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Kuo-Hsiung Lee

• Organizations
  University of North Carolina at Chapel Hill
  
  Eshelman School of Pharmacy
  
  Pharmacy
  
  

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This is a list of publications by this researcher, listed chronologically starting with the most recent first. New publications appear in this list weekly. The source of publications and 'cited by' data for this application is Scopus.

• 1.

  2013

  Qi Wang; Tzu-Hsuan Chen; Kenneth F. Bastow; Susan L. Morris-Natschke; Kuo-Hsiung Lee; Dao-Feng Chen

  Songaricalarins A-E, cytotoxic oplopane sesquiterpenes from Ligularia songarica

  Journal of Natural Products. 2013;76(3):305-310.
  0

• 2.

  2013

  Zhao Dang; Phong Ho; Lei Zhu; Keduo Qian; Kuo-Hsiung Lee; Li Huang; Chin-Ho Chen

  New betulinic acid derivatives for bevirimat-resistant human immunodeficiency virus type-1

  Journal of Medicinal Chemistry. 2013;56(5):2029-2037.
  0

• 3.

  2013

  Ying-Qian Liu; Xiao-Jing Li; Chun-Yan Zhao; Xiang Nan; Jing Tian; Susan L. Morris-Natschke; Zhi-Jun Zhang; Xiao-Ming Yang; Liu Yang; Lin-Hai Li; et al.

  Synthesis and mechanistic studies of novel spin-labeled combretastatin derivatives as potential antineoplastic agents

  Bioorganic and Medicinal Chemistry. 2013;21(5):1248-1256.
  0

• 4.

  2013

  Min Chen; Xiumei Xu; Bing Xu; Panpan Yang; Zhihua Liao; Susan L. Morris-Natschke; Kuo-Hsiung Lee; Daofeng Chen

  Neglschisandrins E-F: Two new lignans and related cytotoxic lignans from Schisandra neglecta

  Molecules. 2013;18(2):2297-2306.
  0

• 5.

  2013

  Shih-Ming Huang; Yung-Yi Cheng; Ming-Hua Chen; Chi-Hung Huang; Li-Jiau Huang; Mei-Hua Hsu; Sheng-Chu Kuo; Kuo-Hsiung Lee

  Design and synthesis of 2-(3-alkylaminophenyl)-6-(pyrrolidin-1-yl)quinolin- 4-ones as potent antitumor agents

  Bioorganic and Medicinal Chemistry Letters. 2013;23(3):699-701.
  0

• 6.

  2013

  Xiao-Feng Wang; Emika Ohkoshi; Sheng-Biao Wang; Ernest Hamel; Kenneth F. Bastow; Susan L. Morris-Natschke; Kuo-Hsiung Lee; Lan Xie

  Synthesis and biological evaluation of N-alkyl-N-(4-methoxyphenyl)pyridin- 2-amines as a new class of tubulin polymerization inhibitors

  Bioorganic and Medicinal Chemistry. 2013;21(3):632-642.
  0

• 7.

  2012

  Ying-Qian Liu; Wei Dai; Chih-Ya Wang; Susan L. Morris-Natschke; Xing-Wen Zhou; Liu Yang; Xiao-Ming Yang; Wen-Qun Li; Kuo-Hsiung Lee

  Design and one-pot synthesis of new 7-acyl camptothecin derivatives as potent cytotoxic agents

  Bioorganic and Medicinal Chemistry Letters. 2012;22(24):7659-7661.
  0

• 8.

  2012

  Yingqian Liu; Keduo Qian; Chih-Ya Wang; Chin-Ho Chen; Xiaoming Yang; Kuo-Hsiung Lee

  Synthesis and biological evaluation of novel spin labeled 18β-glycyrrhetinic acid derivatives

  Bioorganic and Medicinal Chemistry Letters. 2012;22(24):7530-7533.
  0

• 9.

  2012

  Hsin-Yi Hung; Emika Ohkoshi; Masuo Goto; Kyoko Nakagawa-Goto; Kuo-Hsiung Lee

  1-(3,4,5-Trimethoxyphenyl)ethane-1,2-diyl esters, a novel compound class with potent chemoreversal activity

  Bioorganic and Medicinal Chemistry Letters. 2012;22(24):7726-7729.
  0

• 10.

  2012

  Ying Wang; Hui-Chyn Wong; Elizabeth A. Gullen; Wing Lam; Xiaoming Yang; Qian Shi; Kuo-Hsiung Lee; Yung-Chi Cheng

  Cryptopleurine Analogs with Modification of E Ring Exhibit Different Mechanism to Rac-Cryptopleurine and Tylophorine

  PLoS ONE. 2012;7(12).
  0

• 11.

  2012

  Zhao Dang; Kathy Jung; Keduo Qian; Kuo-Hsiung Lee; Li Huang; Chin-Ho Chen

  Synthesis of lithocholic acid derivatives as proteasome regulators

  ACS Medicinal Chemistry Letters. 2012;3(11):925-930.
  0

• 12.

  2012

  Xiao-Feng Wang; Xing-Tao Tian; Emika Ohkoshi; Bingjie Qin; Yi-Nan Liu; Pei-Chi Wu; Mann-Jen Hour; Hsin-Yi Hung; Keduo Qian; Rong Huang; et al.

  Design and synthesis of diarylamines and diarylethers as cytotoxic antitumor agents

  Bioorganic and Medicinal Chemistry Letters. 2012;22(19):6224-6228.
  1

• 13.

  2012

  De-Yang Shen; Chih-Hua Chao; Hsiu-Hui Chan; Guan-Jhong Huang; Tsong-Long Hwang; Chin-Yu Lai; Kuo-Hsiung Lee; Tran Dinh Thang; Tian-Shung Wu

  Bioactive constituents of Clausena lansium and a method for discrimination of aldose enantiomers

  Phytochemistry. 2012;82:110-117.
  0

• 14.

  2012

  Yung-Yi Cheng; Jai-Sing Yang; Shih-Chang Tsai; Chih-Chuang Liaw; Jing-Gung Chung; Li-Jiau Huang; Kuo-Hsiung Lee; Chi-Cheng Lu; Hsi-Cheng Chien; Minoru Tsuzuki; et al.

  The newly synthesized 2-(3-hydroxy-5-methoxyphenyl)-6,7- methylenedioxyquinolin-4-one triggers cell apoptosis through induction of oxidative stress and upregulation of the p38 MAPK signaling pathway in HL-60 human leukemia cells

  Oncology Reports. 2012;28(4):1482-1490.
  0

• 15.

  2012

  Keduo Qian; Ibrahim D. Bori; Chin-Ho Chen; Li Huang; Kuo-Hsiung Lee

  Anti-AIDS agents 90. novel C-28 modified bevirimat analogues as potent HIV maturation inhibitors

  Journal of Medicinal Chemistry. 2012;55(18):8128-8136.
  3

• 16.

  2012

  Lian-Qi Sun; Lei Zhu; Keduo Qian; Bingjie Qin; Li Huang; Chin Ho Chen; Kuo-Hsiung Lee; Lan Xie

  Design, synthesis, and preclinical evaluations of novel 4-substituted 1,5-diarylanilines as potent HIV-1 non-nucleoside reverse transcriptase inhibitor (NNRTI) drug candidates

  Journal of Medicinal Chemistry. 2012;55(16):7219-7229.
  1

• 17.

  2012

  Zhao Dang; Keduo Qian; Phong Ho; Lei Zhu; Kuo-Hsiung Lee; Li Huang; Chin-Ho Chen

  Synthesis of betulinic acid derivatives as entry inhibitors against HIV-1 and bevirimat-resistant HIV-1 variants

  Bioorganic and Medicinal Chemistry Letters. 2012;22(16):5190-5194.
  2

• 18.

  2012

  An-Shen Lin; Kyoko Nakagawa-Goto; Fang-Rong Chang; Donglei Yu; Susan L. Morris-Natschke; Chin-Chung Wu; Shu-Li Chen; Yang-Chang Wu; Kuo-Hsiung Lee

  Erratum: First total synthesis of protoapigenone and its analogues as potent cytotoxic agents (Journal of Medicinal Chemistry (2007) 50 (3921-3927) DOI: 10.1021/jm070363a)

  Journal of Medicinal Chemistry. 2012;55(15):6985.
  0

• 19.

  2012

  Xiaoming Yang; Qian Shi; Chin-Yu Lai; Chi-Yuan Chen; Emika Ohkoshi; Shuenn-Chen Yang; Chih-Ya Wang; Kenneth F. Bastow; Tian-Shung Wu; Shiow-Lin Pan; et al.

  Antitumor agents 295. E-ring hydroxylated antofine and cryptopleurine analogues as antiproliferative agents: Design, synthesis, and mechanistic studies

  Journal of Medicinal Chemistry. 2012;55(15):6751-6761.
  2

• 20.

  2012

  Li-Ting Wang; Shiow-Lin Pan; Tzu-Hsuan Chen; Yizhou Dong; Kuo-Hsiung Lee; Che-Ming Teng

  DYZ-2-90, a Novel Neo-tanshinlactone Ring-Opened Compound, Induces ERK-Mediated Mitotic Arrest and Subsequent Apoptosis by Activating JNK in Human Colorectal Cancer Cells

  ChemBioChem. 2012;13(11):1663-1672.
  0

• 21.

  2012

  Deyong Ye; Qian Shi; Chung-Hang Leung; Seung-Whan Kim; Shin-Young Park; Elizabeth A. Gullen; Zao Li Jiang; Hao Zhu; Susan L. Morris-Natschke; Yung-Chi Cheng; et al.

  Antitumor agents 294. Novel E-ring-modified camptothecin-4β-anilino- 4′-O-demethyl-epipodophyllotoxin conjugates as DNA topoisomerase i inhibitors and cytotoxic agents

  Bioorganic and Medicinal Chemistry. 2012;20(14):4489-4494.
  0

• 22.

  2012

  Jie Li; Hui Ming Hua; Yan Bo Tang; Shipeng Zhang; Emika Ohkoshi; Kuo-Hsiung Lee; Zhi Yan Xiao

  Synthesis and evaluation of novel podophyllotoxin analogs

  Bioorganic and Medicinal Chemistry Letters. 2012;22(13):4293-4295.
  1

• 23.

  2012

  Qian Shi; Koji Wada; Emika Ohkoshi; Li Lin; Rong Huang; Susan L. Morris-Natschke; Masuo Goto; Kuo-Hsiung Lee

  Antitumor agents 290. Design, synthesis, and biological evaluation of new LNCaP and PC-3 cytotoxic curcumin analogs conjugated with anti-androgens

  Bioorganic and Medicinal Chemistry. 2012;20(13):4020-4031.
  0

• 24.

  2012

  Chiao-Ting Yen; Kyoko Nakagawa-Goto; Tsong-Long Hwang; Susan L. Morris-Natschke; Kenneth F. Bastow; Yang-Chang Wu; Kuo-Hsiung Lee

  Design and synthesis of gambogic acid analogs as potent cytotoxic and anti-inflammatory agents

  Bioorganic and Medicinal Chemistry Letters. 2012;22(12):4018-4022.
  0

• 25.

  2012

  Hsin-Yi Hung; Emika Ohkoshi; Masuo Goto; Kenneth F. Bastow; Kyoko Nakagawa-Goto; Kuo-Hsiung Lee

  Antitumor agents. 293. Nontoxic dimethyl-4,4′-dimethoxy-5,6,5′, 6′-dimethylenedioxybiphenyl-2,2′-dicarboxylate (DDB) analogues chemosensitize multidrug-resistant cancer cells to clinical anticancer drugs

  Journal of Medicinal Chemistry. 2012;55(11):5413-5424.
  2

• 26.

  2012

  Ting Zhou; Emika Ohkoshi; Qian Shi; Kenneth F. Bastow; Kuo-Hsiung Lee

  Anti-AIDS agents 89. Identification of DCX derivatives as anti-HIV and chemosensitizing dual function agents to overcome P-gp-mediated drug resistance for AIDS therapy

  Bioorganic and Medicinal Chemistry Letters. 2012;22(9):3219-3222.
  0

• 27.

  2012

  Hsin-Yi Hung; Keduo Qian; Susan L. Morris-Natschke; Chau-Shin Hsu; Kuo-Hsiung Lee

  Recent discovery of plant-derived anti-diabetic natural products

  Natural Product Reports. 2012;29(5):580-606.
  6

• 28.

  2012

  Jiu Xiang Zhu; Dong Lei Yu; Wen Hua Huang; Lan Sun; Yang Lv; Qi Tai Zheng; Kuo Hsiung Lee; Jing Guang Yu

  Goniodilactone and gonioheptenolactone, two novel cytotoxic styryllactones from the leaves of Goniothalamus cheliensis

  Chinese Chemical Letters. 2012;23(5):583-586.
  0

• 29.

  2012

  Kai Xu; Zhiyan Xiao; Yan Bo Tang; Li Huang; Chin-Ho Chen; Emika Ohkoshi; Kuo-Hsiung Lee

  Design and synthesis of naphthoquinone derivatives as antiproliferative agents and 20S proteasome inhibitors

  Bioorganic and Medicinal Chemistry Letters. 2012;22(8):2772-2774.
  3

• 30.

  2012

  Ibrahim D. Bori; Hsin-Yi Hung; Keduo Qian; Chin-Ho Chen; Susan L. Morris-Natschke; Kuo-Hsiung Lee

  Anti-AIDS agents 88. Anti-HIV conjugates of betulin and betulinic acid with AZT prepared via click chemistry

  Tetrahedron Letters. 2012;53(15):1987-1989.
  2

• 31.

  2012

  Lian-Qi Sun; Bingjie Qin; Li Huang; Keduo Qian; Chin-Ho Chen; Kuo-Hsiung Lee; Lan Xie

  Optimization of 2,4-diarylanilines as non-nucleoside HIV-1 reverse transcriptase inhibitors

  Bioorganic and Medicinal Chemistry Letters. 2012;22(7):2376-2379.
  0

• 32.

  2012

  Yizhou Dong; Kyoko Nakagawa-Goto; Chin-Yu Lai; Susan L. Morris-Natschke; Kenneth F. Bastow; Yoon Kim; Eva Y.-H. P. Lee; Kuo-Hsiung Lee

  Antitumor agents. 289. Design, synthesis, and anti-breast cancer activity in vivo of 4-amino-2 H -benzo[ h ]chromen-2-one and 4-amino-7,8,9,10-tetrahydro- 2 h -benzo[ h ]chromen-2-one analogues with improved water solubility

  Journal of Natural Products. 2012;75(3):370-377.
  1

• 33.

  2012

  Mei-Hua Hsu; Chin-Yu Liu; Chiao-Min Lin; Yen-Jung Chen; Chun-Jen Chen; Yu-Fu Lin; Li-Jiau Huang; Kuo-Hsiung Lee; Sheng-Chu Kuo

  2-(3-Methoxyphenyl)-5-methyl-1,8-naphthyridin-4(1H)-one (HKL-1) induces G2/M arrest and mitotic catastrophe in human leukemia HL-60 cells

  Toxicology and Applied Pharmacology. 2012;259(2):219-226.
  2

• 34.

  2012

  Ying Chen; Hong-Rui Liu; Hong-Shan Liu; Ming Cheng; Peng Xia; Keduo Qian; Pei-Chi Wu; Chin-Yu Lai; Yi Xia; Zheng-Yu Yang; et al.

  Antitumor agents 292. Design, synthesis and pharmacological study of S- and O-substituted 7-mercapto- or hydroxy-coumarins and chromones as potent cytotoxic agents

  European Journal of Medicinal Chemistry. 2012;49:74-85.
  2

• 35.

  2012

  Chih-Ya Wang; An-Chi Tsai; Chieh-Yu Peng; Ya-Ling Chang; Kuo-Hsiung Lee; Che-Ming Teng; Shiow-Lin Pan

  Dehydrocostuslactone suppresses angiogenesis in vitro and in vivo through inhibition of AKT/GSK-3β and mtor signaling pathways

  PLoS ONE. 2012;7(2).
  1

• 36.

  2012

  Hui-Chi Huang; Chun-Tang Chiou; Ping-Chun Hsiao; Chia-Ching Liaw; Li-Jie Zhang; Chao-Lin Chang; Ih-Sheng Chen; Wen-Chi Chen; Kuo-Hsiung Lee; Yao-Haur Kuo

  Cytotoxic phenylpropanoids and a new triterpene, turformosinic acid, from Turpinia formosana nakai

  Molecules. 2012;17(2):1837-1851.
  0

• 37.

  2012

  Ying-Qian Liu; Emika Ohkoshi; Lin-Hai Li; Liu Yang; Kuo-Hsiung Lee

  Design, synthesis and cytotoxic activity of novel spin-labeled rotenone derivatives

  Bioorganic and Medicinal Chemistry Letters. 2012;22(2):920-923.
  3

• 38.

  2012

  M. Vijaya Bhaskar Reddy; Yuh-Chiang Shen; Emika Ohkoshi; Kenneth F. Bastow; Keduo Qian; Kuo-Hsiung Lee; Tian-Shung Wu

  Bis-chalcone analogues as potent NO production inhibitors and as cytotoxic agents

  European Journal of Medicinal Chemistry. 2012;47(1):97-103.
  0

• 39.

  2012

  Ting Zhou; Qian Shi; Chin-Ho Chen; Li Huang; Phong Ho; Susan L. Morris-Natschke; Kuo-Hsiung Lee

  Anti-AIDS agents 85. Design, synthesis, and evaluation of 1R,2R-dicamphanoyl-3,3-dimethyldihydropyrano-[2,3-c]xanthen-7(1H)-one (DCX) derivatives as novel anti-HIV agents

  European Journal of Medicinal Chemistry. 2012;47(1):86-96.
  2

• 40.

  2012

  Hsin-Yi Hung; Kyoko Nakagawa-Goto; Harukuni Tokuda; Akira Iida; Nobutaka Suzuki; Susan L. Morris-Natschke; Kuo-Hsiung Lee

  Cancer preventive agents 11. Novel analogs of dimethyl dicarboxylate biphenyl as potent cancer chemopreventive agents

  Pharmaceutical Biology. 2012;50(1):18-24.
  0

• 41.

  2012

  Koji Wada; Emika Ohkoshi; Susan L. Morris-Natschke; Kenneth F. Bastow; Kuo-Hsiung Lee

  Cytotoxic esterified diterpenoid alkaloid derivatives with increased selectivity against a drug-resistant cancer cell line

  Bioorganic and Medicinal Chemistry Letters. 2012;22(1):249-252.
  1

• 42.

  2012

  Mei-Chuan Chen; Shiow-Lin Pan; Qian Shi; Zhiyan Xiao; Kuo-Hsiung Lee; Tsai-Kun Li; Che-Ming Teng

  QS-ZYX-1-61 induces apoptosis through topoisomerase II in human non-small-cell lung cancer A549 cells

  Cancer Science. 2012;103(1):80-87.
  1

• 43.

  2012

  Tian-Shung Wu; Chung-Ren Su; Kuo-Hsiung Lee

  Cytotoxic and anti-HIV phenanthroindolizidine alkaloids from Cryptocarya chinensis

  Natural Product Communications. 2012;7(6):725-727.
  1

• 44.

  2011

  Joana Soares; Brian R. Keppler; Xihong Wang; Kuo-Hsiung Lee; Michael B. Jarstfer

  Ortho-Quinone tanshinones directly inhibit telomerase through an oxidative mechanism mediated by hydrogen peroxide

  Bioorganic and Medicinal Chemistry Letters. 2011;21(24):7474-7478.
  3

• 45.

  2011

  M. Vijaya Bhaskar Reddy; Wei-Jern Tsai; Keduo Qian; Kuo-Hsiung Lee; Tian-Shung Wu

  Structure-activity relationships of chalcone analogs as potential inhibitors of ADP- and collagen-induced platelet aggregation

  Bioorganic and Medicinal Chemistry. 2011;19(24):7711-7719.
  2

• 46.

  2011

  Shin-Ichiro Kurimoto; Yoshiki Kashiwada; Kuo-Hsiung Lee; Yoshihisa Takaishi

  Triterpenes and a triterpene glucoside from Dysoxylum cumingianum

  Phytochemistry. 2011;72(17):2205-2211.
  2

• 47.

  2011

  Chien-Ting Chen; Mei-Hua Hsu; Yung-Yi Cheng; Chin-Yu Liu; Li-Chen Chou; Li-Jiau Huang; Tian-Shung Wu; Xiaoming Yang; Kuo-Hsiung Lee; Sheng-Chu Kuo

  Synthesis and in vitro anticancer activity of 6,7-methylenedioxy (or 5-hydroxy-6-methoxy)-2-(substituted selenophenyl)quinolin-4-one analogs

  European Journal of Medicinal Chemistry. 2011;46(12):6046-6056.
  1

• 48.

  2011

  Jang-Chang Lee; Li-Chen Chou; Chi-Hung Huang; Jing-Gung Chung; Li-Jiau Huang; Kuo-Hsiung Lee; Mien-Chie Hung; Tzong-Der Way; Sheng-Chu Kuo

  CHM-1 induces apoptosis via p38-mediated upregulation of DR5 expression in human ovarian cancer SKOV3 cells

  European Journal of Pharmacology. 2011;670(1):96-104.
  2

• 49.

  2011

  Li Huang; Phong Ho; Jie Yu; Lei Zhu; Kuo-Hsiung Lee; Chin-Ho Chen

  Picomolar dichotomous activity of gnidimacrin against hiv-1

  PLoS ONE. 2011;6(10).
  1

• 50.

  2011

  Hong-Shan Liu; Shi-Qing Xu; Ming Cheng; Ying Chen; Peng Xia; Keduo Qian; Yi Xia; Zheng-Yu Yang; Chin-Ho Chen; Susan L. Morris-Natschke; et al.

  Anti-AIDS agents 87. New bio-isosteric dicamphanoyl-dihydropyranochromone (DCP) and dicamphanoyl-khellactone (DCK) analogues with potent anti-HIV activity

  Bioorganic and Medicinal Chemistry Letters. 2011;21(19):5831-5834.
  0

• 51.

  2011

  Ying Chen; Ming Cheng; Fa-Qiang Liu; Peng Xia; Keduo Qian; Donglei Yu; Yi Xia; Zheng-Yu Yang; Chin-Ho Chen; Susan L. Morris-Natschke; et al.

  Anti-AIDS agents 86. Synthesis and anti-HIV evaluation of 2′,3′-seco-3′-nor DCP and DCK analogues

  European Journal of Medicinal Chemistry. 2011;46(10):4924-4936.
  2

• 52.

  2011

  Shin-Ichiro Kurimoto; Yoshiki Kashiwada; Susan Lynne Morris-Natschke; Kuo-Hsiung Lee; Yoshihisa Takaishi

  Dyscusins A-C, three new steroids from the leaves of Dysoxylum cumingianum

  Chemical and Pharmaceutical Bulletin. 2011;59(10):1303-1306.
  1

• 53.

  2011

  Keduo Qian; Sang-Yong Kim; Hsin-Yi Hung; Li Huang; Chin-Ho Chen; Kuo-Hsiung Lee

  New betulinic acid derivatives as potent proteasome inhibitors

  Bioorganic and Medicinal Chemistry Letters. 2011;21(19):5944-5947.
  4

• 54.

  2011

  Shou-Fang Wu; Tsong-Long Hwang; Shu-Li Chen; Chin-Chung Wu; Emika Ohkoshi; Kuo-Hsiung Lee; Fang-Rong Chang; Yang-Chang Wu

  Bioactive components from the heartwood of Pterocarpus santalinus

  Bioorganic and Medicinal Chemistry Letters. 2011;21(18):5630-5632.
  2

• 55.

  2011

  Qiang Wang; Weidong Hu; Shuyang Wang; Zhenliang Pan; Le Tao; Xiaohe Guo; Keduo Qian; Chin-Ho Chen; Kuo-Hsiung Lee; Junbiao Chang

  Synthesis of new 2′-deoxy-2′-fluoro-4′-azido nucleoside analogues as potent anti-HIV agents

  European Journal of Medicinal Chemistry. 2011;46(9):4178-4183.
  1

• 56.

  2011

  Xiaoming Yang; Qian Shi; Shuenn-Chen Yang; Chi-Yuan Chen; Sung-Liang Yu; Kenneth F. Bastow; Susan L. Morris-Natschke; Pei-Chi Wu; Chin-Yu Lai; Tian-Shung Wu; et al.

  Antitumor agents 288: Design, synthesis, SAR, and biological studies of novel heteroatom-incorporated antofine and cryptopleurine analogues as potent and selective antitumor agents

  Journal of Medicinal Chemistry. 2011;54(14):5097-5107.
  11

• 57.

  2011

  Yoshihisa Asada; Aya Sukemori; Takashi Watanabe; Kuber J. Malla; Takafumi Yoshikawa; Wei Li; Kazuo Koike; Chin-Ho Chen; Toshiyuki Akiyama; Keduo Qian; et al.

  Stelleralides A-C, novel potent anti-HIV daphnane-type diterpenoids from stellera chamaejasm e L.

  Organic Letters. 2011;13(11):2904-2907.
  4

• 58.

  2011

  Sergio Rosselli; Maurizio Bruno; Antonella Maggio; Rosa Angela Raccuglia; Muhammad Safder; Chin-Yu Lai; Kenneth F. Bastow; Kuo-Hsiung Lee

  Cytotoxic geranylflavonoids from Bonannia graeca

  Phytochemistry. 2011;72(9):942-945.
  2

• 59.

  2011

  Ting-Chun Kuo; Po-Cheng Chiang; Chia-Chun Yu; Kyoko Nakagawa-Goto; Kenneth F. Bastow; Kuo-Hsiung Lee; Jih-Hwa Guh

  A unique P-glycoprotein interacting agent displays anticancer activity against hepatocellular carcinoma through inhibition of GRP78 and mTOR pathways

  Biochemical Pharmacology. 2011;81(9):1136-1144.
  4

• 60.

  2011

  Shih-Ming Huang; Jai-Sing Yang; Shih-Chang Tsai; Ming-Hua Chen; Mei-Hua Hsu; Hui-Yi Lin; Li-Chen Chou; Jo-Hua Chinag; Kuo-Hsiung Lee; Li-Jiau Huang; et al.

  The novel synthesized 2-(3-(methylamino)phenyl)-6-(pyrrolidin-1-yl) quinolin-4-one (Smh-3) compound induces G₂/M phase arrest and mitochondrial-dependent apoptotic cell death through inhibition of CDK1 and AKT activity in HL-60 human leukemia cells

  International Journal of Oncology. 2011;38(5):1357-1364.
  7

• 61.

  2011

  Hsiu-Hui Chan; Tsong-Long Hwang; Mopur Vijaya Bhaskar Reddy; Ding-Tzai Li; Keduo Qian; Kenneth F. Bastow; Kuo-Hsiung Lee; Tian-Shung Wu

  Bioactive constituents from the roots of panax japonicus var. major and development of a LC-MS/MS method for distinguishing between natural and artifactual compounds

  Journal of Natural Products. 2011;74(4):796-802.
  4

• 62.

  2011

  Yizhou Dong; Kyoko Nakagawa-Goto; Chin-Yu Lai; Susan L. Morris-Natschke; Kenneth F. Bastow; Kuo-Hsiung Lee

  Antitumor agents 287. Substituted 4-amino-2H-pyran-2-one (APO) analogs reveal a new scaffold from neo-tanshinlactone with in vitro anticancer activity

  Bioorganic and Medicinal Chemistry Letters. 2011;21(8):2341-2344.
  2

• 63.

  2011

  Zhao Dang; Andrew Lin; Phong Ho; Dominique Soroka; Kuo-Hsiung Lee; Li Huang; Chin-Ho Chen

  Synthesis and proteasome inhibition of lithocholic acid derivatives

  Bioorganic and Medicinal Chemistry Letters. 2011;21(7):1926-1928.
  4

• 64.

  2011

  M. Vijaya Bhaskar Reddy; Yuh-Chiang Shen; Jai-Sing Yang; Tsong-Long Hwang; Kenneth F. Bastow; Keduo Qian; Kuo-Hsiung Lee; Tian-Shung Wu

  New bichalcone analogs as NF-κB inhibitors and as cytotoxic agents inducing Fas/CD95-dependent apoptosis

  Bioorganic and Medicinal Chemistry. 2011;19(6):1895-1906.
  4

• 65.

  2011

  Kyoko Nakagawa-Goto; Pei-Chi Wu; Chin-Yu Lai; Ernest Hamel; Hao Zhu; Liying Zhang; Takashi Kozaka; Emika Ohkoshi; Masuo Goto; Kenneth F. Bastow; et al.

  Antitumor agents. 284. new desmosdumotin B analogues with bicyclic B-ring as cytotoxic and antitubulin agents

  Journal of Medicinal Chemistry. 2011;54(5):1244-1255.
  2

• 66.

  2011

  Zehao Huang; Yan Lu; Yinan Liu; Kenneth F. Bastow; Kuohsiung Lee; Daofeng Chen

  Kadsufolins A-D and related cytotoxic lignans from Kadsura oblongifolia

  Helvetica Chimica Acta. 2011;94(3):519-527.
  0

• 67.

  2011

  Yizhou Dong; Susan L. Morris-Natschke; Kuo-Hsiung Lee

  Biosynthesis, total syntheses, and antitumor activity of tanshinones and their analogs as potential therapeutic agents

  Natural Product Reports. 2011;28(3):529-542.
  10

• 68.

  2011

  Mei-Lin Yang; Ping-Chung Kuo; Tsong-Long Hwang; Wen-Fei Chiou; Keduo Qian; Chin-Yu Lai; Kuo-Hsiung Lee; Tian-Shung Wu

  Synthesis, in vitro anti-inflammatory and cytotoxic evaluation, and mechanism of action studies of 1-benzoyl-β-carboline and 1-benzoyl-3-carboxy-β-carboline derivatives

  Bioorganic and Medicinal Chemistry. 2011;19(5):1674-1682.
  9

• 69.

  2011

  Kyoko Nakagawa-Goto; Pei-Chi Wu; Kenneth F. Bastow; Shuenn-Chen Yang; Sung-Liang Yu; Hsuan-Yu Chen; Jau-Chen Lin; Masuo Goto; Susan L. Morris-Natschke; Pan-Chyr Yang; et al.

  Antitumor agents 283. Further elaboration of Desmosdumotin C analogs as potent antitumor agents: Activation of spindle assembly checkpoint as possible mode of action

  Bioorganic and Medicinal Chemistry. 2011;19(5):1816-1822.
  2

• 70.

  2011

  Lalit Oberoi; Toshiyuki Akiyama; Kuo-Hsiung Lee; Shi J. Liu

  The aqueous extract, not organic extracts, of Terminalia arjuna bark exerts cardiotonic effect on adult ventricular myocytes

  Phytomedicine. 2011;18(4):259-265.
  2

• 71.

  2011

  Bai-Bo Xie; Ming-Ying Shang; Xuan Wang; Shao-Qing Cai; Kuo-Hsiung Lee

  A new aristolochic acid derivative from Asarum himalaicum

  Yaoxue Xuebao. 2011;46(2):188-192.
  0

• 72.

  2011

  Yizhou Dong; Kyoko Nakagawa-Goto; Chin-Yu Lai; Yoon Kim; Susan L. Morris-Natschke; Eva Y.-H.P. Lee; Kenneth F. Bastow; Kuo-Hsiung Lee

  Antitumor agents 279. Structure-activity relationship and in vivo studies of novel 2-(furan-2-yl)naphthalen-1-ol (FNO) analogs as potent and selective anti-breast cancer agents

  Bioorganic and Medicinal Chemistry Letters. 2011;21(1):52-57.
  2

• 73.

  2011

  Li-Shian Shi; Chih-Hua Chao; De-Yang Shen; Hsiu-Hui Chan; Chou-Hsiung Chen; Yu-Ren Liao; Shwu-Jen Wu; Yann-Lii Leu; Yuh-Chiang Shen; Yao-Haur Kuo; et al.

  Biologically active constituents from the fruiting body of Taiwanofungus camphoratus

  Bioorganic and Medicinal Chemistry. 2011;19(1):677-683.
  4

• 74.

  2011

  Bai-Bo Xie; Ming-Ying Shang; Kuo-Hsiung Lee; Xuan Wang; Katsuko Komatsu; Shao-Qing Cai

  5-Methoxyaristololactam I, the first natural 5-substituted aristololactam from Asarum ichangense

  Natural Product Communications. 2011;6(1):11-14.
  0

• 75.

  2011

  Pu Zhang; Li Xu; Keduo Qian; Jun Liu; Luyong Zhang; Kuo-Hsiung Lee; Hongbin Sun

  Efficient synthesis and biological evaluation of epiceanothic acid and related compounds

  Bioorganic and Medicinal Chemistry Letters. 2011;21(1):338-341.
  0

• 76.

