Publications of Thomas (Tom) Shearer - Oregon Health & Sciences University

181 Publications

This view shows all the publications associated to this researcher. Select a tab to view the documents within each secion. If you are an authorized user, you can add content by selecting the Edit your profile button above. Access to this tool is managed by a project team at your institution.

Jump to:

Books
Book Chapters
Conference Proceedings
Meeting Abstracts
Presentations
Technical Reports
Other Written Works

181 Publications From Scopus

This is a list of publications by this researcher, listed chronologically starting with the most recent first. New publications appear in this list weekly. The source of publications and 'cited by' data for this application is Scopus.

sort by year | cited by

Select All | Save icon

Export

1.
2013

Emi Nakajima; Ryan D. Walkup; Atsuko Fujii; Thomas R. Shearer; Mitsuyoshi Azuma

Pituitary adenylate cyclase-activating peptide induces neurite outgrowth in cultured monkey trigeminal ganglion cells: Involvement of receptor PAC1
Molecular Vision. 2013;19:174-183.

0
2.
2013

Atsuko Fujii; Ayumi Morimoto-Tochigi; Ryan D. Walkup; Thomas R. Shearer; Mitsuyoshi Azuma

Lacritin-induced secretion of tear proteins from cultured monkey lacrimal acinar cells
Investigative Ophthalmology and Visual Science. 2013;54(4):2533-2540.

0
3.
2012

Yayoi Kishimoto; Chiho Yabuta; Thomas R Shearer; Mitsuyoshi Azuma

FK962 promotes neurite elongation and regeneration of cultured rat trigeminal ganglion cells: possible involvement of GDNF.
Investigative ophthalmology & visual science. 2012;53(9):5312-5319.

0
4.
2011

Emi Nakajima; Katherine B. Hammond; Jennifer L. Rosales; Thomas R. Shearer; Mitsuyoshi Azuma

Calpain, not caspase, is the causative protease for hypoxic damage in cultured monkey retinal cells
Investigative Ophthalmology and Visual Science. 2011;52(10):7059-7067.

1
5.
2011

Takeshi Nakajima; Thomas R. Shearer; Mitsuyoshi Azuma

Involvement of calpain 2 in ionomycin-induced cell death in cultured mouse lens epithelial cells
Current Eye Research. 2011;36(10):930-936.

1
6.
2010

Mitsuyoshi Azuma; Kelly Chung; Atsuko Fujii; Thomas R. Shearer

Patient selection criteria for pilot studies on amelioration of non-neovascular age-related macular degeneration
Journal of Ocular Pharmacology and Therapeutics. 2010;26(4):367-371.

1
7.
2010

Ayumi Morimoto-Tochigi; Ryan D. Walkup; Emi Nakajima; Thomas R. Shearer; Mitsuyoshi Azuma

Mechanism for carbachol-induced secretion of lacritin in cultured monkey lacrimal acinar cells
Investigative Ophthalmology and Visual Science. 2010;51(9):4395-4406.

5
8.
2009

Hong Ma; Ayumi Tochigi; Thomas R. Shearer; Mitsuyoshi Azuma

Calpain inhibitor SNJ-1945 attenuates events prior to angiogenesis in cultured human retinal endothelial cells
Journal of Ocular Pharmacology and Therapeutics. 2009;25(5):409-414.

8
9.
2009

Emi Nakajima; Larry L. David; Michael A. Riviere; Mitsuyoshi Azuma; Thomas R. Shearer

Human and monkey lenses cultured with calcium ionophore form αB-crystallin lacking the c-terminal lysine, a prominent feature of some human cataracts
Investigative Ophthalmology and Visual Science. 2009;50(12):5828-5836.

8
10.
2008

M. Azuma; T.R. Shearer

The Role of Calcium-Activated Protease Calpain in Experimental Retinal Pathology
Survey of Ophthalmology. 2008;53(2):150-163.

29
11.
2007

Yoshiyuki Tamada; Ryan D. Walkup; Thomas R. Shearer; Mitsuyoshi Azuma

Contribution of calpain to cellular damage in human retinal pigment epithelial cells cultured with zinc chelator
Current Eye Research. 2007;32(6):565-573.

2
12.
2007

T. Nakajima; R.D. Walkup; A. Tochigi; T.R. Shearer; M. Azuma

Establishment of an appropriate animal model for lacritin studies: Cloning and characterization of lacritin in monkey eyes
Experimental Eye Research. 2007;85(5):651-658.

9
13.
2007

Chiho Fukiage; Takeshi Nakajima; Yoshiko Takayama; Yoko Minagawa; Thomas R. Shearer; Mitsuyoshi Azuma

PACAP Induces Neurite Outgrowth in Cultured Trigeminal Ganglion Cells and Recovery of Corneal Sensitivity After Flap Surgery in Rabbits
American Journal of Ophthalmology. 2007;143(2):255-262.e1.

5
14.
2007

Takayuki Oka; Takeshi Nakajima; Yoshiyuki Tamada; Thomas R. Shearer; Mitsuyoshi Azuma

Contribution of calpains to photoreceptor cell death in N-methyl-N-nitrosourea-treated rats
Experimental Neurology. 2007;204(1):39-48.

17
15.
2006

Emi Nakajima; Larry L. David; Cory Bystrom; Thomas R. Shearer; Mitsuyoshi Azuma

Calpain-specific proteolysis in primate retina: Contribution of calpains in cell death
Investigative Ophthalmology and Visual Science. 2006;47(12):5469-5475.

17
16.
2006

M. Shih; H. Ma; E. Nakajima; L.L. David; M. Azuma; T.R. Shearer

Biochemical properties of lens-specific calpain Lp85
Experimental Eye Research. 2006;82(1):146-152.

17
17.
2006

T. Nakajima; P.B. Belusko; R.D. Walkup; M. Azuma; T.R. Shearer

Involvement of Egr-1 in lens epithelial cell death induced by selenite
Experimental Eye Research. 2006;82(5):874-878.

