Dhiren R Thakker

UNCCH, Eshelman School of Pharmacy, Pharmacy

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Dhiren R Thakker

• Organizations
  University of North Carolina at Chapel Hill
  
  Eshelman School of Pharmacy
  
  Pharmacy
  
  

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This is a list of publications by this researcher, listed chronologically starting with the most recent first. New publications appear in this list weekly. The source of publications and 'cited by' data for this application is Scopus.

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• 1.

  2013

  Matthew B. Dufek; Beverly M. Knight; Arlene S. Bridges; Dhiren R. Thakker

  P-glycoprotein increases portal bioavailability of loperamide in mouse by reducing first-pass intestinal metabolism

  Drug Metabolism and Disposition. 2013;41(3):642-650.
  0

• 2.

  2013

  Claudia N. Generaux; Garrett R. Ainslie; Arlene S. Bridges; Mohamed A. Ismail; David W. Boykin; Richard R. Tidwell; Dhiren R. Thakker; Mary F. Paine

  Compartmental and enzyme kinetic modeling to elucidate the biotransformation pathway of a centrally acting antitrypanosomal prodrug

  Drug Metabolism and Disposition. 2013;41(2):518-528.
  0

• 3.

  2011

  Xin Ming; Beverly M. Knight; Dhiren R Thakker

  Vectorial transport of fexofenadine across caco-2 cells: Involvement of apical uptake and basolateral efflux transporters

  Molecular Pharmaceutics. 2011;8(5):1677-1686.
  8

• 4.

  2011

  Souzan B. Yanni; P. Brian Smith; Daniel K. Benjamin Jr.; Patrick F. Augustijns; Dhiren R. Thakker; Pieter P. Annaert

  Higher clearance of micafungin in neonates compared with adults: Role of age-dependent micafungin serum binding

  Biopharmaceutics and Drug Disposition. 2011;32(4):222-232.
  7

• 5.

  2011

  Ryan R. Klein; David M. Bourdon; Chester L. Costales; Craig D. Wagner; Wendy L. White; Jon D. Williams; Stephanie N. Hicks; John Sondek; Dhiren R. Thakker

  Direct activation of human phospholipase C by its well known inhibitor U73122

  Journal of Biological Chemistry. 2011;286(14):12407-12416.
  11

• 6.

  2010

  Souzan B. Yanni; Patrick F. Augustijns; Daniel K. Benjamin Jr.; Kim L. R. Brouwer; Dhiren R. Thakker; Pieter P. Annaert

  In vitro investigation of the hepatobiliary disposition mechanisms of the antifungal agent micafungin in humans and rats

  Drug Metabolism and Disposition. 2010;38(10):1848-1856.
  11

• 7.

  2010

  Xin Ming; Dhiren R. Thakker

  Role of basolateral efflux transporter MRP4 in the intestinal absorption of the antiviral drug adefovir dipivoxil

  Biochemical Pharmacology. 2010;79(3):455-462.
  12

• 8.

  2010

  Souzan B. Yanni; Pieter P. Annaert; Patrick Augustijns; Joseph G. Ibrahim; Daniel K. Benjamin Jr.; Dhiren R. Thakker

  In vitro hepatic metabolism explains higher clearance of voriconazole in children versus adults: Role of CYP2C19 and flavin-containing monooxygenase 3

  Drug Metabolism and Disposition. 2010;38(1):25-31.
  13

• 9.

  2009

  Xin Ming; Wujian Ju; Huali Wu; Richard R. Tidwell; James E. Hall; Dhiren R. Thakker

  Transport of dicationic drugs pentamidine and furamidine by human organic cation transporters

  Drug Metabolism and Disposition. 2009;37(2):424-430.
  20

• 10.

  2008

  William R. Proctor; David L. Bourdet; Dhiren R. Thakker

  Mechanisms underlying saturable intestinal absorption of metformin

  Drug Metabolism and Disposition. 2008;36(8):1650-1658.
  17

• 11.

  2008

  Souzan B. Yanni; Pieter P. Annaert; Patrick Augustijns; Arlene Bridges; Yan Gao; Daniel K. Benjamin Jr.; Dhiren R. Thakker

  Role of flavin-containing monooxygenase in oxidative metabolism of voriconazole by human liver microsomes

  Drug Metabolism and Disposition. 2008;36(6):1119-1125.
  14

• 12.

  2008

  Timothy K. Tippin; Dhiren R. Thakker

  Biorelevant refinement of the Caco-2 cell culture model to assess efficacy of paracellular permeability enhancers

  Journal of Pharmaceutical Sciences. 2008;97(5):1977-1992.
  3

• 13.

  2006

  Beverly Knight; Matthew Troutman; Dhiren R Thakker

  Deconvoluting the effects of P-glycoprotein on intestinal CYP3A: a major challenge

  Current Opinion in Pharmacology. 2006;6(5):528-532.
  17

• 14.

  2006

  David L. Bourdet; Dhiren R. Thakker

  Saturable absorptive transport of the hydrophilic organic cation ranitidine in Caco-2 cells: Role of pH-dependent organic cation uptake system and P-glycoprotein

  Pharmaceutical Research. 2006;23(6):1165-1177.
  19

• 15.

  2006

  David L. Bourdet; Gary M. Pollack; Dhiren R. Thakker

  Intestinal absorptive transport of the hydrophilic cation ranitidine: A kinetic modeling approach to elucidate the role of uptake and efflux transporters and paracellular vs. transcellular transport in Caco-2 cells

  Pharmaceutical Research. 2006;23(6):1178-1187.
  21

• 16.

  2005

  David L. Bourdet; John B. Pritchard; Dhiren R. Thakker

  Differential substrate and inhibitory activities of ranitidine and famotidine toward human organic cation transporter 1 (hOCT1; SLC22A1), hOCT2 (SLC22A2), and hOCT3 (SLC22A3)

  Journal of Pharmacology and Experimental Therapeutics. 2005;315(3):1288-1297.
  35

• 17.