  2011

  Yizhou Dong; Kyoko Nakagawa-Goto; Chin-Yu Lai; Susan L. Morris-Natschke; Kenneth F. Bastow; Kuo-Hsiung Lee

  Antitumor agents 281. Design, synthesis, and biological activity of substituted 4-amino-7,8,9,10-tetrahydro-2H-benzo[h]chromen-2-one analogs (ATBO) as potent in vitro anticancer agents

  Bioorganic and Medicinal Chemistry Letters. 2011;21(1):546-549.
  0

• 77.

  2010

  Ting Zhou; Qian Shi; Kenneth F. Bastow; Kuo-Hsiung Lee

  Antitumor agents 286. Design, synthesis, and structure-activity relationships of 3'R,4'R -disubstituted-2',2'-dimethyldihydropyrano[2,3- f ]chromone (DSP) analogues as potent chemosensitizers to overcome multidrug resistance

  Journal of Medicinal Chemistry. 2010;53(24):8700-8708.
  6

• 78.

  2010

  Xingtao Tian; Bingjie Qin; Zhiyuan Wu; Xiaofeng Wang; Hong Lu; Susan L. Morris-Natschke; Chin Ho Chen; Shibo Jiang; Kuo-Hsiung Lee; Lan Xie

  Design, synthesis, and evaluation of diarylpyridines and diarylanilines as potent non-nucleoside HIV-1 reverse transcriptase inhibitors

  Journal of Medicinal Chemistry. 2010;53(23):8287-8297.
  11

• 79.

  2010

  Shwu-Jen Wu; Yann-Lii Leu; Chou-Hsiung Chen; Chih-Hua Chao; De-Yang Shen; Hsiu-Hui Chan; E-Jian Lee; Tian-Shung Wu; Yea-Hwey Wang; Yuh-Chiang Shen; et al.

  Camphoratins A-J, potent cytotoxic and anti-inflammatory triterpenoids from the fruiting body of Taiwanofungus camphoratus

  Journal of Natural Products. 2010;73(11):1756-1762.
  8

• 80.

  2010

  Li-Chen Chou; Meng-Tung Tsai; Mei-Hua Hsu; Sheng-Hung Wang; Tzong-Der Way; Chi-Hung Huang; Hui-Yi Lin; Keduo Qian; Yizhou Dong; Kuo-Hsiung Lee; et al.

  Design, synthesis, and preclinical evaluation of new 5,6- (or 6,7-) disubstituted-2-(fluorophenyl)quinolin-4-one derivatives as potent antitumor agents

  Journal of Medicinal Chemistry. 2010;53(22):8047-8058.
  11

• 81.

  2010

  Shi-Qing Xu; Xin Yan; Ying Chen; Peng Xia; Keduo Qian; Donglei Yu; Yi Xia; Zheng-Yu Yang; Susan L. Morris-Natschke; Kuo-Hsiung Lee

  Anti-AIDS agents 84. Synthesis and anti-human immunodeficiency virus (HIV) activity of 2′-monomethyl-4-methyl- and 1′-thia-4-methyl-(3′R, 4′R)-3′,4′-di-O-(S)-camphanoyl-(+)-cis-khellactone (DCK) analogs

  Bioorganic and Medicinal Chemistry. 2010;18(20):7203-7211.
  4

• 82.

  2010

  Chao-Lin Chang; Li-Jie Zhang; Ru Yin Chen; Li-Ming Yang Kuo; Jhih-Ping Huang; Hui-Chi Huang; Kuo-Hsiung Lee; Yang-Chang Wu; Yao-Haur Kuo

  Antioxidant and anti-inflammatory phenylpropanoid derivatives from calamus quiquesetinervius

  Journal of Natural Products. 2010;73(9):1482-1488.
  8

• 83.

  2010

  Yoshihide Usami; Kyoko Nakagawa-Goto; Jing-Yu Lang; Yoon Kim; Chin-Yu Lai; Masuo Goto; Nobuko Sakurai; Masahiko Taniguchi; Toshiyuki Akiyama; Susan L. Morris-Natschke; et al.

  Antitumor agents. 282. 2′-(R)-O-acetylglaucarubinone, a quassinoid from Odyendyea gabonensis as a potential anti-breast and anti-ovarian cancer agent

  Journal of Natural Products. 2010;73(9):1553-1558.
  6

• 84.

  2010

  Kyoko Nakagawa-Goto; Po-Cheng Chang; Chin-Yu Lai; Hsin-Yi Hung; Tzu-Hsuan Chen; Pei-Chi Wu; Hao Zhu; Alexander Sedykh; Kenneth F. Bastow; Kuo-Hsiung Lee

  Antitumor agents. 280. Multidrug resistance-selective desmosdumotin B analogues

  Journal of Medicinal Chemistry. 2010;53(18):6699-6705.
  5

• 85.

  2010

  Ting Zhou; Qian Shi; Chin-Ho Chen; Hao Zhu; Li Huang; Phong Ho; Kuo-Hsiung Lee

  Anti-AIDS agents 79. Design, synthesis, molecular modeling and structure-activity relationships of novel dicamphanoyl-2′,2′- dimethyldihydropyranochromone (DCP) analogs as potent anti-HIV agents

  Bioorganic and Medicinal Chemistry. 2010;18(18):6678-6689.
  11

• 86.

  2010

  Juan Xiong; Yoshiki Kashiwada; Chin-Ho Chen; Keduo Qian; Susan L. Morris-Natschke; Kuo-Hsiung Lee; Yoshihisa Takaishi

  Conjugates of betulin derivatives with AZT as potent anti-HIV agents

  Bioorganic and Medicinal Chemistry. 2010;18(17):6451-6469.
  1

• 87.

  2010

  Ting Zhou; Qian Shi; Kuo Hsing Lee

  Anti-AIDS agents 83. Efficient microwave-assisted one-pot preparation of angular 2,2-dimethyl-2H-chromone containing compounds

  Tetrahedron Letters. 2010;51(33):4382-4386.
  7

• 88.

  2010

  Shwu-Jen Wu; Hsiu-Hui Chan; Tsong-Long Hwang; Keduo Qian; Susan Morris-Natschke; Kuo-Hsiung Lee; Tian-Shung Wu

  Salviatalin A and salvitrijudin A, two diterpenes with novel skeletons from roots of Salvia digitaloides and anti-inflammatory evaluation

  Tetrahedron Letters. 2010;51(32):4287-4290.
  5

• 89.

  2010

  Li-Shian Shi; Yu-Ren Liao; Ming-Jai Su; An-Sheng Lee; Ping-Chung Kuo; Amooru G. Damu; Sheng-Chu Kuo; Han-Dong Sun; Kuo-Hsiung Lee; Tian-Shung Wu

  Cardiac glycosides from antiaris toxicaria with potent cardiotonic activity

  Journal of Natural Products. 2010;73(7):1214-1222.
  8

• 90.

  2010

  Yizhou Dong; Kyoko Nakagawa-Goto; Chin-Yu Lai; Susan L. Morris-Natschke; Kenneth F. Bastow; Kuo-Hsiung Lee

  Antitumor agents 278. 4-Amino-2H-benzo[h]chromen-2-one (ABO) analogs as potent in vitro anti-cancer agents

  Bioorganic and Medicinal Chemistry Letters. 2010;20(14):4085-4087.
  11

• 91.

  2010

  Qiang Wang; Yanfeng Li; Chuanjun Song; Keduo Qian; Chin-Ho Chen; Kuo-Hsiung Lee; Junbiao Chang

  Synthesis and anti-HIV activity of 2′-deoxy-2′-fluoro-4′-C-ethynyl nucleoside analogs

  Bioorganic and Medicinal Chemistry Letters. 2010;20(14):4053-4056.
  2

• 92.

  2010

  Takashi Kozaka; Kyoko Nakagawa-Goto; Qian Shi; Chin-Yu Lai; Ernest Hamel; Kenneth F. Bastow; Arnold Brossi; Kuo-Hsiung Lee

  Antitumor agents 273. Design and synthesis of N-alkyl-thiocolchicinoids as potential antitumor agents

  Bioorganic and Medicinal Chemistry Letters. 2010;20(14):4091-4094.
  2

• 93.

  2010

  Bingjie Qin; Xingkai Jiang; Hong Lu; Xingtao Tian; Florent Barbault; Li Huang; Keduo Qian; Chin-Ho Chen; Rong Huang; Shibo Jiang; et al.

  Diarylaniline derivatives as a distinct class of HIV-1 non-nucleoside reverse transcriptase inhibitors

  Journal of Medicinal Chemistry. 2010;53(13):4906-4916.
  10

• 94.

  2010

  Jian Tang; Keduo Qian; Bei-Na Zhang; Ying Chen; Peng Xia; Donglei Yu; Yi Xia; Zheng-Yu Yang; Chin-Ho Chen; Susan L. Morris-Natschke; et al.

  Anti-AIDS agents 82: Synthesis of seco-(3′R,4′R)-3′,4′-di-O-(S)-camphanoyl-(+)-cis-khellactone (DCK) derivatives as novel anti-HIV agents

  Bioorganic and Medicinal Chemistry. 2010;18(12):4363-4373.
  9

• 95.

  2010

  Li-Jie Zhang; Chun-Tang Chiou; Jing-Jy Cheng; Hui-Chi Huang; Li-Ming Yang Kuo; Chia-Chin Liao; Kenneth F. Bastow; Kuo-Hsiung Lee; Yao-Haur Kuo

  Cytotoxic polyisoprenyl benzophenonoids from garcinia subelliptica

  Journal of Natural Products. 2010;73(4):557-562.
  9

• 96.

  2010

  Keduo Qian; Reen-Yun Kuo; Chin-Ho Chen; Li Huang; Susan L. Morris-Natschke; Kuo-Hsiung Lee

  Anti-AIDS agents 81. design, synthesis, and structure-activity relationship study of betulinic acid and moronic acid derivatives as potent HIV maturation inhibitors

  Journal of Medicinal Chemistry. 2010;53(8):3133-3141.
  11

• 97.

  2010

  Xiaoming Yang; Qian Shi; Kenneth F. Bastow; Kuo-Hsiung Lee

  Antitumor agents. 274. A new synthetic strategy for E-ring SAR study of antofine and cryptopleurine analogues

  Organic Letters. 2010;12(7):1416-1419.
  21

• 98.

  2010

  Elizabeth R. Sharlow; Todd A. Lyda; Heidi C. Dodson; Gabriela Mustata; Meredith T. Morris; Stephanie S. Leimgruber; Kuo-Hsiung Lee; Yoshiki Kashiwada; David Close; John S. Lazo; et al.

  A target-based high throughput screen yields Trypanosoma brucei hexokinase small molecule inhibitors with antiparasitic activity

  PLoS Neglected Tropical Diseases. 2010;4(4).
  10

• 99.

  2010

  Kuo-Hsiung Lee

  Discovery and development of natural product-derived chemotherapeutic agents based on a medicinal chemistry approach

  Journal of Natural Products. 2010;73(3):500-516.
  62

• 100.

  2010

  Yizhou Dong; Qian Shi; Huei-Chen Pai; Chieh-Yu Peng; Shiow-Lin Pan; Che-Ming Teng; Kyoko Nakagawa-Goto; Donglei Yu; Yi-Nan Liu; Pei-Chi Wu; et al.

  Antitumor agents. 272. Structure-activity relationships and in vivo selective anti-breast cancer activity of novel neo-tanshinlactone analogues

  Journal of Medicinal Chemistry. 2010;53(5):2299-2308.
  19

• 101.

  2010

  Song-Lin Li; Jing-Zheng Song; Chun-Feng Qiao; Yan Zhou; Keduo Qian; Kuo-Hsiung Lee; Hong-Xi Xu

  A novel strategy to rapidly explore potential chemical markers for the discrimination between raw and processed Radix Rehmanniae by UHPLC-TOFMS with multivariate statistical analysis

  Journal of Pharmaceutical and Biomedical Analysis. 2010;51(4):812-823.
  20

• 102.

  2010

  Fang-Rong Chang; Yi-Chung Hsieh; Yung-Fu Chang; Kuo-Hsiung Lee; Yang-Chang Wu; Li-Kwan Chang

  Inhibition of the Epstein-Barr virus lytic cycle by moronic acid

  Antiviral Research. 2010;85(3):490-495.
  3

• 103.

  2010

  Jiawang Liu; Ming Zhao; Keduo Qian; Xiaoyi Zhang; Kuo-Hsiung Lee; Jianhui Wu; Yi-Nan Liu; Shiqi Peng

  Benzyl 1,2,3,5,11,11a-hexahydro-3,3-dimethyl-1-oxo-6H-imidazo[3′,4′:1,2]pyridin[3,4-b]indole-2-substituted acetates: One-pot-preparation, anti-tumor activity, docking toward DNA and 3D QSAR analysis

  Bioorganic and Medicinal Chemistry. 2010;18(5):1910-1917.
  1

• 104.

  2010

  Jin Tatsuzaki; Kyoko Nakagawa-Goto; Harukuni Tokuda; Kuo-Hsiung Lee

  Cancer preventive agents 10. Prenylated dehydrozingerone analogs as potent chemopreventive agents

  Journal of Asian Natural Products Research. 2010;12(3):227-232.
  2

• 105.

  2010

  Yu-Jen Kuo; Yu-Ching Yang; Li-Jie Zhang; Ming-Der Wu; Li-Ming Yang Kuo; Yuh-Chi Kuo; Syh-Yuan Hwang; Cheng-Jen Chou; Kuo-Hsiung Lee; et al.

  Flavanone and diphenylpropane glycosides and glycosidic acyl esters from viscum articulatum

  Journal of Natural Products. 2010;73(2):109-114.
  2

• 106.

  2010

  Qi Wang; Tzu-Hsuan Chen; Kenneth F. Bastow; Kuo-Hsiung Lee; Dao-Feng Chen

  Altaicalarins A-D, cytotoxic bisabolane sesquiterpenes from ligularia altaica

  Journal of Natural Products. 2010;73(2):139-142.
  4

• 107.

  2010

  Li-Chen Chou; Chien-Ting Chen; Jang-Chang Lee; Tzong-Der Way; Chi-Hung Huang; Shih-Ming Huang; Che-Ming Teng; Takao Yamori; Tian-Shung Wu; Chung-Ming Sun; et al.

  Synthesis and preclinical evaluations of 2-(2-fluorophenyl)-6,7- methylenedioxyquinolln-4-one monosodium phosphate (CHM-I-P-Na) as a potent antitumor agent

  Journal of Medicinal Chemistry. 2010;53(4):1616-1626.
  8

• 108.

  2010

  An-Chi Tsai; Shiow-Lin Pan; Hui-Lung Sun; Chih-Ya Wang; Chieh-Yu Peng; Shih-Wei Wang; Ya-Ling Chang; Sheng-Chu Kuo; Kuo-Hsiung Lee; Che-Ming Teng

  CHM-1, a new vascular targeting agent, induces apoptosis of human umbilical vein endothelial cells via p53-mediated death receptor 5 up-regulation

  Journal of Biological Chemistry. 2010;285(8):5497-5506.
  10

• 109.

  2010

  Chiao-Ting Yen; Kyoko Nakagawa-Goto; Tsong-Long Hwang; Pei-Chi Wu; Susan L. Morris-Natschke; Wan-Chun Lai; Kenneth F. Bastow; Fang-Rong Chang; Yang-Chang Wu; Kuo-Hsiung Lee

  Antitumor agents. 271: Total synthesis and evaluation of brazilein and analogs as anti-inflammatory and cytotoxic agents

  Bioorganic and Medicinal Chemistry Letters. 2010;20(3):1037-1039.
  6

• 110.

  2010

  Yizhou Dong; Qian Shi; Kyoko Nakagawa-Goto; Pei-Chi Wu; Susan L. Morris-Natschke; Arnold Brossi; Kenneth F. Bastow; Jing-Yu Lang; Mien-Chie Hung; Kuo-Hsiung Lee

  Antitumor agents 270. Novel substituted 6-phenyl-4H-furo[3,2-c]pyran-4-one derivatives as potent and highly selective anti-breast cancer agents

  Bioorganic and Medicinal Chemistry. 2010;18(2):803-808.
  8

• 111.

  2010

  Sergio Rosselli; Antonella Maria Maggio; Rosa Angela Raccuglia; Susan L. Morris-Natschke; Kenneth F. Bastow; Kuo-Hsiung Lee; Maurizio Bruno

  Acid rearrangment of epoxy-germacranolides and absolute configuration of 1β,10α-epoxy-salonitenolide

  Natural Product Communications. 2010;5(5):675-680.
  2

• 112.

  2010

  Yumi Nishiyama; Kinuko Iwasa; Suguru Okada; Sousuke Takeuchi; Masataka Moriyasu; Miyoko Kamigauchi; Junko Koyama; Atsuko Takeuchi; Harukuni Tokuda; Hye-Sook Kim; et al.

  Geranyl derivatives of isoquinoline alkaloids show increased biological activities

  Heterocycles. 2010;81(5):1193-1229.
  2

• 113.

  2009

  Zhao Dang; Weihong Lai; Keduo Qian; Phong Ho; Kuo-Hsiung Lee; Chin-Ho Chen; Li Huang

  Betulinic acid derivatives as human immunodeficiency virus type 2 (HIV-2) inhibitors

  Journal of Medicinal Chemistry. 2009;52(23):7887-7891.
  18

• 114.

  2009

  Chun-Jen Chen; Yen-Fang Wen; Pi-Tsan Huang; Mei-Hua Hsu; Kuo-Hsiung Lee; Mei-Hwai Chen; Wuu-Chian Shin; Li-Jiau Huang; Sheng-Chu Kuo

  2-(1-Hydroxethyl)-4,8-dihydrobenzo[1,2-b:5,4-b′]dithiophene-4,8-dione (BTP-11) enhances the ATRA-induced differentiation in human leukemia HL-60 cells

  Leukemia Research. 2009;33(12):1664-1669.
  0

• 115.

  2009

  Jianhui Wu; Ming Zhao; Keduo Qian; Kuo-Hsiung Lee; Susan Morris-Natschke; Shiqi Peng

  Novel N-(3-carboxyl-9-benzyl-β-carboline-1-yl)ethylamino acids: Synthesis, anti-tumor evaluation, intercalating determination, 3D QSAR analysis and docking investigation

  European Journal of Medicinal Chemistry. 2009;44(10):4153-4161.
  19

• 116.

  2009

  Xingtao Tian; Bingjie Qin; Hong Lu; Weihong Lai; Shibo Jiang; Kuo-Hsiung Lee; Chin Ho Chen; Lan Xie

  Discovery of diarylpyridine derivatives as novel non-nucleoside HIV-1 reverse transcriptase inhibitors

  Bioorganic and Medicinal Chemistry Letters. 2009;19(18):5482-5485.
  15

• 117.

  2009

  Xiaoming Yang; Qian Shi; Yi-Nan Liu; Guiyu Zhao; Kenneth F. Bastow; Jau-Chen Lin; Shuenn-Chen Yang; Pan-Chyr Yang; Kuo-Hsiung Lee

  Antitumor agents 268. Design, synthesis, and mechanistic studies of new 9-substituted phenanthrene-based tylophorine analogues as potent cytotoxic agents

  Journal of Medicinal Chemistry. 2009;52(16):5262-5268.
  13

• 118.

  2009

  Fei Huang; Ming Zhao; Xiaoyi Zhang; Chao Wang; Keduo Qian; Reen-Yen Kuo; Susan Morris-Natschke; Kuo-Hsiung Lee; Shiqi Peng

  Synthesis, DNA intercalation and 3D QSAR analysis of cis-2,4,5-trisubstituted-1,3-dithiolanes as a novel class of antitumor agents

  Bioorganic and Medicinal Chemistry. 2009;17(16):6085-6095.
  3

• 119.

  2009

  Chung-Ren Su; Sheau Farn Yeh; Chih Miem Liu; Amooru G. Damu; Tsung-Hsiao Kuo; Po-Cheng Chiang; Kenneth F. Bastow; Kuo-Hsiung Lee; Tian-Shung Wu

  Anti-HBV and cytotoxic activities of pyranocoumarin derivatives

  Bioorganic and Medicinal Chemistry. 2009;17(16):6137-6143.
  21

• 120.

  2009

  Yu-Hsun Chang; Mei-Hua Hsu; Sheng-Hung Wang; Li-Jiau Huang; Keduo Qian; Susan L. Morris-Natschke; Ernest Hamel; Sheng-Chu Kuo; Kuo-Hsiung Lee

  Design and synthesis of 2-(3-benzo[b]thienyl)-6,7-methylenedioxyquinolin-4- one analogues as potent antitumor agents that inhibit tubulin assembly

  Journal of Medicinal Chemistry. 2009;52(15):4883-4891.
  9

• 121.

  2009

  Kyoko Nakagawa-Goto; Koji Yamada; Masahiko Taniguchi; Harukuni Tokuda; Kuo-Hsiung Lee

  Cancer preventive agents 9. Betulinic acid derivatives as potent cancer chemopreventive agents

  Bioorganic and Medicinal Chemistry Letters. 2009;19(13):3378-3381.
  9

• 122.

  2009

  Chia-Lin Lee; Fang-Rong Chang; Pei-Wen Hsieh; Michael-Y. Chiang; Chin-Chung Wu; Zih-You Huang; Yu-Hsuan Lan; Mei Chen; Kuo-Hsiung Lee; Hsin-Fu Yen; et al.

  Erratum to "Cytotoxic ent-abietane diterpenes from Gelonium aequoreum" [Phytochemistry 69 (2008) 276-287] (DOI:10.1016/j.phytochem.2007.07.005)

  Phytochemistry. 2009;70(11-12):1478.
  0

• 123.

  2009

  Yizhou Dong; Qian Shi; Yi-Nan Liu; Xiang Wang; Kenneth F. Bastow; Kuo-Hsiung Lee

  Antitumor agents. 266. Design, synthesis, and biological evaluation of novel 2-(furan-2-yl)naphthalen-1-ol derivatives as potent and selective antibreast cancer agents

  Journal of Medicinal Chemistry. 2009;52(11):3586-3590.
  20

• 124.

  2009

  Keduo Qian; Donglei Yu; Chin-Ho Chen; Li Huang; Susan L. Morris-Natschke; Theodore J. Nitz; Karl Salzwedel; Mary Reddick; Graham P. Allaway; et al.

  Anti-AIDS agents. 78. Design, synthesis, metabolic stability assessment, and antiviral evaluation of novel betulinic acid derivatives as potent anti-human immunodeficiency virus (HIV) agents

  Journal of Medicinal Chemistry. 2009;52(10):3248-3258.
  26

• 125.

  2009

  Jau-Chen Lin; Shuenn-Chen Yang; Tse-Ming Hong; Sung-Liang Yu; Shi Qian; Wei Linyi; Hsuan-Yu Chen; Pan-Chyr Yang; Kuo-Hsiung Lee

  Phenanthrene-based tylophorine-1 (PBT-1) inhibits lung cancer cell growth through the Akt and NF-κB pathways

  Journal of Medicinal Chemistry. 2009;52(7):1903-1911.
  10

• 126.

  2009

  Keduo Qian; Susan L. Morris-Natschke; Kuo-Hsiung Lee

  HIV entry inhibitors and their potential in HIV therapy

  Medicinal Research Reviews. 2009;29(2):369-393.
  37

• 127.

  2009

  Kinuko Iwasa; Suguru Okada; Yumi Nishiyama; Sousuke Takeuchi; Masataka Moriyasu; Chisato Tode; Makiko Sugiura; Atsuko Takeuchi; Harukuni Tokuda; Kazuyoshi Takeda; et al.

  Geranyl derivatives of salsolinol show increased biological activities

  Heterocycles. 2009;77(2):1355-1369.
  1

• 128.

  2009

  Chia-Lin Lee; Fang-Rong Chang; Ming-Hon Yen; Donglei Yu; Yi-Nan Liu; Kenneth F. Bastow; Susan L. Morris-Natschke; Yang-Chang Wu; Kuo-Hsiung Lee

  Cytotoxic phenanthrenequinones and 9,10-dihydrophenanthrenes from Calanthe arisanensis

  Journal of Natural Products. 2009;72(2):210-213.
  5

• 129.

  2009

  Midori Takasaki; Takao Konoshima; Mutsuo Kozuka; Harukuni Tokuda; Junko Takayasu; Hoyoku Nishino; Masazumi Miyakoshi; Kenji Mizutani; Kuo-Hsiung Lee

  Cancer preventive agents. Part 8: Chemopreventive effects of stevioside and related compounds

  Bioorganic and Medicinal Chemistry. 2009;17(2):600-605.
  15

• 130.

  2009

  Q. Shi; C.C.-Y. Shih; Kuo-Hsiung Lee

  Novel anti-prostate cancer curcumin analogues that enhance androgen receptor degradation activity⁺

  Anti-Cancer Agents in Medicinal Chemistry. 2009;9(8):904-912.
  13

• 131.

  2009

  Sergio Rosselli; Antonella Maria Maggio; Nicoletta Faraone; Vivienne Spadaro; Susan L. Morris-Natschke; Kenneth F. Bastow; Kuo-Hsiung Lee; Maurizio Bruno

  The cytotoxic properties of natural coumarins isolated from roots of Ferulago campestris (Apiaceae) and of synthetic ester derivatives of aegelinol

  Natural Product Communications. 2009;4(12):1701-1706.
  7

• 132.

  2009

  Reen-Yen Kuo; Keduo Qian; Susan L. Morris-Natschke; Kuo-Hsiung Lee

  Plant-derived triterpenoids and analogues as antitumor and Anti-HIV agents

  Natural Product Reports. 2009;26(10):1321-1344.
  28

• 133.

  2009

  Yizhou Dong; Qian Shi; Kyoko Nakagawa-Goto; Pei-Chi Wu; Kenneth F. Bastow; Susan L. Morris-Natschke; Kuo-Hsiung Lee

  Antitumor agents 269. Non-aromatic ring-A neotanshinlactone analog, TNO, as a new class of potent antitumor agents

  Bioorganic and Medicinal Chemistry Letters. 2009;19(22):6289-6292.
  12

• 134.

  2008

  Lan Xie; Huan-Fang Guo; Hong Lu; Xiao-Mei Zhuang; An-Ming Zhang; Gang Wu; Jin-Xiu Ruan; Ting Zhou; Donglei Yu; Keduo Qian; et al.

  Development and preclinical studies of broad-spectrum anti-HIV agent (3′R,4′R)-3-cyanomethyl-4-methyl-3′,4′-di-O-(S) -camphanoyl-(+)-cis-khellactone (3-cyanomethyl-4-methyl-DCK)

  Journal of Medicinal Chemistry. 2008;51(24):7689-7696.
  7

• 135.

  2008

  Gang Wu; Huan-Fang Guo; Kun Gao; Yi-Nan Liu; Kenneth F. Bastow; Susan L. Morris-Natschke; Kuo-Hsiung Lee; Lan Xie

  Synthesis of unsymmetrical biphenyls as potent cytotoxic agents

  Bioorganic and Medicinal Chemistry Letters. 2008;18(19):5272-5276.
  10

• 136.

  2008

  Hideji Itokawa; Qian Shi; Toshiyuki Akiyama; Susan L. Morris-Natschke; Kuo-Hsiung Lee

  Recent advances in the investigation of curcuminoids

  Chinese Medicine. 2008;3.
  45

• 137.

  2008

  Chia-Lin Lee; Kyoko Nakagawa-Goto; Donglei Yu; Yi-Nan Liu; Kenneth F. Bastow; Susan L. Morris-Natschke; Fang-Rong Chang; Yang-Chang Wu; Kuo-Hsiung Lee

  Cytotoxic calanquinone A from Calanthe arisanensis and its first total synthesis

  Bioorganic and Medicinal Chemistry Letters. 2008;18(15):4275-4277.
  7

• 138.

  2008

  M. Vijaya Bhaskar Reddy; Chung-Ren Su; Wen-Fei Chiou; Yi-Nan Liu; Rosemary Yin-Hwa Chen; Kenneth F. Bastow; Kuo-Hsiung Lee; Tian-Shung Wu

  Design, synthesis, and biological evaluation of Mannich bases of heterocyclic chalcone analogs as cytotoxic agents

  Bioorganic and Medicinal Chemistry. 2008;16(15):7358-7370.
  28

• 139.

  2008

  Li Huang; Donglei Yu; Phong Ho; Keduo Qian; Kuo-Hsiung Lee; Chin-Ho Chen

  Synthesis and proteasome inhibition of glycyrrhetinic acid derivatives

  Bioorganic and Medicinal Chemistry. 2008;16(14):6696-6701.
  15

• 140.

  2008

  Hideji Itokawa; Susan L. Morris-Natschke; Toshiyuki Akiyama; Kuo-Hsiung Lee

  Plant-derived natural product research aimed at new drug discovery

  Journal of Natural Medicines. 2008;62(3):263-280.
  48

• 141.

  2008

  Kyoko Nakagawa-Goto; Kenneth F. Bastow; Tzu-Hsuan Chen; Susan L. Morris-Natschke; Kuo-Hsiung Lee

  Antitumor agents 260. New desmosdumotin B analogues with improved in vitro anticancer activity

  Journal of Medicinal Chemistry. 2008;51(11):3297-3303.
  10

• 142.

  2008

  Chung-Ren Su; Amooru G. Damu; Po-Cheng Chiang; Kenneth F. Bastow; Susan L. Morris-Natschke; Kuo-Hsiung Lee; Tian-Shung Wu

  Total synthesis of phenanthroindolizidine alkaloids (±)-antofine, (±)-deoxypergularinine, and their dehydro congeners and evaluation of their cytotoxic activity

  Bioorganic and Medicinal Chemistry. 2008;16(11):6233-6241.
  12

• 143.

  2008

  Yu Chen; Guohui Cui; Ming Zhao; Chao Wang; Keduo Qian; Susan Morris-Natschke; Kuo-Hsiung Lee; Shiqi Peng

  Synthesis, nano-scale assembly, and in vivo anti-thrombotic activity of novel short peptides containing l-Arg and l-Asp or l-Glu

  Bioorganic and Medicinal Chemistry. 2008;16(11):5914-5925.
  6

• 144.

  2008

  Chieh-Yu Peng; Shiow-Lin Pan; Kuo-Hsiung Lee; Kenneth F. Bastow; Che-Ming Teng

  Molecular mechanism of the inhibitory effect of KS-5 on bFGF-induced angiogenesis in vitro and in vivo

  Cancer Letters. 2008;263(1):114-121.
  5

• 145.

  2008

  An-Shen Lin; Keduo Qian; Yoshihide Usami; Li Lin; Hideji Itokawa; Charleson Hsu; Susan L. Morris-Natschke; Kuo-Hsiung Lee

  5-Hydroxymethyl-2-furfural, a clinical trials agent for sickle cell anemia, and its mono/di-glucosides from classically processed steamed Rehmanniae Radix

  Journal of Natural Medicines. 2008;62(2):164-167.
  15

• 146.

  2008

  Yoshihide Usami; Yi-Nan Liu; An-Shen Lin; Makro Shibano; Toshiyuki Akiyama; Hideji Itokawa; Susan L. Morris-Natschke; Kenneth Bastow; Ryoji Kasai; Kuo-Hsiung Lee

  Antitumor agents. 261. 20(S)-protopanaxadiol and 20(S)-protopanaxatriol as antiangiogenic agents and total assignment of ¹H NMR spectra

  Journal of Natural Products. 2008;71(3):478-481.
  19

• 147.

  2008

  Shih-Wei Wang; Shiow-Lin Pan; Yu-Chun Huang; Jih-Hwa Guh; Po-Cheng Chiang; Der-Yi Huang; Sheng-Chu Kuo; Kuo-Hsiung Lee; Che-Ming Teng

  CHM-1, a novel synthetic quinolone with potent and selective antimitotic antitumor activity against human hepatocellular carcinoma in vitro and in vivo

  Molecular Cancer Therapeutics. 2008;7(2):350-360.
  26

• 148.

  2008

  Wenli Gao; Annie Pei-Chun Chen; Chung-Hang Leung; Elizabeth A. Gullen; Alois Fürstner; Qian Shi; Linyi Wei; Kuo-Hsiung Lee; Yung-Chi Cheng

  Structural analogs of tylophora alkaloids may not be functional analogs

  Bioorganic and Medicinal Chemistry Letters. 2008;18(2):704-709.
  32

• 149.

  2008

  Chia-Lin Lee; Fang-Rong Chang; Pei-Wen Hsieh; Michael-Y. Chiang; Chin-Chung Wu; Zih-You Huang; Yu-Hsuan Lan; Mei Chen; Kuo-Hsiung Lee; Hsin-Fu Yen; et al.

  Cytotoxic ent-abietane diterpenes from Gelonium aequoreum

  Phytochemistry. 2008;69(1):276-287.
  10

• 150.

  2008

  Linyi Wei; Arnold Brossi; Susan L. Morris-Natschke; Kenneth F. Bastow; Kuo-Hsiung Lee

  Antitumor agents 248. Chemistry and antitumor activity of tylophorinerelated alkaloids

  Studies in Natural Products Chemistry. 2008;34(C):3-34.
  6

• 151.

