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Nitric oxide dioxygenation reaction in devS and the initial response to nitric oxide in mycobacterium tuberculosis
Erik T. Yukl; Alexandra Ioanoviciu; Santhosh Sivaramakrishnan; Michiko M. Nakano; Paul R. Ortiz De Montellano; Pierre Moënne-Loccoz(Profiled Authors: Pierre Moenne-Loccoz; Michiko Nakano)
DevS and DosT from Mycobacterium tuberculosis (MTB) are paralogous heme-based sensor kinases that respond to hypoxia and to low concentrations of nitric oxide (NO). Both proteins work with the response regulator DevR as a two-component regulatory system to induce the dormancy regulon in MTB. While DevS and DosT are inactive when dioxygen is bound to the heme Fe(II) at their sensor domain, autokinase activity is observed in their heme Fe(II)-NO counterparts. To date, the conversion between active and inactive states and the reactivity of the heme-oxy complex toward NO have not been investigated. Here, we use stopped-flow UV-vis spectroscopy and rapid freeze quench resonance Raman spectroscopy to probe these reactions in DevS. Our data reveal that the heme-O
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
Erik T. Yukl; Simon De Vries; Pierre Moënne-LoccozJournal of the American Chemical Society. 2009;131(21):7234-7235.
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