  2004

  David L. Bourdet; Kiho Lee; Dhiren R. Thakker

  Photoaffinity labeling of the anionic sites in Caco-2 cells mediating saturable transport of hydrophilic cations ranitidine and famotidine

  Journal of Medicinal Chemistry. 2004;47(11):2935-2938.
  4

• 18.

  2004

  Lian Zhou; Dhiren R. Thakker; Robert D. Voyksner; Mariappan Anbazhagan; David W. Boykin; James E. Hall; Richard R. Tidwell

  Metabolites of an orally active antimicrobial prodrug, 2,5-bis(4-amidinophenyl)furan-bis-O-methylamidoxime, identified by liquid chromatography/tandem mass spectrometry

  Journal of Mass Spectrometry. 2004;39(4):351-360.
  24

• 19.

  2004

  John H. Ansede; Dhiren R. Thakker

  High-Throughput Screening for Stability and Inhibitory Activity of Compounds toward Cytochrome P450-Mediated Metabolism

  Journal of Pharmaceutical Sciences. 2004;93(2):239-255.
  78

• 20.

  2003

  Matthew D. Troutman; Dhiren R. Thakker

  Rhodamine 123 requires carrier-mediated influx for its activity as a P-glycoprotein substrate in Caco-2 cells

  Pharmaceutical Research. 2003;20(8):1192-1199.
  57

• 21.

  2003

  Matthew D. Troutman; Dhiren R. Thakker

  Efflux ratio cannot assess P-glycoprotein-mediated attenuation of absorptive transport: Asymmetric effect of P-glycoprotein on absorptive and secretory transport across Caco-2 cell monolayers

  Pharmaceutical Research. 2003;20(8):1200-1209.
  79

• 22.

  2003

  Matthew D. Troutman; Dhiren R. Thakker

  Novel experimental parameters to quantify the modulation of absorptive and secretory transport of compounds by P-glycoprotein in cell culture models of intestinal epithelium

  Pharmaceutical Research. 2003;20(8):1210-1224.
  84

• 23.

  2003

  Peter D. Ward; Hui Ouyang; Dhiren R. Thakker

  Role of phospholipase C-β in the modulation of epithelial tight junction permeability

  Journal of Pharmacology and Experimental Therapeutics. 2003;304(2):689-698.
  15

• 24.

  2002

  Kiho Lee; Chee Ng; Kim L. R. Brouwer; Dhiren R. Thakker

  Secretory transport of ranitidine and famotidine across Caco-2 cell monolayers

  Journal of Pharmacology and Experimental Therapeutics. 2002;303(2):574-580.
  30

• 25.

  2002

  L. Zhou; K. Lee; D.R. Thakker; D.W. Boykin; R.R. Tidwell; J.E. Hall

  Enhanced permeability of the antimicrobial agent 2,5-bis(4-amidinophenyl)furan across Caco-2 cell monolayers via its methylamidoxime prodrug

  Pharmaceutical Research. 2002;19(11):1689-1695.
  24

• 26.

  2002

  Peter D. Ward; Ryan R. Klein; Matthew D. Troutman; Shaleish Desai; Dhiren R. Thakker

  Phospholipase C-γ modulates epithelial tight junction permeability through hyperphosphorylation of tight junction proteins

  Journal of Biological Chemistry. 2002;277(38):35760-35765.
  24

• 27.

  2002

  Hui Ouyang; Susan L. Morris-Natschke; Khalid S. Ishaq; Peter Ward; Dongzhou Liu; Sarah Leonard; Dhiren R. Thakker

  Structure-activity relationship for enhancement of paracellular permeability across Caco-2 cell monolayers by 3-alkylamido-2-alkoxypropylphosphocholines

  Journal of Medicinal Chemistry. 2002;45(13):2857-2866.
  6

• 28.

  2002

  Lian Zhou; Robert D. Voyksner; Dhiren R. Thakker; Chad E. Stephens; Mariappan Anbazhagan; David W. Boykin; James E. Hall; Richard R. Tidwell

  Characterizing the fragmentation of 2,5-bis (4-amidinophenyl)furan-bis-O-methylamidoxime and selected metabolites using ion trap mass spectrometry

  Rapid Communications in Mass Spectrometry. 2002;16(11):1078-1085.
  12

• 29.

  2002

  Cuiping Chen; Dhiren R. Thakker

  The fallacy of using adrenochrome reaction for measurement of reactive oxygen species formed during cytochrome P450-mediated metabolsim of xenobiotics

  Journal of Pharmacology and Experimental Therapeutics. 2002;300(2):417-420.
  4

• 30.

  2002

  Lian Zhou; Robert D. Voyksner; Dhiren R. Thakker; Chad E. Stephens; Mariappan Anbazhagan; David W. Boykin; Richard R. Tidwell; James E. Hall

  A novel fragmentation pathway involving formation of radical product ions from an antimicrobial prodrug DB289 and selected metabolites using ion trap mass spectrometry

  Proceedings 50th ASMS Conference on Mass Spectrometry and Allied Topics. 2002:479-480.
  0

• 31.

  2002

  Lian Zhou; Dhiren R. Thakker; Robert D. Voyksner; Mariappan Anbazhagan; David W. Boykin; James E. Hall; Richard R. Tidwell

  Metabolites of an orally active antimicrobial prodrug, 2,5-bis(4- amidinophenyl)furan-bis-O-methylamidoxime, identified by liquid chromatography-tandem mass spectrometry

  Proceedings 50th ASMS Conference on Mass Spectrometry and Allied Topics. 2002:467-468.
  0

• 32.