  2007

  Ping-Chung Kuo; Yuh-Chiang Shen; Mei-Lin Yang; Su-Hui Wang; Dinh Thang Tran; Xuan Dung Nguyen; Po-Cheng Chiang; Kuo-Hsiung Lee; E.-Jian Lee; Tian-Shung Wu

  Crotonkinins A and B and related diterpenoids from Croton tonkinensis as anti-inflammatory and antitumor agents

  Journal of Natural Products. 2007;70(12):1906-1909.
  11

• 152.

  2007

  Keduo Qian; Kyoko Nakagawa-Goto; Donglei Yu; Susan L. Morris-Natschke; Theodore J. Nitz; Nicole Kilgore; Graham P. Allaway; Kuo-Hsiung Lee

  Anti-AIDS agents 73: Structure-activity relationship study and asymmetric synthesis of 3-O-monomethylsuccinyl-betulinic acid derivatives

  Bioorganic and Medicinal Chemistry Letters. 2007;17(23):6553-6557.
  16

• 153.

  2007

  An-Shen Lin; Makio Shibano; Kyoko Nakagawa-Goto; Harukuni Tokuda; Hideji Itokawa; Susan L. Morris-Natschke; Kuo-Hsiung Lee

  Cancer preventive agents. 7. Antitumor-promoting effects of seven active flavonolignans from milk thistle (Silybum marianum) on Epstein-Barr virus activation

  Pharmaceutical Biology. 2007;45(10):735-738.
  1

• 154.

  2007

  Shih-Wei Wang; Shiow-Lin Pan; Chieh-Yu Peng; Der-Yi Huang; An-Chi Tsai; Ya-Ling Chang; Jih-Hwa Guh; Sheng-Chu Kuo; Kuo-Hsiung Lee; Che-Ming Teng

  CHM-1 inhibits hepatocyte growth factor-induced invasion of SK-Hep-1 human hepatocellular carcinoma cells by suppressing matrix metalloproteinase-9 expression

  Cancer Letters. 2007;257(1):87-96.
  16

• 155.

  2007

  Madoka Suzuki; Donglei Yu; Susan L. Morris-Natschke; Philip C. Smith; Kuo-Hsiung Lee

  Anti-AIDS agents 66: Syntheses and anti-HIV activity of phenolic and aza 3′,4′-di-O-(-)-camphanoyl-(+)-cis-khellactone (DCK) derivatives

  Bioorganic and Medicinal Chemistry. 2007;15(21):6852-6858.
  5

• 156.

  2007

  Li Huang; Donglei Yu; Phong Ho; Kuo-Hsiung Lee; Chin-Ho Chen

  Synthesis and anti-HIV activity of Bif-functional triterpene derivatives

  Letters in Drug Design and Discovery. 2007;4(7):471-478.
  11

• 157.

  2007

  Kyoko Nakagawa-Goto; Koji Yamada; Seikou Nakamura; Tzu-Hsuan Chen; Po-Cheng Chiang; Kenneth F. Bastow; Shao-Chun Wang; Bill Spohn; Mien-Chie Hung; Fang-Yu Lee; et al.

  Antitumor agents. 258. Syntheses and evaluation of dietary antioxidant-taxoid conjugates as novel cytotoxic agents

  Bioorganic and Medicinal Chemistry Letters. 2007;17(18):5204-5209.
  17

• 158.

  2007

  Jin Tatsuzaki; Masahiko Taniguchi; Kenneth F. Bastow; Kyoko Nakagawa-Goto; Susan L. Morris-Natschke; Hideji Itokawa; Kimiye Baba; Kuo-Hsiung Lee

  Anti-tumor agents 255: Novel glycyrrhetinic acid-dehydrozingerone conjugates as cytotoxic agents

  Bioorganic and Medicinal Chemistry. 2007;15(18):6193-6199.
  29

• 159.

  2007

  Makio Shibano; An-Shen Lin; Hideji Itokawa; Kuo-Hsiung Lee

  Separation and characterization of active flavonolignans of Silybum marianum by liquid chromatography connected with hybrid ion-trap and time-of-flight mass spectrometry (LC-MS/IT-TOF)

  Journal of Natural Products. 2007;70(9):1424-1428.
  21

• 160.

  2007

  An-Shen Lin; Kyoko Nakagawa-Goto; Fang-Rong Chang; Donglei Yu; Susan L. Morris-Natschke; Chin-Chung Wu; Shu-Li Chen; Yang-Chang Wu; Kuo-Hsiung Lee

  First total synthesis of protoapigenone and its analogues as potent cytotoxic agents

  Journal of Medicinal Chemistry. 2007;50(16):3921-3927.
  22

• 161.

  2007

  Qi Wang; Qing Mu; Makio Shibano; Susan L. Morris-Natschke; Kuo-Hsiung Lee; Dao-Feng Chen

  Eremophilane sesquiterpenes from Ligularia macrophylla

  Journal of Natural Products. 2007;70(8):1259-1262.
  12

• 162.

  2007

  Li-Bo Zhou; Tzu-Hsuan Chen; Kenneth F. Bastow; Makio Shibano; Kuo-Hsiung Lee; Dao-Feng Chen

  Filiasparosides A-D, cytotoxic steroidal saponins from the roots of Asparagus filicinus

  Journal of Natural Products. 2007;70(8):1263-1267.
  12

• 163.

  2007

  Yang Wang; Shao-Xu Huang; Peng Xia; Yi Xia; Zheng-Yu Yang; Nicole Kilgore; Susan L. Morris-Natschke; Kuo-Hsiung Lee

  Anti-AIDS agents 72. Bioisosteres (7-carbon-DCKs) of the potent anti-HIV lead DCK

  Bioorganic and Medicinal Chemistry Letters. 2007;17(15):4316-4319.
  11

• 164.

  2007

  Linyi Wei; Qian Shi; Kenneth F. Bastow; Arnold Brossi; Susan L. Morris-Natschke; Kyoko Nakagawa-Goto; Tian-Shung Wu; Shiow-Lin Pan; Che-Ming Teng; Kuo-Hsiung Lee

  Antitumor agents 253. Design, synthesis, and antitumor evaluation of novel 9-substituted phenanthrene-based tylophorine derivatives as potential anticancer agents

  Journal of Medicinal Chemistry. 2007;50(15):3674-3680.
  22

• 165.

  2007

  Kyoko Nakagawa-Goto; Tzu-Hsuan Chen; Chieh-Yu Peng; Kenneth F. Bastow; Jiu-Hong Wu; Kuo-Hsiung Lee

  Antitumor agents 259. Design, syntheses, and structure-activity relationship study of desmosdumotin C analogs

  Journal of Medicinal Chemistry. 2007;50(14):3354-3358.
  6

• 166.

  2007

  Amooru G. Damu; Ping-Chung Kuo; Chung-Ren Su; Tsung-Hsiao Kuo; Tzu-Hsuan Chen; Kenneth F. Bastow; Kuo-Hsiung Lee; Tian-Shung Wu

  Isolation, structures, and structure-cytotoxic activity relationships of withanolides and physalins from Physalis angulata

  Journal of Natural Products. 2007;70(7):1146-1152.
  32

• 167.

  2007

  Kyoko Nakagawa-Goto; Seikou Nakamura; Kenneth F. Bastow; Alexander Nyarko; Chieh-Yu Peng; Fang-Yu Lee; Fang-Chen Lee; Kuo-Hsiung Lee

  Antitumor agents. 256. Conjugation of paclitaxel with other antitumor agents: Evaluation of novel conjugates as cytotoxic agents

  Bioorganic and Medicinal Chemistry Letters. 2007;17(10):2894-2898.
  20

• 168.

  2007

  Yen-Fang Wen; Kuo-Hsiung Lee; Pi-Tsan Huang; Mei-Hwai Chen; Wuu-Chian Shin; Li-Jiau Huang; Mei-Hua Hsu; Chun-Jen Chen; Sheng-Chu Kuo

  Cell differentiation enhancement by hydrophilic derivatives of 4,8-Dihydrobenzo[1,2-b:5,4-b′]dithiophene-4,8-diones in HL-60 leukemia cells

  Bioorganic and Medicinal Chemistry Letters. 2007;17(10):2908-2912.
  5

• 169.

  2007

  Sergio Rosselli; Maurizio Bruno; Antonella Maggio; Gabriella Bellone; Tzu-Hsuan Chen; Kenneth F. Bastow; Kuo-Hsiung Lee

  Cytotoxic activity of some natural and synthetic ent-kauranes

  Journal of Natural Products. 2007;70(3):347-352.
  8

• 170.

  2007

  Zhiming Wen; David E. Martin; Peter Bullock; Kuo-Hsiung Lee; Philip C. Smith

  Glucuronidation of anti-HIV drug candidate bevirimat: Identification of human UDP-glucuronosyltransferases and species differences

  Drug Metabolism and Disposition. 2007;35(3):440-448.
  25

• 171.

  2007

  Shuxing Zhang; Linyi Wei; Ken Bastow; Weifan Zheng; Arnold Brossi; Kuo-Hsiung Lee; Alexander Tropsha

  Antitumor agents 252. Application of validated QSAR models to database mining: Discovery of novel tylophorine derivatives as potential anticancer agents

  Journal of Computer-Aided Molecular Design. 2007;21(1-3):97-112.
  44

• 172.

  2007

  Donglei Yu; Susan L. Morris-Natschke; Kuo-Hsiung Lee

  New developments in natural products-based anti-AIDS research

  Medicinal Research Reviews. 2007;27(1):108-132.
  47

• 173.

  2007

  Xibong Wang; Susan L. Morris-Natschke; Kuo-Hsiung Lee

  New developments in the chemistry and biology of the bioactive constituents of Tanshen

  Medicinal Research Reviews. 2007;27(1):133-148.
  147

• 174.

  2007

  Masafumi Horiuch; Chihiro Murakami; Narihiko Fukamiya; Donglei Yu; Tzu-Hsuan Chen; Kenneth F. Bastow; De-Cheng Zhang; Yoshihisa Takaishi; Yasuhiro Imakura; Kuo-Hsiung Lee

  Erratum: Tripfordines A-C, sesquiterpene pyridine alkaloids from Tripterygium wilfordii, and structure anti-HIV activity relationships of Tripterygium alkaloids (Journal of Natural Products (2006) 69)

  Journal of Natural Products. 2007;70(1):142.
  0

• 175.

  2006

  Min Chen; Nicole Kilgore; Kuo-Hsiung Lee; Dao-Feng Chen

  Rubrisandrins A and B, lignans and related anti-HIV compounds from Schisandra rubriflora

  Journal of Natural Products. 2006;69(12):1697-1701.
  27

• 176.

  2006

  Mamoru Okasaka; Yoshihisa Takaishi; Yoshiki Kashiwada; Olimjon K. Kodzhimatov; Ozodbek Ashurmetov; Ai J. Lin; L. Mark Consentino; Kuo-Hsiung Lee

  Terpenoids from Juniperus polycarpus var. seravschanica

  Phytochemistry. 2006;67(24):2635-2640.
  15

• 177.

  2006

  Kyoko Nakagawa-Goto; Kuo-Hsiung Lee

  Anti-AIDS agents 68. The first total synthesis of a unique potent anti-HIV chalcone from genus Desmos

  Tetrahedron Letters. 2006;47(47):8263-8266.
  10

• 178.

  2006

  Pei-Lin Wu; Yu-Lin Hsu; Tian-Shung Wu; K.F. Bastow; Kuo-Hsiung Lee

  Kalanchosides A-C, new cytotoxic bufadienolides from the aerial parts of Kalanchoe gracilis

  Organic Letters. 2006;8(23):5207-5210.
  17

• 179.

  2006

  Zhengrong Zou; Yanghua Yi; Houming Wu; Xinsheng Yao; Lijun Du; Wu Jiuhong; Chih-Chuang Liaw; Kuo-Hsiung Lee

  Erratum: Intercedensides D-I, cytotoxic triterpene glycosides from the sea cucumber Mensamaria intercedens Lampert (Journal of Natural Products (2005) 68 (540-546))

  Journal of Natural Products. 2006;69(10):1530.
  2

• 180.

  2006

  Jin Tatsuzaki; Kenneth F. Bastow; Kyoko Nakagawa-Goto; Seiko Nakamura; Hideji Itokawa; Kuo-Hsiung Lee

  Dehydrozingerone, chalcone, and isoeugenol analogues as in vitro anticancer agents

  Journal of Natural Products. 2006;69(10):1445-1449.
  17

• 181.

  2006

  Linyi Wei; Arnold Brossi; Ross Kendall; Kenneth F. Bastow; Susan L. Morris-Natschke; Qian Shi; Kuo-Hsiung Lee

  Antitumor agents 251: Synthesis, cytotoxic evaluation, and structure-activity relationship studies of phenanthrene-based tylophorine derivatives (PBTs) as a new class of antitumor agents

  Bioorganic and Medicinal Chemistry. 2006;14(19):6560-6569.
  37

• 182.

  2006

  Donglei Yu; Yojiro Sakurai; Chin-Ho Chen; Fang-Rong Chang; Li Huang; Yoshiki Kashiwada; Kuo-Hsiung Lee

  Anti-AIDS agents 69. Moronic acid and other triterpene derivatives as novel potent anti-HIV agents

  Journal of Medicinal Chemistry. 2006;49(18):5462-5469.
  60

• 183.

  2006

  Xihong Wang; Kyoko Nakagawa-Goto; Kenneth F. Bastow; Ming-Jaw Don; Yun-Lian Lin; Tian-Shung Wu; Kuo-Hsiung Lee

  Antitumor agents. 254. Synthesis and biological evaluation of novel neo-tanshinlactone analogues as potent anti-breast cancer agents

  Journal of Medicinal Chemistry. 2006;49(18):5631-5634.
  21

• 184.

  2006

  Masafumi Horiuch; Chihiro Murakami; Narihiko Fukamiya; Donglei Yu; Tzu-Hsuan Chen; Kenneth F. Bastow; De-Cheng Zhang; Yoshihisa Takaishi; Yasuhiro Imakura; Kuo-Hsiung Lee

  Tripfordines A-C, sesquiterpene pyridine alkaloids from Tripterygium wilfordii, and structure anti-HIV activity relationships of Tripterygium alkaloids

  Journal of Natural Products. 2006;69(9):1271-1274.
  16

• 185.

  2006

  Ping-Chung Kuo; Tsung-Hsiao Kuo; Amooru G. Damu; Chung-Ren Su; E.-Jian Lee; Tian-Shung Wu; Rexen Shu; Chou-Ming Chen; Kenneth F. Bastow; Tzu-Hsuan Chen; et al.

  Physanolide A, a novel skeleton steroid, and other cytotoxic principles from Physalis angulata

  Organic Letters. 2006;8(14):2953-2956.
  26

• 186.

  2006

  Li Lin; Qian Shi; Alexander K. Nyarko; Kenneth F. Bastow; Chin-Chung Wu; Ching-Yuan Su; Charles C.-Y. Shih; Kuo-Hsiung Lee

  Antitumor agents. 250. Design and synthesis of new curcumin analogues as potential anti-prostate cancer agents

  Journal of Medicinal Chemistry. 2006;49(13):3963-3972.
  63

• 187.

  2006

  Madoka Suzuki; Kyoko Nakagawa-Goto; Seikou Nakamura; Harukuni Tokuda; Susan Morris-Natschke; Mutsuo Kozuka; Hoyoku Nishino; Kuo-Hsiung Lee

  Cancer preventive agents. Part 5. Anti-tumor-promoting effects of coumarins and related compounds on Epstein-Barr virus activation and two-stage mouse skin carcinogenesis

  Pharmaceutical Biology. 2006;44(3):178-182.
  7

• 188.

  2006

  Nobuko Sakurai; Kyoko Nakagawa-Goto; Junko Ito; Yojiro Sakurai; Yuka Nakanishi; Kenneth F. Bastow; Gordon Cragg; Kuo-Hsiung Lee

  Cytotoxic Alangium alkaloids from Alangium longiflorum

  Phytochemistry. 2006;67(9):894-897.
  4

• 189.

  2006

  Hui-Chi Huang; Wei-Jern Tsai; Susan L. Morris-Natschke; Harukuni Tokuda; Kuo-Hsiung Lee; Yang-Chang Wu; Yao-Haur Kuo

  Sapinmusaponins F-J, bioactive tirucallane-type saponins from the galls of Sapindus mukorossi

  Journal of Natural Products. 2006;69(5):763-767.
  13

• 190.

  2006

  Li Lin; Qian Shi; Ching-Yuan Su; Charles C.-Y. Shih; Kuo-Hsiung Lee

  Antitumor agents 247. New 4-ethoxycarbonylethyl curcumin analogs as potential antiandrogenic agents

  Bioorganic and Medicinal Chemistry. 2006;14(8):2527-2534.
  30

• 191.

  2006

  Li Huang; Phong Ho; Kuo-Hsiung Lee; Chin-Ho Chen

  Synthesis and anti-HIV activity of bi-functional betulinic acid derivatives

  Bioorganic and Medicinal Chemistry. 2006;14(7):2279-2289.
  39

• 192.

  2006

  Xihong Wang; Kyoko Nakagawa-Goto; Mutsuo Kozuka; Harukuni Tokuda; Hoyoku Nishino; Kuo-Hsiung Lee

  Cancer preventive agents. Part 6: Chemopreventive potential of furanocoumarins and related compounds

  Pharmaceutical Biology. 2006;44(2):116-120.
  5

• 193.

  2006

  Yojiro Sakurai; Nobuko Sakurai; Masahiko Taniguchi; Yuka Nakanishi; Kenneth F. Bastow; Xihong Wang; Gordon M. Cragg; Kuo-Hsiung Lee

  Rautandiols A and B, pterocarpans and cytotoxic constituents from Neorautanenia mitis

  Journal of Natural Products. 2006;69(3):397-399.
  12

• 194.

  2006

  Yang-Hua Yi; Qiang-Zhi Xu; Ling Li; Shi-Long Zhang; Hou-Ming Wu; Jian Ding; Yun-Guang Tong; Wen-Fu Tan; Mei-Hong Li; Fang Tian; et al.

  Philinopsides A and B, two new sulfated triterpene glycosides from the sea cucumber Pentacta quadrangularis

  Helvetica Chimica Acta. 2006;89(1):54-63.
  19

• 195.

  2006

  Fang-Rong Chang; I.-Hsiao Chen; Sin-Chung Liao; Hamad H. Issa; Ken-Ichiro Hayashi; Hiroshi Nozaki; Yang-Chang Wu; Kuo-Hsiung Lee

  Three new agarofuran sesquiter-penes reissantins F-H from Reissantia buchananii

  Planta Medica. 2006;72(1):92-96.
  2

• 196.

  2006

  Li Lin; Kuo-Hsiung Lee

  Structure-activity relationships of curcumin and its analogs with different biological activities

  Studies in Natural Products Chemistry. 2006;33(PART M):785-812.
  5

• 197.

  2006

  Zhiming Wen; Stephan T. Stern; David E. Martin; Kuo-Hsiung Lee; Philip C. Smith

  Structural characterization of anti-HIV drug candidate PA-457 [3-O-(3′,3′-dimethylsuccinyl)-betulinic acid] and its acyl glucuronides in rat bile and evaluation of in vitro stability in human and animal liver microsomes and plasma

  Drug Metabolism and Disposition. 2006;34(9):1436-1442.
  17

• 198.

  2005

  Lan Xie; Chun-Hong Zhao; Ting Zhou; Hai-Feng Chen; Bo-Tao Fan; Xian-Hong Chen; Jian-Zhou Ma; Jing-Yun Li; Zhuo-Yi Bao; Zhaowen Lo; et al.

  Molecular modeling, design, synthesis, and biological evaluation of novel 3′,4′-dicamphanoyl-(+)-cis-khellactone (DCK) analogs as potent anti-HIV agents

  Bioorganic and Medicinal Chemistry. 2005;13(23):6435-6449.
  9

• 199.

  2005

  Maurizio Bruno; Sergio Rosselli; Antonella Maggio; Rosa Angela Raccuglia; Kenneth F. Bastow; Chin-Chung Wu; Kuo-Hsiung Lee

  Cytotoxic activity of some natural and synthetic sesquiterpene lactones

  Planta Medica. 2005;71(12):1176-1178.
  14

• 200.

  2005

  Madoka Suzuki; Yutai Li; Philip C. Smith; James A. Swenberg; David E. Martin; Susan L. Morris-Natschke; Kuo-Hsiung Lee

  Anti-AIDS agents 65: Investigation of the in vitro oxidative metabolism of 3′,4′-di-O-(-)-camphanoyl-(+)-cis-khellactone derivatives as potent anti-HIV agents

  Drug Metabolism and Disposition. 2005;33(11):1588-1592.
  9

• 201.

  2005

  Ming-Jen Cheng; Kuo-Hsiung Lee; Ian-Lih Tsai; Ih-Sheng Chen

  Two new sesquiterpenoids and anti-HIV principles from the root bark of Zanthoxylum ailanthoides

  Bioorganic and Medicinal Chemistry. 2005;13(21):5915-5920.
  19

• 202.

  2005

  Chun Hong Zhao; Ting Zhou; Lan Xie; Jing Yun Li; Zuo Yi Bao; Zhao Wen Lou; Kuo Hsiung Lee

  Synthesis and anti-HIV activity of trisubstituted (3′R, 4′R)-3′,4′-di-O-(S)-camphanoyl-(+)-cis-khellactone (DCK) analogs

  Chinese Chemical Letters. 2005;16(10):1297-1300.
  0

• 203.

  2005

  Mutsuo Kozuka; Masayoshi Oyama; Harukuni Tokuda; Hoyoku Nishino; Kuo-Hsiung Lee

  Cancer preventive agents 3. Antitumor promoting effects of Agaricus blazei

  Pharmaceutical Biology. 2005;43(6):568-572.
  0

• 204.

  2005

  Chih-Chuang Liaw; Fang-Rong Chang; Shu-Li Chen; Chin-Chung Wu; Kuo-Hsiung Lee; Yang-Chang Wu

  Novel cytotoxic monotetrahydrofuranic Annonaceous acetogenins from Annona montana

  Bioorganic and Medicinal Chemistry. 2005;13(15):4767-4776.
  10

• 205.

  2005

  Seikou Nakamura; Mutsuo Kozuka; Kenneth F. Bastow; Harukuni Tokuda; Hoyoku Nishino; Madoka Suzuki; Jin Tatsuzaki; Susan L. Morris Natschke; Sheng-Chu Kuo; Kuo-Hsiung Lee

  Cancer preventive agents, Part 2: Synthesis and evaluation of 2-phenyl-4-quinolone and 9-oxo-9,10-dihydroacridine derivatives as novel antitumor promoters

  Bioorganic and Medicinal Chemistry. 2005;13(14):4396-4401.
  26

• 206.

  2005

  Naonobu Tanaka; Mamoru Okasaka; Youko Ishimaru; Yoshihisa Takaishi; Mitsunobu Sato; Masato Okamoto; Tetsuya Oshikawa; Sharif Uddin Ahmed; L. Mark Consentino; Kuo-Hsiung Lee

  Biyouyanagin A, an anti-HIV agent from Hypericum chinense L. var. salicifolium

  Organic Letters. 2005;7(14):2997-2999.
  44

• 207.

  2005

  Maurizio Bruno; Sergio Rosselli; Antonella Maggio; Rosa Angela Raccuglia; Kenneth F. Bastow; Kuo-Hsiung Lee

  Cytotoxic activity of some natural and synthetic guaianolides

  Journal of Natural Products. 2005;68(7):1042-1046.
  21

• 208.

  2005

  Yao-Haur Kuo; Hui-Chi Huang; L.I.-Ming Yang Kuo; Y.A.-Wen Hsu; Kuo-Hsiung Lee; Fang-Rong Chang; Yang-Chang Wu

  New dammarane-type saponins from the galls of Sapindus mukorossi

  Journal of Agricultural and Food Chemistry. 2005;53(12):4722-4727.
  19

• 209.

  2005

  Kyoko Nakagawa-Goto; Kenneth F. Bastow; Jiu-Hong Wu; Harukuni Tokuda; Kuo-Hsiung Lee

  Total synthesis and bioactivity of unique flavone desmosdumotin B and its analogs

  Bioorganic and Medicinal Chemistry Letters. 2005;15(12):3016-3019.
  9

• 210.

  2005

  Donglei Yu; Carl T. Wild; David E. Martin; Susan L. Morris-Natschke; Chin-Ho Chen; Graham P. Allaway; Kuo-Hsiung Lee

  The discovery of a class of novel HIV-1 maturation inhibitors and their potential in the therapy of HIV

  Expert Opinion on Investigational Drugs. 2005;14(6):681-693.
  27

• 211.

  2005

  Hai-Feng Chen; Bo-Tao Fan; Chen-Yang Zhao; Lan Xie; Chun-Hong Zhao; Ting Zhou; Kuo-Hsiung Lee; Graham Allaway

  Computational studies and drug design for HIV-1 reverse transcriptase inhibitors of 3′,4′-di-O-(S)-camphanoyl-(+)-cis-khellactone (DCK) analogs

  Journal of Computer-Aided Molecular Design. 2005;19(4):243-258.
  10

• 212.

  2005

  Zhengrong Zou; Yanghua Yi; Houming Wu; Xinsheng Yao; Lijun Du; Wu Jiuhong; Chih-Chaung Liaw; Kuo-Hsiung Lee

  Intercedensides D-I, cytotoxic triterpene glycosides from the sea cucumber Mensamaria intercedens lampert

  Journal of Natural Products. 2005;68(4):540-546.
  34

• 213.

  2005

  Narihiko Fukamiya; Kuo-Hsiung Lee; Ilias Muhammad; Chihiro Murakami; Masayohis Okano; Isabelle Harvey; Jerry Pelletier

  Structure-activity relationships of quassinoids for eukaryotic protein synthesis

  Cancer Letters. 2005;220(1):37-48.
  24

• 214.

  2005

  Kyoko Nakagawa-Goto; Jiu-Hong Wu; Kenneth F. Bastow; Chin-Chung Wu; Kuo-Hsiung Lee

  Antitumor agents 243. Syntheses and cytotoxicity of desmosdumotin C derivatives

  Bioorganic and Medicinal Chemistry. 2005;13(6):2325-2330.
  11

• 215.

  2005

  Hui-Kang Wang; Nokuko Sakurai; Charles Y. Shih; Kuo-Hsiung Lee

  LC/TIS-MS fingerprint profiling of cimicifuga species and analysis of 23-Epi-26-deoxyactein in Cimicifuga racemosa commercial products

  Journal of Agricultural and Food Chemistry. 2005;53(5):1379-1386.
  9

• 216.

  2005

  Kyoko Nakagawa-Goto; M. Katherine Jung; Ernest Hamel; Chin-Chung Wu; Kenneth F. Bastow; Arnold Brossi; Shunsaku Ohta; Kuo-Hsiung Lee

  Antitumor agents 238. Anti-tubulin and in vitrocytotoxic effects of N-substituted allocolchicinoids

  Heterocycles. 2005;65(3):541-550.
  12

• 217.

  2005

  Li Huang; Xiong Yuan; Donglei Yu; K.H. Lee; Chin Ho Chen

  Mechanism of action and resistant profile of anti-HIV-1 coumarin derivatives

  Virology. 2005;332(2):623-628.
  29

• 218.

  2005

  Nobuko Sakurai; Mutsuo Kozuka; Harukuni Tokuda; Teruo Mukainaka; Fumio Enjo; Hoyoku Nishino; Masahiro Nagai; Yojiro Sakurai; Kuo-Hsiung Lee

  Cancer preventive agents. Part 1: Chemopreventive potential of cimigenol, cimigenol-3,15-dione, and related compounds

  Bioorganic and Medicinal Chemistry. 2005;13(4):1403-1408.
  15

• 219.

  2005

  Yoshiki Kashiwada; Akihiro Aoshima; Yasumasa Ikeshiro; Yuh-Pan Chen; Hiroshi Furukawa; Masataka Itoigawa; Toshihiro Fujioka; Kunihide Mihashi; L. Mark Cosentino; Susan L. Morris-Natschke; et al.

  Anti-HIV benzylisoquinoline alkaloids and flavonoids from the leaves of Nelumbo nucifera, and structure-activity correlations with related alkaloids

  Bioorganic and Medicinal Chemistry. 2005;13(2):443-448.
  103

• 220.

  2005

  Ya-Yun Lai; Li-Jiau Huang; Kuo-Hsiung Lee; Zhiyan Xiao; Kenneth F. Bastow; Takao Yamori; Sheng-Chu Kuo

  Synthesis and biological relationships of 3′,6-substituted 2-phenyl-4-quinolone-3-carboxylic acid derivatives as antimitotic agents

  Bioorganic and Medicinal Chemistry. 2005;13(1):265-275.
  37

• 221.

  2005

  Kyoko Nakagawa-Goto; Cyril X. Chen; Ernest Hamel; Chin-Chung Wu; Kenneth F. Bastow; Arnold Brossi; Kuo-Hsiung Lee

  Antitumor agents. Part 236: Synthesis of water-soluble colchicine derivatives

  Bioorganic and Medicinal Chemistry Letters. 2005;15(1):235-238.
  13

• 222.

  2005

  Pei-Lin Wu; Tian-Shung Wu; Cai-Xia He; Chia-Hao Su; Kuo-Hsiung Lee

  Constituents from the stems of Hibiscus taiwanensis

  Chemical and Pharmaceutical Bulletin. 2005;53(1):56-59.
  14

• 223.

  2005

  Kyoko Nakagawa-Goto; Jiu-Hong Wu; Kuo-Hsiung Lee

  First total synthesis of desmosdumotin C

  Synthetic Communications. 2005;35(13):1735-1739.
  6

• 224.

  2004

  Ying Chen; Qian Zhang; Beina Zhang; Peng Xia; Yi Xia; Zheng-Yu Yang; Nicole Kilgore; Carl Wild; Susan L. Morris-Natschke; Kuo-Hsiung Lee

  Anti-AIDS agents. Part 56: Synthesis and anti-HIV activity of 7-thia-di-O-(-)-camphanoyl-(+)-cis-khellactone (7-thia-DCK) analogs

  Bioorganic and Medicinal Chemistry. 2004;12(24):6383-6387.
  26

• 225.

  2004

  Yoshiki Kashiwada; Michiko Sekiya; Yasumasa Ikeshiro; Toshihiro Fujioka; Nicole R. Kilgore; Carl T. Wild; Graham P. Allaway; Kuo-Hsiung Lee

  3-O-Glutaryl-dihydrobetulin and related monoacyl derivatives as potent anti-HIV agents

  Bioorganic and Medicinal Chemistry Letters. 2004;14(23):5851-5853.
  11

• 226.

  2004

  Qian Zhang; Ying Chen; Peng Xia; Yi Xia; Zheng-Yu Yang; Donglei Yu; Susan L. Morris-Natschke; Kuo-Hsiung Lee

  Anti-AIDS agents. Part 62: Anti-HIV activity of 2′-substituted 4-methyl-3′,4′-di-O-(-)-camphanoyl-(+)-cis-khellactone (4-methyl DCK) analogs

  Bioorganic and Medicinal Chemistry Letters. 2004;14(23):5855-5857.
  13

• 227.

  2004

  Xihong Wang; Kenneth F. Bastow; Chang-Ming Sun; Yun-Lian Lin; Hsi-Jung Yu; Ming-Jaw Don; Tian-Shung Wu; Seikou Nakamura; Kuo-Hsiung Lee

  Antitumor agents. 239. Isolation, structure elucidation, total synthesis, and anti-breast cancer activity of neo-tanshinlactone from Salvia miltiorrhiza

  Journal of Medicinal Chemistry. 2004;47(23):5816-5819.
  68

• 228.

  2004

  Yousuke Kawaguchi; Toshimasa Ochi; Yoshihisa Takaishi; Kazuyoshi Kawazoe; Kuo-Hsiung Lee

  New sesquiterpenes from Capsicum annuum

  Journal of Natural Products. 2004;67(11):1893-1896.
  13

• 229.

  2004

  Naonobu Tanaka; Yoshihisa Takaishi; Yasuhiro Shikishima; Yuka Nakanishi; Kenneth Bastow; Kuo-Hsiung Lee; Gisho Honda; Michiho Ito; Yoshio Takeda; Olimjon K. Kodzhimatov; et al.

  Prenylated benzophenones and xanthones from Hypericum scabrum

  Journal of Natural Products. 2004;67(11):1870-1875.
  47

• 230.

  2004

  Chih-Chuang Liaw; Fang-Rong Chang; Yang-Chang Wu; Hui-Kang Wang; Yuka Nakanishi; Kenneth F. Bastow; Kuo-Hsiung Lee

  Montacin and cis-montacin, two new cytotoxic monotetrahydrofuran annonaceous acetogenins from Annona montana

  Journal of Natural Products. 2004;67(11):1804-1808.
  8

• 231.