2
18.
2006

Takayuki Oka; Yoshiyuki Tamada; Emi Nakajima; Thomas R. Shearer; Mitsuyoshi Azuma

Presence of calpain-induced proteolysis in retinal degeneration and dysfunction in a rat model of acute ocular hypertension
Journal of Neuroscience Research. 2006;83(7):1342-1351.

28
19.
2006

E. Nakajima; R.D. Walkup; H. Ma; T.R. Shearer; M. Azuma

Low activity by the calpain system in primate lenses causes resistance to calcium-induced proteolysis
Experimental Eye Research. 2006;83(3):593-601.

15
20.
2006

T. Oka; R.D. Walkup; Y. Tamada; E. Nakajima; A. Tochigi; T.R. Shearer; M. Azuma

Amelioration of retinal degeneration and proteolysis in acute ocular hypertensive rats by calpain inhibitor ((1S)-1-((((1S)-1-benzyl-3-cyclopropylamino-2,3-di-oxopropyl)amino)carbo nyl)-3-methylbutyl)carbamic acid 5-methoxy-3-oxapentyl ester
Neuroscience. 2006;141(4):2139-2145.

23
21.
2005

Emi Nakajima; Takeshi Nakajima; Yoko Minagawa; Thomas R. Shearer; Mitsuyoshi Azuma

Contribution of ROCK in contraction of trabecular meshwork: Proposed mechanism for regulating aqueous outflow in monkey and human eyes
Journal of Pharmaceutical Sciences. 2005;94(4):701-708.

29
22.
2005

Yoshiyuki Tamada; Emi Nakajima; Takeshi Nakajima; Thomas R. Shearer; Mitsuyoshi Azuma

Proteolysis of neuronal cytoskeletal proteins by calpain contributes to rat retinal cell death induced by hypoxia
Brain Research. 2005;1050(1-2):148-155.

29
23.
2005

H. Ma; M. Azuma; T.R. Shearer

Degradation of human aquaporin 0 by m-calpain
FEBS Letters. 2005;579(30):6745-6748.

6
24.
2005

Catriona Marshall; Graham A. Hitman; Christopher J. Partridge; Anne Clark; Hong Ma; Thomas R. Shearer; Mark D. Turner

Evidence that an isoform of calpain-10 is a regulator of exocytosis in pancreatic β-cells
Molecular Endocrinology. 2005;19(1):213-224.

58
25.
2005

Lucinda J. G. Robertson; James D. Morton; Masazumi Yamaguchi; Roy Bickerstaffe; Thomas R. Shearer; Mitsuyoshi Azuma

Calpain may contribute to hereditary cataract formation in sheep
Investigative Ophthalmology and Visual Science. 2005;46(12):4634-4640.

20
26.
2004

H. Ma; E. Nakajima; M. Shih; M. Azuma; T.R. Shearer

Expression of calpain small subunit 2 in mammalian tissues
Current Eye Research. 2004;29(4-5):337-347.

3
27.
2004

Takayuki Oka; Thomas R. Shearer; Mitsuyoshi Azuma

Involvement of cyclooxygenase-2 in rat models of conjunctivitis
Current Eye Research. 2004;29(1):27-34.

14
28.
2004

Mitsuyoshi Azuma; Kanako Sakamoto-Mizutani; Takeshi Nakajima; Sayaka Kanaami-Daibo; Yoshiyuki Tamada; Thomas R. Shearer

Involvement of calpain isoforms in retinal degeneration in WBN/Kob rats
Comparative Medicine. 2004;54(5):533-542.

19
29.
2003

Nathan A. Reed; Meryl A. Castellini; Hong Ma; Thomas R. Shearer; Melinda K. Duncan

Protein expression patterns for ubiquitous and tissue specific calpains in the developing mouse lens
Experimental Eye Research. 2003;76(4):433-443.

18
30.
2003

Mitsuyoshi Azuma; Yoshiyuki Tamada; Sayaka Kanaami; Emi Nakajima; Yoshikuni Nakamura; Chiho Fukiage; Neil E. Forsberg; Melinda K. Duncan; Thomas R. Shearer

Differential influence of proteolysis by calpain 2 and Lp82 on in vitro precipitation of mouse lens crystallins
Biochemical and Biophysical Research Communications. 2003;307(3):558-563.

11
31.
2003

P.B. Belusko; T. Nakajima; M. Azuma; T.R. Shearer

Expression changes in mRNAs and mitochondrial damage in lens epithelial cells with selenite
Biochimica et Biophysica Acta - General Subjects. 2003;1623(2-3):135-142.

15
32.
2002

Kirsten J. Lampi; Yung H. Kim; Hans Peter Bächinger; Bruce A. Boswell; Robyn A. Lindner; John A. Carver; Thomas R. Shearer; Larry L. David; Deborah M. Kapfer

Decreased heat stability and increased chaperone requirement of modified human βB1-crystallins
Molecular Vision. 2002;8:359-366.

31
33.
2002

K.J. Lampi; M. Shih; Y. Ueda; T.R. Shearer; L.L. David

Lens proteomics: Analysis of rat crystallin sequences and two-dimensional electrophoresis map
Investigative Ophthalmology and Visual Science. 2002;43(1):216-224.

57
34.
2002

Yoshiyuki Tamada; Chiho Fukiage; Sayaka Daibo; Yukuo Yoshida; Mitsuyoshi Azuma; Thomas R Shearer

Involvement of calpain in hypoxia-induced damage in rat retina in vitro
Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology. 2002;131(2):221-225.

17
35.
2002

Takeshi Nakajima; Emi Nakajima; Chiho Fukiage; Mitsuyoshi Azuma; Thomas R. Shearer

Differential gene expression in the lens epithelial cells from selenite injected rats
Experimental Eye Research. 2002;74(2):231-236.