  2001

  Pieter P. Annaert; Ryan Z. Turncliff; Catherine L. Booth; Dhiren R. Thakker; Kim L. R. Brouwer

  P-glycoprotein-mediated in vitro biliary excretion in sandwich-cultured rat hepatocytes

  Drug Metabolism and Disposition. 2001;29(10):1277-1283.
  52

• 33.

  2000

  Peter D Ward; Tim K Tippin; Dhiren R Thakker

  Enhancing paracellular permeability by modulating epithelial tight junctions

  Pharmaceutical Science and Technology Today. 2000;3(10):346-358.
  101

• 34.

  1999

  Dong-Zhou Liu; Susan L. Morris-Natschke; Louis S. Kucera; Khalid S. Ishaq; Dhiren R. Thakker

  Structure-activity relationships for enhancement of paracellular permeability by 2-alkoxy-3-alkylamidopropylphosphocholines across Caco-2 cell monolayers

  Journal of Pharmaceutical Sciences. 1999;88(11):1169-1174.
  18

• 35.

  1999

  Dong-Zhou Liu; Edward L. Lecluyse; Dhiren R. Thakker

  Dodecylphosphocholine-mediated enhancement of paracellular permeability and cytotoxicity in Caco-2 cell monolayers

  Journal of Pharmaceutical Sciences. 1999;88(11):1161-1168.
  56

• 36.

  1999

  Lee Kiho; Dhiren R. Thakker

  Saturable transport of H₂-antagonists ranitidine and famotidine across Caco-2 cell monolayers

  Journal of Pharmaceutical Sciences. 1999;88(7):680-687.
  33

• 37.

  1998

  Liang-Shang L. Gan; Souzan Yanni; Dhiren R. Thakker

  Modulation of the tight junctions of the Caco-2 cell monolayers by H₂-antagonists

  Pharmaceutical Research. 1998;15(1):53-57.
  28

• 38.

  1997

  Liang-Shang L. Gan; Dhiren R. Thakker

  Applications of the Caco-2 model in the design and development of orally active drugs: Elucidation of biochemical and physical barriers posed by the intestinal epithelium

  Advanced Drug Delivery Reviews. 1997;23(1-3):77-98.
  103

• 39.

  1997

  Shin Hong Kang; Achintya K. Sinhababu; Joseph G. Cory; Beverly S. Mitchell; Dhiren R. Thakker; Moo J. Cho

  Cellular delivery of nucleoside diphosphates: A prodrug approach

  Pharmaceutical Research. 1997;14(6):706-712.
  7

• 40.

  1996

  Achintya K. Sinhababu; Dhiren R. Thakker

  Prodrugs of anticancer agents

  Advanced Drug Delivery Reviews. 1996;19(2):241-273.
  81

• 41.

  1996

  Liang L. Gan; M. Arthur Moseley; Bobbie Khosla; Patrick F. Augustijns T; Imothy P. Bradshaw; R. Wayne Hendren; Dhiren R. Thakker

  CYP3A-like cytochrome P450-mediated metabolism and polarized efflux of cyclosporin A in Caco-2 cells: Interaction between the two biochemical barriers to intestinal transport

  Drug Metabolism and Disposition. 1996;24(3):344-349.
  124

• 42.

  1995

  Achintya K. Sinhababu; Charles C. Boehlert; Liang-Shang Gan; Souzan B. Yanni; Dhiren R. Thakker

  High-performance liquid chromatographic purification, optimization of the assay, and properties of ribonucleoside diphosphate reductase from rabbit bone marrow

  Archives of Biochemistry and Biophysics. 1995;317(1):285-291.
  1

• 43.

  1994

  R.P. Iyer; J.H. Boal; L.R. Phillips; D.R. Thakker; W. Egan

  Synthesis, hydrolytic behavior, and anti-HIV activity of selected acyloxyalkyl esters of trisodium phosphonoformate (foscarnet sodium)

  Journal of Pharmaceutical Sciences. 1994;83(9):1269-1273.
  13

• 44.

  1994

  L.-S. Gan; C. Eads; T. Niederer; A. Bridgers; S. Yanni; P.-H. Hsyu; F.J. Pritchard; D. Thakker

  Use of Caco-2 cells as an in vitro intestinal absorption and metabolism model

  Drug Development and Industrial Pharmacy. 1994;20(4):615-631.
  27

• 45.

  1993

  L.-S. Gan; P.-H. Hsyu; J.F. Pritchard; D. Thakker

  Mechanism of intestinal absorption of ranitidine and ondansetron: Transport across Caco-2 cell monolayers

  Pharmaceutical Research. 1993;10(12):1722-1725.
  57

• 46.

  1993

  P.F. Augustijns; T.P. Bradshaw; L.-S.L. Gan; R.W. Hendren; D.R. Thakker

  Evidence for a polarized efflux system in Caco-2 cells capable of modulating cyclosporin A transport

  Biochemical and Biophysical Research Communications. 1993;197(2):360-365.
  129

• 47.

  1993

  L.-S. Gan; T. Niederer; C. Eads; D. Thakker

  Evidence for predominantly paracellular transport of thyrotropin-releasing hormone across Caco-2 cell monolayers

  Biochemical and Biophysical Research Communications. 1993;197(2):771-777.
  8

• 48.

  1991

  D.R. Thakker; C. Boehlert; W. Levin; D.E. Ryan; P.E. Thomas; H. Yagi; D.M. Jerina

  Novel stereoselectivity of rat liver cytochrome(s) P450 toward enantiomers of the trans-1,2-dihyrodiol of triphenylene

  Archives of Biochemistry and Biophysics. 1991;288(1):54-63.
  0

• 49.

