Scopus Publication Detail
The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in Scopus. This abstract is what is used to create the fingerprint of the publication.
Jason C. Kwan; Mohamed S. Donia; Andrew W. Han; Euichi Hirose; Margo G. Haygood; Eric W. Schmidt(Profiled Author: Margo Haygood)
Proceedings of the National Academy of Sciences of the United States of America. 2012;109(50):20655-20660.Abstract
Secondary metabolites are ubiquitous in bacteria, but by definition, they are thought to be nonessential. Highly toxic secondary metabolites such as patellazoles have been isolated from marine tunicates, where their exceptional potency and abundance implies a role in chemical defense, but their biological source is unknown. Here, we describe the association of the tunicate Lissoclinum patella with a symbiotic α-proteobacterium, Candidatus Endolissoclinum faulkneri, and present chemical and biological evidence that the bacterium synthesizes patellazoles. We sequenced and assembled the complete Ca. E. faulkneri genome, directly from metagenomic DNA obtained from the tunicate, where it accounted for 0.6% of sequence data. We show that the large patellazoles biosynthetic pathway is maintained, whereas the remainder of the genome is undergoing extensive streamlining to eliminate un-needed genes. The preservation of this pathway in streamlined bacteria demonstrates that secondary metabolism is an essential component of the symbiotic interaction.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
Mohamed S. Donia; W. Florian Fricke; Frédéric Partensky; James Cox; Sherif I. Elshahawi; James R. White; Adam M. Phillippy; Michael C. Schatz; Joern Piel; Margo G. Haygood; et al.Proceedings of the National Academy of Sciences of the United States of America. 2011;108(51):E1423-E1432.
Sherif I. Elshahawi; Amaro E. Trindade-Silva; Amro Hanora; Andrew W. Han; Malem S. Flores; Vinicius Vizzoni; Carlos G. Schrago; Carlos A. Soares; Gisela P. Concepcion; Dan L. Distel; et al.Proceedings of the National Academy of Sciences of the United States of America. 2013;110(4):E295-E304.
Margo G. Haygood; Daniel L. DistelNature. 1993;363(6425):154-156.
Appears in this Document