18
36.
2002

Kanako Sakamoto-Mizutani; Chiho Fukiage; Yoshiyuki Tamada; Mitsuyoshi Azuma; Thomas R. Shearer

Contribution of ubiquitous calpains to cataractogenesis in the spontaneous diabetic WBN/Kob rat
Experimental Eye Research. 2002;75(5):611-617.

13
37.
2002

Yoji Ueda; Chiho Fukiage; Marjorie Shih; Thomas R Shearer; Larry L David

Mass measurements of C-terminally truncated alpha-crystallins from two-dimensional gels identify Lp82 as a major endopeptidase in rat lens.
Molecular & cellular proteomics : MCP. 2002;1(5):357-365.

42
38.
2002

Chiho Fukiage; Emi Nakajima; Ma Hong; Mitsuyoshi Azuma; Thomas R. Shearer

Characterization and regulation of lens-specific calpain Lp82
Journal of Biological Chemistry. 2002;277(23):20678-20685.

25
39.
2002

Yung Hae Kim; Deborah M. Kapfer; Jos Boekhorst; Nicolette H. Lubsen; Hans Peter Bächinger; Thomas R. Shearer; Larry L. David; Jimmy B. Feix; Kirsten J. Lampi

Deamidation, but not truncation, decreases the urea stability of a lens structural protein, βB1-crystallin
Biochemistry. 2002;41(47):14076-14084.

50
40.
2001

Kirsten J. Lampi; Julie T. Oxford; Hans Peter Bachinger; Thomas R. Shearer; Larry L. David; Deborah M. Kapfer

Deamidation of human βB1 alters the elongated structure of the dimer
Experimental Eye Research. 2001;72(3):279-288.

48
41.
2001

Y. Tamada; C. Fukiage; K. Mizutani; M. Yamaguchi; Y. Nakamura; M. Azuma; T.R. Shearer

Calpain inhibitor, SJA6017, reduces the rate of formation of selenite cataract in rats
Current Eye Research. 2001;22(4):280-285.

28
42.
2001

Y. Nakamura; C. Fukiage; M. Azuma; T.R. Shearer

Calpain-induced light scattering in young rat lenses is enhanced by UV-B
Journal of Ocular Pharmacology and Therapeutics. 2001;17(1):47-58.

1
43.
2001

Yoji Ueda; Ashley L. McCormack; Thomas R. Shearer; Larry L. David

Purification and characterization of lens specific calpain (Lp82) from bovine lens
Experimental Eye Research. 2001;73(5):625-637.

19
44.
2001

Marjorie Shih; Larry L. David; Kirsten J. Lampi; Hong Ma; Chiho Fukiage; Mitsuyoshi Azuma; Thomas R. Shearer

Proteolysis by m-calpain enhances in vitro light scattering by crystallins from human and bovine lenses
Current Eye Research. 2001;22(6):458-469.

23
45.
2001

Chiho Fukiage; Kanako Mizutani; Yoko Kawamoto; Mitsuyoshi Azuma; Thomas R. Shearer

Involvement of phosphorylation of myosin phosphatase by ROCK in trabecular meshwork and ciliary muscle contraction
Biochemical and Biophysical Research Communications. 2001;288(2):296-300.

12
46.
2001

Hong Ma; Chiho Fukiage; Yung Hae Kim; Melinda K. Duncan; Nathan A. Reed; Marjorie Shih; Mitsuyoshi Azuma; Thomas R. Shearer

Characterization and Expression of Calpain 10: A novel ubiquitous calpain with nuclear localization
Journal of Biological Chemistry. 2001;276(30):28525-28531.

80
47.
2001

Takeshi Nakajima; Chiho Fukiage; Mitsuyoshi Azuma; Hong Ma; Thomas R. Shearer

Different expression patterns for ubiquitous calpains and Capn3 splice variants in monkey ocular tissues
Biochimica et Biophysica Acta - Gene Structure and Expression. 2001;1519(1-2):55-64.

25
48.
2000

T.R. Shearer; H. Ma; M. Shih; C. Fukiage; M. Azuma

Calpains in the lens and cataractogenesis.
Methods in molecular biology (Clifton, N.J.). 2000;144:277-285.

16
49.
2000

H. Ma; M. Shih; C. Fukiage; M. Azuma; M.K. Duncan; N.A. Reed; I. Richard; J.S. Beckmann; T.R. Shearer

Influence of specific regions in Lp82 calpain on protein stability, activity, and localization within lens
Investigative Ophthalmology and Visual Science. 2000;41(13):4232-4239.

26
50.
2000

Y. Sakamoto; T. Nakajima; C. Fukiage; O. Sakai; Y. Yoshida; M. Azuma; T.R. Shearer

Involvement of calpain isoforms in ischemia-reperfusion injury in rat retina
Current Eye Research. 2000;21(1):571-580.

50
51.
2000

H. Ma; M. Shih; I. Hata; C. Fukiage; M. Azuma; T.R. Shearer

Lp85 calpain is an enzymatically active rodent-specific isozyme of lens Lp82
Current Eye Research. 2000;20(3):183-189.

25
52.
2000

Yoshikuni Nakamura; Chiho Fukiage; Marjorie Shih; Hong Ma; Larry L. David; Mitsuyoshi Azuma; Thomas R. Shearer

Contribution of calpain Lp82-induced proteolysis to experimental cataractogenesis in mice
Investigative Ophthalmology and Visual Science. 2000;41(6):1460-1466.

40
53.
2000

Yoshiyuki Tamada; Chiho Fukiage; Daniel L. Boyle; Mitsuyoshi Azuma; Thomas R. Shearer

Involvement of cysteine proteases in bFGF-induced angiogenesis in guinea pig and rat cornea
Journal of Ocular Pharmacology and Therapeutics. 2000;16(3):271-283.