  1991

  G.K.B. Prasad; D.R. Thakker

  Oxidative conversion of 6-fluorobenzo(c)phenanthrene to its K-region oxide by liver microsomes from 3-methylcholanthrene treated rats: Reversal of stereoselectivity of cytochrome P-450c due to the influence of fluoro group

  Biochemical and Biophysical Research Communications. 1991;181(3):1516-1523.
  0

• 50.

  1991

  Mark A. Patrick; Satinder K. Sethi; Steve E. Unger; Seid Mirsadeghi; Anthony A. Ribeiro; Dhiren R. Thakker

  A novel reaction between acetone and the benzo[c]phenanthrene K-region o-quinone containing a Peri-fluoro substituent

  Journal of Organic Chemistry. 1991;56(2):888-891.
  0

• 51.

  1989

  R.P. Iyer; L.R. Phillips; J.A. Biddle; D.R. Thakker; W. Egan

  Synthesis of acyloxyalkyl acylphosphonates as potential prodrugs of the antiviral, trisodium phosphonoformate (foscarnet sodium)

  Tetrahedron Letters. 1989;30(51):7141-7144.
  32

• 52.

  1989

  Seid Mirsadeghi; Ganesh K. B. Prasad; Noel Whittaker; Dhiren R. Thakker

  Synthesis of the K-region monofluoro- and difluorobenzo[c]phenanthrenes

  Journal of Organic Chemistry. 1989;54(13):3091-3096.
  8

• 53.

  1988

  G.K.B. Prasad; S. Mirsadeghi; C. Boehlert; R.A. Byrd; D.R. Thakker

  Oxidative metabolism of the carcinogen 6-fluorobenzo[c]phenanthrene. Effect of a K-region fluoro substituent on the regioselectivity of cytochromes P-450 in liver microsomes from control and induced rats

  Journal of Biological Chemistry. 1988;263(8):3676-3683.
  2

• 54.

  1988

  D.R. Thakker; C. Boehlert; S. Mirsadeghi; W. Levin; D.E. Ryan; P.E. Thomas; H. Yagi; L.K. Pannell; J.M. Sayer; et al.

  Differential stereoselectivity on metabolism of triphenylene by cytochromes P-450 in liver microsomes from 3-methylcholanthrene- and phenobarbital-treated rats

  Journal of Biological Chemistry. 1988;263(1):98-105.
  2

• 55.

  1987

  R.L. Chang; A.W. Wood; A.H. Conney; H. Yagi; J.M. Sayer; D.R. Thakker; D.M. Jerina; W. Levin

  Role of diaxial versus diequatorial hydroxyl groups in the tumorigenic activity of a benzo[a]pyrene bay-region diol epoxide.

  Proceedings of the National Academy of Sciences of the United States of America. 1987;84(23):8633-8636.
  22

• 56.

  1987

  P.J. van Bladeren; S.K. Balani; J.M. Sayer; D.R. Thakker; D.R. Boyd; D.E. Ryah; P.E. Thomas; W. Levin; D.M. Jerina

  Stereoselective formation of benzo(c)phenanthrene (+)-(3S,4R) and (+)-(5S,6R)-oxides by cytochrome P450c in a highly purified and reconstituted system

  Biochemical and Biophysical Research Communications. 1987;145(1):160-167.
  4

• 57.

  1987

  H. Yagi; J.M. Sayer; D.R. Thakker; W. Levin; D.M. Jerina

  Effects of a 6-fluoro substituent on the solvolytic properties of the diastereomeric 7,8-diol 9,10-epoxides of the carcinogen benzo[a]pyrene

  Journal of the American Chemical Society. 1987;109(3):838-846.
  13

• 58.

  1987

  Derek R. Boyd; Deirdre A. Kennedy; John F. Malone; Gerard A. O'Kane; Dhiren T. Thakker; Haruhiko Yagi; Donald M. Jerina

  Synthesis of triphenylene 1,2-oxide (1,2-epoxy-1,2-dihydrophenylene) and absolute configuration of the trans-1,2-dihydro diol metabolite of triphenylene. Crystal structure of (-)-(1R,2R)-trans-2-bromo-1-menthyloxyacetoxy-1,2,3,4- tetrahydrotriphenylene

  Journal of the Chemical Society, Perkin Transactions 1. 1987:369-375.
  0

• 59.

  1986

  W. Levin; R.L. Chang; A.W. Wood; D.R. Thakker; H. Yagi; D.M. Jerina; A.H. Conney

  Tumorigenicity of optical isomers of the diastereomeric bay-region 3,4-diol-1,2-epoxides of benzo(c)phenanthrene in murine tumor models

  Cancer Research. 1986;46(5):2257-2261.
  70

• 60.

  1986

  D.R. Thakker; C. Boehlert; K.L. Kirk; R. Antkowiak; C.R. Creveling

  Regioselectivity of catechol O-methyltransferase: The effect of pH on the site of O-methylation of fluorinated norepinephrines

  Journal of Biological Chemistry. 1986;261(1):178-184.
  13

• 61.

  1986

  D.R. Thakker; W. Levin; H. Yagi; H.J. Yeh; D.E. Ryan; P.E. Thomas; A.H. Conney; D.M. Jerina

  Stereoselective metabolism of the (+)-(S,S)- and (-)-(R,R)-enantiomers of trans-3,4-dihydroxy-3,4-dihydrobenzo[c]-phenanthrene by rat and mouse liver microsomes and by a purified and reconstituted cytochrome P-450 system

  Journal of Biological Chemistry. 1986;261(12):5404-5413.
  26

• 62.

  1985

  D.R. Thakker; C. Boehlert; W. Levin

  Metabolism of triphenylene by liver microsomes from control, phenobarbital(PB)-treated and 3-methylcholanthrene(MC)-treated rats

  Proceedings of the American Association for Cancer Research. 1985;VOL. 26:No. 448.
  0

• 63.

