;79(8):1465-1473.Abstract
Background: Topical injection of simvastatin in methylcellulose gel was shown to stimulate bone growth and inflammation over mouse calvaria and in rat mandible models. The purpose of these pilot studies was to evaluate the potential of locally injected simvastatin in human-sized periodontal defects. Methods: Chronic periodontal defects were created bilaterally in seven 1-year-old beagle dogs: 3-walled intrabony defects distal of the mandibular second premolar and mesial of the fourth premolar and Class II furcation defects at the buccal furcation of the mandibular first molars. The edentulous space distal to the mandibular canine was left undisturbed. After 16 weeks of healing, defect sites were treated with scaling and root planing, andmandible sides were randomly selected to receive three weekly injections of 0.5 mg simvastatin in 30 ml methylcellulose gel and contralateral gel alone (n = 3) or 2.0 mg simvastatin/methylcellulose gel and contralateral gel alone (n = 4). Two months following drug application, block sections, including teeth and surrounding tissues, and submandibular lymph nodes were obtained for histomorphometric analysis. Results: Two trends were noted in this pilot study: buccal edentulous ridge thickness was 29% greater with simvastatin, 0.5 mg, compared to gel alone (P = 0.0845), and the simvastatin groups had bone-height loss in interproximal intrabony and furcation defects, but the length of new cementum in the interproximal intrabony defects was greater with simvastatin, 0.5 mg (0.35 ± 0.14 mm), compared to gel alone (0.06 ± 0.15 mm; P = 0.069). No new cementum was found in furcations. Conclusions: Multiple injections of simvastatin are not appropriate for the treatment of intrabony or furcation defects. However, thisapproach showspotential toaugment bone thickness in closed alveolar environments.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
John Rutledge; Matthew D. Schieber; Judd M. Chamberlain; Matthew Byarlay; Amy C. Killeen; Peter J. Giannini; David B. Marx; Richard A. ReinhardtJournal of Periodontology 2011;82(4):597-605.
David Stein; Yeonju Lee; Marian J. Schmid; Byron Killpack; Mikala A. Genrich; Nagamani Narayana; David B. Marx; Diane M. Cullen; Richard A. ReinhardtJournal of Periodontology 2005;76(11):1861-1870.
J. Bruce Bavitz; Jeffrey B. Payne; David Dunning; Andrew Glenn; Ravi KokaInternational Journal of Periodontics and Restorative Dentistry 2000;20(6):597-603.
Appears in this Document