Oliver Smithies

UNCCH, School of Medicine, Pathology and Laboratory Medicine

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Oliver Smithies

• Organizations
  University of North Carolina at Chapel Hill
  
  School of Medicine
  
  Pathology and Laboratory Medicine
  
  

Help us refine your profile

This is a list of publications by this researcher, listed chronologically starting with the most recent first. New publications appear in this list weekly. The source of publications and 'cited by' data for this application is Scopus.

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• 1.

  2013

  Masao Kakoki; Oleh M. Pochynyuk; Catherine M. Hathaway; Hirofumi Tomita; John R. Hagaman; Hyung-Suk Kim; Oleg L. Zaika; Mykola Mamenko; Yukako Kayashima; Kota Matsuki; et al.

  Primary aldosteronism and impaired natriuresis in mice underexpressing TGFβ1

  Proceedings of the National Academy of Sciences of the United States of America. 2013;110(14):5600-5605.
  0

• 2.

  2012

  Himanshu Vashistha; Pravin C. Singhal; Ashwani Malhotra; Mohammad Husain; Peter Mathieson; Moin A. Saleem; Cyril Kuriakose; Surya Seshan; Anna Wilk; Luis DelValle; et al.

  Null mutations at the p66 and bradykinin 2 receptor loci induce divergent phenotypes in the diabetic kidney

  American Journal of Physiology - Renal Physiology. 2012;303(12):F1629-F1640.
  1

• 3.

  2012

  Hirofumi Tomita; Ryan B. Sanford; Oliver Smithies; Masao Kakoki

  The kallikrein-kinin system in diabetic nephropathy

  Kidney International. 2012;81(8):733-744.
  1

• 4.

  2012

  Feng Li; John R. Hagaman; Hyung-Suk Kim; Nobuyo Maeda; J. Charles Jennette; James E. Faber; S. Ananth Karumanchi; Oliver Smithies; Nobuyuki Takahashi

  eNOS deficiency acts through endothelin to aggravate sFlt-1-induced pre-eclampsia-like phenotype

  Journal of the American Society of Nephrology. 2012;23(4):652-660.
  2

• 5.

  2012

  Oliver Smithies

  How it all began: a personal history of gel electrophoresis.

  Methods in molecular biology (Clifton, N.J.). 2012;869:1-21.
  0

• 6.

  2012

  Nobuyuki Takahashi; Feng Li; Chi-Hong Wang; Nigel Mackman; Nobuyo Maeda; Oliver Smithies; J. Charles Jennette

  Decreased eNOS and high fat diet in diabetic nephropathy

  Therapeutic Research. 2012;33(8):1206-1208.
  0

• 7.

  2012

  Kumar Pandya; Takahide Kohro; Imari Mimura; Mika Kobayashi; Youichiro Wada; Tatsuhiko Kodama; Oliver Smithies

  Distribution of histone3 lysine 4 trimethylation at T3-responsive loci in the heart during reversible changes in gene expression

  Gene Expression. 2012;15(4):183-198.
  0

• 8.

  2012

  Yukako Kayashima; Oliver Smithies; Masao Kakoki

  The kallikrein-kinin system and oxidative stress

  Current Opinion in Nephrology and Hypertension. 2012;21(1):92-95.
  4

• 9.

  2012

  Britni Zajac; Zeenat S. Hakim; Morgan V. Cameron; Oliver Smithies; Joan M. Taylor

  Quantification of myocyte chemotaxis: A role for FAK in regulating directional motility

  Methods in Molecular Biology. 2012;843:111-123.
  2

• 10.

  2011

  Kumar Pandya; Oliver Smithies

  β-MyHC and cardiac hypertrophy: Size does matter

  Circulation Research. 2011;109(6):609-610.
  1

• 11.

  2011

  Raymond Fox; Hyung-Suk Kim; Robert L. Reddick; Gregory C. Kujoth; Tomas A. Prolla; Shuichi Tsutsumi; Youichiro Wada; Oliver Smithies; Nobuyo Maeda

  Mitochondrial DNA polymerase editing mutation, Polg ^D257A, reduces the diabetic phenotype of Akita male mice by suppressing appetite

  Proceedings of the National Academy of Sciences of the United States of America. 2011;108(21):8779-8784.
  1

• 12.

  2011

  Seigo Hatada; William Walton; Tomoko Hatada; Anne Wofford; Raymond Fox; Naiyou Liu; Michael C. Lill; Jeffery H. Fair; Suzanne L. Kirby; Oliver Smithies

  Therapeutic benefits in thalassemic mice transplanted with long-term-cultured bone marrow cells

  Experimental Hematology. 2011;39(3):375-383.e4.
  1

• 13.

  2011

  Chih-Hong Wang; Feng Li; Sylvia Hiller; Hyung-Suk Kim; Nobuyo Maeda; Oliver Smithies; Nobuyuki Takahashi

  A modest decrease in endothelial NOS in mice comparable to that associated with human NOS3 variants exacerbates diabetic nephropathy (Proceedings of the National Academy of Sciences of the United States of America (2011) 108, 5, (2070-2075) DOI:10.1073/pnas.1018766108)

  Proceedings of the National Academy of Sciences of the United States of America. 2011;108(8):3453.
  0

• 14.

  2011

  Chih-Hong Wang; Feng Li; Sylvia Hiller; Hyung-Suk Kim; Nobuyo Maeda; Oliver Smithies; Nobuyuki Takahashi

  A modest decrease in endothelial NOS in mice comparable to that associated with human NOS3 variants exacerbates diabetic nephropathy

  Proceedings of the National Academy of Sciences of the United States of America. 2011;108(5):2070-2075.
  16

• 15.

  2011

  Kumar Pandya; Benjamin Pulli; Scott Bultman; Oliver Smithies

  Reversible epigenetic modifications of the two cardiac myosin heavy chain genes during changes in expression

  Gene Expression. 2011;15(2):51-59.
  2

• 16.

  2010

  Erij Messadi; Marie-Pascale Vincent; Violaine Griol-Charhbili; Chantal Mandet; Juliana Colucci; John H. Krege; Patrick Bruneval; Nadine Bouby; Oliver Smithies; François Alhenc-Gelas; et al.

  Genetically determined angiotensin converting enzyme level and myocardial tolerance to ischemia

  FASEB Journal. 2010;24(12):4691-4700.
  2

• 17.

  2010

  Tetsuo Konno; Dan Chen; Libin Wang; Hiroko Wakimoto; Polakit Teekakirikul; Matthew Nayor; Masataka Kawana; Seda Eminaga; Joshua M. Gorham; Kumar Pandya; et al.

  Heterogeneous myocyte enhancer factor-2 (Mef2) activation in myocytes predicts focal scarring in hypertrophic cardiomyopathy

  Proceedings of the National Academy of Sciences of the United States of America. 2010;107(42):18097-18102.
  9

• 18.

  2010

  Oliver Smithies

  Science brick by brick

  Nature. 2010;467(7317 SUPPL.):S6.
  0

• 19.

  2010

  Adam R. Wende; Jamie Soto; Curtis D. Olsen; Karla M. P. Pires; John C. Schell; Frederic Larrieu-Lahargue; Sheldon E. Litwin; Masao Kakoki; Nobuyuki Takahashi; Oliver Smithies; et al.

  Loss of bradykinin signaling does not accelerate the development of cardiac dysfunction in type 1 diabetic akita mice

  Endocrinology. 2010;151(8):3536-3542.
  5

• 20.

  2010

  Masao Kakoki; Kelli A. Sullivan; Carey Backus; John M. Hayes; Sang Su Oh; Kunjie Hua; Adil M. H. Gasim; Hirofumi Tomita; Ruriko Grant; Sarah B. Nossov; et al.

  Lack of both bradykinin B1 and B2 receptors enhances nephropathy, neuropathy, and bone mineral loss in Akita diabetic mice

  Proceedings of the National Academy of Sciences of the United States of America. 2010;107(22):10190-10195.
  29

• 21.

  2010

  Beverly H Koller; Philippa Marrack; John W Kappler; Oliver Smithies

  Normal development of mice deficient in beta 2M, MHC class I proteins, and CD8+ T cells. 1990.

  Journal of immunology (Baltimore, Md. : 1950). 2010;184(9):4592-4595.
  1

• 22.

  2010

  Beverly H. Koller; Philippa Marrack; John W. Kappler; Oliver Smithies

  Normal development of mice deficient in β₂M, MHC class I proteins, and CD8⁺ T cells

  Journal of Immunology. 2010;184(9):1227-1230.
  0

• 23.

  2009

  Nicola J.A. Scott; Leigh. J. Ellmers; John G. Lainchbury; Nobuyo Maeda; Oliver Smithies; A. Mark Richards; Vicky A. Cameron

  Influence of natriuretic peptide receptor-1 on survival and cardiac hypertrophy during development

  Biochimica et Biophysica Acta - Molecular Basis of Disease. 2009;1792(12):1175-1184.
  7

• 24.

  2009

  Frank C. Brosius III; Charles E. Alpers; Erwin P. Bottinger; Matthew D. Breyer; Thomas M. Coffman; Susan B. Gurley; Raymond C. Harris; Masao Kakoki; Matthias Kretzler; Edward H. Leiter; et al.

  Mouse models of diabetic nephropathy

  Journal of the American Society of Nephrology. 2009;20(12):2503-2512.
  106

• 25.

  2009

  Yau-Sheng Tsai; Lonquan Xu; Oliver Smithies; Nobuyo Maedaa

  Genetic variations in peroxisome proliferator-activated receptor γ expression affect blood pressure

  Proceedings of the National Academy of Sciences of the United States of America. 2009;106(45):19084-19089.
  8

• 26.

  2009

  Anne-Cécille Huby; Maria-Pia Rastaldi; Kathleen Caron; Oliver Smithies; Jean-Claude Dussaule; Christos Chatziantoniou

  Restoration of podocyte structure and improvement of chronic renal disease in transgenic mice overexpressing renin

  PLoS ONE. 2009;4(8).
  20

• 27.

  2009

  Kumar Pandya; Kristine Porter; Howard A. Rockman; Oliver Smithies

  Decreased beta-adrenergic responsiveness following hypertrophy occurs only in cardiomyocytes that also re-express beta-myosin heavy chain

  European Journal of Heart Failure. 2009;11(7):648-652.
  5

• 28.

  2009

  Masao Kakoki; Oliver Smithies

  The kallikreinkinin system in health and in diseases of the kidney

  Kidney International. 2009;75(10):1019-1030.
  22

• 29.

  2009

  Saovaros Svasti; Thipparat Suwanmanee; Suthat Fucharoen; Hong M. Moulton; Michelle H. Nelson; Nobuyo Maeda; Oliver Smithies; Ryszard Kole

  RNA repair restores hemoglobin expression in IVS2-654 thalassemic mice

  Proceedings of the National Academy of Sciences of the United States of America. 2009;106(4):1205-1210.
  22

• 30.

  2009

  Jessica Epple-Farmer; Bisrat G. Debeb; Oliver Smithies; Bert Binas

  Gender-dependent survival of allogeneic trophoblast stem cells in liver

  Cell Transplantation. 2009;18(7):769-776.
  7

• 31.

  2008

  Kumar Pandya; John Cowhig; Joe Brackhan; Suk Kim Hyung; John Hagaman; Mauricio Rojas; Charles W. Carter Jr.; Lan Mao; Howard A. Rockman; et al.

  Discordant on/off switching of gene expression in myocytes during cardiac hypertrophy in vivo

  Proceedings of the National Academy of Sciences of the United States of America. 2008;105(35):13063-13068.
  8

• 32.

  2008

  Oliver Smithies

  Turning pages (Nobel lecture)

  ChemBioChem. 2008;9(9):1342-1359.
  3

• 33.

  2008

  K. Bridget Brosnihan; Jeffrey B. Hodgin; Oliver Smithies; Nobuyo Maeda; Patricia Gallagher

  Tissue-specific regulation of ACE/ACE2 and AT₁/AT₂ receptor gene expression by oestrogen in apolipoprotein E/oestrogen receptor-α knock-out mice

  Experimental Physiology. 2008;93(5):658-664.
  15

• 34.

