David (Jamie) Fitzgerald

School of Medicine, Orthopedics

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Isolation and characterization of the mouse pyruvate dehydrogenase E1α genes

J. Fitzgerald; W.M. Hutchison; H.-H.M. Dahl (Profiled Author: David (Jamie) Fitzgerald)

Biochimica et Biophysica Acta - Gene Structure and Expression. 1992;1131(1):83-90.

We have characterized two mouse genes that code for the E1α subunit of pyruvate dehydrogenase (PDH), Pdha-1 and Pdha-2. The coding regions show a high degree of homology with each other and with the human PDH genes, PDHA1 and PDHA2. Conserved regions include mitochondrial import sequences, phosphorylation sites and a putative TPP binding site. The PDH genes have an analogous chromosomal arrangement to PGK genes in that two isoforms code for a functionally and structurally similar product. Pdha-1 codes for a somatic isoform and maps to the X-chromosome. Pdha-2 is located on an autosome, is intronless and only expressed in spermatogenic cells. Comparison of human and mouse PDH and PGK gene sequences shows that the somatic sequences are more conserved relative to the testis-specific isoforms, and that the mouse PDH E1α genes have experienced a faster rate of DNA change compared to their human counterparts.

PMID: 1581363    

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