The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in Scopus. This abstract is what is used to create the fingerprint of the publication.
Sharon A. Matheny; Chiyuan Chen; Robert L. Kortum; Gina L. Razidlo; Robert E. Lewis; Michael A. White (Profiled Author: Robert E Lewis)
The signal transduction cascade comprising Raf, mitogen-activated protein (MAP) kinase kinase (MEK) and MAP kinase is a Ras effector pathway that mediates diverse cellular responses to environmental cues and contributes to Ras-dependent oncogenic transformation. Here we report that the Ras effector protein Impedes Mitogenic signal Propagation (IMP) modulates sensitivity of the MAP kinase cascade to stimulus-dependent activation by limiting functional assembly of the core enzymatic components through the inactivation of KSR, a scaffold/adaptor protein that couples activated Raf to its substrate MEK. IMP is a Ras-responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination, which releases the inhibition of Raf-MEK complex formation. Thus, Ras activates the MAP kinase cascade through simultaneous dual effector interactions: induction of Raf kinase activity and derepression of Raf-MEK complex formation. IMP depletion results in increased stimulus-dependent MEK activation without alterations in the timing or duration of the response. These observations suggest that IMP functions as a threshold modulator, controlling sensitivity of the cascade to stimulus and providing a mechanism to allow adaptive behaviour of the cascade in chronic or complex signalling environments.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
Steven D. HarrisMycologia 2008;100(6):823-832.
Qingsheng Li; Jacob D. Estes; Patrick M. Schlievert; Lijie Duan; Amanda J. Brosnahan; Peter J. Southern; Cavan S. Reilly; Marnie L. Peterson; Nancy Schultz-Darken; Kevin G. Brunner; et al.Nature 2009;458(7241):1034-1038.
Youngsup Song; Judith Altarejos; Mark O. Goodarzi; Hiroshi Inoue; Xiuqing Guo; Rebecca Berdeaux; Jeong-Ho Kim; Jason Goode; Motoyuki Igata; Jose C. Paz; et al.Nature 2010;468(7326):933-939.
Appears in this Document