  2008

  Natalia Makhanova; John Hagaman; Hyung-Suk Kim; Oliver Smithies

  Salt-sensitive blood pressure in mice with increased expression of aldosterone synthase

  Hypertension. 2008;51(1):134-140.
  30

• 35.

  2007

  Zeenat S. Hakim; Laura A. DiMichele; Jason T. Doherty; Jonathon W. Homeister; Hilary E. Beggs; Louis F. Reichardt; Robert J. Schwartz; Joseph Brackhan; Oliver Smithies; Christopher P. Mack; et al.

  Conditional deletion of focal adhesion kinase leads to defects in ventricular septation and outflow tract alignment

  Molecular and Cellular Biology. 2007;27(15):5352-5364.
  33

• 36.

  2007

  Ryan Dackor; Kim Fritz-Six; Oliver Smithies; Kathleen Caron

  Receptor activity-modifying proteins 2 and 3 have distinct physiological functions from embryogenesis to old age

  Journal of Biological Chemistry. 2007;282(25):18094-18099.
  33

• 37.

  2007

  Naohiro Yamaguchi; Nobuyuki Takahashi; Le Xu; Oliver Smithies; Gerhard Meissner

  Early cardiac hypertrophy in mice with impaired calmodulin regulation of cardiac muscle Ca²⁺ release channel

  Journal of Clinical Investigation. 2007;117(5):1344-1353.
  29

• 38.

  2007

  Masao Kakoki; Robert W. McGarrah; Hyung-Suk Kim; Oliver Smithies

  Bradykinin B1 and B2 receptors both have protective roles in renal ischemia/reperfusion injury

  Proceedings of the National Academy of Sciences of the United States of America. 2007;104(18):7576-7581.
  46

• 39.

  2007

  Kathleen Caron; John Hagaman; Toshio Nishikimi; Hyung-Suk Kim; Oliver Smithies

  Adrenomedullin gene expression differences in mice do not affect blood pressure but modulate hypertension-induced pathology in males

  Proceedings of the National Academy of Sciences of the United States of America. 2007;104(9):3420-3425.
  10

• 40.

  2007

  Leigh J. Ellmers; Nicola J.A. Scott; Jarkko Piuhola; Nobuyo Maeda; Oliver Smithies; Chris M. Frampton; A. Mark Richards; Vicky A. Cameron

  Npr1-regulated gene pathways contributing to cardiac hypertrophy and fibrosis

  Journal of Molecular Endocrinology. 2007;38(1-2):245-257.
  25

• 41.

  2006

  Natalia Makhanova; Maria L.S. Sequeira-Lopez; R Ariel Gomez; Hyung-Suk Kim; Oliver Smithies

  Disturbed homeostasis in sodium-restricted mice heterozygous and homozygous for aldosterone synthase gene disruption

  Hypertension. 2006;48(6):1151-1159.
  23

• 42.

  2006

  Steven D. Crowley; Susan B. Gurley; Maria J. Herrera; Phillip Ruiz; Robert Griffiths; Anil P. Kumar; Hyung-Suk Kim; Oliver Smithies; Thu H. Le; Thomas M. Coffman

  Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney

  Proceedings of the National Academy of Sciences of the United States of America. 2006;103(47):17985-17990.
  166

• 43.

  2006

  Kumar Pandya; Hyung-Suk Kim; Oliver Smithies

  Fibrosis, not cell size, delineates β-myosin heavy chain reexpression during cardiac hyperthrophy and normal aging in vivo

  Proceedings of the National Academy of Sciences of the United States of America. 2006;103(45):16864-16869.
  34

• 44.

  2006

  Manyu Li; Della Yee; Terry R. Magnuson; Oliver Smithies; Kathleen M. Caron

  Reduced maternal expression of adrenomedullin disrupts fertility, placentation, and fetal growth in mice

  Journal of Clinical Investigation. 2006;116(10):2653-2662.
  29

• 45.

  2006

  Osamu Yasuda; Keisuke Fukuo; Xin Sun; Masahito Nishitani; Takamori Yotsui; Masayoshi Higuchi; Takashi Suzuki; Hiromi Rakugi; Oliver Smithies; Nobuyo Maeda; et al.

  Apop-1, a novel protein inducing cyclophilin D-dependent but Bax/Bak-related channel-independent apoptosis

  Journal of Biological Chemistry. 2006;281(33):23899-23907.
  15

• 46.

  2006

  Dominic Ciavatta; Sundeep Kalantry; Terry Magnuson; Oliver Smithies

  A DNA insulator prevents repression of a targeted X-linked transgene but not its random or imprinted X inactivation

  Proceedings of the National Academy of Sciences of the United States of America. 2006;103(26):9958-9963.
  20

• 47.

  2006

  Cinzia Perrino; Sathyamangla V. Naga Prasad; Lan Mao; Takahisa Noma; Zhen Yan; Hyung-Suk Kim; Oliver Smithies; Howard A. Rockman

  Intermittent pressure overload triggers hypertrophy-independent cardiac dysfunction and vascular rarefaction

  Journal of Clinical Investigation. 2006;116(6):1547-1560.
  81

• 48.

  2006

  Masao Kakoki; Catherine M. Kizer; Xianwen Yi; Nobuyuki Takahashi; Hyung-Suk Kim; C. Robert Bagnell; Cora-Jean S. Edgell; Nobuyo Maeda; J. Charles Jennette; Oliver Smithies

  Senescence-associated phenotypes in Akita diabetic mice are enhanced by absence of bradykinin B2 receptors

  Journal of Clinical Investigation. 2006;116(5):1302-1309.
  47

• 49.

  2006

  Ryan T. Dackor; Kimberly Fritz-Six; William P. Dunworth; Carrie L. Gibbons; Oliver Smithies; Kathleen M. Caron

  Hydrops fetalis, cardiovascular defects, and embryonic lethality in mice lacking the calcitonin receptor-like receptor gene

  Molecular and Cellular Biology. 2006;26(7):2511-2518.
  38

• 50.

  2006

  Natalia Makhanova; Gene Lee; Nobuyuki Takahashi; Maria L. Sequeira Lopez; R. Ariel Gomez; Hyung-Suk Kim; Oliver Smithies

  Kidney function in mice lacking aldosterone

  American Journal of Physiology - Renal Physiology. 2006;290(1):F61-F69.
  31

• 51.

  2006

  Masao Kakoki; Hyung-Suk Kim; Cora-Jean S. Edgell; Nobuyo Maeda; Oliver Smithies; David L. Mattson

  Amino acids as modulators of endothelium-derived nitric oxide

  American Journal of Physiology - Renal Physiology. 2006;291(2):F297-F304.
  21

• 52.

  2005

  Seigo Hatada; Larry W. Arnold; Tomoko Hatada; John E. Cowhig Jr.; Dominic Ciavatta; Oliver Smithies

  Isolating gene-corrected stem cells without drug selection

  Proceedings of the National Academy of Sciences of the United States of America. 2005;102(45):16357-16361.
  8

• 53.

  2005

  John R. Hagaman; Simon John; Lonquan Xu; Oliver Smithies; Nobuyo Maeda

  An improved technique for tail-cuff blood pressure measurements with dark-tailed mice

  Contemporary Topics in Laboratory Animal Science. 2005;44(5):43-46.
  3

• 54.

  2005

  Gene Lee; Natalia Makhanova; Kathleen Caron; Maria L. Sequeira Lopez; R. Ariel Gomez; Oliver Smithies; Hyung-Suk Kim

  Homeostatic responses in the adrenal cortex to the absence of aldosterone in mice

  Endocrinology. 2005;146(6):2650-2656.
  22

• 55.

  2005

  Oliver Smithies

  An interview with...Oliver Smithies [interviewed by Magdalena Skipper]

  Nature reviews. Genetics. 2005;6(5):350.
  0

• 56.

  2005

  Oliver Smithies

  Many little things: One geneticist's view of complex diseases

  Nature Reviews Genetics. 2005;6(5):419-425.
  23

• 57.

  2005

  Steven D. Crowley; Susan B. Gurley; Michael I. Oliverio; A. Kathy Pazmino; Robert Griffiths; Patrick J. Flannery; Robert F. Spurney; Hyung-Suk Kim; Oliver Smithies; Thu H. Le; et al.

  Distinct roles for the kidney and systemic tissues in blood pressure regulation by the renin-angiotensin system

  Journal of Clinical Investigation. 2005;115(4):1092-1099.
  130

• 58.

  2005

  Toshio Nishikimi; John R. Hagaman; Nobuyuki Takahashi; Hyung-Suk Kim; Hiroaki Matsuoka; Oliver Smithies; Nobuyo Maeda

  Increased susceptibility to heart failure in response to volume overload in mice lacking natriuretic peptide receptor-A gene

  Cardiovascular Research. 2005;66(1):94-103.
  18

• 59.

  2005

  Kathleen M. I. Caron; Leighton R. James; Gene Lee; Hyung-Suk Kim; Oliver Smithies

  Lifelong genetic minipumps

  Physiological Genomics. 2005;20:203-209.
  6

• 60.

  2005

  Jeffrey H. Fair; Bruce A. Cairns; Michael A. LaPaglia; Montserrat Caballero; W. Andrew Pleasant; Seigo Hatada; Hyung-Suk Kim; Tong Gui; Larysa Pevny; Anthony A. Meyer; et al.

  Correction of factor IX deficiency in mice by embryonic stem cells differentiated in vitro

  Proceedings of the National Academy of Sciences of the United States of America. 2005;102(8):2958-2963.
  30

• 61.

  2005

  Nobuyuki Takahashi; Maria Luisa S. Sequeira Lopez; John E. Cowhig Jr.; Melissa A. Taylor; Tomoko Hatada; Emily Riggs; Gene Lee; R. Ariel Gomez; Hyung-Suk Kim; Oliver Smithies

  Ren1c homozygous null mice are hypotensive and polyuric, but heterozygotes are indistinguishable from wild-type

  Journal of the American Society of Nephrology. 2005;16(1):125-132.
  56

• 62.

  2004

  Thu H. Le; Michael I. Oliverio; Hyung-Suk Kim; Harmony Salzler; Rajesh C. Dash; David N. Howell; Oliver Smithies; Sarah Bronson; Thomas M. Coffman

  A γGT-AT_1A receptor transgene protects renal cortical structure in AT₁ receptor-deficient mice

  Physiological Genomics. 2004;18:290-298.
  7

• 63.

  2004

  Masao Kakoki; Nobuyuki Takahashi; J. Charles Jennette; Oliver Smithies

  Diabetic nephropathy is markedly enhanced in mice lacking the bradykinin B2 receptor

  Proceedings of the National Academy of Sciences of the United States of America. 2004;101(36):13302-13305.
  77

• 64.

  2004

  Stephanie M. Cohen; Seigo Hatada; Bruna P. Brylawski; Oliver Smithies; David G. Kaufman; Marila Cordeiro-Stone

  Complementation of replication origin function in mouse embryonic stem cells by human DNA sequences

  Genomics. 2004;84(3):475-484.
  9

• 65.

  2004

  Yi Jiang; Kumar Pandya; Oliver Smithies; Edward W. Hsu

  Three-dimensional diffusion tensor microscopy of fixed mouse hearts

  Magnetic Resonance in Medicine. 2004;52(3):453-460.
  45

• 66.

  2004

  Jennifer L. Goulet; Amy J. Pace; Mikelle L. Key; Robert S. Byrum; MyTrang Nguyen; Stephen L. Tilley; Scott G. Morham; Robert Langenbach; Jeffrey L. Stock; John D. McNeish; et al.

  E-prostanoid-3 receptors mediate the proinflammatory actions of prostaglandin E₂ in acule cutaneous inflammation

  Journal of Immunology. 2004;173(2):1321-1326.
  31

• 67.

  2004

  Maria Luisa S. Sequeira López; Ellen S. Pentz; Takayo Nomasa; Oliver Smithies; R. Ariel Gomez

  Renin cells are precursors for multiple cell types that switch to the renin phenotype when homeostasis is threatened

  Developmental Cell. 2004;6(5):719-728.
  71

• 68.

  2004

  Masao Kakoki; Yau-Sheng Tsai; Hyung-Suk Kim; Seigo Hatada; Dominic J. Ciavatta; Nobuyuki Takahashi; Larry W. Arnold; Nobuyo Maeda; Oliver Smithies

  Altering the expression in mice of genes by modifying their 3′ regions

  Developmental Cell. 2004;6(4):597-606.
  30

• 69.