  2004

  Zhiyan Xiao; Kenneth F. Bastow; John R. Vance; Robert S. Sidwell; Hui-Kang Wang; Ming S. Chen; Qian Shi; Kuo-Hsiung Lee

  Antitumor agents. 234. Design, synthesis, and biological evaluation of novel 4β-[(4″-benzamido)-amino]-4′-O-demethyl- epipodophyllotoxin derivatives

  Journal of Medicinal Chemistry. 2004;47(21):5140-5148.
  22

• 232.

  2004

  Chih-Chuang Liaw; Fang-Rong Chang; Chin-Chung Wu; Shu-Li Chen; Kenneth F. Bastow; Ken-Ichiro Hayashi; Hiroshi Nozaki; Kuo-Hsiung Lee; Yang-Chang Wu

  Nine new cytotoxic monotetrahydrofuranic annonaceous acetogenins from Annona montana

  Planta Medica. 2004;70(10):948-959.
  13

• 233.

  2004

  Chihiro Murakami; Narihiko Fukamiya; Sadaaki Tamura; Masayoshi Okano; Kenneth F. Bastow; Harukuni Tokuda; Teruo Mukainaka; Hoyoky Nishino; Kuo-Hsiung Lee

  Multidrug-resistant cancer cell susceptibility to cytotoxic quassinoids, and cancer chemopreventive effects of quassinoids and canthin alkaloids

  Bioorganic and Medicinal Chemistry. 2004;12(18):4963-4968.
  23

• 234.

  2004

  Xiao-Kang Zhu; Jian Guan; Zhiyan Xiao; L. Mark Cosentino; Kuo-Hsiung Lee

  Anti-AIDS agents. Part 61: Anti-HIV activity of new podophyllotoxin derivatives

  Bioorganic and Medicinal Chemistry. 2004;12(15):4267-4273.
  23

• 235.

  2004

  Donglei Yu; Chin-Ho Chen; Arnold Brossi; Kuo-Hsiung Lee

  Anti-AIDS agents. 60. Substituted 3′R,4′R-di-O-(-)-camphanoyl- 2′,2′-dimethyldihydropyrano[2,3-f]chromone (DCP) analogues as potent anti-HIV agents

  Journal of Medicinal Chemistry. 2004;47(16):4072-4082.
  47

• 236.

  2004

  Naonobu Tanaka; Nobuyuki Ooba; Hongquan Duan; Yoshihisa Takaishi; Yuka Nakanishi; Kenneth Bastow; Kuo-Hsiung Lee

  Kaurane and abietane diterpenoids from Tripterygium doianum (Celastraceae)

  Phytochemistry. 2004;65(14):2071-2076.
  12

• 237.

  2004

  Pei-Wen Hsieh; Fang-Rong Chang; Kuo-Hsiung Lee; Tsong-Long Hwang; Sue-Ming Chang; Yang-Chang Wu

  A new anti-HIV alkaloid, drymaritin, and a new C-glycoside flavonoid, diandraflavone, from Drymaria diandra

  Journal of Natural Products. 2004;67(7):1175-1177.
  24

• 238.

  2004

  Peng Xia; Zhi-Jian Yin; Ying Chen; Qian Zhang; Beina Zhang; Yi Xia; Zheng-Yu Yang; Nicole Kilgore; Carl Wild; Susan L. Morris-Natschke; et al.

  Anti-AIDS agents. Part 58: Synthesis and anti-HIV activity of 1-thia-di-O-(-)-camphanoyl-(+)-cis-khellactone (1-thia-DCK) analogues

  Bioorganic and Medicinal Chemistry Letters. 2004;14(12):3341-3343.
  16

• 239.

  2004

  Chia-Ying Li; Chun-Hua Lin; Chia-Che Wu; Kuo-Hsiung Lee; Tian-Shung Wu

  Efficient ¹H nuclear magnetic resonance method for improved quality control analyses of Ginkgo constituents

  Journal of Agricultural and Food Chemistry. 2004;52(12):3721-3725.
  21

• 240.

  2004

  Zhiyan Xiao; John R. Vance; Kenneth F. Bastow; Arnold Brossi; Hui-Kang Wang; Kuo-Hsiung Lee

  Antitumor agents. Part 235: Novel 4′-ester etoposide analogues as potent DNA topoisomerase II inhibitors with improved therapeutic potential

  Bioorganic and Medicinal Chemistry. 2004;12(12):3363-3369.
  13

• 241.

  2004

  Zhiyan Xiao; Kenneth F. Bastow; John R. Vance; Kuo-Hsiung Lee

  Antitumor agents. Part 227: Studies on novel 4′-O-demethyl- epipodophyllotoxins as antitumor agents targeting topoisomerase II

  Bioorganic and Medicinal Chemistry. 2004;12(12):3339-3344.
  11

• 242.

  2004

  Shiqing Han; Zhiyan Xiao; Kenneth F. Bastow; Kuo-Hsiung Lee

  Antitumor agents. Part 230: C_4′-esters of GL-331 as cytotoxic agents and DNA topoisomerase II inhibitors

  Bioorganic and Medicinal Chemistry Letters. 2004;14(11):2979-2982.
  5

• 243.

  2004

  Ken-Ichiro Hayashi; Fang-Rong Chang; Yuka Nakanishi; Kenneth F. Bastow; Gordon Cragg; Andrew T. McPhail; Hiroshi Nozaki; Kuo-Hsiung Lee

  Antitumor agents. 233.¹ Lantalucratins A-F, new cytotoxic naphthoquinones from Lantana involucrata

  Journal of Natural Products. 2004;67(6):990-993.
  7

• 244.

  2004

  Yong-Hong Wang; Ai-Jun Hou; Lei Chen; Dao-Feng Chen; Han-Dong Sun; Qin-Shi Zhao; Kenneth F. Bastow; Yuka Nakanish; Xi-Hong Wang; Kuo-Hsiung Lee

  New isoprenylated flavones, artochamins A-E, and cytotoxic principles from Artocarpus chama

  Journal of Natural Products. 2004;67(5):757-761.
  46

• 245.

  2004

  Zhiyan Xiao; Shiqing Han; Kenneth F. Bastow; Kuo-Hsiung Lee

  Antitumor agents. Part 232: Synthesis of cyclosulfite podophyllotoxin analogues as novel prototype antitumor agents

  Bioorganic and Medicinal Chemistry Letters. 2004;14(6):1581-1584.
  8

• 246.

  2004

  Nobuko Sakurai; Jiu-Hong Wu; Yutaka Sashida; Yoshihiro Mimaki; Tamotsu Nikaido; Kazuo Koike; Hideji Itokawa; Kuo-Hsiung Lee

  Anti-AIDS Agents. Part 57: Actein, an anti-HIV principle from the rhizome of Cimicifuga racemosa (black cohosh), and the anti-HIV activity of related saponins

  Bioorganic and Medicinal Chemistry Letters. 2004;14(5):1329-1332.
  27

• 247.

  2004

  Ru-Wei Lin; Ian-Lih Tsai; Chang-Yih Duh; Kuo-Hsiung Lee; Ih-Sheng Chen

  New lignans and cytotoxic constituents from Wikstroemia lanceolata

  Planta Medica. 2004;70(3):234-238.
  10

• 248.

  2004

  Pei-Lin Wu; Fu-Wen Lin; Tian-Shung Wu; Chang-Sheng Kuoh; Kuo-Hsiung Lee; Shiow-Ju Lee

  Cytotoxic and anti-HIV principles from the rhizomes of Begonia nantoensis

  Chemical and Pharmaceutical Bulletin. 2004;52(3):345-349.
  27

• 249.

  2004

  Ping-Chung Kuo; Amooru G. Damu; Kuo-Hsiung Lee; Tian-Shung Wu

  Cytotoxic and antimalarial constituents from the roots of Eurycoma longifolia

  Bioorganic and Medicinal Chemistry. 2004;12(3):537-544.
  46

• 250.

  2004

  Kuo-Hsiung Lee

  Current Developments in the Discovery and Design of New Drug Candidates from Plant Natural Product Leads

  Journal of Natural Products. 2004;67(2):273-283.
  89

• 251.

  2004

  Lan Xie; Donglei Yu; Carl Wild; Graham Allaway; Jim Turpin; Philip C. Smith; Kuo-Hsiung Lee

  Anti-AIDS Agents. 52. Synthesis and Anti-HIV Activity of Hydroxymethyl (3′R,4′R)-3′,4′-Di-O-(S)-camphanoyl-(+)-cis-khellactone Derivatives

  Journal of Medicinal Chemistry. 2004;47(3):756-760.
  25

• 252.

  2004

  Jing Zhou; Xiong Yuan; David Dismuke; Brett M. Forshey; Christopher Lundquist; Kuo-Hsiung Lee; Christopher Aiken; Chin Ho Chen

  Small-Molecule Inhibition of Human Immunodeficiency Virus Type 1 Replication by Specific Targeting of the Final Step of Virion Maturation

  Journal of Virology. 2004;78(2):922-929.
  104

• 253.

  2004

  Peilan Ding; Daofeng Chen; Kenneth F. Bastow; Alexander K. Nyarko; Xihong Wang; Kuo-Hsiung Lee

  Cytotoxic isoprenylated flavonoids from the roots of Sophora flavescens

  Helvetica Chimica Acta. 2004;87(10):2574-2580.
  18

• 254.

  2003

  Pei-Wen Hsieh; Fang-Rong Chang; Andrew T. McPhail; Kuo-Hsiung Lee; Yang-Chang Wu

  New cembranolide analogues from the formosan soft coral Sinularia flexibilis and their cytotoxicity

  Natural Product Research. 2003;17(6):409-418.
  19

• 255.

  2003

  Hironori Ohtsu; Hideji Itokawa; Zhiyan Xiao; Ching-Yuan Su; Charles C.-Y. Shih; Tzuying Chiang; Eugene Chang; YiFen Lee; Shang-Yi Chiu; Chawnshang Chang; et al.

  Antitumor agents 222. Synthesis and anti-androgen activity of new diarylheptanoids

  Bioorganic and Medicinal Chemistry. 2003;11(23):5083-5090.
  28

• 256.

  2003

  Fang-Rong Chang; Ken-Ichiro Hayashi; I-Hsiao Chen; Chih-Chuang Liaw; Kenneth F. Bastow; Yuka Nakanishi; Hiroshi Nozaki; Gordon M. Cragg; Yang-Chang Wu; Kuo-Hsiung Lee

  Antitumor Agents. 228. Five New Agarofurans, Reissantins A-E, and Cytotoxic Principles from Reissantia buchananii

  Journal of Natural Products. 2003;66(11):1416-1420.
  43

• 257.

  2003

  Ping-Chung Kuo; Li-Shian Shi; Amooru G. Damu; Chung-Ren Su; Chieh-Hung Huang; Chih-Huang Ke; Jin-Bin Wu; Ai-Jeng Lin; Kenneth F. Bastow; Kuo-Hsiung Lee; et al.

  Cytotoxic and Antimalarial β-Carboline Alkaloids from the Roots of Eurycoma longifolia

  Journal of Natural Products. 2003;66(10):1324-1327.
  57

• 258.

  2003

  Yi Xia; Zheng-Yu Yang; Peng Xia; Kenneth F. Bastow; Yuka Nakanishi; Priya Nampoothiri; Ernest Hamel; Arnold Brossi; Kuo-Hsiung Lee

  Antitumor agents. Part 226: Synthesis and cytotoxicity of 2-phenyl-4-quinolone acetic acids and their esters

  Bioorganic and Medicinal Chemistry Letters. 2003;13(17):2891-2893.
  35

• 259.

  2003

  Kuo-Hsiung Lee

  Modern research routes to new medicines - From Chinese materia medica

  Chinese Pharmaceutical Journal. 2003;55(4):221-230.
  1

• 260.

  2003

  Masayoshi Oyama; Kenneth F. Bastow; Yoko Tachibana; Yoshiaki Shirataki; Sadaki Yamaguchi; Gordon M. Cragg; Tian-Shung Wu; Kuo-Hsiung Lee

  Antitumor agents 225. Acrofoliones A and B, two novel cytotoxic acetophenone dimers, from Acronychia trifoliolata

  Chinese Pharmaceutical Journal. 2003;55(4):239-245.
  2

• 261.

  2003

  Zheng-Rong Zou; Yang-Hua Yi; Hou-Ming Wu; Jiu-Hong Wu; Chih-Chaung Liaw; Kuo-Hsiung Lee

  Intercedensides A-C, three new cytotoxic triterpene glycosides from the sea cucumber Mensamaria intercedens Lampert

  Journal of Natural Products. 2003;66(8):1055-1060.
  59

• 262.

  2003

  Yuka Nakanishi; Fang-Rong Chang; Chih-Chuang Liaw; Yang-Chang Wu; Kenneth F. Bastow; Kuo-Hsiung Lee

  Acetogenins as selective inhibitors of the human ovarian 1A9 tumor cell line

  Journal of Medicinal Chemistry. 2003;46(15):3185-3188.
  25

• 263.

  2003

  Jiu-Hong Wu; Fang-Rong Chang; Ken-Ichiro Hayashi; Hiroaki Shiraki; Chih-Chuang Liaw; Yuka Nakanishi; Kenneth F. Bastow; Donglei Yu; Ih-Sheng Chen; et al.

  Antitumor agents. Part 218: Cappamensin A, a new in vitro anticancer principle, from Capparis sikkimensis

  Bioorganic and Medicinal Chemistry Letters. 2003;13(13):2223-2225.
  12

• 264.

  2003

  Jiu-Hong Wu; Xi-Hong Wang; Yang-Hua Yi; Kuo-Hsiung Lee

  Anti-AIDS agents 54. A potent anti-HIV chalcone and flavonoids from genus Desmos

  Bioorganic and Medicinal Chemistry Letters. 2003;13(10):1813-1815.
  123

• 265.

  2003

  Donglei Yu; Arnold Brossi; Nicole Kilgore; Carl Wild; Graham Allaway; Kuo-Hsiung Lee

  Anti-HIV agents. Part 55: 3′R,4′R-Di-O-(-)-camphanoyl-2′,2′- dimethyldihydropyrano[2,3-f]chromone (DCP), a novel anti-HIV agent

  Bioorganic and Medicinal Chemistry Letters. 2003;13(9):1575-1576.
  25

• 266.

  2003

  Donglei Yu; Madoka Suzuki; Lan Xie; Susan L. Morris-Natschke; Kuo-Hsiung Lee

  Recent progress in the development of coumarin derivatives as potent anti-HIV agents

  Medicinal Research Reviews. 2003;23(3):322-345.
  147

• 267.

  2003

  Hironori Ohtsu; Yuka Nakanishi; Kenneth F. Bastow; Fang-Yu Lee; Kuo-Hsiung Lee

  Antitumor agents 216. Synthesis and evaluation of paclitaxel-camptothecin conjugates as novel cytotoxic agents

  Bioorganic and Medicinal Chemistry. 2003;11(8):1851-1857.
  20

• 268.

  2003

  Wen-Li Lo; Chin-Chung Wu; Fang-Rong Chang; Wei-Ya Wang; Ashraf Taha Khalil; Kuo-Hsiung Lee; Yang-Chang Wu

  Antiplatelet and anti-HIV constituents from Euchresta formosana

  Natural Product Research. 2003;17(2):91-97.
  6

• 269.

  2003

  Qian Zhang; Ying Chen; Yun Qing Zheng; Peng Xia; Yi Xia; Zheng Yu Yang; Kenneth F. Bastow; Susan L. Morris-Natschke; Kuo-Hsiung Lee

  Synthesis and bioactivity of 4,10-dimethyl-pyridino[2,3-h]quinolin-2(1H)-one-9-carboxylic acid and its esters

  Bioorganic and Medicinal Chemistry. 2003;11(6):1031-1034.
  8

• 270.

  2003

  Nobuko Sakurai; Mutsuo Kozuka; Harukuni Tokuda; Yoshitaka Nobukuni; Junko Takayasu; Hoyoku Nishino; Akiko Kusano; Genjiro Kusano; Masahiro Nagai; Yojiro Sakurai; et al.

  Antitumor agents 220. Antitumor-promoting effects of cimigenol and related compounds on Epstein-Barr virus activation and two-stage mouse skin carcinogenesis

  Bioorganic and Medicinal Chemistry. 2003;11(6):1137-1140.
  17

• 271.

  2003

  Yuh-Chwen Chang; Pei-Wen Hsieh; Fang-Rong Chang; Ru-Rong Wu; Chih-Chuang Liaw; Kuo-Hsiung Lee; Yang-Chang Wu

  Two new protopines argemexicaines A and B and the anti-HIV alkaloid 6-acetonyldihydrochelerythrine from Formosan Argemone mexicana

  Planta Medica. 2003;69(2):148-152.
  31

• 272.

  2003

  Alexander Golbraikh; Min Shen; Zhiyan Xiao; Yun-De Xiao; Kuo-Hsiung Lee; Alexander Tropsha

  Rational selection of training and test sets for the development of validated QSAR models

  Journal of Computer-Aided Molecular Design. 2003;17(2-4):241-253.
  187

• 273.

  2003

  I-Chen Sun; Yoshiki Kashiwada; Susan L Morris-Natschke; Kuo-Hsiung Lee

  Plant-derived terpenoids and analogues as anti-HIV agents.

  Current topics in medicinal chemistry. 2003;3(2):155-169.
  35

• 274.

  2003

  Jiu-Hong Wu; Susan L. Morris-Natschke; Kuo-Hsiung Lee

  Progress in the recent discovery and development of promising anticancer and anti-HIV agents from natural products in the United States

  Journal of the Chinese Chemical Society. 2003;50(1):11-22.
  2

• 275.

  2003

  Ken-ichiro Hayashi; Yuka Nakanishi; Kenneth F. Bastow; Gordon Cragg; Hiroshi Nozaki; Kuo-Hsiung Lee

  Antitumor agents. 221. Buceracidins A and B, two new flavanones from Bucida buceras

  Journal of Natural Products. 2003;66(1):125-127.
  11

• 276.

  2003

  Kuo-Hsiung Lee; Zhiyan Xiao

  Lignans in treatment of cancer and other diseases

  Phytochemistry Reviews. 2003;2(3):341-362.
  37

• 277.

  2002

  Hironori Ohtsu; Zhiyan Xiao; Junko Ishida; Masahiro Nagai; Hui-Kang Wang; Hideji Itokawa; Ching-Yuan Su; Charles Shih; Tzuying Chiang; Eugene Chang; et al.

  Antitumor agents. 217. Curcumin analogues as novel androgen receptor antagonists with potential as anti-prostate cancer agents

  Journal of Medicinal Chemistry. 2002;45(23):5037-5042.
  125

• 278.

  2002

  Maurizio Bruno; Sergio Rosselli; Ivana Pibiri; Nicole Kilgore; Kuo-Hsiung Lee

  Anti-HIV agents derived from the ent-kaurane diterpenoid linearol

  Journal of Natural Products. 2002;65(11):1594-1597.
  17

• 279.

  2002

  Junko Ishida; Hironori Ohtsu; Yoko Tachibana; Yuka Nakanishi; Kenneth F Bastow; Masahiro Nagai; Hui-Kang Wang; Hideji Itokawa; Kuo-Hsiung Lee

  Antitumor agents. Part 214: Synthesis and evaluation of curcumin analogues as cytotoxic agents

  Bioorganic and Medicinal Chemistry. 2002;10(11):3481-3487.
  78

• 280.

  2002

  Shiqing Han; Ernest Hamel; Kenneth F. Bastow; Andrew T. McPhail; Arnold Brossi; Kuo-Hsiung Lee

  Antitumor agents. Part 215: Antitubulin effects of cytotoxic B-Ring modified allocolchicinoids

  Bioorganic and Medicinal Chemistry Letters. 2002;12(20):2851-2853.
  5

• 281.

  2002

  Youichi Shinozaki; Narihiko Fukamiya; Chieko Uchiyama; Masayoshi Okano; Kiyoshi Tagahara; Kenneth F Bastow; Kuo-Hsiung Lee

  Multidrug resistant cancer cells susceptibility to cytotoxic taxane diterpenes from Taxus yunnanensis and Taxus chinensis

  Bioorganic and Medicinal Chemistry Letters. 2002;12(19):2785-2788.
  6

• 282.

  2002

  I-Chen Sun; Chin-Ho Chen; Yoshiki Kashiwada; Jiu-Hong Wu; Hui-Kang Wang; Kuo-Hsiung Lee

  Anti-AIDS agents 49. Synthesis, anti-HIV, and anti-fusion activities of IC9564 analogues based on betulinic acid

  Journal of Medicinal Chemistry. 2002;45(19):4271-4275.
  48

• 283.

  2002

  Dao-Feng Chen; Shun-Xiang Zhang; Mutsuo Kozuka; Quan-Zhong Sun; Ju Feng; Qiang Wang; Teruo Mukainaka; Yoshitaka Nobukuni; Harukuni Tokuda; Hoyoku Nishino; et al.

  Interiotherins C and D, two new lignans from Kadsura interior and antitumor-promoting effects of related neolignans on Epstein-Barr virus activation

  Journal of Natural Products. 2002;65(9):1242-1245.
  65

• 284.

  2002

  Zhiyan Xiao; Yun-De Xiao; Jun Feng; Alexander Golbraikh; Alexander Tropsha; Kuo-Hsiung Lee

  Antitumor agents. 213. Modeling of epipodophyllotoxin derivatives using variable selection k nearest neighbor QSAR method

  Journal of Medicinal Chemistry. 2002;45(11):2294-2309.
  59

• 285.

  2002

  Jiu-Hong Wu; Andrew T. McPhail; Kenneth F. Bastow; Hiroaki Shiraki; Junko Ito; Kuo-Hsiung Lee

  Desmosdumotin C, a novel cytotoxic principle from Desmos dumosus

  Tetrahedron Letters. 2002;43(8):1391-1393.
  18

• 286.

  2002

  Ken-Ichiro Hayashi; Yuka Nakanishi; Kenneth F. Bastow; Gordon Cragg; Hiroshi Nozaki; Kuo-Hsiung Lee

  Antitumor agents. Part 212: Bucidarasins A-C, three new cytotoxic clerodane diterpenes from Bucida buceras

  Bioorganic and Medicinal Chemistry Letters. 2002;12(3):345-348.
  16

• 287.

  2002

  Prapai Wongsinkongman; Arnold Brossi; Hui-Kang Wang; Kenneth F. Bastow; Kuo-Hsiung Lee

  Antitumor agents. Part 209: Pheophorbide-a derivatives as photo-independent cytotoxic agents

  Bioorganic and Medicinal Chemistry. 2002;10(3):583-591.
  29

• 288.

  2002

  Youichi Shinozaki; Narihiko Fukamiya; Masao Fukushima; Masayoshi Okano; Tatsuo Nehira; Kiyoshi Tagahara; Shun-Xiang Zhang; De-Cheng Zhang; Kuo-Hsiung Lee

  Dantaxusins C and D, two novel taxoids from Taxus yunnanensis

  Journal of Natural Products. 2002;65(3):371-374.
  5

• 289.

  2002

  Junko Ishida; Mutsuo Kozuka; Harukuni Tokuda; Hoyoku Nishino; Seiji Nagumo; Kuo-Hsiung Lee; Masahiro Nagai

  Chemopreventive potential of cyclic diarylheptanoids

  Bioorganic and Medicinal Chemistry. 2002;10(10):3361-3365.
  36

• 290.

  2001

  Yong-Ming Zhu; Jing-Kang Shen; Hui-Kang Wang; L.Mark Cosentino; Kuo-Hsiung Lee

  Synthesis and anti-HIV activity of oleanolic acid derivatives

  Bioorganic and Medicinal Chemistry Letters. 2001;11(24):3115-3118.
  38

• 291.

  2001

  Hsing-I Cheng; Wei-Yu Lin; Chang-Yih Duh; Kuo-Hsiung Lee; Ian-Lih Tsai; Ih-Sheng Chen

  New cytotoxic butanolides from Litsea acutivena

  Journal of Natural Products. 2001;64(12):1502-1505.
  28

• 292.

  2001

  Y. Xia; Z.-Y. Yang; P. Xia; T. Hackl; E. Hamel; A. Mauger; J.-H. Wu; K.-H. Lee

  Antitumor agents. 211. Fluorinated 2-phenyl-4-quinolone derivatives as antimitotic antitumor agents

  Journal of Medicinal Chemistry. 2001;44(23):3932-3936.
  75

• 293.

  2001

  Lan Xie; Graham Allaway; Carl Wild; Nicole Kilgore; Kuo-Hsiung Lee

  Anti-AIDS agents. Part 47:† Synthesis and Anti-HIV activity of 3-substituted 3′,4′-di-O-(S)-camphanoyl-(3′R,4′R)-(+)-cis- khellactone derivatives

  Bioorganic and Medicinal Chemistry Letters. 2001;11(17):2291-2293.
  8

• 294.

  2001

  Tetsuro Ito; Toshiyuki Tanaka; Ken-Ichi Nakaya; Munekazu Iinuma; Yoshikazu Takahashi; Hiroshi Naganawa; Masayoshi Ohyama; Yuka Nakanishi; Kenneth F. Bastow; Kuo-Hsiung Lee

  A new resveratrol octamer, vateriaphenol A, in Vateria indica

  Tetrahedron Letters. 2001;42(34):5909-5912.
  21

• 295.

  2001

  Tetsuro Ito; Toshiyuki Tanaka; Ken-Ichi Nakaya; Munekazu Iinuma; Yoshikazu Takahashi; Hiroshi Naganawa; Masayoshi Ohyama; Yuka Nakanishi; Kenneth F Bastow; Kuo-Hsiung Lee

  A novel bridged stilbenoid trimer and four highly condensed stilbenoid oligomers in Vatica rassak

  Tetrahedron. 2001;57(34):7309-7321.
  41

• 296.

  2001

  Yi Xia; Zheng-Yu Yang; Mann-Jen Hour; Sheng-Chu Kuo; Peng Xia; Kenneth F Bastow; Yuka Nakanishi; Priya Nampoothiri; Torben Hackl; et al.

  Antitumor agents. Part 204: Synthesis and biological evaluation of substituted 2-aryl quinazolinones

  Bioorganic and Medicinal Chemistry Letters. 2001;11(9):1193-1196.
  101

• 297.

  2001

  D.S. VanVliet; Y. Tachibana; K.F. Bastow; E.-S. Huang; K.-H. Lee

  Antitumor agents. 207. Design, synthesis, and biological testing of 4β-anilino-2-fluoro-4′-demethylpodophyllotoxin analogues as cytotoxic and antiviral agents

  Journal of Medicinal Chemistry. 2001;44(9):1422-1428.
  47

• 298.

  2001

  Yao-Haur Kuo; Shyh-Yuan Li; Ray-Ling Huang; Ming-Der Wu; Hui-Chi Huang; Kuo-Hsiung Lee

  Schizarin B, C, D, and E, four new lignans from Kadsura matsudai and their antihepatitis activities

  Journal of Natural Products. 2001;64(4):487-490.
  52

• 299.

  2001

  L. Xie; Y. Takeuchi; L.M. Cosentino; A.T. McPhail; K.-H. Lee

  Anti-AIDS agents. 42. Synthesis and anti-HIV activity of disubstituted (3′R,4′R)-3′,4′-di-O-(S)-camphanoyl-(+)-cis- khellactone analogues

  Journal of Medicinal Chemistry. 2001;44(5):664-671.
  85

• 300.

  2001

  Yoshiki Kashiwada; Kimihisa Yamazaki; Yasumasa Ikeshiro; Takashi Yamagishi; Toshihiro Fujioka; Kunihide Mihashi; Koichi Mizuki; L.Mark Cosentino; Keith Fowke; Susan L Morris-Natschke; et al.

  Isolation of rhododaurichromanic acid B and the anti-HIV principles rhododaurichromanic acid A and rhododaurichromenic acid from Rhododendron dauricum

  Tetrahedron. 2001;57(8):1559-1563.
  92

• 301.

  2001

  Ting-Chia Ko; Mann-Jen Hour; Jin-Cherng Lien; Che-Ming Teng; Kuo-Hsiung Lee; Sheng-Chu Kuo; Li-Jiau Huang

  Synthesis of 4-alkoxy-2-phenylquinoline derivatives as potent antiplatelet agents

  Bioorganic and Medicinal Chemistry Letters. 2001;11(3):279-282.
  52

• 302.

  2001

  Y. Kashiwada; J. Chiyo; Y. Ikeshiro; T. Nagao; H. Okabe; L.M. Cosentino; K. Fowke; K.H. Lee

  3,28-di-O-(dimethylsuccnyl)-betulin isomers as anti-HIV agents

  Bioorganic and Medicinal Chemistry Letters. 2001;11(2):183-185.
  30

• 303.

  2001

  Qian Zhang; Ying Chen; Yun Hong Zheng; Wan Yun Sheng; Peng Xia; Yi Xia; Zheng Yu Yang; Kuo Hsiung Lee

  The Synthesis of 7-[1-Aza-2-(dimethylamino)vinyl]-4-methylhydroquinolin-2-ones and their Isomerism in Different Solvents

  Chinese Chemical Letters. 2001;12(1):11-14.
  1

• 304.

  2001

  Qian Shi; Hui-Kang Wang; Kenneth F Bastow; Yoko Tachibana; Ke Chen; Fang-Yu Lee; Kuo-Hsiung Lee

  Antitumor agents 210. synthesis and evaluation of taxoid-epipodophyllotoxin conjugates as novel cytotoxic agents

  Bioorganic and Medicinal Chemistry. 2001;9(11):2999-3004.
  34

• 305.

  2001

  J. Ito; F.-R. Chang; H.-K. Wang; Y.K. Park; M. Ikegaki; N. Kilgore; K.-H. Lee

  Anti-AIDS agents. 48. Anti-HIV activity of moronic acid derivatives and the new melliferone-related triterpenoid isolated from Brazilian propolis

  Journal of Natural Products. 2001;64(10):1278-1281.
  100

• 306.

  2001

  Kinuko Iwasa; Masataka Moriyasu; Yoko Tachibana; Hye-Sook Kim; Yusuke Wataya; Wolfgang Wiegrebe; Kenneth F Bastow; L.Mark Cosentino; Mutsuo Kozuka; et al.

  Simple isoquinoline and benzylisoquinoline alkaloids as potential antimicrobial, antimalarial, cytotoxic, and anti-HIV agents

  Bioorganic and Medicinal Chemistry. 2001;9(11):2871-2884.
  40

• 307.

  2001

  Y. Shinozaki; N. Fukamiya; M. Fukushima; M. Okano; T. Nehira; K. Tagahara; S.-X. Zhang; D.-C. Zhang; K.-H. Lee

  Dantaxusins A and B, two new taxoids from Taxus yunnanensis

  Journal of Natural Products. 2001;64(8):1073-1076.
  6

• 308.

  2001

  J. Ishida; H.-K. Wang; M. Oyama; M.L. Cosentino; C.-Q. Hu; K.-H. Lee

  Anti-AIDS agents. 46.¹ Anti-HIV activity of harman, an anti-HIV principle from Symplocos setchuensis, and its derivatives

  Journal of Natural Products. 2001;64(7):958-960.
  57

• 309.

  2001

  H.-H. Cheng; H.-K. Wang; J. Ito; K.F. Bastow; Y. Tachibana; Y. Nakanishi; Z. Xu; T.-Y. Luo; K.-H. Lee

  Cytotoxic pheophorbide-related compounds from Clerodendrum calamitosum and C. cyrtophyllum

  Journal of Natural Products. 2001;64(7):915-919.
  40

• 310.

  2001

  Lallan Mishra; Ragini Sinha; Hideji Itokawa; Kenneth F Bastow; Yoko Tachibana; Yuka Nakanishi; Nicole Kilgore; Kuo-Hsiung Lee

  Anti-HIV and cytotoxic activities of Ru(II)/Ru(III) polypyridyl complexes containing 2,6-(2′-benzimidazolyl)-pyridine/chalcone as co-ligand

  Bioorganic and Medicinal Chemistry. 2001;9(7):1667-1671.
  34

• 311.

  2001

  Tian-Shung Wu; Zhih-Jing Tsang; Pei-Lin Wu; Fu-Wen Lin; Chia-Yin Li; Che-Ming Teng; Kuo-Hsiung Lee

  New constituents and antiplatelet aggregation and anti-HIV principles of Artemisia capillaris

  Bioorganic and Medicinal Chemistry. 2001;9(1):77-83.
  54

• 312.

  2000

  Kuo-Hsiung Lee; Hui-Kang Wang; Hideji Itokawa; Susan L. Morris-Natschke

  Current perspectives on Chinese medicines and dietary supplements in China, Japan and the United States

  Journal of Food and Drug Analysis. 2000;8(4):219-228.
  8

• 313.