12
54.
2000

M. Azuma; C. Fukiage; M. Higashine; T. Nakajima; H. Ma; T.R. Shearer

Identification and characterization of a retina-specific calpain (Rt88) from rat
Current Eye Research. 2000;21(3):710-720.

32
55.
2000

Y. Tamada; C. Fukiage; Y. Nakamura; M. Azuma; Y.H. Kim; T.R. Shearer

Evidence for apoptosis in the selenite rat model of cataract
Biochemical and Biophysical Research Communications. 2000;275(2):300-306.

39
56.
1999

Y. Nakamura; C. Fukiage; H. Ma; M. Shih; M. Azuma; T.R. Shearer

Decreased sensitivity of lens-specific calpain Lp82 to calpastatin inhibitor
Experimental Eye Research. 1999;69(2):155-162.

27
57.
1999

Mitoshi Kunimatsu; Toyohiro Tada; Yasuko Narita; Yasuhiko Ozaki; Zhen-Qui Liu; Thomas R. Shearer; Makoto Sasaki

Activation of calpain in myocardial infarction: An immunohistochemical study using a calpain antibody raised against active site histidine- containing peptide
Cardiovascular Pathology. 1999;8(1):7-15.

14
58.
1999

Yoshikuni Nakamura; Chiho Fukiage; Mitsuyoshi Azuma; Thomas R. Shearer

Oxidation enhances calpain-induced turbidity in young rat lenses
Current Eye Research. 1999;19(1):33-40.

18
59.
1999

Kevin L. Schey; John G. Fowler; Thomas R. Shearer; Larry David

Modifications to rat lens major intrinsic protein in selenite-induced cataract
Investigative Ophthalmology and Visual Science. 1999;40(3):657-667.

31
60.
1999

H. Ma; I. Hata; M. Shih; C. Fukiage; Y. Nakamura; M. Azuma; T.R. Shearer

Lp82 is the dominant form of calpain in young mouse lens
Experimental Eye Research. 1999;68(4):447-456.

33
61.
1998

T.R. Shearer; H. Ma; M. Shih; I. Hata; C. Fukiage; Y. Nakamura; M. Azuma

Lp82 calpain during rat lens maturation and cataract formation
Current Eye Research. 1998;17(11):1037-1043.

32
62.
1998

Chiho Fukiage; Mitsuyoshi Azuma; Yoshikuni Nakamura; Yoshiyuki Tamada; Thomas R. Shearer

Nuclear cataract and light scattering in cultured lenses from guinea pig and rabbit
Current Eye Research. 1998;17(6):623-635.

13
63.
1998

Hong Ma; Chiho Fukiage; Mitsuyoshi Azuma; Thomas R. Shearer

Cloning and expression of mRNA for calpain Lp82 from rat lens: Splice variant of p94
Investigative Ophthalmology and Visual Science. 1998;39(2):454-461.

71
64.
1998

Kirsten J. Lampi; Zhixiang Ma; Stacy R. A. Hanson; Misuyoshi Azuma; Marjorie Shih; Thomas R. Shearer; David L. Smith; Jean B. Smith; Larry L. David

Age-related changes in human lens crystallins identified by two- dimensional electrophoresis and mass spectrometry
Experimental Eye Research. 1998;67(1):31-43.

143
65.
1998

H. Ma; M. Shih; I. Hata; C. Fukiage; M. Azuma; T.R. Shearer

Protein for Lp82 calpain is expressed and enzymatically active in young rat lens
Experimental Eye Research. 1998;67(2):221-229.

41
66.
1998

M. Shih; K.J. Lampi; T.R. Shearer; L.L. David

Cleavage of beta crystallins during maturation of bovine lens.
Molecular vision. 1998;4:4.

26
67.
1997

Kirsten J. Lampi; Zhixiang Ma; Marjorie Shih; Thomas R. Shearer; Jean B. Smith; David L. Smith; Larry L. David

Sequence analysis of βA3, βB3, and βA4 crystallins completes the identification of the major proteins in young human lens
Journal of Biological Chemistry. 1997;272(4):2268-2275.

125
68.
1997

Chiho Fukiage; Mitsuyoshi Azuma; Yoshikuni Nakamura; Yoshiyuki Tamada; Masayuki Nakamura; Thomas R. Shearer

SJA6017, a newly synthesized peptide aldehyde inhibitor of calpain: Amelioration of cataract in cultured rat lenses
Biochimica et Biophysica Acta - Molecular Basis of Disease. 1997;1361(3):304-312.

57
69.
1997

Hong Ma; Marjorie Shih; David B. Throneberg; Larry L. David; Thomas R. Shearer

Changes in calpain II mRNA in young rat lens during maturation and cataract formation
Experimental Eye Research. 1997;64(3):437-445.

11
70.
1997

M. Azuma; C. Fukiage; L.L. David; T.R. Shearer

Activation of calpain in lens: A review and proposed mechanism
Experimental Eye Research. 1997;64(4):529-538.

50
71.
1997

Kwang-Shik Bae; J. Craig Baumgartner; Thomas R. Shearer; Larry L. David

Occurrence of prevotella nigrescens and prevotella intermedia in infections of endodontic origin
Journal of Endodontics. 1997;23(10):620-623.

30
72.
1997

Chiho Fukiage; Mitsuyoshi Azuma; Yoshikuni Nakamura; Yoshiyuki Tamada; Thomas R. Shearer

Calpain-induced light scattering by crystallins from three rodent species
Experimental Eye Research. 1997;65(6):757-770.

20
73.
1997

T.R. Shearer; H. Ma; C. Fukiage; M. Azuma

Selenite nuclear cataract: review of the model.
Molecular vision. 1997;3:8.

93
74.
1997

T.R. Shearer; M. Shih; K.J. Lampi; L.L. David

Identification and relatve amounts of crystallin polypeptides in rat, bovine, human and chick lenses
Investigative Ophthalmology and Visual Science. 1997;38(4):S205.