  2004

  Kathleen M. I. Caron; Leighton R. James; Hyung-Suk Kim; Josh Knowles; Rick Uhlir; Lan Mao; John R. Hagaman; Wayne Cascio; Howard Rockman; Oliver Smithies

  Cardiac hypertrophy and sudden death in mice with a genetically renin transgene

  Proceedings of the National Academy of Sciences of the United States of America. 2004;101(9):3106-3111.
  19

• 70.

  2004

  Nobuyuki Takahashi; Oliver Smithies

  Human genetics, animal models and computer simulations for studying hypertension

  Trends in Genetics. 2004;20(3):136-145.
  36

• 71.

  2003

  Shang-Jin Shi; Elangovan Vellaichamy; So Yeon Chin; Oliver Smithies; L. Gabriel Navar; Kailash N. Pandey

  Natriuretic peptide receptor A mediates renal sodium excretory responses to blood volume expansion

  American Journal of Physiology - Renal Physiology. 2003;285(4 54-4):F694-F702.
  35

• 72.

  2003

  Thu H. Le; Hyung-Suk Kim; Andrew M. Allen; Robert F. Spurney; Oliver Smithies; Thomas M. Coffman

  Physiological impact of increased expression of the AT₁ angiotensin receptor

  Hypertension. 2003;42(4 I):507-514.
  16

• 73.

  2003

  J. Garey; A. Goodwillie; J. Frohlich; M. Morgan; J.-A. Gustafsson; O. Smithies; K.S. Korach; S. Ogawa; D.W. Pfaff

  Genetic contributions to generalized arousal of brain and behavior

  Proceedings of the National Academy of Sciences of the United States of America. 2003;100(19):11019-11022.
  47

• 74.

  2003

  Jeffrey H. Fair; Bruce A. Cairns; Michael LaPaglia; Jian Wang; Anthony A. Meyer; Hyung Kim; Seigo Hatada; Oliver Smithies; Larysa Pevny

  Induction of hepatic differentiation in embryonic stem cells by co-culture with embryonic cardiac mesoderm

  Surgery. 2003;134(2):189-196.
  38

• 75.

  2003

  Nobuyuki Takahashi; John R. Hagaman; Hyung-Suk Kim; Oliver Smithies

  Minireview: Computer simulations of blood pressure regulation by the renin-angiotensin system

  Endocrinology. 2003;144(6):2184-2190.
  38

• 76.

  2003

  Oliver Smithies

  Why the kidney glomerulus does not clog: A gel permeation/diffusion hypothesis of renal function

  Proceedings of the National Academy of Sciences of the United States of America. 2003;100(7):4108-4113.
  66

• 77.

  2002

  K.E. McDougall; M.J. Perry; R.L. Gibson; J.M. Bright; S.M. Colley; J.B. Hodgin; O. Smithies; J.H. Tobias

  Estrogen-induced osteogenesis in intact female mice lacking ERβ

  American Journal of Physiology - Endocrinology and Metabolism. 2002;283(4 46-4):E817-E823.
  19

• 78.

  2002

  Eun-Hee Shim; Jong-Il Kim; Eui-Suk Bang; Jun-Seok Heo; Jae-Seon Lee; Eun-Young Kim; Jong-Eun Lee; Woong-Yang Park; Soon-Hee Kim; Hyung-Suk Kim; et al.

  Targeted disruption of hsp70.1 sensitizes to osmotic stress

  EMBO Reports. 2002;3(9):857-861.
  54

• 79.

  2002

  Kathleen M. I. Caron; Leighton R. James; Hyung-Suk Kim; Scott G. Morham; Maria Luisa S. Sequeira Lopez; R. Ariel Gomez; Timothy L. Reudelhuber; Oliver Smithies

  A genetically clamped renin transgene for the induction of hypertension

  Proceedings of the National Academy of Sciences of the United States of America. 2002;99(12):8248-8252.
  26

• 80.

  2002

  Hyung-Suk Kim; Gene Lee; Simon W. M. John; Nobuyo Maeda; Oliver Smithies

  Molecular phenotyping for analyzing subtle genetic effects in mice: Application to an angiotensinogen gene titration

  Proceedings of the National Academy of Sciences of the United States of America. 2002;99(7):4602-4607.
  77

• 81.

  2002

  Yan Zhu; Zhao Bian; Ping Lu; Richard H. Karas; Lin Bao; Daniel Cox; Jeffrey Hodgin; Philip W. Shaul; Peter Thorén; Oliver Smithies; et al.

  Abnormal vascular function and hypertension in mice deficient in estrogen receptor β

  Science. 2002;295(5554):505-508.
  285

• 82.

  2002

  Jeffrey B. Hodgin; Joshua W. Knowles; Hyung-Suk Kim; Oliver Smithies; Nobuyo Maeda

  Interactions between endothelial nitric oxide synthase and sex hormones in vascular protection in mice

  Journal of Clinical Investigation. 2002;109(4):541-548.
  32

• 83.

  2002

  Nobuyuki Takahashi; Heddwen L. Brooks; James B. Wade; Wen Liu; Yoshiaki Kondo; Sadayoshi Ito; Mark A. Knepper; Oliver Smithies

  Posttranscriptional compensation for heterozygous disruption of the kidney-specific NaK2Cl cotransporter gene

  Journal of the American Society of Nephrology. 2002;13(3):604-610.
  23

• 84.

  2002

  Yasuhiko Makino; Donald N. Cook; Oliver Smithies; Olivia Y. Hwang; Eric G. Neilson; Laurence A. Turka; Hiroshi Sato; Andrew D. Wells; Theodore M. Danoff

  Impaired T cell function in RANTES-deficient mice

  Clinical Immunology. 2002;102(3):302-309.
  59

• 85.

  2002

  Masayoshi Nomura; Larissa Durbak; Johnny Chan; Oliver Smithies; Jan-Åke Gustafsson; Kenneth S. Korach; Donald W. Pfaff; Sonoko Ogawa

  Genotype/age interactions on aggressive behavior in gonadally intact estrogen receptor β knockout (βERKO) male mice

  Hormones and Behavior. 2002;41(3):288-296.
  81

• 86.

  2002

  L.J. Ellmers; J.W. Knowles; H.-S. Kim; O. Smithies; N. Maeda; V.A. Cameron

  Ventricular expression of natriuretic peptides in NPR1^-/- mice with cardiac hypertrophy and fibrosis

  American Journal of Physiology - Heart and Circulatory Physiology. 2002;283(2 52-2):H707-H714.
  40

• 87.

  2002

  James R. Klinger; Rod R. Warburton; Linda Pietras; Paula Oliver; Jennifer Fox; Oliver Smithies; Nicholas S. Hill

  Targeted disruption of the gene for natriuretic peptide receptor-A worsens hypoxia-induced cardiac hypertrophy

  American Journal of Physiology - Heart and Circulatory Physiology. 2002;282(1 51-1):H58-H65.
  31

• 88.

  2002

  Kathleen M. Caron; Oliver Smithies

  Multiple roles of adrenomedullin revealed by animal models

  Microscopy Research and Technique. 2002;57(1):55-59.
  6

• 89.

  2001

  Wei Huang; Yves Gallois; Nadine Bouby; Patrick Bruneval; Didier Heudes; Marie-France Belair; John H. Krege; Pierre Meneton; Michel Marre; Oliver Smithies; et al.

  Genetically increased angiotensin I-converting enzyme level and renal complications in the diabetic mouse

  Proceedings of the National Academy of Sciences of the United States of America. 2001;98(23):13330-13334.
  85

• 90.

  2001

  Rodney C. Gilmore; Joseph Baker Jr.; Sean Dempsey; Rosemarie Marchan; Robert N.L. Corprew Jr.; Goldie Byrd; Nobuyo Maeda; Oliver Smithies; Richard D. Bukoski; Ken R. Harewood; et al.

  Using PAC nested deletions to order contigs and microsatellite markers at the high repetitive sequence containing Npr3 gene locus

  Gene. 2001;275(1):65-72.
  7

• 91.

  2001

  M.F. Goy; P.M. Oliver; K.E. Purdy; J.W. Knowles; J.E. Fox; P.J. Mohler; X. Qian; O. Smithies; N. Maeda

  Evidence for a novel natriuretic peptide receptor that prefers brain natriuretic peptide over atrial natriuretic peptide

  Biochemical Journal. 2001;358(2):379-387.
  30

• 92.

  2001

  Ellen S. Pentz; Maria Luisa S. Sequeira Lopez; Hyung-Suk Kim; Oscar Carretero; Oliver Smithies; R. Ariel Gomez

  Ren1^d and Ren2 cooperate to preserve homeostasis: Evidence from mice expressing GFP in place of Ren1^d

  Physiological Genomics. 2001;2001(6):45-55.
  8

• 93.

  2001

  E.S. Pentz; M.L. Lopez; H.S. Kim; O. Carretero; O. Smithies; R.A. Gomez

  Ren1d and Ren2 cooperate to preserve homeostasis: evidence from mice expressing GFP in place of Ren1d.

  Physiol Genomics. 2001;6(1):45-55.
  13

• 94.

  2001

  Charles D. Loftin; Darshini B. Trivedi; Howard F. Tiano; James A. Clark; Christopher A. Lee; Jonathan A. Epstein; Scott G. Morham; Matthew D. Breyer; MyTrang Nguyen; et al.

  Failure of ductus arteriosus closure and remodeling in neonatal mice dificient in cyclooxygenase-1 and cyclooxygenase-2

  Proceedings of the National Academy of Sciences of the United States of America. 2001;98(3):1059-1064.
  121

• 95.

  2001

  Kathleen M. Caron; Oliver Smithies

  Extreme hydrops fetalis and cardiovascular abnormalities in mice lacking a functional Adrenomedullin gene

  Proceedings of the National Academy of Sciences of the United States of America. 2001;98(2):615-619.
  188

• 96.

  2001

  Oliver Smithies

  Forty years with homologous recombinations

  Medicina. 2001;61(5 II):652.
  0

• 97.

  2001

  Oliver Smithies

  Mouse solutions to human problems

  Medicina. 2001;61(5 II):665.
  0

• 98.

  2001

  Oliver Smithies

  Forty years with homologous recombination

  Nature Medicine. 2001;7(10):1083-1086.
  25

• 99.

  2001

  M.R. Capecchi; M.J. Evans; O. Smithies

  Generating mice with targeted mutations

  Nature Medicine. 2001;7(10):1086-1090.
  53

• 100.

  2001

  J.W. Knowles; G. Esposito; L. Mao; J.R. Hagaman; J.E. Fox; O. Smithies; H.A. Rockman; N. Maeda

  Pressure-independent enhancement of cardiac hypertrophy in natriuretic peptide receptor A-deficient mice

  Journal of Clinical Investigation. 2001;107(8):975-984.
  162

• 101.

  2001

  Jeffrey B. Hodgin; John H. Krege; Robert L. Reddick; Kenneth S. Korach; Oliver Smithies; Nobuyo Maeda

  Estrogen receptor α is a major mediator of 17β-estradiol's atheroprotective effects on lesion size in Apoe^-/- mice

  Journal of Clinical Investigation. 2001;107(3):333-340.
  116

• 102.

  2001

  K. Athirakul; H.-S. Kim; L.P. Audoly; O. Smithies; T.M. Coffman

  Deficiency of COX-1 causes natriuresis and enhanced sensitivity to ACE inhibition

  Kidney International. 2001;60(6):2324-2329.
  36

• 103.

  2001

  M.E. Gerlofs-Nijland; K.J.M. Assmann; H.B.P.M. Dijkman; J.W.C. Dieker; J.P.H.F. Van Son; S. Mentzel; J.P. Van Kats; A.H. Jan Danser; O. Smithies; P.J.T.A. Groenen; et al.

  Albuminuria in mice after injection of antibodies against aminopeptidase A: Role of angiotensin II

  Journal of the American Society of Nephrology. 2001;12(12):2711-2720.
  7

• 104.

