Scopus Publication Detail
The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in Scopus. This abstract is what is used to create the fingerprint of the publication.
Scott M. Vanderwerf; Johanna Svahn; Susan Olson; R. Keaney Rathbun; Christina Harrington; Jane Yates; Winifred Keeble; David C. Anderson; Praveen Anur; Noemi F. Pereira; et al. (Profiled Authors: Grover Bagby; Christina (Chris) Harrington; Susan Olson)
Tumor necrosis factor alpha (TNF-α) production is abnormally high in Fanconi anemia (FA) cells and contributes to the hematopoietic defects seen in FAcomplementation group C-deficient (Fancc -/-) mice. Applying gene expression microarray and proteomic methods to studies on FANCC-deficient cells we found that genes encoding proteins directly involved in ubiquitinylation are overrepresented in the signature of FA bone marrow cells and that ubiquitinylation profiles of FA-C and complemented cells were substantially different. Finding that Toll-like receptor 8 (TLR8) was one of the proteins ubiquitinylated only in mutant cells, we confirmed that TLR8 (or a TLR8-associated protein) is ubiquitinylated in mutant FA-C cells and that TNF-α production in mutant cells depended upon TLR8 and the canonical downstream signaling intermediates interleukin 1 receptor-associated kinase (IRAK) and IκB kinase-alpha/beta. FANCC-deficient THP-1 cells and macrophages from Fancc -/- mice overexpressed TNF-α in response to TLR8 agonists but not other TLR agonists. Ectopically expressed FANCC point mutants were capable of fully complementing the mitomycin-C hypersensitivity phenotype of FA-C cells but did not suppress TNF-α overproduction. In conclusion, FANCC suppresses TNF-α production in mononuclear phagocytes by suppressing TLR8 activity and this particular function of FANCC is independent of its function in protecting the genome from cross-linking agents. © 2009 by The American Society of Hematology.
PMID: 19850743 PMCID: PMC2796134
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
Angela G. Fleischman; Karl J. Aichberger; Samuel B. Luty; Thomas G. Bumm; Curtis L. Petersen; Shirin Doratotaj; Kavin B. Vasudevan; Dorian H. LaTocha; Fei Yang; Richard D. Press; et al.Blood. 2011;118(24):6392-6398.
Matthew D. Silverman; Bobby Babra; Yuzhen Pan; Stephen R. Planck; James T. RosenbaumMicrovascular Research. 2005;70(1-2):32-42.
Qishen Pang; Winifred Keeble; Tracy A. Christianson; Gregory R. Faulkner; Grover C. BagbyEMBO Journal. 2001;20(16):4478-4489.
Appears in this Document