The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in Scopus. This abstract is what is used to create the fingerprint of the publication.
Trends in Neurosciences 2012;35(3):197-208.Abstract
Human immunodeficiency virus (HIV)-associated neurocognitive disorders (HAND) reflect the spectrum of neural impairments seen during chronic viral infection. Current research efforts focus on improving antiretroviral and adjunctive therapies, defining disease onset and progression, facilitating drug delivery, and halting neurodegeneration and viral resistance. Because HIV is species-specific, generating disease in small-animal models has proved challenging. After two decades of research, rodent HAND models now include those containing a human immune system. Antiviral responses, neuroinflammation and immunocyte blood-brain barrier (BBB) trafficking follow HIV infection in these rodent models. We review these and other rodent models of HAND and discuss their unmet potential in reflecting human pathobiology and in facilitating disease monitoring and therapeutic discoveries. © 2011 Elsevier Ltd.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
Jay A. Nelson; H. Dou; B. Ellison; M. Uberti; H. Xiong; E. Anderson; M. Mellon; H.A. Gelbard; M. Boska; H.E. Gendelman
Coregistration of quantitative proton magnetic resonance spectroscopic imaging with neuropathological and neurophysiological analyses defines the extent of neuronal impairments in murine human immunodeficiency virus type-1 encephalitisJournal of Neuroscience Research 2005;80(4):562-575.
D.M. Toro-Nieves; Y. Rodriguez; M. Plaud; P. Ciborowski; F. Duan; J. Pérez Laspiur; V. Wojna; Loyda M. MeléndezJournal of NeuroVirology 2009;15(1):36-50.
Dawn Eggert; Prasanta K. Dash; Nawal Serradji; Chang-Zhi Dong; Pascal Clayette; Francoise Heymans; Huanyu Dou; Santhi Gorantla; Harris A. Gelbard; et al.Journal of Neuroimmunology 2009;213(1-2):47-59.
Appears in this Document