  2000

  Sonoko Ogawa; April E. Chester; Sylvia Curtis Hewitt; Vickie R. Walker; Jan-Åke Gustafsson; Oliver Smithies; Kenneth S. Korach; Donald W. Pfaff

  Abolition of male sexual behaviors in mice lacking estrogen receptors α and β (αβERKO)

  Proceedings of the National Academy of Sciences of the United States of America. 2000;97(26):14737-14741.
  136

• 105.

  2000

  Seigo Hatada; Koji Nikkuni; Stuart A. Bentley; Suzanne Kirby; Oliver Smithies

  Gene correction in hematopoietic progenitor cells by homologous recombination

  Proceedings of the National Academy of Sciences of the United States of America. 2000;97(25):13807-13811.
  31

• 106.

  2000

  P.C. Chulada; M.B. Thompson; J.F. Mahler; C.M. Doyle; B.W. Gaul; C. Lee; H.F. Tiano; S.G. Morham; O. Smithies; R. Langenbach

  Genetic disruption of Ptgs-1, as well as of Ptgs-2, reduces intestinal tumorigenesis in Min mice

  Cancer Research. 2000;60(17):4705-4708.
  323

• 107.

  2000

  Suzanne Kirby; William Walton; Oliver Smithies

  Hematopoietic stem cells with controllable tEpoR transgenes have a competitive advantage in bone marrow transplantation

  Blood. 2000;95(12):3710-3715.
  11

• 108.

  2000

  Nobuyuki Takahashi; Daniel R. Chernavvsky; R. Ariel Gomez; Peter Igarashi; Hillel J. Gitelman; Oliver Smithies

  Uncompensated polyuria in a mouse model of Bartter's syndrome

  Proceedings of the National Academy of Sciences of the United States of America. 2000;97(10):5434-5439.
  125

• 109.

  2000

  Michael I. Oliverio; Christopher F. Best; Oliver Smithies; Thomas M. Coffman

  Regulation of sodium balance and blood pressure by the AT(1A) receptor for angiotensin II

  Hypertension. 2000;35(2):550-554.
  66

• 110.

  2000

  Olivier Morteau; Scott G. Morham; Rance Sellon; Levinus A. Dieleman; Robert Langenbach; Oliver Smithies; R. Balfour Sartor

  Impaired mucosal defense to acute colonic injury in mice lacking cyclooxygenase-1 or cyclooxygenase-2

  Journal of Clinical Investigation. 2000;105(4):469-478.
  178

• 111.

  2000

  Joshua W. Knowles; Robert L. Reddick; J. Charles Jennette; Edward G. Shesely; Oliver Smithies; Nobuyo Maeda

  Enhanced atherosclerosis and kidney dysfunction in eNOS(-/-)Apoe(-/-) mice are ameliorated by enalapril treatment

  Journal of Clinical Investigation. 2000;105(4):451-458.
  178

• 112.

  2000

  O. Morteau; S.G. Morham; R. Sellon; L.A. Dieleman; R. Langenbach; O. Smithies; R.B. Sartor

  Erratum: Impaired mucosal defence to acute colonic injury in mice lacking cyclooxygenase-1 or cyclooxygenase-2 (Journal of Clinical Investigation (2000) 105 (469-478))

  Journal of Clinical Investigation. 2000;105(7):1023.
  0

• 113.

  2000

  V.F. Norwood; S.G. Morham; O. Smithies

  Postnatal development and progression of renal dysplasia in cyclooxygenase-2 null mice

  Kidney International. 2000;58(6):2291-2300.
  59

• 114.

  2000

  O. Smithies; H.-S. Kim; N. Takahashi; M.H. Edgell

  Importance of quantitative genetic variations in the etiology of hypertension

  Kidney International. 2000;58(6):2265-2280.
  53

• 115.

  2000

  Michael I. Oliverio; Marielle Delnomdedieu; Christopher F. Best; Ping Li; Mariana Morris; Michael F. Callahan; G. Allan Johnson; Oliver Smithies; Thomas M. Coffman

  Abnormal water metabolism in mice lacking the type 1A receptor for ANG II

  American Journal of Physiology - Renal Physiology. 2000;278(1 47-1):F75-F82.
  71

• 116.

  1999

  R.H. Karas; J.B. Hodgin; M. Kwoun; J.H. Krege; M. Aronovitz; W. Mackey; J.A. Gustafsson; K.S. Korach; O. Smithies; M.E. Mendelsohn

  Estrogen inhibits the vascular injury response in estrogen receptor β- deficient female mice

  Proceedings of the National Academy of Sciences of the United States of America. 1999;96(26):15133-15136.
  190

• 117.

  1999

  Chandra Nataraj; Michael I. Oliverio; Roslyn B. Mannon; Peter J. Mannon; Laurent P. Audoly; Carmen S. Amuchastegui; Phillip Ruiz; Oliver Smithies; Thomas M. Coffman

  Angiotensin II regulates cellular immune responses through a calcineurin-dependent pathway

  Journal of Clinical Investigation. 1999;104(12):1693-1701.
  156

• 118.

  1999

  Nobuyuki Takahashi; Oliver Smithies

  Gene targeting approaches to analyzing hypertension

  Journal of the American Society of Nephrology. 1999;10(7):1598-1605.
  38

• 119.

  1999

  Maomichi Matsukawa; Wojciech J. Grzesik; Nobuyuki Takahashi; Kailash N. Pandey; Stephen Pang; Mitsuo Yamauchi; Oliver Smithies

  The natriuretic peptide clearance receptor locally modulates the physiological effects of the natriuretic peptide system

  Proceedings of the National Academy of Sciences of the United States of America. 1999;96(13):7403-7408.
  187

• 120.

  1999

  Hyung-Suk Kim; Nobuyo Maeda; Goo Taeg Oh; Lucas G. Fernandez; R. Ariel Gomez; Oliver Smithies

  Homeostasis in mice with genetically decreased angiotensinogen is primarily by an increased number of renin-producing cells

  Journal of Biological Chemistry. 1999;274(20):14210-14217.
  36

• 121.

  1999

  James R. Klinger; Rod R. Warburton; Linda A. Pietras; Oliver Smithies; Richard Swift; Nicholas S. Hill

  Genetic disruption of atrial natriuretic peptide causes pulmonary hypertension in normoxic and hypoxic mice

  American Journal of Physiology - Lung Cellular and Molecular Physiology. 1999;276(5 20-5):L868-L874.
  38

• 122.

  1999

  Timothy Traynor; Tianxin Yang; Yuning G. Huang; John H. Krege; Josie P. Briggs; Oliver Smithies; Jürgen Schnermann

  Tubuloglomerular feedback in ACE-deficient mice

  American Journal of Physiology - Renal Physiology. 1999;276(5 45-5):F751-F757.
  30

• 123.

  1999

  Donald N. Cook; Oliver Smithies; Robert M. Strieter; Jeffrey A. Frelinger; Jonathan S. Serody

  CD8⁺ T cells are a biologically relevant source of macrophage inflammatory protein-1α in vivo

  Journal of Immunology. 1999;162(9):5423-5428.
  55

• 124.

  1999

  Seigo Hatada; William Kuziel; Oliver Smithies; Nobuyo Maeda

  The influence of chromosomal location on the expression of two transgenes in mice

  Journal of Biological Chemistry. 1999;274(2):948-955.
  21

• 125.

  1999

  Robert J. Fern; Christine M. Yesko; Barbara A. Thornhill; Hyung-Suk Kim; Oliver Smithies; Robert L. Chevalier

  Reduced angiotensinogen expression attenuates renal interstitial fibrosis in obstructive nephropathy in mice

  Journal of Clinical Investigation. 1999;103(1):39-46.
  99

• 126.

  1999

  O. Smithies

  Alexander George Ogston: 30 January 1911-29 June 1996.

  Biographical memoirs of fellows of the Royal Society. Royal Society (Great Britain). 1999;45:351-364.
  1

• 127.

  1999

  O. Smithies

  Quantitative genetic variations and essential hypertension.

  Harvey lectures. 1999;95:1-20.
  1

• 128.

  1999

  Kailash N. Pandey; Paula M. Oliver; Nobuyo Maeda; Oliver Smithies

  Hypertension associated with decreased testosterone levels in natriuretic peptide receptor-A gene-knockout and gene-duplicated mutant mouse models

  Endocrinology. 1999;140(11):5112-5119.
  39

• 129.

  1998

  John H. Krege; Jeffrey B. Hodgin; John F. Couse; Eva Enmark; Margaret Warner; Joel F. Mahler; Madhabananda Sar; Kenneth S. Korach; Jan-Åke Gustafsson; Oliver Smithies

  Generation and reproductive phenotypes of mice lacking estrogen receptor β

  Proceedings of the National Academy of Sciences of the United States of America. 1998;95(26):15677-15682.
  970

• 130.

  1998

  Dennis W. Thomas; Roslyn B. Mannon; Peter J. Mannon; Anne Latour; Julie A. Oliver; Maureane Hoffman; Oliver Smithies; Beverly H. Koller; Thomas M. Coffman

  Coagulation defects and altered hemodynamic responses in mice lacking receptors for thromboxane A₂

  Journal of Clinical Investigation. 1998;102(11):1994-2001.
  153

• 131.

  1998

  Randy J. Thresher; Martha Hotz Vitaterna; Yasuhide Miyamoto; Aleksey Kazantsev; David S. Hsu; Claude Petit; Christopher P. Selby; Lale Dawut; Oliver Smithies; Joseph S. Takahashi; et al.

  Role of mouse cryptochrome blue-light photoreceptor in circadian photoresponses

  Science. 1998;282(5393):1490-1494.
  223

• 132.

  1998

  Terrence M. Tumpey; Hao Cheng; Donald N. Cook; Oliver Smithies; John E. Oakes; Robert N. Lausch

  Absence of macrophage inflammatory protein-1α prevents the development of blinding herpes stromal keratitis

  Journal of Virology. 1998;72(5):3705-3710.
  88

• 133.

  1998

  J.B. Schnermann; T. Traynor; T. Yang; Y.G. Huang; J.H. Krege; O. Smithies; J.P. Briggs

  Tubuloglomerular feedback in Angiotensin Converting Enzyme (ACE)-deficient mice

  FASEB Journal. 1998;12(4):A108.
  1

• 134.

  1998

  A.R. Reddick; P. Oliver; J. Fox; O. Smithies; N. Maeda

  Generalized arteriopathy in mice lacking naturetic peptide receptor

  FASEB Journal. 1998;12(4):A324.
  0

• 135.

  1998

  Jada Lewis; Baoli Yang; Ronald Kim; Halina Sierakowska; Ryszard Kole; Oliver Smithies; Nobuyo Maeda

  A common human β globin splicing mutation modeled in mice

  Blood. 1998;91(6):2152-2156.
  38

• 136.

  1998

  John R. Hagaman; Jeffrey S. Moyer; Eric S. Bachman; Mathilde Sibony; Patricia L. Magyar; Jeffrey E. Welch; Oliver Smithies; John H. Krege; Deborah A. O'Brien

  Angiotensin-converting enzyme and male fertility

  Proceedings of the National Academy of Sciences of the United States of America. 1998;95(5):2552-2557.
  191

• 137.

  1998

  Paula M. Oliver; Simon W. M. John; Kit E. Purdy; Ron Kim; Nobuyo Maeda; Michael F. Goy; Oliver Smithies

  Natriuretic peptide receptor 1 expression influences blood pressures of mice in a dose-dependent manner

  Proceedings of the National Academy of Sciences of the United States of America. 1998;95(5):2547-2551.
  87

• 138.

  1998

  Radu Daniel Rudic; Edward G. Shesely; Nobuyo Maeda; Oliver Smithies; Steven S. Segal; William C. Sessa

  Direct evidence for the importance of endothelium-derived nitric oxide in vascular remodeling

  Journal of Clinical Investigation. 1998;101(4):731-736.
  480

• 139.

  1998

  Michael I. Oliverio; Kirsten Madsen; Christopher F. Best; Masaki Ito; Nobuyo Maeda; Oliver Smithies; Thomas M. Coffman

  Renal growth and development in mice lacking AT(1A) receptors for angiotensin II

  American Journal of Physiology - Renal Physiology. 1998;274(1 43-1):F43-F50.
  62

• 140.