  2000

  M.-J. Hour; L.-J. Huang; S.-C. Kuo; Y. Xia; K. Bastow; Y. Nakanishi; E. Hamel; K.-H. Lee

  6-alkylamino- and 2,3-dihydro-3′-methoxy-2-phenyl-4-quinazolinones and related compounds: Their synthesis, cytotoxicity, and inhibition of tubulin polymerization

  Journal of Medicinal Chemistry. 2000;43(23):4479-4487.
  146

• 314.

  2000

  Junko Ishida; Mutsuo Kozuka; Hui-Kang Wang; Takao Konoshima; Harukuni Tokuda; Masato Okuda; Xiao Yang Mou; Hoyoku Nishino; Nobuko Sakurai; et al.

  Antitumor-promoting effects of cyclic diarylheptanoids on Epstein-Barr virus activation and two-stage mouse skin carcinogenesis

  Cancer Letters. 2000;159(2):135-140.
  41

• 315.

  2000

  Masao Fukushima; Narihiko Fukamiya; Masayoshi Okano; Tatsuo Nehira; Kiyoshi Tagahara; Shun-Xiang Zhang; De-Cheng Zhang; Yoko Tachibana; Kenneth F. Bastow; et al.

  Cytotoxity of non-alkaloidal taxane diterpenes from Taxus chinensis against a paclitaxel-resistant cell line

  Cancer Letters. 2000;158(2):151-154.
  6

• 316.

  2000

  Sadaaki Tamura; Narihiko Fukamiya; Xiao-Yang Mou; Teruo Mukainaka; Harukuni Tokuda; Hoyoku Nishino; Kiyoshi Tagahara; Kazuo Koike; Kuo-Hsiung Lee; et al.

  Conversion of quassinoids for enhancement of inhibitory effect against Epstein-Barr virus early antigen activation. Introduction of lipophilic side chain and esterification of diosphenol

  Chemical and Pharmaceutical Bulletin. 2000;48(6):876-878.
  4

• 317.

  2000

  Zheng-Yu Yang; Yi Xia; Peng Xia; Arnold Brossi; L. Mark Cosentino; Kuo-Hsiung Lee

  Anti-AIDS agents Part 41: Synthesis and anti-HIV activity of 3',4'-di-o-(-)-camphanoyl-(+)-cis-khellactone (DCK) lactam analogues

  Bioorganic and Medicinal Chemistry Letters. 2000;10(10):1003-1005.
  17

• 318.

  2000

  Yi Xia; Zheng-Yu Yang; Peng Xia; Kenneth F. Bastow; Yuka Nakanishi; Kuo-Hsiung Lee

  Antitumor agents. Part 202: Novel 2'-amino chalcones: Design, synthesis and biological evaluation

  Bioorganic and Medicinal Chemistry Letters. 2000;10(8):699-701.
  94

• 319.

  2000

  Ping Zhou; Yoshihisa Takaishi; Hongquan Duan; Bei Chen; Gisho Honda; Michiho Itoh; Yoshio Takeda; Olimjon K. Kodzhimatov; Kuo-Hsing Lee

  Coumarins and bicoumarin from Ferula sumbul: Anti-HIV activity and inhibition of cytokine release

  Phytochemistry. 2000;53(6):689-697.
  86

• 320.

  2000

  Jang-Yang Chang; Xin Guo; Hong-Xing Chen; Zaoli Jiang; Qin Fu; Hui-Kang Wang; Kenneth F. Bastow; Xiao-Kang Zhu; Jian Guan; Kuo-Hsiung Lee; et al.

  Unique biochemical, cytotoxic, and antitumor activity of camptothecin and 4β-amino-4'-O-demethylepipodophyllotoxin conjugates

  Biochemical Pharmacology. 2000;59(5):497-508.
  18

• 321.

  2000

  Hongquan Duan; Yoshihisa Takaishi; Yasuhiro Imakura; Yongfong Jia; Duan Li; L. Mark Cosentino; Kuo-Hsiung Lee

  Sesquiterpene alkaloids from Tripterygium hypoglaucum and Tripterygium wilfordii: A new class of potent anti-HIV agents

  Journal of Natural Products. 2000;63(3):357-361.
  73

• 322.

  2000

  Shun-Xiang Zhang; Jun Feng; Sheng-Chu Kuo; Arnold Brossi; Ernest Hamel; Alexander Tropsha; Kuo-Hsiung Lee

  Antitumor agents. 199. Three-dimensional quantitative structure-activity relationship study of the colchicine binding site ligands using comparative molecular field analysis

  Journal of Medicinal Chemistry. 2000;43(2):167-176.
  79

• 323.

  2000

  Yoko Tachibana; Zhu Xiao-Kang; Preethi Krishnan; Lee Kuo-Hsiung; Kenneth F. Bastow; Kf Bastow

  Characterization of human lung cancer cells resistant to 4'-O-demethyl-4β-nitro-4'-fluoroanilino)-4- desoxypodophyllotoxin, a unique compound in the epipodophyllotoxin antitumor class

  Anti-Cancer Drugs. 2000;11(1):19-28.
  4

• 324.

  2000

  Y. Kashiwada; T. Nagao; A. Hashimoto; Y. Ikeshiro; H. Okabe; L.M. Cosentino; K.-H. Lee

  Anti-AIDS agents 38. Anti-HIV activity of 3-O-acyl ursolic acid derivatives

  Journal of Natural Products. 2000;63(12):1619-1622.
  85

• 325.

  2000

  Masataka Itoigawa; Yoshiki Kashiwada; Chihiro Ito; Hiroshi Furukawa; Yoko Tachibana; Kenneth F. Bastow; Kuo-Hsiung Lee

  Antitumor agents. 203. Carbazole alkaloid murrayaquinone A and related synthetic carbazolequinones as cytotoxic agent

  Journal of Natural Products. 2000;63(7):896-897.
  40

• 326.

  2000

  K.-H. Lee

  Research and future trends in the pharmaceutical development of medicinal herbs from Chinese medicine

  Public Health Nutrition. 2000;3(4 A):515-522.
  41

• 327.

  2000

  Z. Xu; F.-R. Chang; H.-K. Wang; Y. Kashiwada; A.T. McPhail; K.F. Bastow; Y. Tachibana; M. Cosentino; K.-H. Lee

  Anti-HIV agents 45¹ and antitumor agents 205.² Two new sesquiterpenes, leitneridanins A and B, and the cytotoxic and anti-HIV principles from Leitneria floridana

  Journal of Natural Products. 2000;63(12):1712-1715.
  31

• 328.

  2000

  Shyh-Yuan Li; Ming-Der Wu; Chi-We Wang; Yao-Haur Kou; Ray-Ling Huang; Kuo-Hsiung Lee

  A novel anti-HBeAg homolignan, taiwanschirin D from Kadsura matsudai

  Chemical and Pharmaceutical Bulletin. 2000;48(12):1992-1993.
  9

• 329.

  2000

  Yoshiki Kashiwada; Junko Chiyo; Yasumasa Ikeshiro; Tsuneatsu Nagao; Hikaru Okabe; L. Mark Cosentino; Keith Fowke; Susan L. Morris-Natschke; Kuo-Hsiung Lee

  Synthesis and anti-HIV activity of 3-alkylamido-3-deoxy-betulinic acid derivatives

  Chemical and Pharmaceutical Bulletin. 2000;48(9):1387-1390.
  22

• 330.

  2000

  M. Okano; N. Fukamiya; K.H. Lee

  Bioactive quassinoids

  Studies in Natural Products Chemistry. 2000;23(C):285-333.
  7

• 331.

  1999

  Yi Xia; Zheng-Yu Yang; Arnold Brossi; Kuo-Hsiung Lee

  Asymmetric Solid-Phase Synthesis of (3′R,4′R)-Di-O-cis-acyl 3-Carboxyl Khellactones

  Organic Letters. 1999;1(13):2113-2115.
  10

• 332.

  1999

  Junko Ishida; Hui-Kang Wang; Kenneth F. Bastow; Chang-Qi Hu; Kuo-Hsiung Lee

  Antitumor agents 201. Cytotoxicity of harmine and β-carboline analogs

  Bioorganic and Medicinal Chemistry Letters. 1999;9(23):3319-3324.
  78

• 333.

  1999

  Masayoshi Ohyama; Toshiyuki Tanaka; Tetsuro Ito; Munekazu Iinuma; Kenneth F. Bastow; Kuo-Hsiung Lee

  Antitumor agents 200. Cytotoxicity of naturally occurring resveratrol oligomers and their acetate derivatives

  Bioorganic and Medicinal Chemistry Letters. 1999;9(20):3057-3060.
  60

• 334.

  1999

  Shun-Xiang Zhang; Kenneth F. Bastow; Yoko Tachibana; Sheng-Chu Kuo; Ernest Hamel; Anthony Mauger; Ven L. Narayanan; Kuo-Hsiung Lee

  Antitumor agents. 196. Substituted 2-thienyl-1,8-naphthyridin-4-ones: Their synthesis, cytotoxicity, and inhibition of tubulin polymerization

  Journal of Medicinal Chemistry. 1999;42(20):4081-4087.
  54

• 335.

  1999

  Peng Xia; Zheng-Yu Yang; Yi Xia; Yun-Qing Zheng; L.Mark Cosentino; Kuo-Hsiung Lee

  Anti-AIDS agents. Part 36: 17-carboxylated steroids as potential anti-HIV agents

  Bioorganic and Medicinal Chemistry. 1999;7(9):1907-1911.
  9

• 336.

  1999

  Lan Xie; Yasuo Takeuchi; L. Mark Cosentino; Kuo-Hsiung Lee

  Anti-AIDS agents. 37. Synthesis and structure-activity relationships of (3'R,4'R)-(+)-cis-khellactone derivatives as novel potent anti-HIV agents

  Journal of Medicinal Chemistry. 1999;42(14):2662-2672.
  95

• 337.

  1999

  X.-K. Zhu; J. Guan; Y. Tachibana; K.F. Bastow; Sung Jin Cho; H. Cheng H.-; Y.-C. Cheng; M. Gurwith; K.-H. Lee

  Antitumor agents. 194. Synthesis and biological evaluations of 4-β- mono-, -di-, and -trisubstituted aniline-4'-O-demethyl-podophyllotoxin and related compounds with improved pharmacological profiles

  Journal of Medicinal Chemistry. 1999;42(13):2441-2446.
  47

• 338.

  1999

  Kuo-Hsiung Lee

  Anticancer drug design based on plant-derived natural products

  Journal of Biomedical Science. 1999;6(4):236-250.
  63

• 339.

  1999

  Zheng-Yu Yang; Yi Xia; Peng Xia; Arnold Brossi; Kuo-Hsiung Lee

  A concise regiospecific synthesis of 8,8-dimethyl-2H, 8H-pyrano [6, 5- h]quinolin-2-one and related compounds

  Tetrahedron Letters. 1999;40(24):4505-4506.
  8

• 340.

  1999

  Yu-Hua Chao; Sheng-Chu Kuo; Kelvin Ku; I-Ping Chiu; Chun-Hsiung Wu; Anthony Mauger; Hui-Kang Wang; Kuo-Hsiung Lee

  Synthesis and cytotoxicity of Methyl-4,8-dihydrobenzo[1,2-b:5,4-b']dithiophene-4,8-dione derivatives

  Bioorganic and Medicinal Chemistry. 1999;7(6):1025-1031.
  10

• 341.

  1999

  Hongquan Duan; Yoshihisa Takaishi; Masahiko Bando; Masaru Kido; Yasuo Imakura; KuoHsiung Lee

  Novel sesquiterpene esters with alkaloid and monoterpene and related compounds from Tripterygium Hypoglaucum: A new class of potent anti-HIV agents

  Tetrahedron Letters. 1999;40(15):2969-2972.
  29

• 342.

  1999

  Shakila Rahman; Narihiko Fukamiya; Harukuni Tokuda; Hoyoku Nishino; Kiyoshi Tagahara; Kuo-Hsiung Lee; Masayoshi Okano

  Three new quassinoid derivatives and related compounds as antitumor promoters from Brucea javanica

  Bulletin of the Chemical Society of Japan. 1999;72(4):751-756.
  12

• 343.

  1999

  David S. VanVliet; Kuo-Hsiung Lee

  A high yield preparation of 2-fluoropodophyllotoxin

  Tetrahedron Letters. 1999;40(12):2259-2262.
  13

• 344.

  1999

  Zheng-Yu Yang; Yi Xia; Peng Xia; Yoko Tachibana; Kenneth F. Bastow; Kuo-Hsiung Lee

  Antitumor agents 187: Synthesis and cytotoxicity of substituted 8,8- dimethyl-2H,8H-pyrano[6,5-h]quinoline-2-one and related compounds

  Bioorganic and Medicinal Chemistry Letters. 1999;9(5):713-716.
  13

• 345.

  1999

  Toshimitsu Hayashi; Tatsuhiko Nakano; Mutsuo Kozuka; Donald R. McPhail; Andrew T. McPhail; Kuo-Hsiung Lee

  Antitumor agents. 190.₁ Absolute stereochemistry of the cytotoxic germacranolides, tomenphantins A and B, from Elephantopus tomentosus

  Journal of Natural Products. 1999;62(2):302-304.
  11

• 346.

  1999

  Asok Banerjee; Lorraine T. Kasmala; Ernest Hamel; Li Sun; Kuo-Hsiung Lee

  Interaction of novel thiocolchicine analogs with the tubulin isoforms from bovine brain

  Biochemical and Biophysical Research Communications. 1999;254(2):334-337.
  5

• 347.

  1999

  Kazuma Hirata; Chihiro Ito; Hiroshi Furukawa; Masataka Itoigawa; L. Mark Cosentino; Kuo-Hsiung Lee

  Substituted 7H-pyrido[4,3-c]carbazoles with potent anti-HIV activity

  Bioorganic and Medicinal Chemistry Letters. 1999;9(2):119-122.
  40

• 348.

  1999

  Jian Guan; Xiao-Kang Zhu; Arnold Brossi; Yoko Tachibana; Kenneth F. Bastow; Pascal Verdier-Pinard; Ernest Hamel; Andrew T. McPhail; Kuo-Hsiung Lee

  Antitumor agents. 192. Antitubulin effect and cytotoxicity of C(7)-oxygenated allocolchicinoids

  Collection of Czechoslovak Chemical Communications. 1999;64(2):217-228.
  16

• 349.

  1999

  Ke Chen; Qian Shi; Zhu-Lian Li; Chi-Duen Poon; Ren-Jiu Tang; Kuo-Hsiung Lee

  Structures and stereochemistry of pseudolarolides K and L, novel triterpene dilactones from Pseudolarix kaempferi

  Journal of Asian Natural Products Research. 1999;1(3):207-214.
  6

• 350.

  1999

  Yi Xia; Zheng-Yu Yang; Susan L. Morris-Natschke; Kuo-Hsiung Lee

  Recent advances in the discovery and development of quinolones and analogs as antitumor agents

  Current Medicinal Chemistry. 1999;6(3):179-194.
  22

• 351.

  1999

  Dao-Feng Chen; Shun-Xiang Zhang; Hui-Kang Wang; Shi-Yuan Zhang; Quan-Zhong Sun; L. Mark Cosentino; Kuo-Hsiung Lee

  Novel anti-HIV lancilactone C and related triterpenes from Kadsura lancilimba

  Journal of Natural Products. 1999;62(1):94-97.
  74

• 352.

  1999

  Masao Fukushima; Junko Takeda; Narihiko Fukamiya; Masayoshi Okano; Kiyoshi Tagahara; Shun-Xiang Zhang; De-Cheng Zhang; Kuo-Hsiung Lee

  A new taxoid, 19-acetoxytaxagifine, from Taxus chinensis

  Journal of Natural Products. 1999;62(1):140-142.
  8

• 353.

  1999

  Kuo-Hsiung Lee

  Recent advances in the discovery and development of plant-derived natural products and their analogs as anti-HIV agents

  Pure and Applied Chemistry. 1999;71(6):1045-1051.
  24

• 354.

  1999

  L. Kuo-Hsiung

  Novel antitumor agents from higher plants

  Medicinal Research Reviews. 1999;19(6):569-596.
  66

• 355.

  1998

  Aimin He; Mingshi Wang; Hongyan Hao; Decheng Zhang; Kuo-Hsiung Lee

  Hepatoprotective triterpenes from Sedum sarmentosum

  Phytochemistry. 1998;49(8):2607-2610.
  20

• 356.

  1998

  Toshihiro Fujioka; Miyako Yamamoto; Yoshiki Kashiwada; Hiroko Fujii; Kunihide Mihashi; Yasumasa Ikeshiro; Ih-Sheng Chen; Kuo-Hsiung Lee

  Novel cytotoxic diterpenes from the stem of Dysoxylum kuskusense

  Bioorganic and Medicinal Chemistry Letters. 1998;8(24):3479-3482.
  8

• 357.

  1998

  Li-Jiau Huang; Fu-Chaio Chang; Kuo-Hsiung Lee; Jih-Pyang Wang; Che-Ming Teng; Sheng-Chu Kuo

  Synthesis and antiplatelet, antiinflammatory, and antiallergic activities of substituted 3-chloro-5,8-dimethoxy-1,4-naphthoquinone and related compounds

  Bioorganic and Medicinal Chemistry. 1998;6(12):2261-2269.
  16

• 358.

  1998

  Yu-Hua Chao; Sheng-Chu Kuo; Chun-Hsiung Wu; Chun-Yann Lee; Anthony Mauger; I.-Chen Sun; Susan L. Morris-Natschke; Kuo-Hsiung Lee

  Synthesis and cytotoxicity of 2-acetyl-4,8-dihydrobenzodithiophene-4,8- dione derivatives

  Journal of Medicinal Chemistry. 1998;41(23):4658-4661.
  9

• 359.

  1998

  I.-Chen Sun; Hui-Kang Wang; Yoshiki Kashiwada; Jing-Kang Shen; L. Mark Cosentino; Chin-Ho Chen; Li-Ming Yang; Kuo-Hsiung Lee

  Anti-AIDS agents. 34. Synthesis and structure-activity relationships of betulin derivatives as anti-HIV agents

  Journal of Medicinal Chemistry. 1998;41(23):4648-4657.
  86

• 360.

  1998

  Jian Guan; Xiao-Kang Zhu; Yoko Tachibana; Kenneth F. Bastow; Arnold Brossi; Ernest Hamel; Kuo-Hsiung Lee

  Antitumor agents. Part 186: Synthesis and biological evaluation of demethylcolchiceinamide analogues as cytotoxic DNA topoisomerase II inhibitors

  Bioorganic and Medicinal Chemistry. 1998;6(11):2127-2131.
  6

• 361.

  1998

  Li-Jiau Huang; Sheng-Chu Kuo; Cherng-Yih Perng; Yu-Hua Chao; Tian-Shung Wu; Andrew T. McPhail; Anthony Mauger; Huey-Hwa Cheng; Kuo-Hsiung Lee

  Synthesis and cytotoxicity of acetyl-4H, 9H-naphtho[2,3-b]thiophene- 4,9-diones

  Bioorganic and Medicinal Chemistry Letters. 1998;8(19):2763-2768.
  7

• 362.

  1998

  Li-Jiau Huang; Ming-Chieh Hsieh; Che-Ming Teng; Kuo-Hsiung Lee; Sheng-Chu Kuo

  Synthesis and antiplatelet activity of phenyl quinolones

  Bioorganic and Medicinal Chemistry. 1998;6(10):1657-1662.
  55

• 363.

  1998

  Ming-Chieh Hsieh; Li-Jiau Huang; Tian-Shung Wu; Kuo-Hsiung Lee; Che-Ming Teng; Sheng-Chu Kuo

  Synthesis and antiplatelet activity of 3,5,6,7,8,2',3' and 4'- disubsituted 2-phenyl-4-quinolones

  Chinese Pharmaceutical Journal. 1998;50(5):277-288.
  1

• 364.

  1998

  Yoshiki Kashiwada; Hui-Kang Wang; Tsuneatsu Nagao; Susumu Kitanaka; Ichiro Yasuda; Toshihiro Fujioka; Takashi Yamagishi; L. Mark Cosentino; Mutsuo Kozuka; et al.

  Anti-AIDS agents, 30. Anti-HIV activity of oleanolic acid, pomolic acid, and structurally related triterpenoids

  Journal of Natural Products. 1998;61(9):1090-1095.
  163

• 365.

  1998

  Lan Xie; Yasuo Takeuchi; L. Mark Cosentino; Kuo-Hsiung Lee

  Anti-AIDS agents 33.¹ Synthesis and anti-HIV activity of mono-methyl substituted 3',4'-di-O-(-)-camphanoyl-(+)-cis-khellactone (DCK) analogues

  Bioorganic and Medicinal Chemistry Letters. 1998;8(16):2151-2156.
  25

• 366.

  1998

  Riichi Tawa; Dayuan Gao; Masashi Takami; Yasuhiro Imakura; Kuo-Hsiung Lee; Hiromu Sakurai

  Binding affinity of Cu(II)-VP-16 (etoposide) complex and its analogues to DNA and hydroxyl radical generation during DNA strand breaks

  Bioorganic and Medicinal Chemistry. 1998;6(7):1003-1008.
  8

• 367.

  1998

  Zheng-Yu Yang; Yi Xia; Peng Xia; L. Mark Cosentino; Kuo-Hsiung Lee

  Anti-AIDS agents 31. Synthesis and anti-HIV activity of 4-substituted 3',4'-di-O-(-)-camphanoyl-(+)-cis-khellactone (DCK) thiolactone analogs

  Bioorganic and Medicinal Chemistry Letters. 1998;8(12):1483-1486.
  16

• 368.

  1998

  Qian Shi; Ke Chen; Xin Chen; Arnold Brossi; Pascal Verdier-Pinard; Ernest Hamel; Andrew T. McPhail; Alexander Tropsha; Kuo-Hsiung Lee

  Antitumor Agents. 183. Syntheses, Conformational Analyses, and Antitubulin Activity of Allothiocolchicinoids

  Journal of Organic Chemistry. 1998;63(12):4018-4025.
  24

• 369.

  1998

  Qian Shi; Ke Chen; Susan L. Morris-Natschke; Kuo-Hsiung Lee

  Recent progress in the development of tubulin inhibitors as antimitotic antitumor agents

  Current Pharmaceutical Design. 1998;4(3):219-248.
  97

• 370.

  1998

  Jian Guan; Xiao-Kang Zhu; Yoko Tachibana; Kenneth F. Bastow; Arnold Brossi; Ernest Hamel; Kuo-Hsiung Lee

  Antitumor agents. 185. Synthesis and biological evaluation of tridemethylthiocolchicine analogues as novel topoisomerase II inhibitors

  Journal of Medicinal Chemistry. 1998;41(11):1956-1961.
  15

• 371.

  1998

  I-Chen Sun; Jing-Kang Shen; Hui-Kang Wang; L. Mark Cosentino; Kuo-Hsiung Lee

  Anti-AIDS agents. 32.¹ Synthesis and anti-HIV activity of betulin derivatives

  Bioorganic and Medicinal Chemistry Letters. 1998;8(10):1267-1272.
  35

• 372.

  1998

  Ming-Chieh Hsieh; Li-Jiau Huang; Kuo-Hsiung Lee; Tian-Shung Wu; Sheng-Chih Chen; Che-Ming Teng; Sheng-Chu Kuo

  Synthesis and antiplatelet activity of 3,5,6,7,8,2',3' and 4'- monosubstituted 2-phenyl-4-quinolones

  Chinese Pharmaceutical Journal. 1998;50(2):67-80.
  4

• 373.

  1998

  Fang-Rong Chang; Pey-Yuh Yang; Jung-Yaw Lin; Kuo-Hsiung Lee; Yang-Chang Wu

  Bioactive kaurane diterpenoids from Annona glabra

  Journal of Natural Products. 1998;61(4):437-439.
  33

• 374.

  1998

  Yi Xia; Zheng-Yu Yang; Peng Xia; Kenneth F. Bastow; Yoko Tachibana; Sheng-Chu Kuo; Ernest Hamel; Torben Hackl; Kuo-Hsiung Lee

  Antitumor agents. 181. Synthesis and biological evaluation of 6,7,2',3',4'-substituted-1,2,3,4-tetrahydro-2-phenyl-4-quinolones as a new class of antimitotic antitumor agents

  Journal of Medicinal Chemistry. 1998;41(7):1155-1162.
  136

• 375.

  1998

  Jian Guan; Arnold Brossi; Xiao-Kang Zhu; Hui-Kang Wang; Kuo-Hsiung Lee

  Oxidation products of phenolic thiocolchicines: Ring a quinones and dienones

  Synthetic Communications. 1998;28(9):1585-1591.
  4

• 376.

  1998

  Q. Shi; K. Chen; A. Brossi; P. Verdier-Pinard; E. Hamel; A.T. McPhail; H. Lee K.-

  Syntheses and antitubulin activity of compounds derived from reaction of thiocolchicone with amines: Lactams, alcohols, and ester analogs of allothiocolchicinoids

  Helvetica Chimica Acta. 1998;81(6):1023-1037.
  30

• 377.

  1998

  Hui-Kang Wang; Yi Xia; Zheng-Yu Yang; Susan L. Morris Natschke; Kuo-Hsiung Lee

  Recent advances in the discovery and development of flavonoids and their analogues as antitumor and anti-HIV agents

  Advances in Experimental Medicine and Biology. 1998;439:191-225.
  80

• 378.

  1997

  Zev Lidert; David H. Young; Margaret M. Bowers-Daines; Samuel E. Sherba; Raj J. Mehta; Barry C. Lange; Colin Swithenbank; Hiroshi Kiyokawa; Mary G. Johnson; Susan L. Morris-Natschke; et al.

  1,4-Bis-(2,3-epoxypropylamino)-9,10-anthracenedione and related compounds as potent antifungal and antimicrobial agents

  Bioorganic and Medicinal Chemistry Letters. 1997;7(24):3153-3158.
  2

• 379.

  1997

  Jin-Cherng Lien; Li-Jiau Huang; Jih-Pyang Wang; Che-Ming Teng; Kuo-Hsiung Lee; Sheng-Chu Kou

  Synthesis and antiplatelet, antiinflammatory, and antiallergic activities of 2-substituted 3-chloro-1,4-naphthoquinone derivatives

  Bioorganic and Medicinal Chemistry. 1997;5(12):2111-2120.
  33

• 380.

  1997

  Fumio Hashimoto; Yoshiki Kashiwada; L. Mark Cosentino; Chin-Ho Chen; Patricia E. Garrett; Kuo-Hsiung Lee

  Anti-AIDS agents - XXVII. Synthesis and anti-HIV activity of betulinic acid and dihydrobetulinic acid derivatives

  Bioorganic and Medicinal Chemistry. 1997;5(12):2133-2143.
  85

• 381.

  1997

  Qian Shi; Pascal Verdier-Pinard; Arnold Brossi; Ernest Hamel; Kuo-Hsiung Lee

  Antitumor Agents-CLXXV. Anti-tubulin action of (+)-thiocolchicine prepared by partial synthesis

  Bioorganic and Medicinal Chemistry. 1997;5(12):2277-2282.
  13

• 382.

  1997

  Catherine Tung-Ling Lee; Victor Chih-Kuang Lin; Shun-Xiang Zhang; Xiao-Kang Zhu; David VanVliet; Hong Hu; Scott A. Beers; Zhe-Qing Wang; L. Mark Cosentino; Susan L. Morris-Natschke; et al.

  Anti-AIDS agents. 29 Anti-HIV activity of modified podophyllotoxin derivatives

  Bioorganic and Medicinal Chemistry Letters. 1997;7(22):2897-2902.
  24

• 383.

  1997

  Yoshiki Kashiwada; Toshihiro Fujioka; Kunihide Mihashi; Ih-Sheng Chen; Hajime Katayama; Yasumasa Ikeshiro; Kuo-Hsiung Lee

  Antitumor agents. 180. Chemical studies and cytotoxic evaluation of cumingianosides and cumindysoside A, antileukemic triterpene glucosides with a 14,18-cycloapotirucallane skeleton

  Journal of Natural Products. 1997;60(11):1105-1114.
  8

• 384.

  1997

  Yasuo Takeuchi; Lan Xie; L. Mark Cosentino; Kuo-Hsiung Lee

  Anti-AIDS agents - XXVIII. Synthesis and anti-HIV activity of methoxy substitute 3',4'-di-O-(-)-Camphanoyl-(+)-cis-Khellactone (DCK) analogues

  Bioorganic and Medicinal Chemistry Letters. 1997;7(20):2573-2578.
  30

• 385.

  1997

  Hidemitsu Hara; Naoki Maruyama; Shinsuke Yamashita; Yasuhisa Hayashi; Kuo-Hsiung Lee; Kenneth F. Bastow; Chairul; Ryuji Marumoto; Yasuhiro Imakura

  Elecanacin, a novel new naphthoquinone from the bulb of Eleutherine americana

  Chemical and Pharmaceutical Bulletin. 1997;45(10):1714-1716.
  30

• 386.

  1997

  Shakila Rahman; Narihiko Fukamiya; Masayoshi Okano; Kiyoshi Tagahara; Kuo-Hsiung Lee

  Anti-tuberculosis activity of quassinoids

  Chemical and Pharmaceutical Bulletin. 1997;45(9):1527-1529.
  29

• 387.

  1997

  Kenneth F. Bastow; Hui-Kang Wang; Yung-Chi Cheng; Kuo-Hsiung Lee

  Antitumor Agents-CLXXIII. Synthesis and evaluation of camptothecin-4β-amino-4'-O-demethyl epipodophyllotoxin conjugates as inhibitors of mammalian DNA topoisomerases and as cytotoxic agents

  Bioorganic and Medicinal Chemistry. 1997;5(8):1481-1488.
  32

• 388.

  1997

  Dao-Feng Chen; Shun-Xiang Zhang; Lan Xie; Jing-Xi Xie; Ke Chen; Yoshiki Kashiwada; Bing-Nan Zhou; Pei Wang; L. Mark Cosentino; Kuo-Hsiung Lee

  Anti-AIDS agents-XXVI. Structure-activity correlations of gomisin-G-related anti-HIV lignans from Kadsura interior and of related synthetic analogues

  Bioorganic and Medicinal Chemistry. 1997;5(8):1715-1723.
  117

• 389.

  1997

  Mary G. Johnson; Hiroshi Kiyokawa; Shohei Tani; Junko Koyama; Susan L. Morris-Natschke; Anthony Mauger; Margaret M. Bowers-Daines; Barry C. Lange; Kuo-Hsiung Lee

  Antitumor Agents-CLXVII. Synthesis and structure-activity correlations of the cytotoxic anthraquinone 1,4-bis-(2,3-epoxypropylamino)-9,10-anthracenedione, and of related compounds

  Bioorganic and Medicinal Chemistry. 1997;5(8):1469-1479.
  26

• 390.

  1997

  Nobuhiro Ohno; Narihiko Fukamiya; Masayoshi Okano; Kiyoshi Tagahara; Kuo-Hsiung Lee

  Synthesis of cytotoxic fluorinated quassinoids

  Bioorganic and Medicinal Chemistry. 1997;5(8):1489-1495.
  14

• 391.

  1997

  Ke Chen; Sheng-Chu Kuo; Ming-Chieh Hsieh; Anthony Mauger; Chii M. Lin; Ernest Hamel; Kuo-Hsiung Lee

  Antitumor agents. 174. 2',3',4',5,6,7-Substituted 2-phenyl-1,8- naphthyridin-4-ones: Their synthesis, cytotoxicity, and inhibition of tubulin polymerization

  Journal of Medicinal Chemistry. 1997;40(14):2266-2275.
  56

• 392.

  1997

  Hui-Kang Wang; Susan L. Morris-Natschke; Kuo-Hsiung Lee

  Recent advances in the discovery and development of topoisomerase inhibitors as antitumor agents

  Medicinal Research Reviews. 1997;17(4):367-425.
  113

• 393.

  1997

  Tian-Shung Wu; Meei-Jen Liou; Chang-Sheng Kuoh; Che-Ming Teng; Tsuneatsu Nagao; Kuo-Hsiung Lee

  Cytotoxic and antiplatelet aggregation principles from Aglaia elliptifolia

  Journal of Natural Products. 1997;60(6):606-608.
  42

• 394.

  1997

  Shakila Rahman; Narihiko Fukamiya; Nobuhiro Ohno; Harukuni Tokuda; Hoyoku Nishino; Kiyoshi Tagahara; Kuo-Hsiung Lee; Masayoshi Okano

  Inhibitory effects of quassinoid derivatives on Epstein-Barr virus early antigen activation

  Chemical and Pharmaceutical Bulletin. 1997;45(4):675-677.
  9

• 395.

  1997

  Qian Shi; Pascal Verdier-Pinard; Arnold Brossi; Ernest Hamel; Andrew T. McPhail; Kuo-Hsiung Lee

  Antitumor agents. 172. Synthesis and biological evaluation of novel deacetamidothiocolchicin-7-ols and ester analogs as antitubulin agents

  Journal of Medicinal Chemistry. 1997;40(6):961-966.
  36

• 396.