  1985

  D.R. Thakker; N. Shirai; W. Levin

  Metabolism of dibenz[c,h]acridine by rat liver microsomes and by cytochrome P450c with and without epoxide hydrolase

  Proceedings of the American Association for Cancer Research. 1985;VOL. 26:No. 449.
  1

• 64.

  1984

  D.R. Thakker; H. Yagi; J.M. Sayer; U. Kapur; W. Levin; R.L. Chang; A.W. Wood; A.H. Conney; D.M. Jerina

  Effects of a 6-fluoro substitutent on the metabolism of benzo(a)pyrene 7,8-dihydrodiol to bay-region diol epoxides by rat liver enzymes

  Journal of Biological Chemistry. 1984;259(18):11249-11256.
  7

• 65.

  1984

  W. Levin; R.L. Chang; A.W. Wood; H. Yagi; D.R. Thakker; D.M. Jerina; A.H. Conney

  High stereoselectivity among the optical isomers of the diastereomeric bay-region diol-epoxides of benz[a]anthracene in the expression of tumorigenic activity in murine tumor models

  Cancer Research. 1984;44(3):929-933.
  15

• 66.

  1983

  Wayne Levin; Alexander W. Wood; Richard L. Chang; Melvin S. Newman; Dhiren R. Thakker; Allan H. Conney; Donald M. Jerina

  The effect of steric strain in the bay-region of polycyclic aromatic hydrocarbons: Tumorigenicity of alkyl-substituted benz[a]anthracenes

  Cancer Letters. 1983;20(2):139-146.
  1

• 67.

  1983

  Y. Ittah; D.R. Thakker; W. Levin; M. Croisy-Delcey; D.E. Ryan; P.E. Thomas; A.H. Conney; D.M. Jerina

  Metabolism of benzo[c]phenanthrene by rat liver microsomes and by a purified monooxygenase system reconstituted with different isozymes of cytochrome P-450

  Chemico-Biological Interactions. 1983;45(1):15-28.
  16

• 68.

  1983

  A.W. Wood; R.L. Chang; W. Levin; H. Yagi; D.R. Thakker; P.J. van Bladeren; D.M. Jerina; A.H. Conney

  Mutagenicity of the enantiomers of the diastereomeric bay-region benz(a)anthracene 3,4-diol-1,2-epoxides in bacterial and mammalian cells

  Cancer Research. 1983;43(12 I):5821-5825.
  8

• 69.

  1983

  K.P. Vyas; P.J. van Bladeren; D.R. Thakker; H. Yagi; J.M. Sayer; W. Levin; D.M. Jerina

  Regioselectivity and stereoselectivity in the metabolism of trans-1,2-dihydroxy-1,2-dihydrobenz[a]anthracene by rat liver microsomes

  Molecular Pharmacology. 1983;24(1):115-123.
  5

• 70.

  1983

  D.R. Buhler; F. Unlu; D.R. Thakker; T.J. Slaga; A.H. Conney; A.W. Wood; R.L. Chang; W. Levin; D.M. Jerina

  Effect of 6-fluoro substituent on the metabolism and biological activity of benzo(a)pyrene

  Cancer Research. 1983;43(4):1541-1549.
  6

• 71.

  1983

  H. Yagi; D.R. Thakker; Y. Ittah; M. Croisy-Delcey; D.M. Jerina

  Synthesis and assignment of absolute configuration to the trans 3,4-dihydrodiols and 3,4-diol-1,2-epoxides of benzo[c]phenanthrene

  Tetrahedron Letters. 1983;24(13):1349-1352.
  20

• 72.

  1982

  P.J. van Bladeren; R.N. Armstrong; D. Cobb; D.R. Thakker; D.E. Ryan; P.E. Thomas; N.D. Sharma; D.R. Boyd; W. Levin; D.M. Jerina

  Stereoselective formation of benz[a]anthracene (+)-(5S,6R)-oxide and (+)-(8R,9S)-oxide by a highly purified and reconstituted system containing cytochrome P-450c

  Biochemical and Biophysical Research Communications. 1982;106(2):602-609.
  2

• 73.

  1982

  K.P. Vyas; W. Levin; H. Yagi; D.R. Thakker; D.E. Ryan; P.E. Thomas; A.H. Conney; D.M. Jerina

  Stereoselective metabolism of the (+)- and (-)-enantiomers of trans-1,2-dihydroxy-1,2-dihydrochrysene to bay-region 1,2-diol-3,4-epoxide diastereomers by rat liver enzymes

  Molecular Pharmacology. 1982;22(1):182-189.
  7

• 74.

  1982

  K.P. Vyas; D.R. Thakker; W. Levin; H. Yagi; A.H. Conney; D.M. Jerina

  Stereoselective metabolism of the optical isomers of trans-1,2-dihydroxy-1,2-dihydrophenanthrene to bay-region diol epoxides by rat liver microsomes

  Chemico-Biological Interactions. 1982;38(2):203-213.
  2

• 75.

  1982

  D.R. Thakker; W. Levin; H. Yagi; M. Tada; D.E. Ryan; P.E. Thomas; A.H. Conney; D.M. Jerina

  Stereoselective metabolism of the (+)- and (-)-enantiomers of trans-3,4-dihydrobenz[a]anthracene by rat liver microsomes and by a purified and reconstituted cytochrome P-450 system

  Journal of Biological Chemistry. 1982;257(9):5103-5110.
  14

• 76.

  1982

  W. Levin; A. Wood; R. Chang; D. Ryan; P. Thomas; H. Yagi; D. Thakker; K. Vyas; C. Boyd; S.Y. Chu; et al.

  Oxidative metabolism of polycyclic aromatic hydrocarbons to ultimate carcinogens

  Drug Metabolism Reviews. 1982;13(4):555-580.
  49

• 77.