  1998

  M.I. liverio; H.-S. Kim; M. Ito; T. Le; L. Audoly; C.F. Bests; S. Hiller; K. Kluckman; N. Maeda; O. Smithies; et al.

  Reduced growth, abnormal kidney structure, and type 2 (AT₂) angiotensin receptor-mediated blood pressure regulation in mice lacking both AT(1A) and AT(1B) receptors for angiotensin II

  Proceedings of the National Academy of Sciences of the United States of America. 1998;95(26):15496-15501.
  180

• 141.

  1998

  Suzanne Kirby; William Wallon; Oliver Smithies

  Erythropoietin-induced competitive expansion of transplanted tepor transgenic hematopoietic stem cells in vivo

  Experimental Hematology. 1998;26(8):814.
  0

• 142.

  1997

  Paula M. Oliver; Jennifer E. Fox; Ron Kim; Howard A. Rockman; Hyung-Suk Kim; Robert L. Reddick; Kailash N. Pandey; Sharon L. Milgram; Oliver Smithies; Nobuyo Maeda

  Hypertension, cardiac hypertrophy, and sudden death in mice lacking natriuretic peptide receptor A

  Proceedings of the National Academy of Sciences of the United States of America. 1997;94(26):14730-14735.
  334

• 143.

  1997

  Oliver Smithies

  A mouse view of hypertension

  Hypertension. 1997;30(6):1318-1324.
  46

• 144.

  1997

  Hui-Feng Lin; Nobuyo Maeda; Oliver Smithies; David L. Straight; Darrel W. Stafford

  A coagulation factor IX-deficient mouse model for human hemophilia B

  Blood. 1997;90(10):3962-3966.
  160

• 145.

  1997

  William A. Kuziel; Sharon J. Morgan; Tracey C. Dawson; Stephanie Griffin; Oliver Smithies; Klaus Ley; Nobuyo Maeda

  Severe reduction in leukocyte adhesion and monocyte extravasation in mice deficient in CC chemokine receptor 2

  Proceedings of the National Academy of Sciences of the United States of America. 1997;94(22):12053-12058.
  391

• 146.

  1997

  Olga V. Savinova; Naomichi Matsukawa; Oliver Smithies; Simon W. M. John

  Mouse natriuretic peptide receptor 3 gene maps to proximal chromosome 15

  Mammalian Genome. 1997;8(10):788.
  2

• 147.

  1997

  Baohong Tian; Qing Cheng Meng; Yiu-Fai Chen; John H. Krege; Oliver Smithies; Suzanne Oparil

  Blood pressures and cardiovascular homeostasis in mice having reduced or absent angiotensin-converting enzyme gene function

  Hypertension. 1997;30(1):128-133.
  40

• 148.

  1997

  Hirohisa Tsuda; Catherine E. Maynard-Currie; Laura H. Reid; Takayuki Yoshida; Koji Edamura; Nobuyo Maeda; Oliver Smithies; Aya Jakobovits

  Inactivation of the mouse HPRT locus by a 203-bp retroposon insertion and a 55-kb gene-targeted deletion: Establishment of new HPRT-deficient mouse embryonic stem cell lines

  Genomics. 1997;42(3):413-421.
  17

• 149.

  1997

  Tammy E. MacTaggart; Masaki Ito; Oliver Smithies; Simon W.M. John

  Mouse angiotensin receptor genes Agtr1a and Agtr1b map to Chromosomes 13 and 3

  Mammalian Genome. 1997;8(4):294-295.
  15

• 150.

  1997

  Michael I. Oliverio; Christopher F. Best; Hyung-Suk Kim; William J. Arendshorst; Oliver Smithies; Thomas M. Coffman

  Angiotensin II responses in AT(1a) receptor-deficient mice: A role for AT(1B) receptors in blood pressure regulation

  American Journal of Physiology - Renal Physiology. 1997;272(4 41-4):F515-F520.
  117

• 151.

  1997

  Robin L. Davisson; Hyung-Suk Kim; John H. Krege; Donna J. Lager; Oliver Smithies; Curt D. Sigmund

  Complementation of reduced survival, hypotension, and renal abnormalities in angiotensinogen-deficient mice by the human renin and human angiotensinogen genes

  Journal of Clinical Investigation. 1997;99(6):1258-1264.
  51

• 152.

  1997

  Karl F. Hilgers; Vasantha Reddi; John H. Krege; Oliver Smithies; R. Ariel Gomez

  Aberrant renal vascular morphology and renin expression in mutant mice lacking angiotensin-converting enzyme

  Hypertension. 1997;29(1 II):216-221.
  57

• 153.

  1997

  John H. Krege; Hyung-Suk Kim; Jeffrey S. Moyer; J. Charles Jennette; Li Peng; Sylvia K. Hiller; Oliver Smithies

  Angiotensin-converting enzyme gene mutations, blood pressures, and cardiovascular homeostasis

  Hypertension. 1997;29(1 II):150-157.
  99

• 154.

  1997

  John H. Krege; Jeffrey S. Moyer; Laura L. Langenbach; Li Peng; Sunny H. Zhang; Nobuyo Maeda; Robert L. Reddick; Oliver Smithies

  Angiotensin-converting enzyme gene and atherosclerosis

  Arteriosclerosis, Thrombosis, and Vascular Biology. 1997;17(7):1245-1250.
  13

• 155.

  1997

  Michael I. Oliverio; Christopher F. Best; Hyung-Suk Kim; William J. Arendshorst; Oliver Smithies; Thomas M. Coffman

  Angiotensin II responses in at _1A receptor-deficient mice: A role for at _1B receptors in blood pressure regulation

  American Journal of Physiology. 1997;272(4 PART 2):F521-F530.
  1

• 156.

  1996

  Edward G. Shesely; Nobuyo Maeda; H.-S. Kim; Kaushik M. Desai; John H. Krege; Victor E. Laubach; Paula A. Sherman; William C. Sessa; Oliver Smithies

  Elevated blood pressures in mice lacking endothelial nitric oxide synthase

  Proceedings of the National Academy of Sciences of the United States of America. 1996;93(23):13176-13181.
  551

• 157.

  1996

  Lori R. Toth; Terry J. Smith; Caroline Jones; Harshini V. De Silva; Oliver Smithies; Nobuyo Maeda

  Two distinct apolipoprotein B alleles in mice generated by a single 'in-out' targeting

  Gene. 1996;178(1-2):161-168.
  11

• 158.

  1996

  Patricia T. Bozza; Jennifer L. Payne; Scott G. Morham; Robert Langenbach; Oliver Smithies; Peter F. Weller

  Leukocyte lipid body formation and eicosanoid generation: Cyclooxygenase-independent inhibition by aspirin

  Proceedings of the National Academy of Sciences of the United States of America. 1996;93(20):11091-11096.
  82

• 159.

  1996

  Suzanne L. Kirby; Donald N. Cook; William Walton; Oliver Smithies

  Proliferation of multipotent hematopoietic cells controlled by a truncated erythropoietin receptor transgene

  Proceedings of the National Academy of Sciences of the United States of America. 1996;93(18):9402-9407.
  23

• 160.

  1996

  Sarah K. Bronson; Elizabeth G. Plaehn; Kimberly D. Kluckman; John R. Hagaman; Nobuyo Maeda; Oliver Smithies

  Single-copy transgenic mice with chosen-site integration

  Proceedings of the National Academy of Sciences of the United States of America. 1996;93(17):9067-9072.
  187

• 161.

  1996

  S.W.M. John; A.T. Veress; U. Honrath; C.K. Chong; L. Peng; O. Smithies; H. Sonnenberg

  Blood pressure and fluid-electrolyte balance in mice with reduced or absent ANP

  American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 1996;271(1 40-1):R109-R114.
  69

• 162.

  1996

  Scott G. Morham; Kimberly D. Kluckman; Nectarios Voulomanos; Oliver Smithies

  Targeted disruption of the mouse topoisomerase I gene by camptothecin selection

  Molecular and Cellular Biology. 1996;16(12):6804-6809.
  95

• 163.

  1996

  Scott G. Morham; Robert Langenbach; Joel Mahler; Oliver Smithies

  Characterization of prostaglandin H synthase 2 deficient mice and implications for mechanisms of NSAID action

  Advances in Experimental Medicine and Biology. 1996;407:131-138.
  10

• 164.

  1996

  R.L. Davisson; H.-S. Kim; J.H. Krege; O. Smithies; C.D. Sigmurid

  Development oh transgenic mice containing a functional human, but lacking a functional mouse reninangiotensin system

  FASEB Journal. 1996;10(3):A21.
  1

• 165.

  1996

  R.L. Davisson; Y. Ding; H.S. Kirn; J.H. Krege; D.O. Hardy; J.F. Catterall; O. Smithies; C.D. Siymund

  Development of transgenic animal models for studying the renin-angiotensin system in hypertension. Renal function and renal development

  Journal of Investigative Medicine. 1996;44(3):321a.
  0

• 166.

  1996

  Jada Lewis; Baoli Yang; Pete Detloff; Oliver Smithies

  Gene modification via 'plug and socket' gene targeting

  Journal of Clinical Investigation. 1996;98(11 SUPPL.):S3-S5.
  15

• 167.

  1995

  Baoli Yang; Suzanne Kirby; Jada Lewis; Peter J. Detloff; Nobuyo Maeda; Oliver Smithies

  A mouse model for β⁰-thalassemia

  Proceedings of the National Academy of Sciences of the United States of America. 1995;92(25):11608-11612.
  112

• 168.

  1995

  Victor E. Laubach; Edward G. Shesely; Oliver Smithies; Paula A. Sherman

  Mice lacking inducible nitric oxide synthase are not resistant to lipopolysaccharide-induced death

  Proceedings of the National Academy of Sciences of the United States of America. 1995;92(23):10688-10692.
  399

• 169.

  1995

  Oliver Smithies; Nobuyo Maeda

  Gene targeting approaches to complex genetic diseases: Atherosclerosis and essential hypertension

  Proceedings of the National Academy of Sciences of the United States of America. 1995;92(12):5266-5272.
  118

• 170.

  1995

  Hyung-Suk Kim; John H. Krege; Kimberly D. Kluckman; John R. Hagaman; Jeffrey B. Hodgin; Christopher F. Best; J. Charles Jennette; Thomas M. Coffman; Nobuyo Maeda; Oliver Smithies

  Genetic control of blood pressure and the angiotensinogen locus

  Proceedings of the National Academy of Sciences of the United States of America. 1995;92(7):2735-2739.
  462

• 171.

  1995

  M. Ito; M.I. Oliverio; P.J. Mannon; C.F. Best; N. Maeda; O. Smithies; T.M. Coffman

  Regulation of blood pressure by the type 1A angiotensin II receptor gene

  Proceedings of the National Academy of Sciences of the United States of America. 1995;92(8):3521-3525.
  391

• 172.

  1995

  S.K. Bronson; O. Smithies; J.T. Mascarello

  High incidence of XXY and XYY males among the offspring of female chimeras from embryonic stem cells

  Proceedings of the National Academy of Sciences of the United States of America. 1995;92(8):3120-3123.
  20

• 173.

  1995

  D.N. Cook; M.A. Beck; T.M. Coffman; S.L. Kirby; J.F. Sheridan; I.B. Pragnell; O. Smithies

  Requirement of MIP-1α for an inflammatory response to viral infection

  Science. 1995;269(5230):1583-1585.
  472

• 174.

  1995

  J.H. Krege; J.B. Hodgin; J.R. Hagaman; O. Smithies

  A noninvasive computerized tail-cuff system for measuring blood pressure in mice

  Hypertension. 1995;25(5):1111-1115.
  320

• 175.

  1995

  S.W.M. John; J.H. Krege; P.M. Oliver; J.R. Hagaman; J.B. Hodgin; S.C. Pang; T.G. Flynn; O. Smithies

  Genetic decreases in atrial natriuretic peptide and salt-sensitive hypertension

  Science. 1995;267(5198):679-681.
  395

• 176.

  1995

  J.H. Krege; S.W.M. John; L.L. Langenbach; J.B. Hodgin; J.R. Hagaman; E.S. Bachman; J.C. Jennette; D.A. O'Brien; O. Smithies

  Male-female differences in fertility and blood pressure in ACE-deficient mice

  Nature. 1995;375(6527):146-148.
  451

• 177.