0
75.
1997

M. Azuma; C. Fukiage; Y. Nakamura; Y. Tamada; T.R. Shearer

Proteolytically-induced precipitation in mouse lens crystallins
Investigative Ophthalmology and Visual Science. 1997;38(4):S297.

0
76.
1997

T. Mizuno; T.R. Shearer

Role of calcium in crystallin precipitation after proteolysis by Calpain
Investigative Ophthalmology and Visual Science. 1997;38(4):S297.

0
77.
1997

L.L. David; M. Shih; K.J. Lampi; T.R. Shearer

Comparison of β-crystallin cleavage sites suggests that different proteolytic activities predominate in rat, human, and bovine lenses
Investigative Ophthalmology and Visual Science. 1997;38(4):S297.

0
78.
1997

H. Ma; M. Taytor; T. Mizuno; M. Shih; L.L. David; T.R. Shearer

Changes in rat lens calpastatin mrna during aging
Investigative Ophthalmology and Visual Science. 1997;38(4):S581.

0
79.
1997

I.I. Maami; T.R. Shearer

Identification and expression of mrna for lensspecihccalpain: Lp74
FASEB Journal. 1997;11(9):A1223.

0
80.
1996

M. Azuma; C. Fukiage; T.R. Shearer

A mechanism for activation of m-calpain during proteolysis of α-crystallin
Investigative Ophthalmology and Visual Science. 1996;37(3):S602.

0
81.
1996

C. Fukiage; M. Azuma; T.R. Shearer

Effect of cysteine protease inhibitor on bFGF-induced angiogenesis in guinea pig cornea
Investigative Ophthalmology and Visual Science. 1996;37(3):S546.

0
82.
1996

T.R. Shearer; H. Ma; D.B. Throneburg; L.L. David

Calpain II mRNA expression in young rat lens is relatively high and dynamic
Investigative Ophthalmology and Visual Science. 1996;37(3):S602.

0
83.
1996

T. Mizuno; M. Shih; L.L. David; T.R. Shearer

Crystallins vary in their tendency to precipitate after proteolysis
Investigative Ophthalmology and Visual Science. 1996;37(3):S598.

0
84.
1996

H. Ma; M. Shih; D.B. Thronebera; L.L. David; T.R. Shearer

Quantitative analysis of calpain ii mrna in rat tissues
FASEB Journal. 1996;10(6):A1405.

0
85.
1996

Thomas R. Shearer; Marjorie Shih; Toshihiro Mizuno; Larry L. David

Crystallins from rat lens are especially susceptible to calpain-induced light scattering compared to other species
Current Eye Research. 1996;15(8):860-868.

17
86.
1996

T.R. Shearer; D.B. Throneburg; M. Shih

In vitro precipitation of rat lens crystallins by calpain I - A calpain requiring low amounts of calcium for activation
Ophthalmic Research. 1996;28(SUPPL. 2):109-114.

6
87.
1995

M. Azuma; E. Inoue; T. Oka; T.R. Shearer

Proteolysis by calpain is an underlying mechanism for formation of sugar cataract in rat lens
Current Eye Research. 1995;14(1):27-34.

25
88.
1995

N. Iwasaki; L.L. David; T.R. Shearer

Crystallin degradation and insolubilization in regions of young rat lens with calcium ionophore cataract
Investigative Ophthalmology and Visual Science. 1995;36(2):502-509.

11
89.
1995

T.R. Shearer; M. Shih; M. Azuma; L.L. David

Precipitation of crystallins from young rat lens by endogenous
Experimental Eye Research. 1995;61(2):141-150.

33
90.
1994

L.L. David; M. Azuma; T.R. Shearer

Cataract and the acceleration of calpain-induced β-crystallin insolubilization occurring during normal maturation of rat lens
Investigative Ophthalmology and Visual Science. 1994;35(3):785-793.

71
91.
1993

M.J. Kelley; L.L. David; N. Iwasaki; J. Wright; T.R. Shearer

α-Crystallin chaperone activity is reduced by calpain II in vitro and in selenite cataract
Journal of Biological Chemistry. 1993;268(25):18844-18849.

75
92.
1993

K. Kadoya; M. Azuma; L.L. David; T.R. Shearer

Role of calpain in hydrogen peroxide induced cataract
Current Eye Research. 1993;12(4):341-346.

19
93.
1993

L.L. David; T.R. Shearer

β-Crystallins insolubilized by calpain II in vitro contain cleavage sites similar to β-crystallins insolubilized during cataract
FEBS Letters. 1993;324(3):265-270.

40
94.
1993

L.L. David; T.R. Shearer; M. Shih

Sequence analysis of lens β-crystallins suggests involvement of calpain in cataract formation
Journal of Biological Chemistry. 1993;268(3):1937-1940.

89
95.
1992

Mitsuyoshi Azuma; Larry L. David; Thomas R. Shearer

Superior prevention of calcium ionophore cataract by E64d
BBA - Molecular Basis of Disease. 1992;1180(2):215-220.

29
96.
1992

K.J. Lampi; K. Kadoya; M. Azuma; L.L. David; T.R. Shearer

Comparison of cell-permeable calpain inhibitors and E64 in reduction of cataract in cultured rat lenses
Toxicology and Applied Pharmacology. 1992;117(1):53-57.

15
97.
1992

M. Azuma; L.L. David; T.R. Shearer

Hydration and elevated calcium alone do not produce xylose nuclear cataract: Role of proteolysis by calpain
Ophthalmic Research. 1992;24(1):8-14.

11
98.
1992

T.R. Shearer; L.L. David; R.S. Anderson; M. Azuma

Review of selenite cataract
Current Eye Research. 1992;11(4):357-369.

82
99.
1992

M. Azuma; T.R. Shearer

Involvement of calpain in diamide-induced cataract in cultured lenses
FEBS Letters. 1992;307(3):313-317.

