Scopus Publication Detail
The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in Scopus. This abstract is what is used to create the fingerprint of the publication.
Nobilamides A-H, long-acting transient receptor potential vanilloid-1 (TRPV1) antagonists from mollusk-associated bacteria
Zhenjian Lin; Christopher A. Reilly; Rowena Antemano; Ronald W. Hughen; Lenny Marett; Gisela P. Concepcion; Margo G. Haygood; Baldomero M. Olivera; Alan Light; Eric W. Schmidt(Profiled Author: Margo Haygood)
Journal of Medicinal Chemistry. 2011;54(11):3746-3755.Abstract
New compounds nobilamides A-H and related known compounds A-3302-A and A-3302-B were isolated based upon their suppression of capsaicin-induced calcium uptake in a mouse dorsal root ganglion primary cell culture assay. Two of these compounds, nobilamide B and A-3302-A, were shown to be long-acting antagonists of mouse and human TRPV1 channels, abolishing activity for >1 h after removal of drug presumably via a covalent attachment. Other derivatives also inhibited the TRPV1 channel, albeit with low potency, affording a structure-activity profile to support the proposed mechanism of action. While the activities were modest, we propose a new mechanism of action and a new site of binding for these inhibitors that may spur development of related analogues for treatment of pain. © 2011 American Chemical Society.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
Zhenjian Lin; Malem Flores; Imelda Forteza; Niel M. Henriksen; Gisela P. Concepcion; Gary Rosenberg; Margo G. Haygood; Baldomero M. Olivera; Alan R. Light; Thomas E. Cheatham; et al.Journal of Natural Products. 2012;75(4):644-649.
Zhenjian Lin; Rowena R. Antemano; Ronald W. Hughen; Ma. Diarey B. Tianero; Olivier Peraud; Margo G. Haygood; Gisela P. Concepcion; Baldomero M. Olivera; Alan Light; Eric W. SchmidtJournal of Natural Products. 2010;73(11):1922-1926.
Manoj P. Samant; Richard White; Doley J. Hong; Glenn Croston; P. Michael Conn; Jo Ann Janovick; Jean RivierJournal of Medicinal Chemistry. 2007;50(9):2067-2077.
Appears in this Document