  1982

  D.R. Buhler; F. Unlu; D.R. Thakker; T.J. Slaga; M.S. Newman; W. Levin; A.H. Conney; D.M. Jerina

  Metabolism and tumorigenicity of 7-, 8-, 9-, and 10-fluorobenz[a]pyrenes

  Cancer Research. 1982;42(11):4779-4783.
  4

• 78.

  1982

  Haruhiko Yagi; Kamlesh P. Vyas; Masao Tada; Dhiren R. Thakker; Donald M. Jerina

  Synthesis of the enantiomeric bay-region diol epoxides of benz[a]anthracene and chrysene

  Journal of Organic Chemistry. 1982;47(6):1110-1117.
  14

• 79.

  1981

  D.R. Thakker; W. Levin; H. Yagi; A.H. Conney; D.M. Jerina

  Regio- and stereoselectivity of hepatic cytochrome P-450 toward polycyclic aromatic hydrocarbon substrates.

  Advances in Experimental Medicine and Biology. 1981;136 Pt A:525-539.
  1

• 80.

  1981

  B. Kedzierski; D.R. Thakker; R.N. Armstrong; D.M. Jerina

  absolute configuration of the k-region 4,5-dihydrodiols and 4,5-oxide of benzo[a]pyrene

  Tetrahedron Letters. 1981;22(5):405-408.
  2

• 81.

  1981

  D.M. Jerina; J.M. Sayer; H. Yagi; M. Croisy-Delcey; Y. Ittah; D.R. Thakker; A.W. Wood; R.L. Chang; W. Levin; A.H. Conney

  Highly tumorigenic bay-region diol epoxides from the weak carcinogen benzo[c]phenanthrene.

  Advances in Experimental Medicine and Biology. 1981;136 Pt A:501-523.
  6

• 82.

  1981

  D.R. Thakker; W. Levin; M. Buening; et.al.

  Species-specific enhancement by 7,8-benzoflavone of hepatic microsomal metabolism of benzo[e]pyrene 9,10-dihydrodiol to bay-region diol epoxides

  Cancer Research. 1981;41(4):1389-1396.
  4

• 83.

  1981

  M. Nordqvist; D.R. Thakker; K.P. Vyas; H. Yagi; W. Levin; D.E. Ryan; P.E. Thomas; A.H. Conney; D.M. Jerina

  Metabolism of chrysene and phenanthrene to bay-region diol epoxides by rat liver enzymes

  Molecular Pharmacology. 1981;19(1):168-178.
  35

• 84.

  1981

  D.R. Thakker; W. Levin; H. Yagi

  Stereoselective metabolism of (+)- and (-)-benzo(a)anthracene 3,4-dihydrodiols by rat liver microsomes and a reconstituted cytochrome P-450 system

  Proceedings of the American Association for Cancer Research. 1981;Vol. 22:387.
  0

• 85.

  1980

  A.W. Wood; R.L. Chang; M.T. Huang; W. Levin; R.E. Lehr; S. Kumar; D.R. Thakker; H. Yagi; D.M. Jerina; A.H. Conney

  Mutagenicity of benzo(e)pyrene and triphenylene tetrahydroepoxides and diol-epoxides in bacterial and mammalian cells

  Cancer Research. 1980;40(6):1985-1989.
  4

• 86.

  1980

  W. Levin; M.K. Buening; A.W. Wood; R.L. Chang; B. Kedzierski; D.R. Thakker; D.R. Boyd; G.S. Gadaginamath; R.N. Armstrong; H. Yagi; et al.

  An enantiomeric interaction in the metabolism and tumorigenicity of (+)- and (-)-benzo[a]pyrene 7,8-oxide

  Journal of Biological Chemistry. 1980;255(19):9067-9074.
  16

• 87.

  1979

  Dale L. Whalen; Angela M. Ross; Jean A. Montemarano; Dhiren R. Thakker; Harukiko Yagi; Donald M. Jerina

  General acid catalysis in the hydrolysis of benzo[a]pyrene 7,8-diol 9,10-epoxides [19]

  Journal of the American Chemical Society. 1979;101(17):5086-5088.
  10

• 88.

  1979

  Haruhiko Yagi; Dhiren R. Thakker; Roland E. Lehr; Donald M. Jerina

  Benzo-ring diol epoxides of benzo[e]pyrene and triphenylene

  Journal of Organic Chemistry. 1979;44(19):3439-3442.
  4

• 89.

  1979

  D.R. Thakker; W. Levin; S. Turujman

  Absolute stereochemistry of the trans dihydrodiols formed from benzo[a]anthracene (BA) by rat liver microsomes

  Proceedings of the American Association for Cancer Research. 1979;Vol. 20:No. 898.
  0

• 90.

  1979

  D.R. Thakker; W. Levin; H. Yagi; S. Turujman; D. Kapadia; A.H. Conney; D.M. Jerina

  Absolute stereochemistry of the trans-dihydrodiols formed from benzo[a]anthracene by liver microsomes

  Chemico-Biological Interactions. 1979;27(2-3):145-161.
  4

• 91.

  1979

  M. Nordqvist; D.R. Thakker; W. Levin; H. Yagi; D.E. Ryan; P.E. Thomas; A.H. Conney; D.M. Jerina

  The highly tumorigenic 3,4-dihydrodiol is a principal metabolite formed from dibenzo[a,h]anthracene by liver enzymes

  Molecular Pharmacology. 1979;16(2):643-655.
  10

• 92.

  1979

  W. Levin; M.K. Buening; A.W. Wood; R.L. Chang; D.R. Thakker; D.M. Jerina; A.H. Conney

  Tumorigenic activity of 3-methylcholanthrene metabolites on mouse skin and in newborn mice

  Cancer Research. 1979;39(9):3549-3553.
  8

• 93.