  1995

  S.G. Morham; R. Langenbach; C.D. Loftin; H.F. Tiano; N. Vouloumanos; J.C. Jennette; J.F. Mahler; K.O. Kluckman; A. Ledford; C.A. Lee; et al.

  Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse

  Cell. 1995;83(3):473-482.
  844

• 178.

  1995

  O. Smithies

  Early days of gel electrophoresis

  Genetics. 1995;139(1):1-4.
  9

• 179.

  1995

  R. Langenbach; S.G. Morham; H.F. Tiano; C.D. Loftin; B.I. Ghanayem; P.C. Chulada; J.F. Mahler; C.A. Lee; E.H. Goulding; K.D. Kluckman; et al.

  Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid- induced inflammation and indomethacin-induced gastric ulceration

  Cell. 1995;83(3):483-492.
  807

• 180.

  1995

  J.F. Couse; S.W. Curtis; T.F. Washburn; J. Lindzey; T.S. Golding; D.B. Lubahn; O. Smithies; K.S. Korach

  Analysis of transcription and estrogen insensitivity in the female mouse after targeted disruption of the estrogen receptor gene

  Molecular Endocrinology. 1995;9(11):1441-1454.
  313

• 181.

  1994

  Sarah K. Bronson; Oliver Smithies

  Altering mice by homologous recombination using embryonic stem cells

  Journal of Biological Chemistry. 1994;269(44):27155-27158.
  127

• 182.

  1994

  O. Smithies; H.-S. Kim

  Targeted gene duplication and disruption for analyzing quantitative genetic traits in mice

  Proceedings of the National Academy of Sciences of the United States of America. 1994;91(9):3612-3615.
  121

• 183.

  1994

  J. Nadeau; B. Wold; A. Bernstein; R. Davis; U. Helwig; B. Hogan; D. Housman; R. Klausner; O. Smithies; B. Graham

  Technology advancement for studying gene expression and gene function: A workshop report - National Institutes of Health

  Mammalian Genome. 1994;5(3):127-130.
  0

• 184.

  1994

  P.J. Detloff; J. Lewis; S.W.M. John; W.R. Shehee; R. Langenbach; N. Maeda; O. Smithies

  Deletion and replacement of the mouse adult β-globin genes by a 'plug and socket' repeated targeting strategy

  Molecular and Cellular Biology. 1994;14(10):6936-6943.
  49

• 185.

  1993

  N.C. Luetteke; Ting Hu Qiu; R.L. Peiffer; P. Oliver; O. Smithies; D.C. Lee

  TGFα deficiency results in hair follicle and eye abnormalities in targeted and waved-1 mice

  Cell. 1993;73(2):263-278.
  389

• 186.

  1993

  T.M. Coffman; S. Geier; S. Ibrahim; R. Griffiths; R. Spurney; O. Smithies; B. Koller; F. Sanfilippo

  Improved renal function in mouse kidney allografts lacking MHC class I antigens

  Journal of Immunology. 1993;151(1):425-435.
  31

• 187.

  1993

  Hyung Suk Kim; Karen M. Lyons; Eiichi Saitoh; Edwin A. Azen; Oliver Smithies; Nobuyo Maeda

  The structure and evolution of the human salivary proline-rich protein gene family

  Mammalian Genome. 1993;4(1):3-14.
  16

• 188.

  1993

  W.R. Shehee; P. Oliver; O. Smithies

  Lethal thalassemia after insertional disruption of the mouse major adult β-globin gene

  Proceedings of the National Academy of Sciences of the United States of America. 1993;90(8):3177-3181.
  51

• 189.

  1993

  D.B. Lubahn; J.S. Moyer; T.S. Golding; J.F. Couse; K.S. Korach; O. Smithies

  Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene

  Proceedings of the National Academy of Sciences of the United States of America. 1993;90(23):11162-11166.
  1106

• 190.

  1993

  O. Smithies

  Animal models of human genetic diseases

  Trends in Genetics. 1993;9(4):112-116.
  55

• 191.

  1993

  N.M. Desai; H. Bassiri; J. Kim; B.H. Koller; O. Smithies; C.F. Barker; A. Naji; J.F. Markmann

  Islet allograft, islet xenograft, and skin allograft survival in CD8⁺ T lymphocyte-deficient mice

  Transplantation. 1993;55(4):718-722.
  27

• 192.

  1993

  N.M. Desai; H. Bassiri; J.S. Odorico; B.H. Koller; O. Smithies; A. Naji; C.F. Barker; J.F. Markmann

  Pancreatic islet allograft and xenograft survival in CD8⁺ T-lymphocyte- deficient recipients

  Transplantation Proceedings. 1993;25(1 SUPPL. 1):961-962.
  8

• 193.

  1992

  Melanie K. Spriggs; Beverley H. Koller; Timothy Sato; Philip J. Morrissey; William C. Fanslow; Oliver Smithies; Robert F. Voice; Michael B. Widmer; Charles R. Maliszewski

  β₂-Microglobulin^-, CD8⁺ T-cell-deficient mice survive inoculation with high doses of vaccinia virus and exhibit altered IgG responses

  Proceedings of the National Academy of Sciences of the United States of America. 1992;89(13):6070-6074.
  92

• 194.

  1992

  Beverly H. Koller; Oliver Smithies

  Altering genes in animals by gene targeting

  Annual Review of Immunology. 1992;10:705-730.
  100

• 195.

  1992

  O. Smithies

  On making animal models of common human genetic diseases by gene targeting

  British Journal of Haematology. 1992;82(1):212-213.
  0

• 196.

  1992

  J.F. Markmann; H. Bassiri; N.M. Desai; J.S. Odorico; J.I. Kim; B.H. Koller; O. Smithies; C.F. Barker

  Indefinite survival of MHC class I-deficient murine pancreatic islet allografts

  Transplantation. 1992;54(6):1085-1089.
  54

• 197.

  1992

  L.L. Clarke; B.R. Grubb; S.E. Gabriel; O. Smithies; B.H. Koller; R.C. Boucher

  Defective epithelial chloride transport in a gene-targeted mouse model of cystic fibrosis

  Science. 1992;257(5073):1125-1128.
  149

• 198.

  1992

  J.N. Snouwaert; K.K. Brigman; A.M. Latour; N.N. Malouf; R.C. Boucher; O. Smithies; B.H. Koller

  An animal model for cystic fibrosis made by gene targeting

  Science. 1992;257(5073):1083-1088.
  451

• 199.

  1991

  Kim Hyung-Suk; Bradley W. Popovich; W.Ronald Shehee; Edward G. Shesely; Oliver Smithies

  Problems encountered in detecting a targeted gene by the polymerase chain reaction

  Gene. 1991;103(2):227-233.
  10

• 200.

  1991

  Edward G. Shesely; Hyung-Suk Kim; W. Ronald Shehee; Thalia Papayannopoulou; Oliver Smithies; Bradley W. Popovich

  Correction of a human β^S-globin gene by gene targeting

  Proceedings of the National Academy of Sciences of the United States of America. 1991;88(10):4294-4298.
  18

• 201.

  1991

  Laura H. Reid; Edward G. Shesely; Hyung-Suk Kim; Oliver Smithies

  Cotransformation and Gene Targeting in Mouse Embryonic Stem Cells

  Molecular and Cellular Biology. 1991;11(5):2769-2777.
  31

• 202.

  1991

  B.H. Koller; H.-S. Kim; A.M. Latour; K. Brigman; R.C. Boucher Jr.; P. Scambler; B. Wainwright; O. Smithies

  Toward an animal model of cystic fibrosis: Targeted interruption of exon 10 of the cystic fibrosis transmembrane regulator gene in embryonic stem cells

  Proceedings of the National Academy of Sciences of the United States of America. 1991;88(23):10730-10734.
  42

• 203.

  1991

  V. Valancius; O. Smithies

  Testing an 'in-out' targeting procedure for making subtle genomic modifications in mouse embryonic stem cells

  Molecular and Cellular Biology. 1991;11(3):1402-1408.
  62

• 204.

  1991

  F. Schwartz; N. Maeda; O. Smithies; R. Hickey; W. Edelmann; A. Skoultchi; R. Kucherlapati

  A dominant positive and negative selectable gene for use in mammalian cells

  Proceedings of the National Academy of Sciences of the United States of America. 1991;88(23):10416-10420.
  30

• 205.

  1991

  A.B. Metzenberg; G. Wurzer; T.H.J. Huisman; O. Smithies

  Homology requirements for unequal crossing over in humans

  Genetics. 1991;128(1):143-161.
  43

• 206.

  1991

  V. Valancius; O. Smithies

  Double-strand gap repair in a mammalian gene targeting reaction

  Molecular and Cellular Biology. 1991;11(9):4389-4397.
  39

• 207.

  1990

  Beverly H. Koller; Philippa Marrack; John W. Kappler; Oliver Smithies

  Normal development of mice deficient in β₂M, MHC class I proteins, and CD8⁺ T cells

  Science. 1990;248(4960):1227-1230.
  480

• 208.

  1990

  Hyung-Suk Kim; Oliver Smithies; Nobuyo Maeda

  A physical map of the human salivary proline-rich protein gene cluster covers over 700 kbp of DNA

  Genomics. 1990;6(2):260-267.
  9

• 209.

  1990

  P.S. Henthorn; O. Smithies; D.L. Mager

  Molecular analysis of deletions in the human β-globin gene cluster: Deletion junctions and locations of breakpoints

  Genomics. 1990;6(2):226-237.
  55

• 210.

  1990

  L.H. Reid; R.G. Gregg; O. Smithies; B.H. Koller

  Regulatory elements in the introns of the human HPRT gene are necessary for its expression in embryonic stem cells

  Proceedings of the National Academy of Sciences of the United States of America. 1990;87(11):4299-4303.
  32

• 211.

  1989

  B.H. Koller; L.J. Hagemann; T.J.R. Doetschman Hagaman; S. Huang; P.J. Williams; N.L. First; N. Maeda; O. Smithies

  Germ-line transmission of a planned alteration made in a hypoxanthine phosphoribosyltransferase gene by homologous recombination in embryonic stem cells

  Proceedings of the National Academy of Sciences of the United States of America. 1989;86(22):8927-8931.
  70

• 212.

  1989

  B.H. Koller; O. Smithies

  Inactivating the β₂-microglobulin locus in mouse embryonic stem cells by homologous recombination

  Proceedings of the National Academy of Sciences of the United States of America. 1989;86(22):8932-8935.
  82

• 213.

  1989

  D.J. Endean; O. Smithies

  Replication of plasmid DNA in fertilized Xenopus eggs is sensitive to both the topology and size of the injected template

  Chromosoma. 1989;97(4):307-314.
  4

• 214.

  1988

  Hyung-Suk Kim; O. Smithies

  Recombinant fragment assay for gene targetting based on the polymerase chain reaction

  Nucleic Acids Research. 1988;16(18):8887-8903.
  34

• 215.

  1988

  K.M. Lyons; J.H. Stein; O. Smithies

  Length polymorphisms in human proline-rich protein genes generated by intragenic unequal crossing over

  Genetics. 1988;120(1):267-278.
  15

• 216.

  1988

  K.M. Lyons; E.A. Azen; P.A. Goodman; O. Smithies

  Many protein products from a few loci: Assignment of human salivary proline-rich proteins to specific loci

  Genetics. 1988;120(1):255-265.
  22

• 217.

  1988

  N. Maeda; D.L. Ebert; T.M. Doers; M. Newman; J. Hasler-Rapacz; A.D. Attie; J. Rapacz; O. Smithies

  Molecular genetics of the apolipoprotein B gene in pigs in relation to atherosclerosis

  Gene. 1988;70(2):213-229.
  13

• 218.

  1988

  E. Saitoh; S. Isemura; K. Sanada; H.-S. Kim; O. Smithies; N. Maeda

  Cystatin superfamily. Evidence that family II cystatin genes are evolutionarily related to family III cystatin genes

  Biological Chemistry Hoppe-Seyler. 1988;369(SUPPL. 5):191-197.
  6

• 219.

  1988

  A.K. Nandi; R.S. Roginski; R.G. Gregg; O. Smithies; A.I. Skoultchi

  Regulated expression of genes inserted at the human chromosomal β-globin locus by homologous recombination

  Proceedings of the National Academy of Sciences of the United States of America. 1988;85(11):3845-3849.
  6

• 220.

