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Megan M. Yardley; Letisha Wyatt; Sheraz Khoja; Liana Asatryan; Marcia J. Ramaker; Deborah A. Finn; Ronald L. Alkana; Nhat Huynh; Stan G. Louie; Nicos A. Petasis; et al. (Profiled Author: Deborah (Deb) Finn)
The high rate of therapeutic failure in the management of alcohol use disorders (AUDs) underscores the urgent need for novel and effective strategies that can deter ethanol consumption. Recent findings from our group showed that ivermectin (IVM), a broad-spectrum anthelmintic with high tolerability and optimal safety profile in humans and animals, antagonized ethanol-mediated inhibition of P2X4 receptors (P2X4Rs) expressed in Xenopus oocytes. This finding prompted us to hypothesize that IVM may reduce alcohol consumption; thus, in the present study we investigated the effects of this agent on several models of alcohol self-administration in male and female C57BL/6 mice. Overall, IVM (1.25-10 mg/kg, intraperitoneal) significantly reduced 24-h alcohol consumption and intermittent limited access (4-h) binge drinking, and operant alcohol self-administration (1-h). The effects on alcohol intake were dose-dependent with the significant reduction in intake at 9 h after administration corresponding to peak IVM concentrations (C
PMID: 22465817 PMCID: PMC3372603
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
Matthew M. Ford; Andrea M. Fretwell; Jeffrey D. Nickel; Gregory P. Mark; Moriah N. Strong; Naomi Yoneyama; Deborah A. FinnNeuropharmacology. 2009;57(3):250-258.
Michelle A. Tanchuck; Naomi Yoneyama; Matthew M. Ford; Andrea M. Fretwell; Deborah A. FinnAlcohol. 2011;45(1):33-44.
Andrey E. Ryabinin; Agustin Galvan-Rosas; Ryan K. Bachtell; Fred O. RisingerPsychopharmacology. 2003;165(3):296-305.
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