The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in Scopus. This abstract is what is used to create the fingerprint of the publication.
Frank J. Accurso; Richard B. Moss; Robert W. Wilmott; Ran D. Anbar; Amy E. Schaberg; Todd A. Durham; Bonnie W. Ramsey; R. Ahrens; R. Anbar; D. Lindner; et al. (Profiled Author: John Louis Colombo)
American Journal of Respiratory and Critical Care Medicine 2011;183(5):627-634.Abstract
Rationale: Intervention for cystic fibrosis lung disease early in its course has the potential to delay or prevent progressive changes that lead to irreversible airflow obstruction. Denufosol is a novel ion channel regulator designed to correct the ion transport defect and increase the overall mucociliary clearance in cystic fibrosis lung disease by increasing chloride secretion, inhibiting sodium absorption, and increasing ciliary beat frequency in the airway epithelium independently of cystic fibrosis transmembrane conductance regulator genotype. Objectives: To evaluate the efficacy and safety of denufosol in patients with cystic fibrosis who had normal to mildly impaired lung function characteristic of early cystic fibrosis Methods: A total of 352 patients greater than or equal to 5 years old with cystic fibrosis who had FEV 1 greater than or equal to 75% of predicted normal were randomized to receive inhaled denufosol, 60 mg, or placebo three times daily in a Phase 3, randomized, double-blind, placebo-controlled, 24-week trial. Measurements and Main Results: Main outcome measures included change in FEV 1 from baseline to Week 24 endpoint and adverse events. Mean change from baseline to Week 24 endpoint in FEV 1 (primary efficacy endpoint) was 0.048 L for denufosol (n = 178) and 0.003 L for placebo (n = 174; P = 0.047). No significant differences between groups were observed for secondary endpoints including exacerbation rate and other measures of lung function. Denufosol was well tolerated with adverse event and growth profiles similar to placebo. Conclusions: Denufosol improved lung function relative to placebo in cystic fibrosis patients with normal to mildly impaired lung function. Clinical trial registered with www.clinicaltrials.gov (NCT00357279).
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
Donald P. Tashkin; Stephen Rennard; J. Taylor Hays; Wendy Ma; David Lawrence; Theodore C. LeeChest 2011;139(3):591-599.
Stephen I. Rennard; Charles Fogarty; Steven Kelsen; William Long; Joe Ramsdell; James Allison; Donald Mahler; Constantine Saadeh; Thomas Siler; Phillip Snell; et al.American Journal of Respiratory and Critical Care Medicine 2007;175(9):926-934.
K. Negishi; K. Matsumoto; T. Bessho; F. Tada; H. HayatsuNucleic acids symposium series 1988;(19):33-36.
Appears in this Document