  1988

  T. Doetschman; N. Maeda; O. Smithies

  Targeted mutation of the Hprt gene in mouse embryonic stem cells

  Proceedings of the National Academy of Sciences of the United States of America. 1988;85(22):8583-8587.
  77

• 221.

  1987

  A.I. Skoultchi; A. Nandi; R.S. Roginski; R.G. Gregg; O. Smithies

  Expression of genes inserted at the human beta-globin locus by homologous recombination.

  Progress in clinical and biological research. 1987;251:581-594.
  1

• 222.

  1987

  K.-Y. Song; F. Schwartz; N. Maeda; O. Smithies; R. Kucherlapati

  Accurate modification of a chromosomal plasmid by homologous recombination in human cells

  Proceedings of the National Academy of Sciences of the United States of America. 1987;84(19):6820-6824.
  8

• 223.

  1987

  E. Saitoh; H.-S. Kim; O. Smithies; N. Maeda

  Human cysteine-proteinase inhibitors: Nucleotide sequence analysis of three members of the cystatin gene family

  Gene. 1987;61(3):329-338.
  24

• 224.

  1987

  T. Doetschman; R.G. Gregg; N. Maeda; M.L. Hooper; D.W. Melton; S. Thompson; O. Smithies

  Targetted correction of a mutant HPRT gene in mouse embryonic stem cells

  Nature. 1987;330(6148):576-578.
  248

• 225.

  1986

  O. Smithies; P.A. Powers

  Gene conversions and their relation to homologous chromosome pairing.

  Philosophical transactions of the Royal Society of London. Series B: Biological sciences. 1986;312(1154):291-302.
  32

• 226.

  1986

  N. Maeda; S.M. McEvoy; H.F. Harris; T.H. Huisman; O. Smithies

  Polymorphisms in the human haptoglobin gene cluster: Chromosomes with multiple haptoglobin-related (Hpr) genes

  Proceedings of the National Academy of Sciences of the United States of America. 1986;83(19):7395-7399.
  14

• 227.

  1986

  P.A. Powers; O. Smithies

  Short gene conversions in the human fetal globin gene region: A by-product of chromosome pairing during meiosis?

  Genetics. 1986;112(2):343-358.
  24

• 228.

  1986

  S.S. Boggs; R.G. Gregg; N. Borenstein; O. Smithies

  Efficient transformation and frequent single-site, single-copy insertion of DNA can be obtained in mouse erythroleukemia cells transformed by electroporation

  Experimental Hematology. 1986;14(10):988-994.
  18

• 229.

  1986

  O. Smithies

  Direct alteration of a gene in the human genome

  Journal of Inherited Metabolic Disease. 1986;9(SUPPL. 1):92-97.
  0

• 230.

  1986

  N. Maeda; O. Smithies

  The evolution of multigene families: human haptoglobin genes.

  Annual Review of Genetics. 1986;20:81-108.
  70

• 231.

  1986

  R.G. Gregg; O. Smithies

  Targeted modification of human chromosomal genes

  Cold Spring Harbor Symposia on Quantitative Biology. 1986;51(2):1093-1099.
  2

• 232.

  1986

  P.S. Henthorn; D.L. Mager; T.H.J. Huisman; O. Smithies

  A gene deletion ending within a complex array of repeated sequences 3' to the human β-globin gene cluster

  Proceedings of the National Academy of Sciences of the United States of America. 1986;83(14):5194-5198.
  45

• 233.

  1985

  Dixie L. Mager; Paula S. Henthorn; Oliver Smithies

  A Chinese γ⁺(^Aγδβ)⁰ thalassemia deletion: Comparison to other deletions in the human β-globin gene cluster and sequence analysis of the breakpoints

  Nucleic Acids Research. 1985;13(18):6559-6575.
  27

• 234.

  1985

  P.S. Henthorn; O. Smithies; T. Nakatsuji; A.E. Felice; M.B. Gardiner; A.L. Reese; T.H. Huisman

  ((A)γδβ)°-thalassaemia in blacks is due to a deletion of 34 kbp of DNA

  British Journal of Haematology. 1985;59(2):343-356.
  3

• 235.

  1985

  N. Maeda; H.S. Kim; E.A. Azen; O. Smithies

  Differential RNA splicing and post-translational cleavages in the human salivary proline-rich protein gene system

  Journal of Biological Chemistry. 1985;260(20):11123-11130.
  36

• 236.

  1985

  Q. Li; P.A. Powers; O. Smithies

  Nucleotide sequence of 16-kilobase pairs of DNA 5' to the human ε-globin gene

  Journal of Biological Chemistry. 1985;260(28):14901-14910.
  10

• 237.

  1985

  O. Smithies; R.G. Gregg; S.S. Boggs; M.A. Koralewski; R.S. Kucherlapati

  Insertion of DNA sequences into the human chromosomal β-globin locus by homologous recombination

  Nature. 1985;317(6034):230-234.
  228

• 238.

  1984

  Patricia A. Powers; Cigdem Altay; Titus H.J. Huisman; Oliver Smithies

  Two novel arrangements of the human fetal globin genes: G_γ-G_γ and A_γ-A_γ

  Nucleic Acids Research. 1984;12(18):7023-7034.
  7

• 239.

  1984

  John Devereux; Paul Haeberli; Oliver Smithies

  A comprehensive set of sequence analysis programs for the VAX

  Nucleic Acids Research. 1984;12(1 PART1):387-395.
  5832

• 240.

  1984

  E. Azen; K.M. Lyons; T. McGonigal; N.L. Barrett; L.S. Clements; N. Maeda; E.F. Vanin; D.M. Carlson; O. Smithies

  Clones from the human gene complex coding for salivary proline-rich proteins

  Proceedings of the National Academy of Sciences of the United States of America. 1984;81(17 I):5561-5565.
  5

• 241.

  1984

  R.S. Kucherlapati; E.M. Eves; K.Y. Song; B.S. Morse; O. Smithies

  Homologous recombination between plasmids in mammalian cells can be enhanced by treatment of input DNA

  Proceedings of the National Academy of Sciences of the United States of America. 1984;81(10 I):3153-3157.
  36

• 242.

  1984

  O. Smithies; M.A. Koralewski; K.Y. Song; R.S. Kucherlapati

  Homologous recombination with DNA introduced into mammalian cells

  Cold Spring Harbor Symposia on Quantitative Biology. 1984;VOL. 49:161-170.
  12

• 243.

  1983

  Elio F. Vanin; Paula S. Henthom; Dimitris Kioussis; Frank Grosveld; Oliver Smithies

  Unexpected relationships between four large deletions in the human β-globin gene cluster

  Cell. 1983;35(3 PART 2):701-709.
  34

• 244.

  1983

  Raymond S. Roginski; Arthur I. Skoultchi; Paula Henthorn; Oliver Smithies; Nancy Hsiung; Raju Kucherlapati

  Coordinate modulation of transfected HSV thymidine kinase and human globin genes

  Cell. 1983;35(1):149-155.
  1

• 245.

  1983

  N. Maeda; J.B. Bliska; O. Smithies

  Recombination and balanced chromosome polymorphism suggested by DNA sequences 5' to the human δ-globin gene

  Proceedings of the National Academy of Sciences of the United States of America. 1983;80(16 I):5012-5016.
  13

• 246.

  1982

  Shi-Hsiang Shen; Oliver Smithies

  Human globin ψB₂ is not a globin-related sequence

  Nucleic Acids Research. 1982;10(23):7809-7818.
  0

• 247.

  1982

  O. Smithies

  The control of globin and other eukaryotic genes

  Journal of Cellular Physiology. 1982;110(Suppl. 1):137-143.
  2

• 248.

  1981

  Oliver Smithies; William R. Engels; John R. Devereux; Jerry L. Slightom; Shi-hsiang Shen

  Base substitutions, length differences and DNA strand asymmetries in the human ^Gγ and ^Aγ fetal globin gene region

  Cell. 1981;26(3 PART 1):345-353.
  38

• 249.

  1981

  S. Shen; J.L. Slightom; O. Smithies

  A history of the human fetal globin gene duplication

  Cell. 1981;26(2):191-203.
  52

• 250.

  1981

  M.D. Poulik; C.S. Shinnick; O. Smithies

  Partial amino acid sequences of human and dog post-gamma globulins

  Molecular Immunology. 1981;18(6):569-572.
  7

• 251.

  1980

  A. Efstratiadis; J.W. Posakony; T. Maniatis; R.M. Lawn; C. O'Connell; R.A. Spritz; J.K. DeRiel; B.G. Forget; S.M. Weissman; J.L. Slightom; et al.

  The structure and evolution of the human β-globin gene family

  Cell. 1980;21(3):653-668.
  171

• 252.

  1980

  J.L. Slightom; A.E. Blechl; O. Smithies

  Human fetal (G)γ- and (A)γ-globin genes: Complete nucleotide sequences suggest that DNA can be exchanged between these duplicated genes

  Cell. 1980;21(3):627-638.
  127

• 253.

  1980

  Elio F. Vanin; Gregory I. Goldberg; Philip W. Tucker; Oliver Smithies

  A mouse α-globin-related pseudogene lacking intervening sequences

  Nature. 1980;286(5770):222-226.
  12

• 254.

  1979

  M.D. Poulik; O. Smithies

  Partial amino acid sequences of rabbit and rat β₂-microglobulins

  Molecular Immunology. 1979;16(9):731-734.
  0

• 255.

  1978

  B. Frangione; E.C. Franklin; O. Smithies

  Unusual genes at the aminoterminus of human immunoglobulin variants

  Nature. 1978;273(5661):400-401.
  0

• 256.

  1978

  F.R. Blattner; A.E. Blechl; K. Denniston-Thompson; H.E. Faber; J.E. Richards; J.L. Slightom; P.W. Tucker; O. Smithies

  Cloning human fetal γ globin and mouse α-type globin DNA: Preparation and screening of shotgun collections

  Science. 1978;202(4374):1279-1284.
  5

• 257.

  1978

  O. Smithies; A.E. Blechl; K. Denniston-Thompson; N. Newell; J.E. Richards; J.L. Slightom; P.W. Tucker; F.R. Blattner

  Cloning human fetal γ globin and mouse α-type globin DNA: Characterization and partial sequencing

  Science. 1978;202(4374):1284-1289.
  2

• 258.

  1977

  I.D. Walker; O. Smithies; B. Ballou; E.F. Freedlender; C.J. Shinnick

  Protein sequencing with radioisotopes

  Trends in Biochemical Sciences. 1977;2(8):N179-N184.
  0

• 259.

  1977

  Byron Ballou; Oliver Smithies

  A simplified chloral hydrate electrophoresis system for analysis of biological membranes

  Analytical Biochemistry. 1977;80(2):616-623.
  0

• 260.

  1977

  E.F. Freedlender; L. Taichman; O. Smithies

  Segregation of some chromosomal proteins during cell replication

  Cold Spring Harbor Symposia on Quantitative Biology. 1977;42(1):417-420.
  0

• 261.

  1977

  Elizabeth F. Freedlender; Lorne Taichman; Oliver Smithies

  Nonrandom distribution of chromosomal proteins during cell replication

  Biochemistry. 1977;16(9):1802-1808.
  0

• 262.

  1976

  H.E. Faber; R.S. Kucherlapati; M.D. Poulik; F.H. Ruddle; O. Smithies

  β₂-Microglobulin locus on human chromosome 15

  Somatic Cell Genetics. 1976;2(2):141-153.
  1

• 263.

  1976

  B. Ballou; D.J. McKean; E.F. Freedlender; O. Smithies

  HLA membrane antigens: sequencing by intrinsic radioactivity

  Proceedings of the National Academy of Sciences of the United States of America. 1976;73(12):4487-4491.
  0

• 264.

  1976

  R.S. Kucherlapati; H.E. Faber; M.D. Poulik; F.H. Ruddle; O. Smithies

  Assignment of the gene for beta 2 microglobulin to human chromosome 15

  Cytogenetics and Cell Genetics. 1976;16(1-5):178-180.
  0

• 265.