  1979

  P.G. Wislocki; M.K. Buening; W. Levin; R.E. Lehr; D.R. Thakker; D.M. Jerina; A.H. Conney

  Tumorigenicity of the diastereomeric benz[a]anthracene 3,4-diol-1,2-epoxides and the (+)- and (-)-enantiomers of benz[a]anthracene 3,4-dihydrodiol in newborn mice

  Journal of the National Cancer Institute. 1979;63(1):201-204.
  6

• 94.

  1979

  A.W. Wood; W. Levin; D.R. Thakker; H. Yagi; R.L. Chang; D.E. Ryan; P.E. Thomas; P.M. Dansette; N. Whittaker; S. Turujman; et al.

  Biological activity of benzo[e]pyrene. An assessment based on mutagenic activities and metabolic profiles of the polycyclic hydrocarbon and its derivatives

  Journal of Biological Chemistry. 1979;254(11):4408-4415.
  13

• 95.

  1979

  D.R. Thakker; W. Levin; H. Yagi; D. Ryan; P.E. Thomas; J.M. Karle; R.E. Lehr; D.M. Jerina; A.H. Conney

  Metabolism of Benzo[a]anthracene to its tumorigenic 3,4-dihydrodiol.

  Molecular Biology. 1979;15(1):138-153.
  3

• 96.

  1979

  R.L. Chang; A.W. Wood; W. Levin; H.D. Mah; D.R. Thakker; D.M. Jerina; A.H. Conney

  Differences in mutagenicity and cytotoxicity of (+) and (-) benzo[a]pyrene 4,5-oxide: A synergistic interaction of enantiomers

  Proceedings of the National Academy of Sciences of the United States of America. 1979;76(9):4280-4284.
  2

• 97.

  1978

  D.R. Thakker; W. Levin; A.W. Wood

  9,10-Dihydrodiols of 1-hydroxy-3-methylcholanthrene: potential proximate carcinogens derived from 3-methylcholanthrene

  Proceedings of the American Association for Cancer Research. 1978;Vol. 19:No. 800.
  0

• 98.

  1978

  D.R. Thakker; H. Yagi; R.E. Lehr; W. Levin; M. Buening; A.Y. Lu; R.L. Chang; A.W. Wood; A.H. Conney; D.M. Jerina

  Metabolism of trans-9, 10-dihydroxy-9, 10-dihydrobenzo[a]pyrene occurs primarily by arylhydroxylation rather than formation of a diol epoxide

  Molecular Pharmacology. 1978;14(3):502-513.
  7

• 99.

  1978

  Dhiren R. Thakker; Haruhiko Yagi; Donald M. Jerina

  [28] Analysis of polycyclic aromatic hydrocarbons and their metabolites by high-pressure liquid chromatography

  Methods in Enzymology. 1978;52(C):279-296.
  2

• 100.

  1978

  D.R. Thakker; W. Levin; A.W. Wood; A.H. Conney; T.A. Stoming; D.M. Jerina

  Metabolic formation of 1,9,10-trihydroxy-9,10-dihydro-3-methylcholanthrene: A potential proximate carcinogen from 3-methylcholanthrene [17]

  Journal of the American Chemical Society. 1978;100(2):645-647.
  3

• 101.

  1978

  J. Kapitulnik; P.G. Wislocki; W. Levin; H. Yagi; D.R. Thakker; H. Akagi; M. Koreeda; D.M. Jerina; A.H. Conney

  Marked differences in the carcinogenic activity of optically pure (+)- and (-)trans-7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene in newborn mice

  Cancer Research. 1978;38(9):2661-2665.
  10

• 102.

  1978

  W. Levin; D.R. Thakker; A.W. Wood; R.L. Chang; R.E. Lehr; D.M. Jerina; A.H. Conney

  Evidence that benzo(a)anthracene 3,4-diol-1,2-epoxide is an ultimate carcinogen on mouse skin

  Cancer Research. 1978;38(6):1705-1710.
  11

• 103.

  1978

  A.W. Wood; R.L. Chang; W. Levin; P.E. Thomas; D. Ryan; T.A. Stoming; D.R. Thakker; D.M. Jerina; A.H. Conney

  Metabolic activation of 3-methylcholanthrene and its metabolites to products mutagenic to bacterial and mammalian cells

  Cancer Research. 1978;38(10):3398-3404.
  11

• 104.

  1978

  D.R. Thakker; H. Yagi; R.E. Lehr

  Metabolism and biological activity of benzo[a]pyrene 9,10-dihydrodiol

  Federation Proceedings. 1978;37(3):No.2811.
  0

• 105.

  1978

  D.M. Jerina; D.R. Thakker; H. Yagi

  Carcinogenicity of benzo[a]pyrene derivatives: The bay region theory

  Pure and Applied Chemistry. 1978;50(9-10):1033-1044.
  0

• 106.

  1978

  M.K. Buening; P.G. Wislocki; H. Levin; H. Yagi; D.R. Thakker; H. Akagi; M. Koreeda; D.M. Jerina; A.H. Conney

  Tumorigenicity of the optical enantiomers of the diastereomeric benzo[a]pyrene 7,8-diol-9,10-epoxides in newborn mice: exceptional activity of (+)-7β,8α-dihydroxy-9α,10α-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene

  Proceedings of the National Academy of Sciences of the United States of America. 1978;75(11):5358-5361.
  196

• 107.

  1977

  Ronald T Borchardt; Dhiren R Thakker

  [64] Labeling of catechol-O-methyltransferase with N-haloacetyl derivatives

  Methods in Enzymology. 1977;46(C):554-561.
  0

• 108.

  1977

  H. Yagi; H. Akagi; D.R. Thakker; H.D. Mah; M. Koreeda; D.M. Jerina

  Absolute stereochemistry of the highly mutagenic 7,8-diol 9,10-epoxides derived from the potent carcinogen trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene [15]

  Journal of the American Chemical Society. 1977;99(7):2358-2359.
  30

• 109.