22
100.
1992

M. Azuma; R.S. Anderson; S. Sameshima; T. Matsumoto; L.L. David; T.R. Shearer

Calpain in rat cornea
Investigative Ophthalmology and Visual Science. 1992;33(8):2476-2482.

3
101.
1992

Kirsten J. Lampi; Larry L. David; Thomas R. Shearer

Association of calpain with insoluble pellet of rat lens
Experimental Eye Research. 1992;55(2):369-375.

2
102.
1992

Larry L. David; Jay W. Wright; Thomas R. Shearer

Calpain II induced insolubilization of lens β-crystallin polypeptides may induce cataract
BBA - Molecular Basis of Disease. 1992;1139(3):210-216.

35
103.
1992

M. Azuma; T.R. Shearer

Induction of elongation in cultured rat lens epithelial cells by FGF and inhibition by selenite
Investigative Ophthalmology and Visual Science. 1992;33(8):2528-2531.

5
104.
1992

R.S. Anderson; T.R. Shearer

Selenite nuclear cataractogenesis: A scanning electron microscope study
Current Eye Research. 1992;11(12):1147-1160.

3
105.
1991

M. Azuma; L.L. David; T.R. Shearer

Cysteine protease inhibitor E64 reduces the rate of formation of selenite cataract in the whole animal
Current Eye Research. 1991;10(7):657-666.

30
106.
1991

T.R. Shearer; M. Azuma; L.L. David; T. Murachi

Amelioration of cataracts and proteolysis in cultured lenses by cysteine protease inhibitor E64
Investigative Ophthalmology and Visual Science. 1991;32(3):533-540.

20
107.
1990

M. Azuma; T.R. Shearer; T. Matsumoto; L.L. David; T. Murachi

Calpain II in two in vivo models of sugar cataract
Experimental Eye Research. 1990;51(4):393-401.

17
108.
1990

T.R. Shearer; M. Azuma; L.L. David; Y. Yamagata; T. Murachi

Calpain and calpastatin in rabbit corneal epithelium
Current Eye Research. 1990;9(1):39-44.

2
109.
1990

H. Watanabe; M. Komoto; L.L. David; T.R. Shearer

Changes in crystallin concentration in rat aqueous and vitreous humors after selenium-induced reversible cortical cataract
Japanese Journal of Ophthalmology. 1990;34(4):472-478.

3
110.
1989

H. Watanabe; T.R. Shearer

lens crystallins in aqueous and vitreous humor in selenite overdose cataract
Current Eye Research. 1989;8(5):479-486.

6
111.
1989

L.L. David; M.D. Varnum; K.J. Lampi; T.R. Shearer

Calpain II in human lens
Investigative Ophthalmology and Visual Science. 1989;30(2):269-275.

45
112.
1989

K.M. Westover; M.K. DiLoreto; T.R. Shearer

The relationship of breastfeeding to oral development and dental concerns.
ASDC journal of dentistry for children. 1989;56(2):140-143.

10
113.
1989

L.L. David; T.R. Shearer

Role of proteolysis in lenses: A review
Lens and Eye Toxicity Research. 1989;6(4):725-747.

30
114.
1989

M.D. Varnum; L.L. David; T.R. Shearer

Age-related changes in calpain II and calpastatin in rat lens
Experimental Eye Research. 1989;49(6):1053-1065.

12
115.
1988

R.S. Anderson; D.R. Trune; T.R. Shearer

Histologic changes in selenite cortical cataract
Investigative Ophthalmology and Visual Science. 1988;29(9):1418-1427.

3
116.
1988

L.L. David; L.J. Takemoto; R.S. Anderson; T.R. Shearer

Proteolytic changes in main intrinsic polypeptide (MIP26) from membranes in selenite cataract
Current Eye Research. 1988;7(4):411-417.

11
117.
1988

D.I. Rosenstein; G. Chiodo; J.W. Ho; K. Westover; T.R. Shearer

Effect of proper dentures on nutritional status.
General dentistry. 1988;36(2):127-129.

3
118.
1987

T.R. Shearer; L.L. David; R.S. Anderson

Selenite cataract: A review
Current Eye Research. 1987;6(2):289-300.

34
119.
1987

R.K. Huston; T.R. Shearer; B.J. Jelen; P.D. Whall; J.W. Reynolds

Relationship of antioxidant enzymes to trace metals in premature infants
Journal of Parenteral and Enteral Nutrition. 1987;11(2):163-168.

10
120.
1987

L.L. David; B.M. Dickey; T.R. Shearer

Origin of urea-soluble protein in the selenite cataract. Role of β-crystallin proteolysis and calpain II
Investigative Ophthalmology and Visual Science. 1987;28(7):1148-1156.

6
121.
1987

K.R. Hightower; L.L. David; T.R. Shearer

Regional distribution of free calcium in selenite cataract: Relation to calpain II
Investigative Ophthalmology and Visual Science. 1987;28(10):1702-1706.

21
122.
1987

K.M. Westover; L.C. Allender; J.W. Ho; T.R. Shearer

Alternative sweeteners: a review.
General dentistry. 1987;35(5):397-401.

1
123.
1986

L.L. David; T.R. Shearer

Purification of calpain II from rat lens and determination of endogenous substrates
Experimental Eye Research. 1986;42(3):227-238.

38
124.
1986

R.S. Anderson; T.R. Shearer; C.K. Claycomb

Selenite-induced epithelial damage and cortical cataract
Current Eye Research. 1986;5(1):53-61.

13
125.
1986

Thomas R. Shearer; Larry L. David; Ruth S. Anderson

Selenite decreases phase separation temperature in rat lens
Experimental Eye Research. 1986;42(5):503-506.

3
126.
1986

K.M. Westover; T.R. Shearer

Eating disorders in dental service.
The Journal of the Oregon Dental Association. 1986;55(4):32-33.