  1997

  Zheng Ji; Hui-Kang Wang; Kenneth F. Bastow; Xiao-Kang Zhu; Sung Jin Cho; Yung-Chi Cheng; Kuo-Hsiung Lee

  Antitumor agents. 177. Design, syntheses, and biological evaluation of novel etoposide analogs bearing pyrrolecarboxamidino group as DNA topoisomerase II inhibitors

  Bioorganic and Medicinal Chemistry Letters. 1997;7(5):607-612.
  24

• 397.

  1997

  Kengo Kubota; Narihiko Fukamiya; Harukuni Tokuda; Hoyoku Nishino; Kiyoshi Tagahara; Kuo-Hsiung Lee; Masayoshi Okano

  Quassinoids as inhibitors of Epstein-Barr virus early antigen activation

  Cancer Letters. 1997;113(1-2):165-168.
  15

• 398.

  1997

  Riichi Tawa; Masashi Takami; Yasuhiro Imakura; Kuo-Hsiung Lee; Hiromu Sakurai

  Effects of CpG methylation to double stranded DNA breaks by Cu(II)-podophyllotoxin derivative complexes

  Bioorganic and Medicinal Chemistry Letters. 1997;7(4):489-494.
  9

• 399.

  1997

  Toshihiro Fujioka; Akio Sakurai; Kunihide Mihashi; Yoshiki Kashiwada; Ih-Sheng Chen; Kuo-Hsiung Lee

  Antitumor agents. 168. Dysoxylum cumingianum. IV. The structures of cumingianosides G-O, new triterpene glucosides with a 14,18- cycloapotirucallane-type skeleton from Dysoxylum cumingianum, and their cytotoxicity against human cancer cell lines

  Chemical and Pharmaceutical Bulletin. 1997;45(1):68-74.
  18

• 400.

  1997

  Toshihiro Fujioka; Akio Sakurai; Kunihide Mihashi; Yoshiki Kashiwada; Ih-Sheng Chen; Kuo-Hsiung Lee

  Antitumor agents. 169. Dysoxylum cumingianum. V. Cumingianosides P and Q, new cytotoxic triterpene glucosides with an apotirucallane-type skeleton from Dysoxylum cumingianum

  Chemical and Pharmaceutical Bulletin. 1997;45(1):202-206.
  10

• 401.

  1997

  J.-F. Zeng; G.-L. Li; J.-K. Shen; D.-Y. Zhu; K. Chen; K.-H. Lee

  Manuifolins D, E, and F: New isoflavonoids from Maackia tenuifolia

  Journal of Natural Products. 1997;60(9):918-920.
  7

• 402.

  1997

  Yao-Haur Kuo; Chi-I Chang; Shyh-Yuan Li; Cheng-Jen Chou; Chieh-Fu Chen; Yueh-Hsiung Kuo; Kuo-Hsiung Lee

  Cytotoxic constituents from the stems of Diospyros maritima

  Planta Medica. 1997;63(4):363-365.
  29

• 403.

  1997

  Riichi Tawa; Masashi Takami; Yasuhiro Imakura; Kuo-Hsiung Lee; Hiromu Sakurai

  Breaks in double-strand DNA by Cu(II) complexes of etoposide (VP-16) and its derivatives, as evaluated by S1 nuclease treatment

  Biological and Pharmaceutical Bulletin. 1997;20(9):1002-1005.
  3

• 404.

  1997

  Ke Chen; Sheng-Chu Kuo; Ming-Chieh Hsieh; Anthony Mauger; Chii M. Lin; Ernest Hamel; Kuo-Hsiung Lee

  Antitumor agents. 178. Synthesis and biological evaluation of substituted 2-aryl-1,8-naphthyridin-4(1H)-ones as antitumor agents that inhibit tubulin polymerization

  Journal of Medicinal Chemistry. 1997;40(19):3049-3056.
  69

• 405.

  1997

  Hui-Kang Wang; Kuo-Hsiung Lee

  Plant-derived anticancer agents and their analogs currently in clinical use or in clinical trials

  Botanical Bulletin of Academia Sinica. 1997;38(4):225-235.
  10

• 406.

  1997

  Tian-Shung Wu; Yann-Lii Leu; Chang-Sheng Kuoh; Shwu-Duan Jiang; Chieh-Fu Chen; Kuo-Hsiung Lee

  Cytotoxic Principles from Saussurea Lappa and Corydalis Turtshaninovii f. Yanhusuo

  Journal of the Chinese Chemical Society. 1997;44(3):357-359.
  7

• 407.

  1996

  Toshihiro Fujioka; Yoshiki Kashiwada; Hikaru Okabe; Kunihide Mihashi; Kuo-Hsiung Lee

  Antitumor agents 171. Cytotoxicities of lobatosides B, C, D, and E, cyclic bisdesmosides isolated from Actinostemma lobatum maxim

  Bioorganic and Medicinal Chemistry Letters. 1996;6(23):2807-2810.
  7

• 408.

  1996

  Kengo Kubota; Narihiko Fukamiya; Masayoshi Okano; Kiyoshi Tagahara; Kuo-Hsiung Lee

  Two new quassinoids, ailantinols C and D, from Ailanthus Altissima

  Bulletin of the Chemical Society of Japan. 1996;69(12):3613-3617.
  9

• 409.

  1996

  Ke Chen; Yi-Ling Zhang; Zhu-Lian Li; Qian Shi; Chi-Duen Poon; Ren-Jiu Tang; Andrew T. McPhail; Kuo-Hsiung Lee

  Structure and stereochemistry of pseudolarolide J, a novel nortriterpene lactone from Pseudolarix kaempferi

  Journal of Natural Products. 1996;59(12):1200-1202.
  8

• 410.

  1996

  Dao-Feng Chen; Shun-Xiang Zhang; Ke Chen; Bing-Nan Zhou; Pei Wang; L. Mark Cosentino; Kuo-Hsiung Lee

  Two new lignans, interiotherins A and B, as anti-HIV principles from Kadsura interior

  Journal of Natural Products. 1996;59(11):1066-1068.
  95

• 411.

  1996

  Yun-Lian Lin; Jun-Chih Ou; Yueh-Hsiung Kuo; Jung-Kuei Lin; Kuo-Hsiung Lee

  Napalolides A-D, four new sesquiterpene lactones from Carpesium nepalense

  Journal of Natural Products. 1996;59(10):991-993.
  13

• 412.

  1996

  Kengo Kubota; Narihiko Fukamiya; Tomomi Hamada; Masayoshi Okano; Kiyoshi Tagahara; Kuo-Hsiung Lee

  Two new quassinoids, ailantinols A and B, and related compounds from Ailanthus altissima

  Journal of Natural Products. 1996;59(7):683-686.
  25

• 413.

  1996

  Yang-Chang Wu; Yu-Chun Hung; Fang-Rong Chang; Mark Cosentino; Hui-Kang Wang; Kuo-Hsiung Lee

  Identification of ent-16β,17-dihydroxykauran-19-oic acid as an anti- HIV principle and isolation of the new diterpenoids annosquamosins A and B from Annona squamosa

  Journal of Natural Products. 1996;59(6):635-637.
  79

• 414.

  1996

  Jin-Cherng Lien; Li-Jiau Huang; Jih-Pyang Wang; Che-Ming Teng; Kuo-Hsiung Lee; Sheng-Chu Kuo

  Synthesis and antiplatelet, antiinflammatory and antiallergic activities of 2,3-disubstituted 1,4-naphthoquinones

  Chemical and Pharmaceutical Bulletin. 1996;44(6):1181-1187.
  26

• 415.

  1996

  Hui-Kang Wang; Kenneth F. Bastow; L. Mark Cosentino; Kuo-Hsiung Lee

  Antitumor agents. 166. Synthesis and biological evaluation of 5,6,7,8-substituted-2-phenylthiochromen-4-ones

  Journal of Medicinal Chemistry. 1996;39(10):1975-1980.
  39

• 416.

  1996

  Li-Ming Yang; Shwu-Jiuan Lin; Tsang-Hsiung Yang; Kuo-Hsiung Lee

  Synthesis and anti-HIV activity of dibenzylbutyrolactone lignans

  Bioorganic and Medicinal Chemistry Letters. 1996;6(8):941-944.
  29

• 417.

  1996

  Sung Jin Cho; Alexander Tropsha; Matthew Sufness; Yung-Chi Cheng; Kuo-Hsiung Lee

  Antitumor agents. 163. Three-dimensional quantitative structure-activity relationship study of 4′-O-demethylepipodophyllotoxin analogs using the modified CoMFA/q²-GRS approach

  Journal of Medicinal Chemistry. 1996;39(7):1383-1395.
  74

• 418.

  1996

  Sheng-Chu Kuo; Toshiro Ibuka; Li-Jiau Huang; Jin-Cherng Lien; Shyue-Ren Yean; Shung-Chieh Huang; Daniel Lednicer; Susan Morris-Natsehke; Kuo-Hsiung Lee

  Synthesis and cytotoxicity of 1,2-disubstituted naphth[2,3-d]imidazole-4,9-diones and related compounds

  Journal of Medicinal Chemistry. 1996;39(7):1447-1451.
  15

• 419.

  1996

  Sung Jin Cho; Yoshiki Kashiwada; Kenneth F. Bastow; Yung-Chi Cheng; Kuo-Hsiung Lee

  Antitumor agents. 164. Podophenazine, 2″,3″-dichloropodophenazine, benzopodophenazine, and their 4β-p-nitroaniline derivatives as novel DNA topoisomerase II inhibitors

  Journal of Medicinal Chemistry. 1996;39(7):1396-1402.
  47

• 420.

  1996

  Fumlo Hashimoto; Yoshiki Kashiwada; Gen-Ichiro Nonaka; Itsuo Nishioka; Toshihiro Nohara; L. Mark Cosentino; Kuo-Hsiung Lee

  Evaluation of tea polyphenols as anti-HIV agents

  Bioorganic and Medicinal Chemistry Letters. 1996;6(6):695-700.
  20

• 421.

  1996

  Masayoshi Okano; Narihiko Fukamiya; Kiyoshi Tagahara; Mark Cosentino; Thomas Tung-Ying Lee; Susan Morris-Natschke; Kuo-Hsiung Lee

  Anti-HIV activity of quassinoids¹

  Bioorganic and Medicinal Chemistry Letters. 1996;6(6):701-706.
  27

• 422.

  1996

  Ernest Hamel; Chii M. Lin; Jacqueline Plowman; Hui-Kang Wang; Kuo-Hsiung Lee; Kenneth D. Paull

  Antitumor 2,3-dihydro-2-(aryl)-4(1H)-quinazolinone derivatives: Interactions with tubulin

  Biochemical Pharmacology. 1996;51(1):53-59.
  75

• 423.

  1996

  Y. Kashiwada; F. Hashimoto; L.M. Cosentino; C.-H. Chen; P.E. Garrett; K.H. Lee -

  Betulinic acid and dihydrobetulinic acid derivatives as potent anti-HIV agents

  Journal of Medicinal Chemistry. 1996;39(5):1016-1017.
  159

• 424.

  1996

  Chun-Nan Lin; Chi-Wen Kiang; Chai-Ming Lu; Ru-Rong Wu; Kuan-Han Lee

  Garcinielliptin oxide, a triterpenoid with a novel skeleton, isolated from Garcinia subelliptica

  Chemical Communications. 1996;(11):1315-1316.
  10

• 425.

  1996

  Yao-Haur Kuo; Cheng-Jen Chou; Li-Ming Yang Kuo; Yun-Yu Hu; Yue-Chih Chen; Chieh-Fu Chen; Kuo-Hsiung Lee

  A sesquiterpene ester from Celastrus Hindsii

  Phytochemistry. 1996;41(2):549-551.
  13

• 426.

  1996

  Xi Ping Pan; De Quan Yu; Kuo Hsiung Lee

  The structural elucidation and absolute configurations of two new polyoxygenated cyclohexenes from Uvaria grandiflora roxb

  Chinese Chemical Letters. 1996;7(3):241-244.
  5

• 427.

  1995

  Ke Chen; Qian Shi; Toshihiro Fujioka; Tatsuhiko Nakano; Chang-Qi Hu; Ji-Qin Jin; Robert E. Kilkuskie; Kuo-Hsiung Lee

  Anti-AIDS agents-XIX. Neotripterifordin, a novel anti-HIV principle from Tripterygium wilfordii: Isolation and structural elucidation

  Bioorganic and Medicinal Chemistry. 1995;3(10):1345-1348.
  20

• 428.

  1995

  Li-Ming Yang; Chieh-Fu Chen; Kuo-Hsiung Lee

  Synthesis of rutaecarpine and cytotoxic analogues

  Bioorganic and Medicinal Chemistry Letters. 1995;5(5):465-468.
  48

• 429.

  1995

  Masayoshi Okano; Narihiko Fukamiya; Kiyoshi Tagahara; Harukuni Tokuda; Akio Iwashima; Hoyoku Nishino; Kuo-Hsiung Lee

  Inhibitory effects of quassinoids on Epstein-Barr virus activation

  Cancer Letters. 1995;94(2):139-146.
  24

• 430.

  1995

  Satsuki Ohnishi; Narihiko Fukamiya; Masayoshi Okano; Kiyoshi Tagahara; Kuo-Hsiung Lee

  Bruceosides D, E, and F, three new cytotoxic quassinoid glucosides from Brucea javanica

  Journal of Natural Products. 1995;58(7):1032-1038.
  29

• 431.

  1995

  K.-H. Lee; H.-K. Wang

  Current status of bioanalysis of etoposide and related compounds

  Journal of Food and Drug Analysis. 1995;3(4):209-232.
  14

• 432.

  1995

  Yao-Haur Kuo; Chieh-Fu Chen; Li-Ming Yang Kuo; Ming-Lu King; Chia-Fu Chen; Kuo-Hsiung Lee

  Celahinine A, a new sesquiterpene pyridine alkaloid from Celastrus hindsii

  Journal of Natural Products. 1995;58(11):1735-1738.
  11

• 433.

  1995

  Kazumori Imamura; Narihiko Fukamiya; Megumi Nakamura; Masayoshi Okano; Kiyoshi Tagahara; Kuo-Hsiung Lee

  Bruceanols G and H, cytotoxic quassinoids from Brucea antidysenterica

  Journal of Natural Products. 1995;58(12):1915-1919.
  7

• 434.

  1995

  Y. Kashiwada; K.F. Bastow; K.-H. Lee

  Novel lignan derivatives as selective inhibitors of DNA topoisomerase II

  Bioorganic and Medicinal Chemistry Letters. 1995;5(8):905-908.
  18

• 435.

  1995

  Y. Fukushima; K.F. Bastow; T. Ohba; K.H. Lee

  Antiviral activity of dammarane saponins against herpes simplex virus I

  International Journal of Pharmacognosy. 1995;33(1):2-6.
  7

• 436.

  1995

  H.-K. Wang; S.-Y. Liu; K.-M. Hwang; A.T. McPhail; K.-H. Lee

  The synthesis of 5-substituted camptothecins as potential inhibitors of DNA topoisomerase I

  Bioorganic and Medicinal Chemistry Letters. 1995;5(1):77-82.
  16

• 437.

  1995

  Shunxiang Zhang; Catherine Tung-Ling Lee; Ke Chen; Yoshiki Kashiwada; De-Cheng Zhang; Andrew T. McPhail; Kuo-Hsiung Lee

  Erratum: Structure and stereochemistry of taxuchin A, a new 11(15→1) abeo-taxane type diterpene from Taxus Chinensis (Journal of the Chemical Society, Chemical Communications (1994) (1561))

  Journal of the Chemical Society, Chemical Communications. 1995;(10):1093.
  0

• 438.

  1995

  Takao Konoshima; Ichiro Yasuda; Yoshiki Kashiwada; L. Mark Cosentino; Kuo-Hsiung Lee

  Anti-aids agents, 21. Triterpenoid saponins as anti-HIV principles from fruits of Gleditsia japonica and Gymnocladus chinensis, and a structure-activity correlation

  Journal of Natural Products. 1995;58(9):1372-1377.
  39

• 439.

  1995

  Qian Shi; Ke Chen; Leping Li; Jer-Jang Chang; Cari Autry; Mutsuo Kozuka; Takao Konoshima; James R. Estes; Chii M. Lin; Ernest Hamel; et al.

  Antitumor agents, 154. Cytotoxic and antimitotic flavonols from Polanisia dodecandra

  Journal of Natural Products. 1995;58(4):475-482.
  53

• 440.

  1995

  Yoshiki Kashiwada; Toshihiro Fujioka; Kunihide Mihashi; Nobuhiro Marubayashi; Koichi Mizuki; Ih-Sheng Chen; Kuo-Hsiung Lee

  Antitumor agents, 157.¹ Absolute structures of cumingianosides A-F, antileukemic triterpene glucosides, and structures of the hydrolysates of cumingianoside A

  Journal of Natural Products. 1995;58(4):495-503.
  8

• 441.

  1995

  L. Xie; M.T. Crimmins; K.-H. Lee

  Asymmetric synthesis of 3',4'-di-O-(-)-camphanoyl-(+)-cis-khellactone (DCK), a potent anti-HIV agent

  Tetrahedron Letters. 1995;36(26):4529-4532.
  22

• 442.

  1995

  Yoshiki Kashiwada; Makoto Nishizawa; Takashi Yamagishi; Takashi Tanaka; Gen-Ichiro Nonaka; L. Mark Cosentino; James V. Snider; Kuo-Hsiung Lee

  Anti-AIDS agents, 18. 1 Sodium and potassium salts of caffeic acid tetramers from Arnebia euchroma as anti-HIV agents

  Journal of Natural Products. 1995;58(3):392-400.
  49

• 443.

  1995

  Shun-Xiang Zhang; Ke Chen; Xing-Jie Liu; De-Cheng Zhang; Tien-Wen Tao-Wiedmann; Shao-Ling Leu; Andrew T. Mcphail; Kuo-Hsiung Lee

  The isolation and structural elucidation of three new neolignans, puberulins A, B, and C, as platelet activating factor receptor antagonists from Piper Puberulum

  Journal of Natural Products. 1995;58(4):540-547.
  11

• 444.

  1995

  Lan Xie; Jing-Xi Xie; Yoshiki Kashiwada; L. Mark Cosentino; Shwu-Huey Liu; Rekha B. Pai; Yung-Chi Cheng; Kuo-Hsiung Lee

  Anti-AIDS (acquired immune deficiency syndrome) agents. 17. New brominated hexahydroxybiphenyl derivatives as potent anti-HIV agents

  Journal of Medicinal Chemistry. 1995;38(16):3003-3008.
  28

• 445.

  1995

  Yao-Haur Kuo; Jun-Chih Ou; Kuo-Hsiung Lee; Chieh-Fu Chen

  A new triterpene lactone, maytenfolone, and a new sesquiterpene pyridine alkaloid, emarginatine H, from the leaves of Maytenus diversifolia

  Journal of Natural Products. 1995;58(7):1103-1108.
  7

• 446.

  1994

  Makoto Miyahara; Yoshiki Kashiwada; Xin Guo; Hong-Xing Chen; Yung-Chi Cheng; Kuo-Hsiung Lee

  Nitrosourea derivatives of 3′,4′-didemethoxy-3′,4′-dioxo-4-deoxypodophyllotoxin and urea derivatives of 4′-O-demethylpodophyllotoxin as potent inhibitors of human DNA topoisomerase II

  Heterocycles. 1994;39(1):361-369.
  10

• 447.

  1994

  Hui-Kang Wang; Su-Yin Liu; Kou-Maou Hwang; Glen Taylor; Kuo-Hsiung Lee

  Synthesis of novel water-soluble 7-(aminoacylhydrazono)-formyl camptothecins with potent inhibition of DNA topoisomerase I

  Bioorganic and Medicinal Chemistry. 1994;2(12):1397-1402.
  19

• 448.

  1994

  Kenneth F. Bastow; Masataka Itoigawa; Hiroshi Furukawa; Yoshiki Kashiwada; Ibrahim D. Bori; Lawrence M. Ballas; Kuo-Hsiung Lee

  Antiproliferative actions of 7-substituted 1,3-dihydroxyacridones; possible involvement of DNA topoisomerase II and protein kinase C as biochemical targets

  Bioorganic and Medicinal Chemistry. 1994;2(12):1403-1411.
  17

• 449.

  1994

  Thomas Tung-Ying Lee; Yoshiki Kashiwada; Li Huang; James Snider; Mark Cosentino; Kuo-Hsiung Lee

  Suksdorfin: an anti-HIV principle from Lomatium suksdorfii, its structure-activity correlation with related coumarins, and synergistic effects with anti-AIDS nucleosides

  Bioorganic and Medicinal Chemistry. 1994;2(10):1051-1056.
  46

• 450.

  1994

  Kuo Yao-Haur; Chen Chung-Hsiung; King Ming-Lu; Wu Tian-Shung; Lee Kuo-Hsiung

  Sesquiterpene pyridine alkaloids from Maytenus emarginata: Emarginatine-C and -D and cytotoxic emarginatine-E and emarginatinine

  Phytochemistry. 1994;35(3):803-807.
  13

• 451.

  1994

  Chung-Hsiung Chen; Li-Ming Yang; Thomas Tung-Ying Lee; Ya-Ching Shen; De-Cheng Zhang; De-Ji Pan; Andrew T. McPhail; Donald R. McPhail; Su-Yin Liu; De-Hua Li; et al.

  Antitumor agents-CLI. Bis(helenalinyl)glutarate and bis(isoalantodiol-B)glutarate, potent inhibitors of human DNA topoisomerase II

  Bioorganic and Medicinal Chemistry. 1994;2(2):137-145.
  15

• 452.

  1994

  Huang Li; Yoshiki Kashiwada; L.Mark Cosentino; Sharon Fan; Chen Chin-Ho; Andrew T. McPhail; Toshihiro Fujioka; Kunihide Mihashi; Lee Kuo-Hsiung

  Anti-AIDS agents. 15. Synthesis and anti-HIV activity of dihydroseselins and related analogs¹

  Journal of Medicinal Chemistry. 1994;37(23):3947-3955.
  86

• 453.

  1994

  H.-K. Wang; S.-Y. Liu; K.-M. Hwang; G. Taylor; K.-H. Lee

  Novel water-soluble 7-(acylhydrazono)-formyl camptothecins as potent inhibitors of DNA topoisomerase I

  Bioorganic and Medicinal Chemistry Letters. 1994;4(4):579-582.
  2

• 454.

  1994

  A. Yamashita; R. Tawa; Y. Imakura; K.-H. Lee; H. Sakurai

  Site-specific DNA cleavage by Cu(II) complexes of podophyllotoxin derivatives

  Biochemical Pharmacology. 1994;47(10):1920-1925.
  12

• 455.

  1994

  Yi-Lin Zhang; Alexander Tropsha; Andrew T. McPhail; Kuo-Hsiung Lee

  Antitumor agents. 152. In vitro inhibitory activity of etoposide derivative NPF against human tumor cell lines and a study of its conformation by X-ray crystallography, molecular modeling, and NMR spectroscopy

  Journal of Medicinal Chemistry. 1994;37(10):1460-1464.
  27

• 456.

  1994

  L. Huang; Y. Kashiwada; L.M. Cosentino; S. Fan; K.-H. Lee

  3',4'-D1-O-(-)-camphanoyl-(+)-cis-khellactone and related compounds: A new class of potent anti-HIV agents

  Bioorganic and Medicinal Chemistry Letters. 1994;4(4):593-598.
  22

• 457.

  1994

  Yao-Haur Kuo; Ming-Lu King; Chia-Fu Chen; Haur-Young Chen; Chung-Hsiung Chen; Ke Chen; Kuo-Hsiung Lee

  Two new macrolide sesquiterpene pyridine alkaloids from Maytenus emarginata: Emarginatine G and the cytotoxic emarginatine F

  Journal of Natural Products. 1994;57(2):263-269.
  52

• 458.

  1994

  Leping Li; Hui-Kang Wang; Sheng-Chu Kuo; Tian-Shung Wu; Dan Lednicer; Chii M. Lin; Ernest Hamel; Kuo-Hsiung Lee

  Antitumor agents. 150. 2′,3′,4′,5′,5,6,7-substituted 2-phenyl-4-quinolones and related compounds: Their synthesis, cytotoxicity, and inhibition of tubulin polymerization

  Journal of Medicinal Chemistry. 1994;37(8):1126-1135.
  96

• 459.

  1994

  T. Konoshima; Y. Kashiwada; M. Takasaki; M. Kozuka; I. Yasuda; L.M. Cosentino; K.-H. Lee

  Cucurbitacin F derivatives, anti-HIV principles from Cowania mexicana

  Bioorganic and Medicinal Chemistry Letters. 1994;4(11):1323-1326.
  7

• 460.

  1994

  Chang-Qi Hu; K.E. Chen; Qian Shi; Robert E. Kilkuskie; Yung-Chi Cheng; Kuo-Hsiung Lee

  Anti-aids agents, 10. Acacetin-7-O-β-D-galactopyranoside, an anti-HIV principle from Chrysanthemum morifolium and a structure-activity correlation with some related flavonoids

  Journal of Natural Products. 1994;57(1):42-51.
  114

• 461.

  1994

  S. Zhang; C.T.-L. Lee; K. Chen; Y. Kashiwada; D.-C. Zhang; A.T. McPhail; K.-H. Lee

  Structure and stereochemistry of taxuchin A, a new 11(15 → 1) abeo-taxane type diterpene from Taxus chinensis

  Journal of the Chemical Society - Series Chemical Communications. 1994;(13):1561-1562.
  19

• 462.

  1994

  Shunxiang Zhang; Catherine Tung-Ling Lee; Yoshiki Kashiwada; Ke Chen; De-Cheng Zhang; Kuo-Hsiung Lee

  Yunantaxusin A, a new 11(15 → 1)-abeo-taxane from Taxus yunnanensis

  Journal of Natural Products. 1994;57(11):1580-1583.
  15

• 463.

  1994

  Shunxiang Zhang; Catherine Tung-Ling Lee; Ke Chen; Yoshiki Kashiwada; De-Cheng Zhang; Andrew T. McPhail; Kuo-Hsiung Lee

  Erratum: structure and stereochemistry of taxuchin A, a new 11(15→1) Abeo-Taxane type diterpene from Taxus Chinensis. (Journal of the Chemical Society, Chemical Communications (1994) (1561))

  Journal of the Chemical Society, Chemical Communications. 1994;(23):2738.
  0

• 464.

  1994

  Xiao-Ming Zhou; Kenneth Jiann-Hung Lee; Ji Cheng; Shihn-Sheng Wu; Hong-Xing Chen; Xin Guo; Yung-Chi Cheng; Kuo-Hsiung Lee

  Antitumor Agents. 144. New γ-Lactone Ring-Modified Arylamino Etoposide Analogs as Inhibitors of Human DNA Topoisomerase II

  Journal of Medicinal Chemistry®. 1994;37(2):287-292.
  32

• 465.

  1994

  Y. Kashiwada; L. Huang; L.M. Ballas; J.B. Jiang; W.P. Janzen; K.-H. Lee

  New hexahydroxybiphenyl derivatives as inhibitors of protein kinase C

  Journal of Medicinal Chemistry. 1994;37(1):195-200.
  41

• 466.

  1994

  Leping Li; Hui-Kang Wang; Sheng-Chu Kuo; Tian-Shung Wu; Anthony Mauger; Chii M. Lin; Ernest Hamel; Kuo-Hsiung Lee

  Antitumor agents 155. Synthesis and biological evaluation of 3′,6,7-substituted 2-phenyl-4-quinolones as antimicrotubule agents

  Journal of Medicinal Chemistry. 1994;37(20):3400-3407.
  109

• 467.

  1994

  Tian-Shung Wu; Shiow-Chyn Huang; Pei0Lin Wu; Kuo-Hsiung Lee

  Structure and synthesis of clausenaquinone-a. A novel carbazolequinone alkaloid and bioactive principle from clausena excavata

  Bioorganic and Medicinal Chemistry Letters. 1994;4(20):2395-2398.
  19

• 468.

  1994

  Yi-Lin Zhang; Xin Guo; Yung-Chi Cheng; Kuo-Hsiung Lee

  Antitumor agents. 148.^§ synthesis and biological evaluation of novel 4β-Amino derivatives of etoposide with better pharmacological profiles

  Journal Of Medicinal Chemistry®. 1994;37(4):446-452.
  30

• 469.

  1994

  Toshihiro Fujioka; Yoshiki Kashiwada; Robert E. Kilkuskie; L. Mark Cosentino; Lawrence M. Ballas; Jack B. Jiang; William P. Janzen; Ih-Sheng Chen; Kuo-Hsiung Lee

  Anti-AIDS agents, 11. Betulinic acid and platanic acid as anti-HIV principles from Syzigium claviflorum, and the anti-HIV activity of structurally related triterpenoids

  Journal of Natural Products. 1994;57(2):243-247.
  249

• 470.

  1994

  R. Tang; K. Chen; M. Cosentino; K.-H. Lee

  Apigenin-7-O-β-D-glucopyranoside, an anti-HIV principle from Kummerowia striata

  Bioorganic and Medicinal Chemistry Letters. 1994;4(3):455-458.
  8

• 471.

  1993

  Yoshiki Kashiwada; Li Sun; Hiroshi Tatematsu; Kenneth F. Bastow; Kuo-Hsiung Lee

  Structures of tetra-O-demethylcolchicine, -isocolchicine, and 10-O-demethylcolchicine derivatives

  Heterocycles. 1993;36(11):2531-2540.
  2

• 472.

  1993

  Kenneth F. Bastow; Hiroshi Tatematsu; Li Sun; Yasuhiro Fukushima; Kuo-Hsiung Lee

  Synthesis and biological evaluation of tetrademethyl isocolchicine derivatives as inhibitors of DNA topoisomerase action in vitro

  Bioorganic and Medicinal Chemistry. 1993;1(3):227-234.
  5

• 473.

  1993

  Ya-Ching Shen; Chung-Hsiung Chen; Kuo-Hsiung Lee

  Secoiridoid dilactones from Fraxinus uhdei

  Phytochemistry. 1993;33(6):1531-1533.
  14

• 474.

  1993

  Yoshiki Kashiwada; De-Cheng Zhang; Yuh-Pan Chen; Chang-Ming Cheng; Hsien-Tsung Chen; Hsien-Chang Chang; Jer-Jang Chang; Kuo-Hsuing Lee

  Antitumor agents, 145. Cytotoxic asprellic acids A and C and asprellic acid B, new p-coumaroyl triterpenes, from Ilex asprella

  Journal of Natural Products. 1993;56(12):2077-2082.
  12

• 475.

  1993

  Kazunori Imamura; Narihiko Fukamiya; Masayoshi Okano; Kiyoshi Tagahara; Kuo-Hsiung Lee

  Bruceanols D, E, and F. Three new cytotoxic quassinoids from Brucea antidysenterica

  Journal of Natural Products. 1993;56(12):2091-2097.
  16

• 476.

  1993

  Leping Li; Hui-Kang Wang; Jer-Jang Chang; Andrew T. McPhail; Donald R. McPhail; Hiroki Terada; Takao Konoshima; Midori Kokumai; Mutsuo Kozuka; James R. Estes; et al.

  Antitumor agents, 138. Rotenoids and isoflavones as cytotoxic constituents from Amorpha fruticosa

  Journal of Natural Products. 1993;56(5):690-698.
  47

• 477.

  1993

  Li Sun; Ernest Hamel; Chii M. Lin; Susan B. Hastie; Amy Pyluck; Kuo-Hsiung Lee

  Antitumor agents. 141. Synthesis and biological evaluation of novel thiocolchicine analogs: N-acyl-, N-aroyl-, and N-(substituted benzyl)deacetylthiocolchicines as potent cytotoxic and antimitotic compounds

  Journal of Medicinal Chemistry. 1993;36(10):1474-1479.
  18

• 478.

  1993

  Hui-Ying Li; Nan-Jun Sun; Yoshiki Kashiwada; Li Sun; James V. Snider; L. Mark Cosentino; Kuo-Hsiung Lee

  Anti-AIDS agents, 9. Suberosol, a new C₃₁ lanostane-type triterpene and anti-HIV principle from Polyalthia suberosa

  Journal of Natural Products. 1993;56(7):1130-1133.
  47

• 479.

  1993

  Sheng-Chu Kuo; Hong-Zin Lee; Jung-Pin Juang; Yih-Tyng Lin; Tian-Shung Wu; Jer-Jang Chang; Dan Lednicer; Kenneth D. Paull; Chii M. Lin; Ernest Hamel; et al.

  Synthesis and cytotoxicity of 1,6,7,8-substituted 2-(4′-substituted phenyl)-4-quinolones and related compounds: Identification as antimitotic agents interacting with tubulin

  Journal of Medicinal Chemistry. 1993;36(9):1146-1156.
  148

• 480.