  1977

  E. Bresnick; J.B. Vaught; D.R. Thakker

  Nuclear metabolism of benzo(a)pyrene (BP) and of (±)trans 7,8 dihydroxy 7,8 dihydro BP: chromatographic analysis of aralkylated DNA

  Proceedings of the American Association for Cancer Research. 1977;Vol. 18:No. 132.
  0

• 110.

  1977

  H. Yagi; D.R. Thakker; O. Hernandez; M. Koreeda; D.M. Jerina

  Synthesis and reactions of the highly mutagenic 7,8-diol 9,10-epoxides of the carcinogen benzo[a]pyrene

  Journal of the American Chemical Society. 1977;99(5):1604-1611.
  67

• 111.

  1977

  D.R. Thakker; H. Yagi; H. Akagi; M. Koreeda; A.H. Lu; W. Levin; A.W. Wood; A.H. Conney; D.M. Jerina

  Metabolism of benzo[a]pyrene. VI. Stereoselective metabolism of benzo[a]pyrene and benzo[a]pyrene 7,8 dihydrodiol to diol epoxides

  Chemico-Biological Interactions. 1977;16(3):281-300.
  39

• 112.

  1977

  A.W. Wood; R.L. Chang; W. Levin; H. Yagi; D.R. Thakker; D.M. Jerina; A.H. Conney

  Differences in mutagenicity of the optical enantiomers of the diastereomeric benzo[a]pyrene 7,8-diol-9,10-epoxides

  Biochemical and Biophysical Research Communications. 1977;77(4):1389-1396.
  57

• 113.

  1977

  D.R. Thakker; H. Yagi; W. Levin; A.Y. Lu; A.H. Conney; D.M. Jerina

  Stereospecificity of microsomal and purified epoxide hydrase from rat liver. Hydration of arene oxides of polycyclic hydrocarbons

  Journal of Biological Chemistry. 1977;252(18):6328-6334.
  23

• 114.

  1977

  E. Bresnick; T.A. Stoming; J.B. Vaught; D.R. Thakker; D.M. Jerina

  Nuclear metabolism of benzo(a)pyrene and of (±)-trans-7,8-dihydroxy-7,8,-dihydrobenzo(a)pyrene. Comparative chromatographic analysis of alkylated DNA

  Archives of Biochemistry and Biophysics. 1977;183(1):31-37.
  5

• 115.

  1977

  Dale L. Whalen; Jean A. Montemarano; Dhiren R. Thakker; Haruhiko Yagi; Donald M. Jerina

  Changes of mechanisms and product distributions in the hydrolysis of benzo[a]pyrene-7,8-diol 9,10-epoxide metabolites induced by changes in pH [30]

  Journal of the American chemical society. 1977;99(16):5522-5524.
  23

• 116.

  1977

  H. Yagi; D.R. Thakker; O. Hernandez; M. Koreeda; D.M. Jerina

  Erratum: Synthesis and reactions of the highly mutagenic 7,8-diol 9,10-epoxides of the carcinogen benzo[a]pyrene (Journal of the American Chemical Society (1977) 99, (1604))

  Journal of the American Chemical Society. 1977;99(15):5228.
  0

• 117.

  1976

  D.R. Thakker; H. Yagi; A.Y.H. Lu; W. Levin; A.H. Conney

  Metabolism of benzo[a]pyrene: Conversion of (±) trans 7,8 dihydroxy 7,8 dihydrobenzo[a]pyrene to highly mutagenic 7,8 diol 9,10 epoxides

  Proceedings of the National Academy of Sciences of the United States of America. 1976;73(10):3381-3385.
  36

• 118.

  1976

  Ronald T. Borchardt; Dhiren R. Thakker; Victor D. Warner; Dale B. Mirth; Jayant N. Sane

  Catechol O-methyltransferase. 8. Structure-activity relationships for inhibition by 8-hydroxyquinolines

  Journal of Medicinal Chemistry. 1976;19(4):558-560.
  2

• 119.

  1976

  R.T. Borchardt; D.R. Thakker

  Evidence for sulfhydryl groups at the active site of catechol O methyltransferase

  Biochimica et Biophysica Acta. 1976;445(3):598-609.
  0

• 120.

  1976

  R.T. Borchardt; J.R. Reid; D.R. Thakker; Y.O. Liang; R.W. Wightman; R.N. Adams

  Catechol O-methyltransferase. 9. Mechanism of inactivation by 6-hydroxydopamine

  Journal of Medicinal Chemistry. 1976;19(10):1201-1209.
  6

• 121.

  1975

  Ronald T. Borchardt; Dhiren R. Thakker

  Catechol O-methyltransferase. 6. Affinity labeling with N-haloacetyl-3,5-dimethoxy-4-hydroxyphenylalkylamines

  Journal of Medicinal Chemistry. 1975;18(2):152-158.
  2

• 122.

  1975

  R.T. Borchardt; C.F. Cheng; D.R. Thakker

  Purification of catechol o methyltransferase by affinity chromatography

  Biochemical and Biophysical Research Communications. 1975;63(1):69-77.
  1

• 123.

  1975

  Ronald T. Borchardt; Dhiren R. Thakker

  Affinity labeling of catechol o-methyltransferase by N-haloacetyl derivatives of 3,5-dimethoxy-4-hydroxyphenylethylamine and 3,4-dimethoxy-5-hydroxyphenylethylamine. kinetics of inactivation

  Biochemistry. 1975;14(20):4543-4551.
  2

• 124.

  1973

  R.T. Borchardt; D. Thakker

  Affinity labeling of catechol O methyltransferase with N iodoacetyl 3,5 dimethoxy 4 hydroxyphenylethylamine

  Biochemical and Biophysical Research Communications. 1973;54(3):1233-1239.
  0