0
127.
1986

R. Anderson; T.R. Shearer

Glycol methacrylate sections of the crystalline lens
Stain Technology. 1986;61(6):381-382.

0
128.
1985

J.W. Suttie; A.B. Clay; T.R. Shearer

Dental fluorosis in bovine temporary teeth
American Journal of Veterinary Research. 1985;46(2):404-408.

5
129.
1985

T.R. Shearer; R.S. Anderson

Histologic changes during selenite cataractogenesis: A light micrscopy study
Experimental Eye Research. 1985;40(4):557-565.

4
130.
1984

T.R. Shearer; J.W. Ridlington; D.E. Goeger; P.D. Whanger

Uptake of⁷⁵Se in cataractous rat lens proteins
Biological Trace Element Research. 1984;6(3):195-205.

0
131.
1984

N.J. Russell; J.E. Royland; E.L. McCawley; T.R. Shearer

Ultrastructural study of selenite-induced nuclear cataracts
Investigative Ophthalmology and Visual Science. 1984;25(6):751-757.

1
132.
1984

L.L. David; T.R. Shearer

State of sulfhydryl in selenite cataract
Toxicology and Applied Pharmacology. 1984;74(1):109-115.

27
133.
1984

L.L. David; T.R. Shearer

Calcium-activated proteolysis in the lens nucleus during selenite cataractogenesis
Investigative Ophthalmology and Visual Science. 1984;25(11):1275-1283.

45
134.
1984

L.L. David; T.R. Shearer

Selenite cataractogenesis in young rats: Loss of lens nuclear polypeptide above 24 K daltons and possible role of calcium activated protease
Federation Proceedings. 1984;43(3):no. 1104.

0
135.
1983

T.R. Shearer; R.S. Anderson; J.L. Britton

Influence of selenite and fourteen trace elements on cataractogenesis in the rat
Investigative Ophthalmology and Visual Science. 1983;24(4):417-423.

11
136.
1983

T.R. Shearer; R.S. Anderson; J.L. Britton; E.A. Palmer

Early development of selenium-induced cataract: Slit lamp evaluation
Experimental Eye Research. 1983;36(6):781-788.

10
137.
1983

H.Y. Park; T.R. Shearer

In vitro release of nickel and chromium from simulated orthodontic appliances
American Journal of Orthodontics. 1983;84(2):156-159.

75
138.
1982

T.R. Shearer; J.L. Britton

Calcification in molar teeth of rats exposed to cadmium during development
Nutrition Reports International. 1982;25(2):311-316.

0
139.
1982

T.R. Shearer; B.E. Johnson; J.W. Ridlington; P.D. Whanger

Chemical location of cadmium in developing rat molars.
Journal of Dental Research. 1982;61(3):510-511.

1
140.
1982

K.S. Johnson; T.R. Shearer

Nutrition practices in holistic dentistry: a critical review of the literature.
The Journal of the Oregon Dental Association. 1982;51(3):36-37, 63.

0
141.
1982

R.K. Huston; G.I. Benda; C.V. Carlson; T.R. Shearer; J.W. Reynolds; R.C. Neerhout

Selenium and vitamin E sufficiency in premature infants requiring total parenteral nutrition.
Journal of Parenteral and Enteral Nutrition. 1982;6(6):507-510.

11
142.
1982

T.R. Shearer; R.S. Anderson; J.L. Britton

Uptake and distribution of radioactive selenium in cataractous rat lens
Current Eye Research. 1982;2(8):561-564.

5
143.
1982

T.R. Shearer; K. Larson; J. Neuschwander; B. Gedney

Minerals in the hair and nutrient intake of austistic children
Journal of Autism and Developmental Disorders. 1982;12(1):25-34.

36
144.
1982

T.R. Shearer; L.L. David

Role of calcium in selenium cataract
Current Eye Research. 1982;2(11):777-784.

13
145.
1982

N.J. Russell; J.L. Britton; T.R. Shearer

Transmission electron microscopy and selenium concentrations in selenium-induced cataract
Federation Proceedings. 1982;41(3):No. 1511.

0
146.
1981

B.E. Johnson; T.R. Shearer; P.D. Whanger

Metabolism of cadmium by developing rat molars
Federation Proceedings. 1981;40(3 II):No. 3725.

0
147.
1980

J.L. Britton; T.R. Shearer; D.J. DeSart

Cariostasis by moderate doses of selenium in the rat model
Archives of Environmental Health. 1980;35(2):74-76.

0
148.
1980

T.R. Shearer; J.L. Britton; D.J. DeSart; J.R. Johnson

Influence of cadmium on caries and the cariostatic properties of fluoride in rats
Archives of Environmental Health. 1980;35(3):176-180.

4
149.
1980

T.R. Shearer; J.L. Britton

Role of post-developmental cadmium in caries and cariostasis by fluoride
Federation Proceedings. 1980;39(3 II):3327.

0
150.
1980

T.R. Shearer; K.L. Elmer; A.C. Brown; C. Wyss

Computer facilitated dietary analysis.
The Journal of the Oregon Dental Association. 1980;49(3):29-31.

0
151.
1980

T.R. Shearer; J.R. Johnson; D.J. DeSart

Cadmium gradient in human and bovine enamel.
Journal of Dental Research. 1980;59(6):1072.

1
152.
1980

T.R. Shearer; D.F. DeSart; R.E. Isman; S.M. Sanzi-Schaedel; T.M. Pickles

Sugar content of vending machine foods.
The Journal of the Oregon Dental Association. 1980;49(4):32-34.

0
153.
1980

T.R. Shearer; J.L. Britton; D.J. DeSart; J.W. Suttie

Microhardness of molar teeth in cattle with fluorosis.
American Journal of Veterinary Research. 1980;41(9):1543-1545.