  1993

  T. Konoshima; H. Terada; M. Kokumai; M. Kozuka; H. Tokuda; J.R. Estes; L. Li; H.-K. Wang; K.-H. Lee

  Studies on inhibitors of skin tumor promotion, XII. Rotenoids from Amorpha fruticosa

  Journal of Natural Products (Lloydia). 1993;56(6):843-848.
  33

• 481.

  1993

  Guo-Fu Chen; Zhu-Lian Li; De-Ji Pan; Cheng-Min Tang; Xiang He; Guang-Yi Xu; Ke Chen; Kuo-Hsiung Lee

  The isolation and structural elucidation of four novel triterpene lactones, pseudolarolides A, B, C, and D, from Pseudolarix kaempferi

  Journal of Natural Products. 1993;56(7):1114-1122.
  34

• 482.

  1993

  K.F. Bastow; I.D. Bori; Y. Fukushima; Y. Kashiwada; T. Tanaka; G. Nonaka; I. Nishioka; K.-H. Lee

  Inhibition of DNA topoisomerases by sanguiin H-6, a cytotoxic dimeric ellagitannin from Sanguisorba officinalis

  Planta Medica. 1993;59(3):240-245.
  21

• 483.

  1993

  K.F. Bastow; H. Tatematsu; I.D. Bori; Y. Fukushima; L. Sun; B. Goz; K.-H. Lee

  Induction of reversible protein-linked DNA breaks in human osteogenic sarcoma cells by novel cytocidal colchicine derivatives which inhibit DNA topoisomerase II in vitro: Absence of cross-resistance in a colchicine-resistant sub-clone

  Bioorganic and Medicinal Chemistry Letters. 1993;3(6):1045-1050.
  9

• 484.

  1993

  Z.-Q. Wang; Y.-C. Shen; H.-X. Chen; J.-Y. Chang; X. Guo; Y.-C. Cheng; K.-H. Lee

  Antitumor agents 126. Novel 4β-substituted anilino derivatives of 3',4'-O,O-didemethylpodophyllotoxin as potent inhibitors of human DNA topoisomerase II

  Pharmaceutical Research. 1993;10(3):343-350.
  8

• 485.

  1993

  T. Konoshima; M. Takasaki; M. Kozuka; M. Haruna; K. Ito; J.R. Estes; K.-H. Lee

  Constituents of rosaceous plants. I. Structures of new triterpenoids from Cowania mexicana

  Chemical and Pharmaceutical Bulletin. 1993;41(9):1612-1615.
  16

• 486.

  1993

  X.-M. Zhou; Z.-Q. Wang; H.-X. Chen; Y.-C. Cheng; K.-H. Lee

  Antitumor agents. 125. New 4β-benzoylamino derivatives of 4'-O-demethyl-4-desoxypodophyllotoxin and 4β-benzoyl derivatives of 4'-O-demethylpodophyllotoxin as potent inhibitors of human DNA topoisomerase II

  Pharmaceutical Research. 1993;10(2):214-219.
  14

• 487.

  1993

  Li Sun; Andrew T. McPhail; Ernest Hamel; Chii M. Lin; Susan B. Hastie; Jer-Jang Chang; Kuo-Hsiung Lee

  Antitumor agents. 139. Synthesis and biological evaluation of thiocolchicine analogs 5,6-dihydro-6(S)-(acyloxy)- and 5,6-dihydro-6(S)-[(aroyloxy)methyl]-1,2,3-trimethoxy-9-(methylthio)-8H- cyclohepta[a]naphthalen-8-ones as novel cytotoxic and antimitotic agents

  Journal of Medicinal Chemistry. 1993;36(5):544-551.
  22

• 488.

  1992

  Xiuzhen Yan; Kuohsiung Lee; Yamagishi Takashi

  Isolation and identification of cytotoxic components from bryophyllum pinnatum

  Chinese Journal of Cancer Research. 1992;4(4):1-3.
  0

• 489.

  1992

  Yoshiki Kashiwada; Toshihiro Fujioka; Jer-Jang Chang; Ih-Sheng Chen; Kunihide Mihashi; Kuo-Hsiung Lee

  Anti-tumor agents. 136. Cumingianosides A-F, potent antileukemic new triterpene glucosides, and cumindysosides A and B, trisnor- and tetranortriterpene glucosides with a 14,18-cycloapoeuphane-type skeleton from Dyaoxylum cumingianum

  Journal of Organic Chemistry. 1992;57(25):6946-6953.
  27

• 490.

  1992

  K. Imamura; N. Fukamiya; M. Okano; K. Tagahara; K.-H. Lee

  Catalytic hydrogenation of dehydro quassinoids and cytotoxic antitumor activity of the hydrogenation products

  Bulletin of the Chemical Society of Japan. 1992;65(10):2684-2689.
  3

• 491.

  1992

  Ke. Chen; Qian Shi; Yoshiki Kashiwada; De-Cheng Zhang; Chang-Qi Hu; Ji.-Qin Jin; Hiroshi Nozaki; Robert E. Kilkuskie; Enzo Tramontano; Yung-Chi Cheng; et al.

  Anti-aids agents, 6 . Salaspermic acid, an anti-HIV principle from Tripterygium wilfordii, and the structure-activity correlation with its related compounds

  Journal of Natural Products. 1992;55(3):340-346.
  34

• 492.

  1992

  Hong Hu; Zhe-Qing Wang; Su-Ying Liu; Yung-Chi Cheng; Kuo-Hsiung Lee

  Antitumor agents. 123. Synthesis and human DNA topoisomerase II inhibitory activity of 2′-chloro derivatives of etoposide and 4β-(arylamino)-4′-O-demethylpodophyllotoxins

  Journal of Medicinal Chemistry. 1992;35(5):866-871.
  17

• 493.

  1992

  Zhe-Qing Wang; Hong Hu; Hong-Xin Chen; Yung-Chi Cheng; Kuo-Hsiung Lee

  Antitumor agents. 124. New 4β-substituted aniline derivatives of 6,7-O,O-demethylene-4′-O-demethylpodophyllotoxin and related compounds as potent inhibitors of human DNA topoisomerase II

  Journal of Medicinal Chemistry. 1992;35(5):871-877.
  37

• 494.

  1992

  Ke Chen; Qian Shi; Toshihiro Fujioka; De-Cheng Zhang; Chang-Qi Hu; Ji-Qin Jin; Robert E. Kilkuskie; Kuo-Hsiung Lee

  Anti-aids agents, 4. Tripterifordin, a novel anti-HIV principle from Tripterygium wilfordii: Isolation and structural elucidation

  Journal of Natural Products. 1992;55(1):88-92.
  32

• 495.

  1992

  A.A. Grippo; I.H. Hall; H. Kiyokawa; O. Muraoka; Y.-C. Shen; K.-H. Lee

  The cytotoxicity of helenalin, its mono and difunctional esters, and related sesquiterpene lactones in murine and human tumor cells

  Drug Design and Discovery. 1992;8(3):191-206.
  21

• 496.

  1992

  R.E. Kilkuskie; Y. Kashiwada; G. Nonaka; I. Nishioka; A.J. Bodner; Y.-C. Cheng; K.-H. Lee

  HIV and reverse transcriptase inhibition by tannins

  Bioorganic and Medicinal Chemistry Letters. 1992;2(12):1529-1534.
  17

• 497.

  1992

  X. Yan; K. Lee; T. Yamagishi

  Isolation and identification of cytotoxic components from Bryophyllum pinnatum

  Acta Academiae Medicinae Shanghai. 1992;19(3):206-208.
  2

• 498.

  1992

  Y. Kashiwada; T. Fujioka; J.-J. Chang; I.-S. Chen; K. Mihashi; K.-H. Lee

  Cumindysoside A, a novel cytotoxic trisnortriterpene glucoside with a 14,18-cycloapoeuphane-type skeleton from Dysoxylum cumingianum

  Bioorganic and Medicinal Chemistry Letters. 1992;2(5):395-398.
  5

• 499.

  1992

  Y. Kashiwada; L. Huang; R.E. Kilkuskie; A.J. Bodner; K.-H. Lee

  New hexahydroxydiphenyl derivatives as potent inhibitors of HIV replication in H9 lymphocytes

  Bioorganic and Medicinal Chemistry Letters. 1992;2(3):235-238.
  8

• 500.

  1992

  Yi-Lin Zhang; Ya-Ching Shen; Zhe-Qing Wang; Hong-Xing Chen; Xin Guo; Yung-Chi Cheng; Kuo-Hsiung Lee

  Antitumor agents, 130. Novel 4β-arylamino derivatives of 3′,4′-didemethoxy-3′,4′-dioxo-4-deoxypodophyllotoxin as potent inhibitors of human DNA topoisomerase II

  Journal of Natural Products. 1992;55(8):1100-1111.
  26

• 501.

  1992

  Qian Shi; Ke Chen; Toshihiro Fujioka; Yoshiki Kashiwada; Jer-Jang Chang; Mutsuo Kozuka; James R. Estes; Andrew T. McPhail; Donald R. McPhail; Kuo-Hsiung Lee

  Antitumor agents, 135. Structure and stereochemistry of polacandrin, a new cytotoxic triterpene from Polanisia dodecandra

  Journal of Natural Products. 1992;55(10):1488-1497.
  9

• 502.

  1992

  Narihiko Fukamiya; Masayoshi Okano; Mitsgu Miyamoto; Kiyoshi Tagahara; Kuo-Hsiung Lee

  Antitumor agents, 127. bruceoside C, a new cytotoxic quassinoid glucoside, and related compounds from Brucea Javanica

  Journal of Natural Products. 1992;55(4):468-475.
  35

• 503.

  1992

  Yoshiki Kashiwada; Gen-Ichiro Nonaka; Itsuo Nishioka; Jer-Jang Chang; Kuo-Hsiung Lee

  Antitumor agents, 129. Tannins and related compounds as selective cytotoxic agents

  Journal of Natural Products. 1992;55(8):1033-1043.
  106

• 504.

  1992

  Hui-Kang Wang; Jing-Xi Xie; Jer-Jang Chang; Kou-Maou Hwang; Su-Ying Liu; Lawrence M. Ballas; Jack B. Jiang; Kuo-Hsiung Lee

  Antitumor agents. 134. New shiraiachrome-A- and calphostin-C-related perylene derivatives as cytotoxic and antiviral agents and inhibitors of protein kinase C

  Journal of Medicinal Chemistry. 1992;35(15):2717-2721.
  12

• 505.

  1992

  Y. Kashiwada; G.-I. Nonaka; I. Nishioka; L.M. Ballas; J.B. Jiang; W.P. Janzen; K.-H. Lee

  Tannins as selective inhibitors of protein kinase C

  Bioorganic and Medicinal Chemistry Letters. 1992;2(3):239-244.
  24

• 506.

  1991

  Dennis E. Chapman; David J. Holbrook; Stephen G. Chaney; Iris H. Hall; Lee Kuo-Hsiung

  In vivo and in vitro effects of helenalin on mouse hepatic microsomal cytochrome P450

  Biochemical Pharmacology. 1991;41(2):229-235.
  1

• 507.

  1991

  H. Sakurai; T. Miki; Y. Imakura; M. Shibuya; K.-H. Lee

  Metal- and photo-induced cleavage of DNA by podophyllotoxin, etoposide, and their related compounds

  Molecular Pharmacology. 1991;40(6):965-973.
  24

• 508.

  1991

  Xiao-Ming Zhou; Zhe-Qing Wang; Jang-Yang Chang; Hong-Xing Chen; Yung-Chi Cheng; Kuo-Hsiung Lee

  Antitumor agents. 120. New 4-substituted benzylamine and benzyl ether derivatives of 4′-O-demethylepipodophyollotoxin as potent inhibitors of human DNA topoisomerase II

  Journal of Medicinal Chemistry. 1991;34(12):3346-3350.
  37

• 509.

  1991

  H. Tatematsu; M. Mori; T.-H. Yang; J.-J. Chang; T.T.-Y. Lee; K.-H. Lee

  Cytotoxic principles of Securinega virosa: Virosecurinine and viroallosecurinine and related derivatives

  Journal of Pharmaceutical Sciences. 1991;80(4):325-327.
  22

• 510.

  1991

  A.A. Grippo; S.D. Wyrick; K.-H. Lee; R.P. Shrewsbury; I.H. Hall

  Disposition of an antineoplastic sesquiterpene lactone, [³H]-plenolin, in BDF₁ mice

  Planta Medica. 1991;57(4):309-314.
  5

• 511.

  1991

  D.-Y. Zhang; M. Mori; I.H. Hall; K.-H. Lee

  Anti-inflammatory agents. V. Amylose from Pinellia ternata

  International Journal of Pharmacognosy. 1991;29(1):29-32.
  0

• 512.

  1991

  Yang-Chang Wu; Chang-Yih Duh; Fang-Rong Chang; Gwo-Yuan Chang; Shang-Kwei Wang; Jer-Jang Chang; Donald R. Mcphail; Andrew T. Mcphail; Kuo-Hsiung Lee

  The crystal structure and cytotoxicity of goniodiol-7-monoacetate from Goniothalamus Amuyon

  Journal of Natural Products. 1991;54(4):1077-1081.
  48

• 513.

  1991

  I.H. Hall; K.H. Lee

  The effects of α-methylene-γ-lactone purines and pyrimidines on L1210 lymphoid leukemia nucleic acid metabolism

  Anticancer Research. 1991;11(1):337-342.
  2

• 514.

  1991

  Tian-Shung Wu; Yuh-Meei Lin; Mitsumasa Haruna; De-Ji Pan; Tetsuro Shingu; Yuh-Pan Chen; Hong-Yen Hsu; Tatsuhiko Nakano; Kuo-Hsiung Lee

  Antitumor agents, 119 . Kansuiphorins A and B, two novel antileukemic diterpene esters from Euphorbia kansui

  Journal of Natural Products. 1991;54(3):823-829.
  56

• 515.

  1991

  Hiroshi Tatematsu; Robert E. Kilkuskie; Alice J. Corrigan; Anne J. Bodner; Kuo-Hsiung Lee

  Anti-aids agents, 3. Inhibitory effects of colchicine derivatives on HIV replication in H9 lymphocyte cells

  Journal of Natural Products. 1991;54(2):632-637.
  8

• 516.

  1991

  Takayuki Matsuzaki; Narihiko Fukamiya; Masayoshi Okano; Tomoyuki Fujita; Kiyoshi Tagahara; Kuo-Hsiung̀ Lee

  Picrasinoside H, a new quassinoid glucoside, and related compounds from the stem wood of Picrasma ailanthoides

  Journal of Natural Products. 1991;54(3):844-848.
  9

• 517.

  1991

  Hiroshi Nozaki; Yukinaga Matsuura; Satomi Hirono; Ryoji Kasai; Toshiji Tada; Mitsuru Nakayama; Kuo-Hsiung Lee

  Maytensifolin-C, a friedelane alcohol from Maytenus diversifolia

  Phytochemistry. 1991;30(11):3819-3821.
  2

• 518.

  1991

  Pan De-Ji; Hu Chang-Qi; Chang Jer-Jang; Thomas Tung-Ying Lee; Chen Yuh-Pan; Hsu Hong-Yen; Donald R. Mcphail; Andrew T. Mcphail; Lee Kuo-Hsiung

  Kansuiphorin-C and -D, cytotoxic diterpenes from Euphorbia kansui

  Phytochemistry. 1991;30(3):1018-1020.
  10

• 519.

  1990

  Yasuhiro Imakura; Katsutoshi Hachiya; Tomomi Ikemoto; Shigeru Kobayashi; Shinsuke Yamashita; Jinsaku Sakakibara; Forrest T. Smith; Kuo-Hsiung Lee

  Antimalarial artemisinin analogs: Synthesis of 2,3-desethano-12-deoxoartemisinin-related compounds

  Heterocycles. 1990;31(12):2125-2129.
  9

• 520.

  1990

  Iris H. Hall; Anne A. Grippo; David J. Holbrook; Jer-Jang Chang; Li-Ming Yang; Stephen G. Chaney; Kuo-Hsiung Lee

  Renal, hepatic, cardiac and thymic acute toxicity afforded by bis(helenalinyl)malonate in BDF₁ mice

  Toxicology. 1990;64(2):205-216.
  1

• 521.

  1990

  Guo-Fu Chen; Zhu-Lian Li; Cheng-Min Tang; Xiang He; Ke Chen; De-Ji Pan; Chang-Qi Hu; Donald R. McPhail; Andrew T. McPhail; Kuo-Hsiung Lee

  Structure and stereochemistry of pseudolarolide-I, A novel cytotoxic peroxytriterpene dilactone from Pseudolarix kaempferi

  Heterocycles. 1990;31(11):1903-1906.
  9

• 522.

  1990

  Yasuhiro Imakura; Katsutoshi Hachiya; Tomomi Ikemoto; Shinsuke Yamashita; Masaru Kihara; Shigeru Kobayashi; Tetsuro Shingu; Wilbur K. Milhous; Kuo-Hsiung Lee

  Acid degradation products of qinghaosu and their structure-activity relationships

  Heterocycles. 1990;31(6):1011-1016.
  13

• 523.

  1990

  Zhe-Qing Wang; Yao-Haur Kuo; Dora Schnur; J. Phillip Bowen; Su-Ying Liu; Fu-Sheng Han; Jang-Yang Chang; Yung-Chi Cheng; Kuo-Hsiung Lee

  Antitumor agents. 113. New 4β-arylamino derivatives of 4′-O-demethylepipodophyllotoxin and related compounds as potent inhibitors of human DNA topoisomerase II

  Journal of Medicinal Chemistry. 1990;33(9):2660-2666.
  71

• 524.

  1990

  Hiroshi Nozaki; Yukinaga Matsuura; Satomi Hirono; Ryoji Kasai; Jer-Jang Chang; Kuo-Hsiung Lee

  Antitumor agents, 116. Cytotoxic triterpenes from Maytenus diversifolia

  Journal of Natural Products. 1990;53(4):1039-1041.
  17

• 525.

  1990

  Gen-Ichiro Nonaka; Itsuo Nishioka; Makoto Nishizawa; Takashi Yamagishi; Yoshiki Kashiwada; Ginger E. Dutschman; Anne J. Bodner; Robert E. Kilkuskie; Yung-Chi Cheng; Kuo-Hsiung Lee

  Anti-aids agents, 2: Inhibitory effects of tannins on HIV reverse transcriptase and HIV replication in H9 lymphocyte cells

  Journal of Natural Products. 1990;53(3):587-595.
  80

• 526.

  1990

  Chang-Qi Hu; Jer-Jang Chang; Kuo-Hsiung Lee

  Antitumor agents, 115. Seselidiol, a new cytotoxic polyacetylene from Seseli mairei

  Journal of Natural Products. 1990;53(4):932-935.
  14

• 527.

  1990

  Kuo-Hsiung Lee; Scott A. Beers; Masami Mori; Zhe-Qing Wang; Yao-Haur Kuo; Li Li; Su-Ying Liu; Jang-Yang Chang; Fu-Sheng Han; Yung-Chi Cheng

  Antitumor agents. 111. New 4-hydroxylated and 4-halogenated anilino derivatives of 4′-demethylepipodophyllotoxin as potent inhibitors of human DNA topoisomerase II

  Journal of Medicinal Chemistry. 1990;33(5):1364-1368.
  60

• 528.

  1990

  Yao-Haur Kuo; Chung-Hsiung Chen; Li-Ming Yang Kuo; Ming-Lu King; Tian-Shung Wu; Mitsumasa Haruna; Kuo-Hsiung Lee

  Antitumor agents, 112. Emarginatine B, A novel potent cytotoxic sesquiterpene pyridine alkaloid from Maytenus emarginata

  Journal of Natural Products. 1990;53(2):422-428.
  17

• 529.

  1990

  Tsuyoshi Toyota; Narihiko Fukamiya; Masayoshi Okano; Kiyoshi Tagahara; Jer-Jang Chang; Kuo-Hsiung Lee

  Antitumor agents, 118. The isolation and characterization of bruceanic acid A, its methyl ester, and the new bruceanic acids B, C, and D, from Brucea antidysenterica

  Journal of Natural Products. 1990;53(6):1526-1532.
  13

• 530.

  1990

  Guo-Fu Chen; Zhu-Lian Li; Ke Chen; Cheng-Min Tang; Xiang He; De-Ji Pan; Chang-Qi Hu; Donald R. McPhail; Andrew T. McPhail; Kuo-Hsiung Lee

  Structure and stereochemistry of pseudolarolide E, a novel triterpene dilactone from Pseudolarix kaempferi

  Journal of the Chemical Society, Chemical Communications. 1990;(16):1113-1114.
  7

• 531.

  1989

  Dennis E. Chapman; David J. Holbrook; Stephen G. Chaney; Iris H. Hall; Kuo-Hsiung Lee

  In vitro inhibition of mouse hepatic mixed-function oxidase enzymes by helenalin and alantolactone

  Biochemical Pharmacology. 1989;38(22):3913-3923.
  11

• 532.

  1989

  William B. Parker; Makoto Nishizawa; Michael H. Fisher; Ning Ye; Kuo-Hsiung Lee; Yung-Chi Cheng

  Characterization of a novel inhibitor of human DNA polymerases: 3,4,5-tri-O-galloylquinic acid

  Biochemical Pharmacology. 1989;38(21):3759-3765.
  12

• 533.

  1989

  Yao-Haur Kuo; Chung-Hsiung Chen; Li-Ming Yang Kuo; Ming-Lu King; Tian-Shung Wu; Sheng-Teh Lu; Ih-Sheng Chen; Donald R. McPhail; Andrew T. McPhail; Kuo-Hsiung Lee

  Structure and stereochemistry of emarginatine-A, a novel cytotoxic sesquiterpene pyridine alkaloid from Maytenus emarginata: X-ray crystal structure of emarginatine-a monohydrate

  Heterocycles. 1989;29(8):1465-1468.
  14

• 534.

  1989

  Yan Xiu-Zhen; Kuo Yao-Haur; Lee Tsong-Jyh; Shih To-Shii; Chen Chung-Hsiung; Donald R. Mcphail; Andrew T. Mcphail; Lee kuo-Hsiung

  Cytotoxic components of Diospyros morrisiana

  Phytochemistry. 1989;28(5):1541-1543.
  5

• 535.

  1989

  Lu Sheng-Teh; Hwang Jeng-Fen; Wu Tian-Shung; Donald R. McPhail; Andrew T. McPhail; Kuo-Hsiung Lee

  Alkaloids of Corydalis pallida var. sparsimamma and the structure and stereochemistry of pallimamine

  Phytochemistry. 1989;28(4):1245-1249.
  0

• 536.

  1989

  Wu Yang-Chang; Chen Chung-Hsiung; Yang Tsang-Hsiung; Lu sheng-Teh; Donald R. Mcphail; Andrew T. Mcphail; Lee Kuo-Hsiung

  Cytotoxic aporphines from artabotrys uncinatus and the structure and stereochemistry of artacinatine

  Phytochemistry. 1989;28(8):2191-2195.
  8

• 537.

  1989

  Y.-M. Lin; F.-C. Chen; K.H. Lee -.

  Hinokiflavone, a cytotoxic principle from Rhus succedanea and the cytotoxicity of the related biflavonoids

  Planta Medica. 1989;55(2):166-168.
  25

• 538.

  1989

  Makoto Nishizawa; Takashi Yamagishi; Ginger E. Dutschman; William B. Parker; Anne J. Bodner; Robert E. Kilkuskie; Yung-Chi Cheng; Kuo-Hsiung Lee

  Anti-aids agents, 1. Isolation and characterization of four new tetragalloylquinic acids as a new class of HIV reverse transcriptase inhibitors from tannic acid

  Journal of Natural Products. 1989;52(4):762-768.
  48

• 539.

  1989

  Lee S. Thurston; Yasuhiro Imakura; Mitsumasa Haruna; De-Hua Li; Zong-Chao Liu; Su-Ying Liu; Yung-Chi Cheng; Kuo-Hsiung Lee

  Antitumor agents. 100. Inhibition of human DNA topoisomerase II by cytotoxic ether and ester derivatives of podophyllotoxin and α-peltatin

  Journal of Medicinal Chemistry. 1989;32(3):604-608.
  27

• 540.

  1989

  Masayoshi Okano; Narihiko Fukamiya; Tsuyoshi Toyota; Kiyoshi Tagahara; Kuo-Hsiung Lee

  Antitumor agents, 104. Isolation of yadanziosides M and P from Brucea antidysenterica and identification of bruceantinoside B as a mixture of yadanzioside P and bruceantinoside C

  Journal of Natural Products. 1989;52(2):398-401.
  7

• 541.

  1989

  Tian-Shung Wu; Meei-Jen Liou; Chwan-Jen Lee; Ting-Ting Jong; Andrew T. McPhail; Donald R. McPhail; Kuo-Hsiung Lee

  Structure and synthesis of murrapanine, a novel skeletal indole-naphthoquinone alkaloid and cytotoxic principal from Murraya paniculata var. omphalocarpa

  Tetrahedron Letters. 1989;30(48):6649-6652.
  14

• 542.

  1989

  I.H. Hall; A.A. Grippo; D.J. Holbrook; G. Roberts; H.-C. Lin; H.L. Kim; K.H. Lee

  Role of thiol agents in protecting against the toxicity of helenalin in tumor-bearing mice

  Planta Medica. 1989;55(6):513-517.
  10

• 543.

  1989

  Tian-Shung Wu; Meei-Ling Wang; Ting-Ting Jong; Andrew T. McPhail; Donald R. McPhail; Kuo-Hsiung Lee

  X-ray crystal structure of acrovestone, a cytotoxic principle from Acronychia pedunculata

  Journal of Natural Products. 1989;52(6):1284-1289.
  12

• 544.

  1989

  Kuo-Hsiung Lee; Yasuhiro Imakura; Mitsumasa Haruna; Scott A. Beers; Lee S. Thurston; Hua-Juan Dai; Chung-Hsiung Chen; Su-Ying Liu; Yung-Chi Cheng

  Antitumor agents, 107. New cytotoxic 4-alkylamino analogues of 4′-demethyl-epipodophyllotoxin as inhibitors of human DNA topoisomerase II

  Journal of Natural Products. 1989;52(3):606-613.
  66

• 545.

  1989

  Takashi Yamagishi; Mitsumasa Haruna; Xiu-Zhen Yan; Jer-Jang Chang; Kuo-Hsiung Lee

  Antitumor agents, 110. Bryophyllin B, a novel potent cytotoxic bufadienolide from Bryophyllum pinnatum

  Journal of Natural Products. 1989;52(5):1071-1079.
  32

• 546.

  1989

  S. Liu; B.-D. Hwang; M. Haruna; Y. Imakura; K.-H. Lee; Y.-C. Cheng

  Podophyllotoxin analogs: Effects on DNA topoisomerase II, tubulin polymerization, human tumor KB cells, and their VP-16-resistant variants

  Molecular Pharmacology. 1989;36(1):78-82.
  28

• 547.

  1988

  Yang-Chang Wu; Tian-Shung Wu; Masatake Niwa; Sheag-Teh Lu; Yoshimasa Hirata; Donald R. Mcphail; Andrew T. Mcphail; Kuo-Hsiung Lee

  Structure and stereochemistry of thalicsiline, a new antiinflammatory C₂₀-diterpenoid alkaloid from Thalictrum sessile

  Heterocycles. 1988;27(8):1813-1816.
  3

• 548.

  1988

  Wu Tian-Shung; Huang Shiow-Chyn; Lu Sheng-Teh; Wu Yang-Chang; Donald R. McPhail; Andrew T. McPhail; Kuo-Hsiung Lee

  Structure and stereochemistry of corytensine, a new phthalideisoquinoline alkaloid from Corydalis ochotensis

  Heterocycles. 1988;27(7):1565-1568.
  1

• 549.

  1988

  Dennis E. Chapman; G.B. Roberts; D.J. Reynolds; Anne A. Grippo; David J. Holbrook; Iris H. Hall; Stephen G. Chaney; J. Chang; K.H. Lee

  Acute toxicity of helenalin in bdf1 mice

  Toxicological Sciences. 1988;10(2):302-312.
  2

• 550.

  1988

  Dennis E. Chapman; G.B. Roberts; D.J. Reynolds; Anne A. Grippo; David J. Holbrook; Iris H. Hall; Stephen G. Chaney; J. Chang; K.H. Lee

  Acute toxicity of helenalin in BDF1 mice

  Fundamental and Applied Toxicology. 1988;10(2):302-312.
  5

• 551.

  1988

  Y. Imakura; T. Yokoi; T. Yamagishi; J. Koyama; H. Hu; D.R. McPhail; A.T. McPhail; K.-H. Lee

  Synthesis of desethanoqinghaosu, a novel analogue of the antimalarial qinghaosu

  Journal of the Chemical Society - Series Chemical Communications. 1988;(5):372-374.
  8

• 552.

  1988

  I.H. Hall; W.L. Williams Jr.; A.A. Grippo; K.-H. Lee; D.J. Holbrook; S.G. Chaney

  Inhibition of nucleic acid synthesis in P-388 lymphocytic leukemia cells in culture by sesquiterpine lactones

  Anticancer Research. 1988;8(1):33-42.
  21

• 553.

  1988

  T. Yamagishi; X.-Z. Yan; R.-Y. Wu; D.R. McPhail; A.T. McPhail; K.-H. Lee

  Structure and stereochemistry of bryophyllin-A, a novel potent cytotoxic bufadienolide orthoacetate from Bryophyllum pnnatum

  Chemical and Pharmaceutical Bulletin. 1988;36(4):1615-1617.
  18

• 554.

  1988

  K.-H. Lee; Y.-M. Lin; T.-S. Wu; D.-C. Zhang; T. Yamagishi; T. Hayashi; I.H. Hall; J.-J. Chang; R.-Y. Wu; T.-H. Yang

  The cytotoxic principles of Prunella vulgaris, Psychotria serpens, and Hyptis capitata: Ursolic acid and related derivatives

  Planta Medica. 1988;54(4):308-311.
  90

• 555.

  1988

  Scott A. Beers; Yasuhiro Imakura; Hua-Juan Dai; De-Hua Li; Yung-Chi Cheng; Kuo-Hsiung Lee

  Antitumor agents, 99. Synthetic ring C aromatized podophyllotoxin analogues as potential inhibitors of human DNA topoisomerase II

  Journal of Natural Products. 1988;51(5):901-905.
  19

• 556.

  1988

  Tian-Shung Wu; Hsien-Ju Tien; Mou-Yung Yeh; Kuo-Hsiung Lee

  Isolation and cytotoxicity of rhinacanthin-A and -B, two; naphthoquinones, from Rhinacanthus nasutus

  Phytochemistry. 1988;27(12):3787-3788.
  25

• 557.

  1988

  Takashi Yamagishi; De-Cheng Zhang; Jer-Jang Chang; Donald R. McPhail; Andrew T. McPhail; Kuo-Hsiung Lee

  The cytotoxic principles of Hyptis capitata and the structures of the new triterpenes hyptatic acid-A and -B

  Phytochemistry. 1988;27(10):3213-3216.
  52

• 558.

  1988

  Tian-Shung Wu; Ting-Ting Jong; Wei-Mei Ju; Andrew T. McPhail; Donald R. McPhail; Kuo-Hsiung Lee

  Structures and stereochemistry of melicophyllone A and hypocholesterolemic melicophyllone B, novel sesquiterpene lactones from Melicope triphylla

  Journal of the Chemical Society, Chemical Communications. 1988;(14):956-957.
  2

• 559.

  1988

  Yang-Chang Wu; Sheng-Teh Lu; Jer-Jang Changi; Kuo-Hsiung Lee

  Cytotoxic aporphinoid alkaloids from thalictrum sessile

  Phytochemistry. 1988;27(5):1563-1564.
  9

• 560.

  1988

  W.L. Williams Jr.; I.H. Hall; A.A. Grippo; C.B. Oswald; K.H. Lee; D.J. Holbrook; S.G. Chaney

  Inhibition of nucleic acid synthesis in P-388 lymphocytic leukemia tumor cells by helenalin and bis(helenalinyl)malonate in vivo

  Journal of Pharmaceutical Sciences. 1988;77(2):178-184.
  8

• 561.

  1988

  L.-M. Yang; R.-Y. Wu; A.T. McPhail; T. Yokoi; K.-H. lee

  Neihumicin, a new cytotoxic antibiotic from Micromonospora neihuensis. II. Structural determination and total synthesis

  Journal of Antibiotics. 1988;41(4):488-493.
  6

• 562.

  1988

  T. Yokoi; L.-M. Yang; T. Yokoi; R.-Y. Wu; K.-H. Lee

  Neihumicin, a new cytotoxic antibiotic from Micromonospora neihuensis. III. Structure-activity relationships

  Journal of Antibiotics. 1988;41(4):494-501.
  8

• 563.

  1988

  Narihiko Fukamiya; Masayoshi Okano; Kiyoshi Tagahara; Takaaki Aratani; Kuo-Hsiung Lee

  Antitumor agents, 93. Bruceanol C, a new cytotoxic quassinoid from brucea antidysenterica

  Journal of Natural Products. 1988;51(2):349-352.
  11

• 564.

