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Neuroactive diol and acyloin metabolites from cone snail-associated bacteria

Zhenjian Lin; Lenny Marett; Ronald W. Hughen; Malem Flores; Imelda Forteza; Mary Anne Ammon; Gisela P. Concepcion; Samuel Espino; Baldomero M. Olivera; Gary Rosenberg; et al.

(Profiled Author: Margo Haygood)

Bioorganic and Medicinal Chemistry Letters. 2013;23(17):4867-4869.

Abstract

The bacterium Gordonia sp. 647 W.R.1a.05 was cultivated from the venom duct of the cone snail, Conus circumcisus. The Gordonia sp. organic extract modulated the action potential of mouse dorsal root ganglion neurons. Assay-guided fractionation led to the identification of the new compound circumcin A (1) and 11 known analogs (2-12). Two of these compounds, kurasoin B (7) and soraphinol A (8), were active in a human norepinephrine transporter assay with Ki values of 2575 and 867 nM, respectively. No neuroactivity had previously been reported for compounds in this structural class. Gordonia species have been reproducibly isolated from four different cone snail species, indicating a consistent association between these organisms. © 2013 Elsevier Ltd. All rights reserved.


PMID: 23880542     PMCID: PMC3779075    

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