0
154.
1980

T.R. Shearer; J.L. Britton

SELENIUM-INDUCED CATARACT.
Trace Substances in Environmental Health: Proceedings of University of Missouri's Annual Conference on Trace Substances in Environmental Health. 1980:287-293.

0
155.
1980

T.R. Shearer; D.W. McCormack; D.J. DeSart; J.L. Britton; M.T. Lopez

Histological evaluation of selenium induced cataracts
Experimental Eye Research. 1980;31(3):327-333.

3
156.
1980

T.R. Shearer; J.L. Britton; D.J. DeSart

Influence of post-developmental cadmium on caries and cariostasis by fluoride
Environmental Health Perspectives. 1980;VOL.34:219-221.

3
157.
1979

T.R. Shearer; J.L. Britton; J.R. Johnson; D.J. Desart

Sex difference in the caries promoting properties of developmental cadmium
Federation Proceedings. 1979;38(3 I):No. 1172.

0
158.
1979

J.R. Johnson; T.R. Shearer

Selenium uptake into teeth determined by fluorimetry
Journal of Dental Research. 1979;58(8):1836-1839.

2
159.
1979

T.R. Shearer; E.W. Lis; K.S. Johnson

Zinc concentrations in the amniotic fluid of high risk pregnant women
Nutrition Reports International. 1979;19(2):209-213.

0
160.
1979

T.R. Shearer; E.W. Lis; K.S. Johnson; J.R. Johnson; G.H. Prescott

Copper and zinc in the amniotic fluid and serum from high-risk pregnant women
Proceedings of the Society for Experimental Biology and Medicine. 1979;161(3):382-385.

1
161.
1978

T.R. Shearer; J.L. Britton

Fluoride-selenium interaction in developing enamel
Federation Proceedings. 1978;37(3):No. 2395.

0
162.
1978

T.R. Shearer; H.E. Howard; D.J. DeSart

Breast-feeding and nursing caries.
The Journal of the Oregon Dental Association. 1978;47(3):17.

0
163.
1978

T.R. Shearer; D.L. Kolstad; J.W. Suttie

Bovine dental fluorosis: histologic and physical characteristics.
American Journal of Veterinary Research. 1978;39(4):587-602.

11
164.
1978

T.R. Shearer; D.L. Kolstad; J.W. Suttie

Electron probe microanalysis of fluorotic bovine teeth.
American Journal of Veterinary Research. 1978;39(9):1393-1398.

2
165.
1977

T.R. Shearer; J.L. Britton

Relationship of dietary selenium to selenium uptake by teeth
Federation Proceedings. 1977;36(3):No. 4654.

0
166.
1976

T.R. Shearer; J.L. Britton

Protein synthesis in the teeth of rats receiving selenium
Federation Proceedings. 1976;35(3):No.2058.

0
167.
1976

T.R. Shearer; J.W. Ridlington

Fluoride selenium interaction in the hard and soft tissues of the rat
Journal of Nutrition. 1976;106(4):451-456.

3
168.
1975

T.R. Shearer

Developmental and postdevelopmental uptake of dietary organic and inorganic selenium into the molar teeth of rats
Journal of Nutrition. 1975;105(3):338-347.

3
169.
1975

T.R. Shearer; D.M. Hadjimarkos

Geographic distribution of selenium in human milk
Archives of Environmental Health. 1975;30(5):230-233.

19
170.
1974

T.R. Shearer

A device for measuring the pattern of food and water intake in small laboratory animals
Archives of Oral Biology. 1974;19(3):269-270,IN9.

0
171.
1974

T.R. Shearer

Comparative metabolic responses of rat kidney and liver to acute doses of fluoride
Proceedings of the Society for Experimental Biology and Medicine. 1974;146(1):209-212.

0
172.
1973

D.M. Hadjimarkos; T.R. Shearer

Selenium content of human nails: a new index for epidemiologic studies of dental caries.
Journal of Dental Research. 1973;52(2):389.

2
173.
1973

T.R. Shearer; D.M. Hadjimarkos

Comparative distribution of 75 Se in the hard and soft tissues of mother rats and their pups.
Journal of Nutrition. 1973;103(4):553-559.

2
174.
1973

D.M. Hadjimarkos; T.R. Shearer

Selenium in mature human milk.
American Journal of Clinical Nutrition. 1973;26(6):583-585.

3
175.
1973

T.R. Shearer

Lack of effect of selenium on glycolytic and citric acid cycle intermediates in rat kidney and liver
Proceedings of the Society for Experimental Biology and Medicine. 1973;144(2):688-691.

1
176.
1972

D.M. Hadjimarkos; T.R. Shearer

Selenium concentration in human saliva.
Caries Research. 1972;6(1):70.

0
177.
1972

T.R. Shearer

Liver citrate levels in parathyroidectomized rats fed toxic amounts of inorganic fluoride
Archives of Oral Biology. 1972;17(11):1629-1632.

0
178.
1971

T.R. Shearer; J.J. Le Saouter; J.W. Suttie

Effect of toxic levels of dietary fluoride on citrate metabolism in the rat.
Journal of Nutrition. 1971;101(8):1037-1044.

0
179.
1971

D.M. Hadjimarkos; T.R. Shearer

Selenium concentration in human saliva.
American Journal of Clinical Nutrition. 1971;24(10):1210-1211.

1
180.
1971

T.R. Shearer; J.W. Suttie

The effect of dietary fluoride on plasma free amino acid concentrations in the rat.
Proceedings of the Society for Experimental Biology and Medicine. 1971;138(2):661-664.

0
181.
1967

T.R. Shearer; J.W. Suttie

Effect of fluoride administration on plasma fluoride and food intake in the rat.
The American journal of physiology. 1967;212(5):1165-1168.

1

Thomas (Tom) Shearer School of Dentistry, Integrative Biosciences

Thomas (Tom) Shearer

181 Publications

Thomas (Tom) Shearer
School of Dentistry, Integrative Biosciences