  1988

  R.-Y. Wu; L.-M. Yang; T. Yokoi; K.-H. Lee

  Neihumicin, a new cytotoxic antibiotic from Micromonospora neihuensis. I. The producing organism, fermentation, isolation and biological properties

  Journal of Antibiotics. 1988;41(4):481-487.
  3

• 565.

  1987

  J.D. Page; S.G. Chaney; I.H. Hall; K.H. Lee; D.J. Holbrook

  Inhibition of inosine monophosphate dehydrogenase by sesquiterpene lactones

  BBA - General Subjects. 1987;926(2):186-194.
  14

• 566.

  1987

  I.H. Hall; K.H. Lee; H.C. Sykes

  Anti-inflammatory agents; IV. Structure activity relationships of sesquiterpene lactone esters derived from helenalin

  Planta Medica. 1987;53(2):153-156.
  4

• 567.

  1987

  Wu Yang-Chang; Lu Sheng-Teh; Wu Tian-Shung; Lee Kuo-Hsiung

  Kuafumine, a novel cytotoxic oxoaporphine alkaloid from Fissistigma glaucescens

  Heterocycles. 1987;26(1):9-12.
  7

• 568.

  1987

  Toshimitsu Hayashi; Forrest T. Smith; Kuo-Hsiung Lee

  Antitumor agents. 89. Psychorubrin, a new cytotoxic naphthoquinone from Psychotria rubra and its structure-activity relationships

  Journal of Medicinal Chemistry. 1987;30(11):2005-2008.
  68

• 569.

  1987

  Narihiko Fukamiya; Masayoshi Okano; Kiyoshi Tagahara; Takaaki Aratani; Yoshihiro Muramoto; Kuo-Hsiung Lee

  Antitumor agents, 90. Bruceantinoside C, a new cytotoxic quassinoid glycoside from Brucea antidysenterica

  Journal of Natural Products. 1987;50(6):1075-1079.
  13

• 570.

  1987

  Kuo-Hsiung Lee; Gregory K. Rice; Iris H. Hall; Venkataraman Amarnath

  Antitumor agents. 86. Synthesis and cytotoxicity of α-methylene-γ-lactone-bearing purines

  Journal of Medicinal Chemistry. 1987;30(3):586-588.
  11

• 571.

  1987

  Zev Lidert; Keith Wing; Judith Polonsky; Yasuhiro Imakura; Masayoshi Okano; Shohei Tani; Yuh-Meei Lin; Hiroshi Kiyokawa; Kuo-Hsiung Lee

  Insect antifeedant and growth inhibitory activity of forty-six quassinoids on two species of agricultural pests

  Journal of Natural Products. 1987;50(3):442-448.
  23

• 572.

  1987

  Kuo-Hsiung Lee; Shohei Tani; Yasuhiro Imakura

  Antimalarial agents, 4. Synthesis of a brusatol analog and biological activity of brusatol-related compounds

  Journal of Natural Products. 1987;50(5):847-851.
  7

• 573.

  1987

  Toshimitsu Hayashi; Junko K. Oyama; Andrew T. Mcphail; Kuo-Hsiung Lee

  Structure and absolute stereochemistry of tomenphantopin-A and -B two cytotoxic sesquiterpene lactones from elephantopus tomentosus

  Phytochemistry. 1987;26(4):1065-1068.
  6

• 574.

  1987

  I.H. Hall; A.A. Grippo; K.-H. Lee; S.G. Chaney; D.J. Holbrook

  Effect of helenalin and bis(helenalinyl)malonate on nucleic acid and protein synthesis in human KB carcinoma cells

  Pharmaceutical Research. 1987;4(6):509-514.
  2

• 575.

  1986

  Hiroshi Nozaki; Hideyo Suzuki; Teruhisa Hirayama; Ryoji Kasai; Rong-Yang Wu; Kuo-Hsiung Lee

  Antitumour triterpenes of Maytenus diversifolia

  Phytochemistry. 1986;25(2):479-485.
  48

• 576.

  1986

  T. Konoshima; K.-H. Lee

  Antitumor agents, 82. Cytotoxic sapogenols from Aesculus hippocastanum

  Journal of Natural Products. 1986;49(4):650-656.
  27

• 577.

  1986

  Lee S. Thurston; Hiroshi Irie; Shohei Tani; Fu-Sheng Han; Zong-Chao Liu; Yung-Chi Cheng; Kuo-Hsiung Lee

  Antitumor agents. 78. Inhibition of human DNA topoisomerase II by podophyllotoxin and α-peltatin analogues

  Journal of Medicinal Chemistry. 1986;29(8):1547-1550.
  22

• 578.

  1986

  Gregory K. Rice; Toshio Yokoi; Toshimitsu Hayashi; Hideyo Suzuki; Kuo-Hsiung Lee; Andrew T. McPhail

  Structure and stereochemistry of radermasinin, a novel cytotoxic triterpene lactone from Radermachia sinica. X-ray crystal structure of radermasinin monohydrate

  Journal of the Chemical Society, Chemical Communications. 1986;(18):1397-1398.
  0

• 579.

  1986

  Decheng Zhang; Mitsumasa Haruna; Andrew T. McPhail; Kuo-Hsiung Lee

  Cytotoxic germacranolides of Elephantopus carolinianus and the structure and stereochemistry of isodeoxyelephantopin

  Phytochemistry. 1986;25(4):899-904.
  12

• 580.

  1986

  N. Fukamiya; K.-H. Lee

  Antitumor agents, 81. Justicidin-A and diphyllin, two cytotoxic principles from Justicia procumbens

  Journal of Natural Products. 1986;49(2):348-350.
  53

• 581.

  1986

  Y. Zhao; W.K. Hanton; K.-H. Lee

  Antimalarial agents, 2. Artesunate, an inhibitor of cytochrome oxidase activity in Plasmodium berghei

  Journal of Natural Products. 1986;49(1):139-142.
  8

• 582.

  1986

  Iris H Hall; Yei-Fei Liou; C.Brent Oswald; Kuo-Hsiung Lee

  The effects of Genkwadaphnin and Gnidilatidin on the growth of P-388, L-1210 leukemia and KB carcinoma cells in Vitro

  European Journal of Cancer and Clinical Oncology. 1986;22(1):45-52.
  10

• 583.

  1986

  Narihiko Fukamiya; Masayoshi Okano; Takaaki Aratani; Kenji Negoro; Andrew T. McPhail; Motoharu Ju-Ichi; Kuo-Hsiung Lee

  Antitumor agents, 79. Cytotoxic antileukemic alkaloids from Brucea antidysenterica

  Journal of Natural Products. 1986;49(3):428-434.
  10

• 584.

  1986

  T. Konoshima; K.-H. Lee

  Antitumor agents, 85. Cicutoxin, an antileukemic principle from Cicuta maculata, and the cytotoxicity of the related derivatives

  Journal of Natural Products. 1986;49(6):1117-1121.
  7

• 585.

  1985

  Mitsumasa Haruna; Gregory Rice; Kuo-Hsiung Lee

  Antitumor agents, 71. Nudaphantin, a new cytotoxic germacranolide, and elephantopin from Elephantopus nudatus

  Journal of Natural Products. 1985;48(1):93-96.
  3

• 586.

  1985

  Masayoshi Okano; Narihiko Fukamiya; Takaaki Aratani; Motoharu Juichi; Kuo-Hsiung Lee

  Antitumor agents, 74. Bruceanol-A and -B, two new antileukemic quassinoids from Brucea antidysenterica

  Journal of Natural Products. 1985;48(6):972-975.
  13

• 587.

  1985

  Y.M. Lin; M. Juichi; R.Y. Wu; K.H. Lee

  Antitumor agents LXIX. Alkaloids of Ochrosia acuminata

  Planta Medica. 1985;NO. 6:545-546.
  2

• 588.

  1985

  Shohei Tani; Narihiko Fukamiya; Hiroshi Kiyokawa; H.A. Musallam; Robert O. Pick; Kuo-Hsiung Lee

  Antimalarial agents. 1. α-Santonin-derived cyclic peroxide as potential antimalarial agent

  Journal of Medicinal Chemistry. 1985;28(11):1743-1744.
  9

• 589.

  1985

  Chien-Chih Chen; Yuh-Pan Chen; Hong-Yen Hsu; Kuo-Hsiung Lee; Shohei Tani; Andrew T. McPhail

  Bauhinin, a new nitrile glucoside from Bauhinia championii

  Journal of Natural Products. 1985;48(6):933-937.
  18

• 590.

  1985

  P. Chang; K.-H. Lee.

  Antitumor agents, 75. Synthesis of cytotoxic anthraquinones digiferruginol and morindaparvin-B

  Journal of Natural Products. 1985;48(6):948-951.
  7

• 591.

  1984

  Kuo-Hsiung Lee; Nanao Hayashi; Masayoshi Okano; Hiroshi Nozaki; Motoharu Ju-Ichi

  Antitumor agents, 65. Brusatol and cleomiscosin-A, antileukemic principles from Brucea javanica

  Journal of Natural Products. 1984;47(3):550-551.
  13

• 592.

  1984

  W.L. Williams Jr.; Stephen G. Chaney; Iris H. Hall; Kuo-Hsiung Lee

  Indirect inactivation of rabbit reticulocyte initiation factor eIF-2 by helenalin and bis(helenalinyl) malonate

  Biochemistry. 1984;23(23):5637-5644.
  4

• 593.

  1984

  Pong Chang; Kuo-Hsiung Lee

  Cytotoxic antileukemic anthraquinones from Morinda parvifolia

  Phytochemistry. 1984;23(8):1733-1736.
  30

• 594.

  1984

  Kuo-Hsiung Lee; Hiroshi Nozaki; Andrew T. McPhail

  Structure and stereochemistry of maytensifolin-a, a novel hydroperoxy-nortriterpene from maytenus diversifolia

  Tetrahedron Letters. 1984;25(7):707-710.
  3

• 595.

  1983

  W.Lee Williams Jr.; Stephen G. Chaney; Walker Willingham III; R.Tobias Considine; Iris H. Hall; Kuo-Hsiung Lee

  Selective inactivation of rabbit reticulocyte initiation factor eIF-3 by helenalin

  BBA - Gene Structure and Expression. 1983;740(2):152-162.
  3

• 596.

  1983

  Yei-Fei Liou; Iris H. Hall; Kuo-Hsiung Lee; W.L. Williams Jr.; Stephen G. Chaney

  Investigation of sesquiterpene lactones as protein synthesis inhibitors of P-388 lymphocytic leukemia cells

  BBA - Gene Structure and Expression. 1983;739(2):190-196.
  2

• 597.

  1983

  I.H. Hall; K.H. Lee; Y. Imakura; M. Okano; A. Johnson

  Anti-inflammatory agents. III: Structure-activity relationships of brusatol and related quassinoids

  Journal of Pharmaceutical Sciences. 1983;72(11):1282-1284.
  19

• 598.

  1983

  I.H. Hall; K.H. Lee; Y. Imakura; D. Sims

  Antitumor agents. LXIII: The effects of microlenin on nucleic acid and protein syntheses of Ehrlich ascites cells

  Journal of Pharmaceutical Sciences. 1983;72(9):1008-1011.
  4

• 599.

  1983

  R.K. Levy; I.H. Hall; K.H. Lee

  Antitumor agents. LXII: Synthesis and biological evaluation of podophyllotoxin esters and related derivatives

  Journal of Pharmaceutical Sciences. 1983;72(10):1158-1161.
  15

• 600.

  1983

  P. Chang; K.H. Lee

  Morindaparvin A

  Drugs of the Future. 1983;8(8):686.
  0

• 601.

  1983

  I.H. Hall; Y.F. Liou; K.H. Lee; S.G. Chaney; W. Willingham Jr.

  Antitumor agents. LIX: Effects of quassinoids on protein synthesis of a number of murine tumors and normal cells

  Journal of Pharmaceutical Sciences. 1983;72(6):626-630.
  7

• 602.

  1982

  Y.F. Liou; I.H. Hall; K.H. Lee

  Antitumor agents. LIV: The effects of daphnoretin on in vitro protein synthesis of Ehrlich ascites carcinoma cells and other tissues

  Journal of Pharmaceutical Sciences. 1982;71(7):745-749.
  19

• 603.

  1982

  I.H. Hall; K. Tagahara; K.H. Lee

  Antitumor agents. LIII: The effects of daphnoretin on nucleic acid and protein synthesis of Ehrlich ascites tumor cells

  Journal of Pharmaceutical Sciences. 1982;71(7):741-744.
  17

• 604.

  1982

  Pong Chang; Kuo-Hsiung Lee; Tetsuro Shingu; Teruhisa Hirayama; Iris H. Hall; Huan-Chang Huang

  Antitumor agents 50. Morindaparvin-a, a new antileukemic anthraquinone, and alizarin-1-methyl ether from Morinda parvifolia, and the antileukemic activity of the related derivatives

  Journal of Natural Products. 1982;45(2):206-210.
  15

• 605.

  1982

  I.H. Hall; Y.F. Liou; K.H. Lee

  Antitumor antigens XLVII; The effects of bisbrusatolyl malonate on P-388 lymphocyte leukemia cell metabolism

  Journal of Pharmaceutical Sciences. 1982;71(2):257-262.
  1

• 606.

  1982

  I.H. Hall; Y.F. Liou; M. Okano; K.H. Lee

  Antitumor agents XLVI: In vitro effects of esters of brusatol, bisbrusatol, and related compounds on nucleic acid and protein synthesis of P-388 lymphocytic leukemia cells

  Journal of Pharmaceutical Sciences. 1982;71(3):345-348.
  4

• 607.

  1982

  K.H. Lee; M. Okano; I.H. Hall; D.A. Brent; B. Soltmann

  Antitumor agents XLV: Bisbrusatolyl and brusatolyl esters and related compounds as novel potent antileukemic agents

  Journal of Pharmaceutical Sciences. 1982;71(3):338-345.
  14

• 608.

  1982

  I.H. Hall; Y.F. Liou; K.H. Lee

  Antitumor agents LII: The effects of molephantinin on nucleic acid and protein synthesis of Ehrlich ascites cells

  Journal of Pharmaceutical Sciences. 1982;71(6):687-690.
  1

• 609.

  1982

  Kuo-Hsiung Lee; Hiroshi Nozaki; Iris H. Hall; Ryoji Kasai; Teruhisa Hirayama; Hideyo Suzuki; Rong-Yang Wu; Huan-Chang Huang

  Antitumor agents 60. Maytansine, an antileukemic principle from Maytenus diversifolia

  Journal of Natural Products. 1982;45(4):509-510.
  8

• 610.

  1982

  Y.F. Liou; I.H. Hall; K.H. Lee

  Antitumor agents LVI: The protein synthesis inhibition by genkwadaphnin and yuanhuacine of P-388 lymphocytic leukemia cells

  Journal of Pharmaceutical Sciences. 1982;71(12):1340-1344.
  13

• 611.

  1982

  Ryoji Kasai; Tetsuro Shingu; Rong-Yang Wu; Iris H. Hall; Kuo-Hsiung Lee

  Antitumor agents 57. The isolation and structural elucidation of microhelenin-E, a new antileukemic nor-pseudoguaianolide, and microhelenin-F from Helenium microcephalum

  Journal of Natural Products. 1982;45(3):317-320.
  1

• 612.

  1982

  H. Nozaki; H. Suzuki; K.H. Lee; A.T. McPhail

  Structure and stereochemistry of maytenfolic acid and maytenfoliol, two new antileukemic triterpenes from Maytenus diversifolia: X-ray crystal structures

  Journal of the Chemical Society - Series Chemical Communications. 1982;No. 18:1048-1051.
  10

• 613.

  1982

  Hideyo Suzuki; Kuo-Hsiung Lee; Mitsumasa Haruna; Toshiyuki Iida; Kazuo Ito; Huan-Chang Huang

  (+)-Arctigenin, a lignan from Wikstroemia indica

  Phytochemistry. 1982;21(7):1824-1825.
  13

• 614.

  1982

  Nanao Hayashi; Kuo-Hsiung Lee; Iris H. Hall; Andrew T. McPhail; Huan-Chang Huang

  Structure and stereochemistry of (-)-odorinol, an antileukemic diamide from Aglaia odorata

  Phytochemistry. 1982;21(9):2371-2373.
  19

• 615.

  1981

  Walker Willingham Jr.; Edward A. Stafford; Steven H. Reynolds; Stephen G. Chaney; Kuo-Hsiung Lee; Masayoshi Okano; Iris H. Hall

  Mechanism of eukaryotic protein synthesis inhibition by brusatol

  BBA Section Nucleic Acids And Protein Synthesis. 1981;654(2):169-174.
  9

• 616.

  1981

  Kuo-Hsiung Lee; Toshiro Ibuka; Donald Sims; Osamu Muraoka; Hiroshi Kiyokawa; Iris H. Hall; Hyeong L. Kim

  Antitumor agents. 44. Bis(helenalinyl) esters and related derivatives as novel potent antileukemic agents

  Journal of Medicinal Chemistry. 1981;24(8):924-927.
  8

• 617.

  1981

  Masayoshi Okano; Kuo-Hsiung Lee

  Antitumor agents. 43. Conversion of bruceoside-A into bruceantin

  Journal of Organic Chemistry. 1981;46(6):1138-1141.
  5

• 618.

  1981

  Kuo-Hsiung Lee; Kiyoshi Tagahara; Hideyo Suzuki; Rong-Yang Wu; Mitsumasa Haruna; Iris H. Hall; Huan-Chang Huang; Kazuo Ito; Toshiyuki Iida; Jeng-Shiow Lai

  Antitumor agents. 49. Tricin,kaempferol-3-0-β-D-glucopyranoside and (+)-nortrachelogenin, antileukemic principles from Wikstroemia indica

  Journal of Natural Products. 1981;44(5):530-535.
  64

• 619.

  1981

  Masayoshi Okano; Kuo-Hsiung Lee; Iris H. Hall; Fred E. Boettner

  Antitumor agents. 39. Bruceantinoside-A and -B, novel antileukemic quassinoid glucosides from Brucea antidysenterica

  Journal of Natural Products. 1981;44(4):470-474.
  15

• 620.

  1981

  I.H. Hall; K.H. Lee; M. Okano; D. Sims; T. Ibuka; Y.F. Liou; Y. Imakura

  Antitumor agents XLII: Comparison of antileukemic activity of helenalin, brusatol, and bruceantin and their esters on different strains of P-388 lymphocytic leukemic cells

  Journal of Pharmaceutical Sciences. 1981;70(10):1147-1150.
  5

• 621.

  1981

  Ryoji Kasal; Kuo-Hsiung Lee; Huan-Chang Huang

  Genkwadaphnin, a potent antileukemic diterpene from Daphne genkwa

  Phytochemistry. 1981;20(11):2592-2594.
  17

• 622.

  1980

  I.H. Hall; K.H. Lee; W.L. Williams Jr.; T. Kimura; T. Hirayama

  Antitumor agents XLI: Effects of eupaformosanin on nucleic acid, protein, and anaerobic and aerobic glycolytic metabolism of Ehrlich ascites cells

  Journal of Pharmaceutical Sciences. 1980;69(3):294-297.
  3

• 623.

  1980

  K.H. Lee; T. Ibuka; H. Furukawa; M. Kozuka; R.Y. Wu; I.H. Hall; H.C. Huang

  Antitumor agents XXXVIII: Isolation and structural elucidation of novel germacranolides and triterpenes from Elephantopus mollis

  Journal of Pharmaceutical Sciences. 1980;69(9):1050-1056.
  15

• 624.

  1980

  Y. Imakura; K.H. Lee; D. Sims; R.Y. Wu; I.H. Hall; H. Furukawa; M. Itoigawa; K. Yonaha

  Antitumor agents XXXVI: Structure elucidation of sesquiterpene lactones microhelenins-A, B, and C, microlenin acetate, and plenolin from Helenium microcephalum

  Journal of Pharmaceutical Sciences. 1980;69(9):1044-1049.
  1

• 625.

  1980

  I.H. Hall; C.O. Starnes Jr.; K.H. Lee; T.G. Waddell

  Mode of action of sesquiterpene lactones as anti-inflammatory agents

  Journal of Pharmaceutical Sciences. 1980;69(5):537-543.
  64

• 626.

  1980

  I.H. Hall; K.H. Lee; C.O. Starnes; O. Muraoka; Y. Sumida; T.G. Waddell

  Antihyperlipidemic activity of sesquiterpene lactones and related compounds

  Journal of Pharmaceutical Sciences. 1980;69(6):694-697.
  12

• 627.

  1979

  I.H. Hall; K.H. Lee; C.O. Starnes; Y. Sumida; R.Y. Wu; T.G. Waddell; J.W. Cochran; K.G. Gerhart

  Anti-inflammatory activity of sesquiterpene lactones and related compounds

  Journal of Pharmaceutical Sciences. 1979;68(5):537-542.
  84

• 628.

  1979

  Donald Sims; Kuo-Hsiung Lee; Rong-Yang Wu; Hiroshi Furukawa; Masataka Itoigawa; Kazue Yonaha

  Antitumor agents 37.' the isolation and structural elucidation of isohelenol, a new antileukemic sesquiterpene lactone, and isohelenalin from helenium microcephalum

  Journal Of Natural Products. 1979;42(3):282-286.
  3

• 629.

  1979

  S.A. Eigebaly; I.H. Hall; K.H. Lee; Y. Sumida; Y. Imakura; R.Y. Wu

  Antitumor agents XXXV: Effects of brusatol, bruceoside A, and bruceantin on P-388 lymphocytic leukemia cell respiration

  Journal of Pharmaceutical Sciences. 1979;68(7):887-890.
  3

• 630.

  1979

  I.H. Hall; K.H. Lee; S.A. Eigebaly; Y. Imakura; Y. Sumida; R.Y. Wu

  Antitumor agents XXXIV: Mechanism of action of bruceoside A and brusatol on nucleic acid metabolism of P-388 lymphocytic leukemia cells

  Journal of Pharmaceutical Sciences. 1979;68(7):883-887.
  9

• 631.

  1979

  Kuo-Hsiung Lee; Yasuhiro Imakura; Yoshio Sumida; Rong-Yang Wu; Iris H. Hall; Huan-Chang Huang

  Antitumor agents. 33. Isolation and structural elucidation of bruceoside-A and -B, novel antileukemic quassinoid glycosides, and brucein-D and -E from Brucea javanica

  Journal of Organic Chemistry. 1979;44(13):2180-2185.
  42

• 632.

  1978

  Kuo-Hsiung Lee; Eng-Chun Mar; Masao Okamoto; Iris H. Hall

  Antitumor agents. 32. Synthesis and antitumor activity of cyclopentenone derivatives related to helenalin

  Journal of Medicinal Chemistry. 1978;21(8):819-822.
  6

• 633.

  1978

  I.H. Hall; K.H. Lee; S.A. Eigebaly

  Antitumor agents XXVII: Effects of helenalin on anaerobic and aerobic metabolism on Ehrlich ascites cells

  Journal of Pharmaceutical Sciences. 1978;67(4):552-554.
  1

• 634.

  1978

  I.H. Hall; K.H. Lee; S.A. Eigebaly

  Antitumor agents XXIX: Effects of eupahyssopin on nucleic acid, protein, anaerobic, and aerobic metabolism of Ehrlich ascites tumor cells

  Journal of Pharmaceutical Sciences. 1978;67(9):1232-1235.
  2

• 635.

  1978

  I.H. Hall; K.H. Lee; C.O. Starnes; S.A. Eigebaly; T. Ibuka; Y.S. Wu; T. Kimura; M. Haruna

  Antitumor agents XXX: Evaluation of α-methylene-γ-lactone-containing agents for inhibition of tumor growth, respiration, and nucleic acid synthesis

  Journal of Pharmaceutical Sciences. 1978;67(9):1235-1239.
  19

• 636.

  1978

  Kuo-Hsiung Lee; Toshiro Ibuka; Eng-Chun Mar; Iris H. Hall

  Antitumor agents. 31. Helenalin sym-dimethylethylenediamine reaction products and related derivatives

  Journal of Medicinal Chemistry. 1978;21(7):698-701.
  3

• 637.

  1978

  Y. Imakura; K.H. Lee; D. Sims; I.H. Hall

  Antitumor agents XXVIII: Structural elucidation of the novel antitumor sesquiterpene lactone, microlenin, from Helenium microcephalum

  Journal of Pharmaceutical Sciences. 1978;67(9):1228-1232.
  1

• 638.

  1977

  Kuo-Hsiung Lee; Takeatsu Kimura; Mitsumasa Haruna; Andrew T. McPhail; Kay D. Onan; Huang Huan-Chang

  Structure and stereochemistry of eupaformosanin, a new antileukemic and antisarcoma germacranolide from Eupatorium formosanum

  Phytochemistry. 1977;16(7):1068-1070.
  8

• 639.

  1977

  Iris H. Hall; Kuo-Hsiung Lee; Eng Chun Mar; Charles O. Starnes; Thomas G. Waddell

  Antitumor agents. 21. A proposed mechanism for inhibition of cancer growth by tenulin and helenalin and related cyclopentenones

  Journal of Medicinal Chemistry. 1977;20(3):333-337.
  53

• 640.

  1977

  K.H. Lee; I.H. Hall; E.C. Mar; C.O. Starnes; S.A. ElGebaly; T.G. Waddell; R.I. HADGRAFT; C.G. Ruffner; I. Weidner

  Sesquiterpene antitumor agents: inhibitors of cellular metabolism

  Science. 1977;196(4289):533-536.
  103

• 641.

  1977

  K.H. Lee; M. Haruna; H.C. Huang; B.S. Wu; I.H. Hall

  Antitumor agents XXIII: Helenalin, an antitumor principle from Anaphalis morrisonicola HAY

  Journal of Pharmaceutical Sciences. 1977;66(8):1194-1195.
  3

• 642.

  1977

  Kuo-Hsiung Lee; Yih-Shiong Wu; Iris H. Hall

  Antitumor agents. 25. Synthesis and antitumor activity of uracil and thymine α-methylene-γ-lactones and related derivatives

  Journal of Medicinal Chemistry. 1977;20(7):911-914.
  13

• 643.

  1977

  Kuo-Hsiung Lee; Yasuhiro Imakura; Huan-Chang Huang

  Bruceoside-A, a novel antileukaemic quassinoid glycoside from Brucea javanica

  Journal of the Chemical Society, Chemical Communications. 1977;(2):69-70.
  3

• 644.

  1977

  Lee Kuo-Hsiung; Toshiro Ibuka; Wu Rong-Yang; T.A. Geissman

  Structure-antimicrobial activity relationships among the sesquiterpene lactones and related compounds

  Phytochemistry. 1977;16(8):1177-1181.
  12

• 645.

  1977

  Lee Kuo-Hsiung; Yasuhiro Imakura; Donald Sims; Andrew T. McPhail; Kay D. Onan

  Antitumor sesquiterpene lactones from Helenium microcephalum: Isolation of mexicanin-E and structural characterization of microhelenin-B and -C

  Phytochemistry. 1977;16(3):393-395.
  0

• 646.

  1976

  Kuo-Hsiung Lee; Yasuhiro Imakura; Donald Sims; Andrew T. McPhail; Kay D. Onan

  Structure and stereochemistry of microlenin, a novel antitumour dimeric sesquiterpene lactone from Helenium microcephalum; X-ray crystal structure

  Journal of the Chemical Society, Chemical Communications. 1976;(10):341-342.
  2

• 647.

  1976

  K.H. Lee; Y. Imakura; D. Sims

  Antitumor agents XVII: Structure and stereochemistry of microhelenin A, a new antitumor sesquiterpene lactone from Helenium microcephalum

  Journal of Pharmaceutical Sciences. 1976;65(9):1410-1412.
  0

• 648.

  1976

  K.H. Lee; T. Kimura; M. Okamoto

  The structure and stereochemistry of eupahyssopin, a new antitumor germacranolide from Eupatorium hyssopifolium

  Tetrahedron Letters. 1976;No. 14:1051-1054.
  1

• 649.

  1975

  Kuo-Hsiung Lee; Sun-Hyuk Kim; Hiroshi Furukawa; Claude Piantadosi; Eng-Shang Huang

  Antitumor agents. 11. 1 Synthesis and cytotoxic activity of epoxides of helenalin related derivatives

  Journal of Medicinal Chemistry. 1975;18(1):59-63.
  6

• 650.

  1975

  K.H. Lee; T. Mazumder; H.C. Huang; D.L. Harris

  Antitumor agents XIV: Molephantinin, a new potent antitumor Sesquiterpene lactone from Elephantopus mollis

  Journal of Pharmaceutical Sciences. 1975;64(6):1077-1078.
  12

• 651.

  1975

  Kuo-Hsiung Lee; Toshiro Ibuka; Sun-Hyuk Kim; Bruce R. Vestal; Iris H. Hall; Eng-Shang Huang

  Antitumor agents. 16. Steroidal α-methylene-γ-lactones

  Journal of Medicinal Chemistry. 1975;18(8):812-817.
  12

• 652.

  1975

  K.H. Lee; C.M. Cowherd; T. Wolo McA.

  Antitumor agents XV: deoxyelephantopin, an antitumor principle from Elephantopus carolinianus Willd.

  Journal of Pharmaceutical Sciences. 1975;64(9):1572-1573.
  9

• 653.

  1975

  Andrew T. McPhail; Kay D. Onan; Hiroshi Furukawa; Kuo-Hsiung Lee

  Structure and stereochemistry of carolenalone, a new sesquiterpene lactone from north carolina helenium autumnale L.

  Tetrahedron Letters. 1975;16(14):1229-1232.
  0

• 654.

  1974

  Lee Kuo-Hsiung; Toshiro Ibuka; Andrew T. McPhail; Key D. Onan; T.A. Geissman; T.G. Waddell

  The structure and absolute configuration of plenolin, a cytotoxic sesquiterpene lactone

  Tetrahedron Letters. 1974;15(13):1149-1152.
  0

• 655.

  1974

  K.H. Lee; S.H. Kim; C. Piantadosi

  Antitumor agents VIII: synthesis and cytotoxic activity of O,O' bis(acrylyl) α,ω alkanediols

  Journal of Pharmaceutical Sciences. 1974;63(7):1162-1163.
  2

• 656.

  1974

  Kazuo Ito; Hiroshi Furukawa; Toshiyuki Iida; Kuo-Hsiung Lee; Taito O. Soine

  Conversion of tetrahydroberberine into pavinane-type alkaloids

  Journal of the Chemical Society, Chemical Communications. 1974;(24):1037-1038.
  4

• 657.

  1974

  K.H. Lee; T. Ibuka; R.Y. Wu

  Beta unsubstituted cyclopentenone, a structural requirement for antimicrobial and cytotoxic activities

  Chemical and Pharmaceutical Bulletin. 1974;22(9):2206-2208.
  5

• 658.

  1973

  Kuo-Hsiung Lee; Ronald Meek; Claude Piantadosi; Eng-Shang Huang

  Antitumor agents. 4. Cytotoxicity and in vivo activity of helenalin esters and related derivatives

  Journal of Medicinal Chemistry. 1973;16(3):299-301.
  27

• 659.

  1973

  Hiroshi Furukawa; Kuo-Hsiung Lee; Tetsuro Shingu; Ronald Meck; Claude Piantadosi

  Carolenin and carolenalin, two new guaianolides in Helenium autumnale L. from North Carolina

  Journal of Organic Chemistry. 1973;38(9):1722-1725.
  0

• 660.

  1973

  Andrew T. Mcphail; Key D. Onan; Kuo-Hsiung Lee; Hiroshi Furukawa; Sun-Hyuk Kim; Claude Piantadosi

  Transformations of helenalin : crystal structure analysis of the oxide from the reaction with hydrogen chloride

  Tetrahedron Letters. 1973;14(46):4641-4644.
  1

• 661.

  1973

  Kuo-Hsiung Lee; Hiroshi Furukawa; Mutsuo Kozuka; Huan-Chang Huang; Patricia A. Luhan; Andrew T. McPhail

  Molephantin, a novel cytotoxic germacranolide from Elephantopus mollis. X-ray crystal structure

  Journal of the Chemical Society, Chemical Communications. 1973;(14):476-477.
  5

• 662.

  1972

  Kuo-Hsiung Lee; Hiroshi Furukawa; Eng-Shang Huang

  Antitumor agents. 3 Synthesis and cytotoxic activity of helenalin amine adducts and relate derivatives

  Journal of Medicinal Chemistry. 1972;15(6):609-611.
  27

• 663.

  1971

  C.H. Chen; T.O. Soine; K.H. Lee

  Total synthesis of ( )-bisnorargemonine.

  Journal of Pharmaceutical Sciences. 1971;60(11):1634-1638.
  5

• 664.

  1970

  C.H. Chen; T.O. Soine; K.H. Lee

  Total synthesis of (plus or minus)-bisnorargemonine.

  Journal of Pharmaceutical Sciences. 1970;59(10):1529-1530.
  0