  1975

  M.D. Poulik; E.S. Shinnick; O. Smithies

  Partial amino acid sequences of rabbit and rat B₂ microglobulins

  Federation Proceedings. 1975;34(3):No. 4109.
  0

• 266.

  1975

  M.D. Poulik; D. Farrah; G.H. Malek; C.J. Shinnick; O. Smithies

  Low molecular weight urinary proteins. I. Partial amino acid sequences of the retinol binding proteins of man and dog

  Biochimica et Biophysica Acta. 1975;412(2):326-334.
  0

• 267.

  1975

  T.M. Shinnick; E. Lund; O. Smithies; F.R. Blattner

  Hybridization of labeled RNA to DNA in agarose gels

  NUCLEIC ACIDS RES. 1975;2(10):1911-1929.
  4

• 268.

  1974

  O. Smithies

  Letter: Recombinant DNA molecules.

  Genetics. 1974;77(4):819-820.
  0

• 269.

  1974

  J.S. Finlayson; M. Potter; C.S. Shinnick; O. Smithies

  Components of the major urinary protein complex of inbred mice: Determination of NH₂-terminal sequences and comparison with homologous components from wild mice

  Biochemical Genetics. 1974;11(4):325-335.
  4

• 270.

  1974

  David J. McKean; Erwin H. Peters; James I. Waldby; O. Smithies

  Amino acid sequence determination with radioactive proteins

  Biochemistry. 1974;13(15):3048-3051.
  0

• 271.

  1974

  O. Smithies

  Immunoglobulin genes: arranged in tandem or in parallel?

  Cold Spring Harbor Symposia on Quantitative Biology. 1974;38:725-737.
  0

• 272.

  1973

  James W. Fett; Harold F. Deutsch; Oiver Smithies

  Hinge-regIon deletion localized in the IgG₁-globulin Mcg

  Immunochemistry. 1973;10(2):115-118.
  5

• 273.

  1973

  O. Smithies

  Immunoglobulin genes: arranged in tandem or in parallel?

  Symposia on Quantitative Biology. 1973;VOL.38:725-737.
  0

• 274.

  1972

  O. Smithies; M.D. Poulik

  Dog homologue of human 2 -microglobulin.

  Proceedings of the National Academy of Sciences of the United States of America. 1972;69(10):2914-2917.
  5

• 275.

  1972

  S.E. Kornguth; L.R. Kozel; O. Smithies

  Probable identity of tissue specific histone with encephalitogenic protein.

  Nature: New biology. 1972;237(71):49-50.
  0

• 276.

  1972

  O. Smithies; M.D. Poulik

  Initiation of protein synthesis at an unusual position in an immunoglobulin gene?

  Science. 1972;175(4018):187-189.
  0

• 277.

  1971

  M.D. Poulik; D.L. Ballantyne; C.J. Shinnick; O. Smithies

  Partial amino acid sequences of two urinary proteins characteristic of tubular proteinemia.

  Journal of Laboratory and Clinical Medicine. 1971;78(5):822.
  0

• 278.

  1971

  M.T. Sung; G.H. Dixon; O. Smithies

  Phosphorylation and synthesis of histones in regenerating rat liver.

  Journal of Biological Chemistry. 1971;246(5):1358-1364.
  0

• 279.

  1971

  O. Smithies; D. Gibson; E.M. Fanning; R.M. Goodfliesh; J.G. Gilman; D.L. Ballantyne

  Quantitative procedures for use with the edman-begg sequenator. Partial sequences of two unusual immunoglobulin light chains, Rzf and Sac

  Biochemistry. 1971;10(26):4912-4921.
  4

• 280.

  1971

  David Gibson; Michael Levanon; Oliver Smithies

  Heterogeneity of normal human immunoglobulin light chains. Nonallelic variation in the constant region of λ chains

  Biochemistry. 1971;10(16):3114-3122.
  1

• 281.

  1971

  O. Smithies; D.M. Gibson; E.M. Fanning; M.E. Percy; D.M. Parr; G.E. Connell

  Deletions in immunoglobulin polypeptide chains as evidence for breakage and repair in DNA

  Science. 1971;172(3983):574-577.
  0

• 282.

  1970

  O. Smithies

  Pathways through networks of branched DNA

  Science. 1970;169(3948):882-883.
  1

• 283.

  1969

  E.A. Azen; O. Smithies; O. Hiller

  High-voltage starch-gel electrophoresis in the study of post-albumin proteins and C'3 (ß_1e-globulin) polymorphism

  Biochemical Genetics. 1969;3(3):215-228.
  0

• 284.

  1969

  M. Sung; O. Smithies

  Differential elution of histones from gel-trapped nuclei.

  Biopolymers - Peptide Science Section. 1969;7(1):39-58.
  0

• 285.

  1968

  O. Smithies

  Genetics of variability.

  Brookhaven symposia in biology. 1968;21(1):243-258.
  0

• 286.

  1968

  Edwin A. Azen; Oliver Smithies

  Genetic polymorphism of C′3(β_1C-globulin) in human serum

  Science. 1968;162(3856):905-907.
  6

• 287.

  1968

  John G. Gilman; Oliver Smithies

  Fetal hemoglobin variants in mice

  Science. 1968;160(3830):885-886.
  0

• 288.

  1968

  T.G. Wegmann; O. Smithies

  Improvement of the microtiter hemagglutination method.

  Transfusion. 1968;8(1):47.
  2

• 289.

  1967

  A.J. Claflin; O. Smithies

  Antibody-producing cells in division.

  Science. 1967;157(796):1561-1562.
  2

• 290.

  1967

  O. Smithies

  Antibody variability

  Science. 1967;157(3786):267-273.
  7

• 291.

  1966

  G.E. Connell; O. Smithies; G.H. Dixon

  Gene action in the human haptoglobins. II. Isolation and physical characterization of alpha polypeptide chains

  Journal of Molecular Biology. 1966;21(2):225-228,IN5-IN6,229.
  5

• 292.

  1966

  O. Smithies; G.E. Connell; G.H. Dixon

  Gene action in the human haptoglobins. I. Dissociation into constituent polypeptide chains

  Journal of Molecular Biology. 1966;21(2):213-220,IN1-IN4,221-224.
  2

• 293.

  1966

  A.J. Claflin; O. Smithies; R.K. Meyer

  Antibody responses in bursa-deficient chickens.

  Journal of Immunology. 1966;97(5):693-699.
  1

• 294.

  1966

  O. Smithies

  Somatic mutations and proteins.

  Proceedings of the Royal Society of London. Series B. Biological sciences. 1966;164(995):320-327.
  0

• 295.

  1966

  R. Ceppellini; S. Dray; J.L. Fahey; E.C. Franklin; H. Fudenberg; P.G.H. Gell; H.C. Goodman; R. Grubb; M. Harboe; R.L. Kirk; et al.

  Notation for genetic factors of human immunoglobulins

  Nature. 1966;209(5024):653-655.
  0

• 296.

  1965

  O. SMITHIES

  CHARACTERIZATION OF GENETIC VARIANTS OF BLOOD PROTEINS.

  Vox sanguinis. 1965;10:359-362.
  9

• 297.

  1965

  E.A. AZEN; S. ORR; O. SMITHIES

  STARCH-GEL ELECTROPHORESIS OF ERYTHROCYTE STROMA.

  The Journal of laboratory and clinical medicine. 1965;65:440-449.
  0

• 298.

  1965

  O. Smithies

  Chromosomal rearrangements and protein structure.

  Bibliotheca haematologica. 1965;23:373-374.
  0

• 299.

  1965

  O. Smithies

  Characterization of genetic variants of blood proteins.

  Bibliotheca haematologica. 1965;23:1175-1177.
  0

• 300.

  1965

  Oliver Smithies

  Disulfide-bond cleavage and formation in proteins

  Science. 1965;150(3703):1595-1598.
  5

• 301.

  1965

  Oliver Smithies

  Antibody induction and tolerance

  Science. 1965;149(3680):151-156.
  0

• 302.

  1964

  O. SMITHIES

  GEL ELECTROPHORESIS: INTRODUCTORY REMARKS.

  Annals of the New York Academy of Sciences. 1964;121:309.
  0

• 303.

  1964

  O. SMITHIES

  STARCH-GEL ELECTROPHORESIS.

  Metabolism: clinical and experimental. 1964;13:SUPPL:974-984.
  0

• 304.

  1964

  O. SMITHIES

  CHROMOSOMAL REARRANGEMENTS AND PROTEIN STRUCTURE.

  Cold Spring Harbor symposia on quantitative biology. 1964;29:309-319.
  1

• 305.

  1963

  W.E. Nance; O. Smithies

  New haptoglobin alleles: A prediction confirmed

  Nature. 1963;198(4883):869-870.
  0

• 306.

  1963

  O. Smithies

  Gamma-globulin variability: A genetic hypothesis

  Nature. 1963;199(4900):1231-1236.
  3

• 307.

  1963

  Walter E. Nance; Alice Claflin; Oliver Smithies

  Lactic dehydrogenase: Genetic control in man

  Science. 1963;142(3595):1075-1076.
  1

• 308.

  1962

  O. SMITHIES

  Molecular size and starch-gel electrophoresis.

  Archives of biochemistry and biophysics. 1962;Suppl 1:125-131.
  9

• 309.

  1962

  N.E. SIMPSON; H.H. GUNSON; O. SMITHIES

  Frequencies of blood groups, serum haptoglobins and levels of slow alpha2-globulin in diabetics and their relatives.

  Diabetes. 1962;11:329-333.
  0

• 310.

  1962

  O. SMITHIES; G.E. CONNELL; G.H. DIXON

  Inheritance of haptoglobin subtypes.

  American journal of human genetics. 1962;14:14-21.
  25

• 311.

  1962

  G.E. Connell; G.H. Dixon; O. Smithies

  Subdivision of the three common haptoglobin types based on 'hidden' differences [47]

  Nature. 1962;193(4814):505-506.
  7

• 312.

  1962

  O. Smithies; G.E. Connell; G.H. Dixon

  Chromosomal rearrangements and the evolution of haptoglobin genes

  Nature. 1962;196(4851):232-236.
  17

• 313.

  1960

  H. HARRIS; S.D. LAWLER; E.B. ROBSON; O. SMITHIES

  The occurrence of two unusual serum protein phenotypes in a single pedigree.

  Annals of human genetics. 1960;24:63-69.
  2

• 314.

  1959

  O. SMITHIES; O. HILLER

  The genetic control of transferrins in humans.

  The Biochemical journal. 1959;72(1):121-126.
  7

• 315.

  1959

  G.E. CONNELL; O. SMITHIES

  Human haptoglobins: estimation and purification.

  The Biochemical journal. 1959;72(1):115-121.
  11

• 316.

  1959

  O. SMITHIES

  An improved procedure for starch-gel electrophoresis: further variations in the serum proteins of normal individuals.

  The Biochemical journal. 1959;71(3):585-587.
  26

• 317.

  1959

  O. Smithies

  Zone Electrophoresis in Starch Gels and its Application to Studies of Serum Proteins

  Advances in Protein Chemistry. 1959;14(C):65-113.
  10

• 318.

  1959

  E.R. Giblett; C.G. Hickman; O. Smithies

  Serum transferrins

  Nature. 1959;183(4675):1589-1590.
  14

• 319.

  1958

  M.D. POULIK; O. SMITHIES

  Comparison and combination of the starch-gel and filter-paper electrophoretic methods applied to human sera: two-dimensional electrophoresis.

  The Biochemical journal. 1958;68(4):636-643.
  5

• 320.

  1958

  W.R. Horsfall; O. Smithies

  Genetic control of some human serum β-globulins

  Science. 1958;128(3314):35.
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• 321.

  1958

  O. Smithies

  Third allele at the serum β-globulin locus in humans [15]

  Nature. 1958;181(4617):1203-1204.
  2

• 322.

  1957

  O. Smithies

  Variations in human serum β-globulins [21]

  Nature. 1957;180(4600):1482-1483.
  26

• 323.

  1957

  G.H. Dixon; O. Smithies

  Zone electrophoresis of cabbage enzymes in starch gels

  BBA - Biochimica et Biophysica Acta. 1957;23(C):198-199.
  1

• 324.

  1956

  O. Smithies; M.D. Poulik

  Two-dimensional electrophoresis of serum proteins [2]

  Nature. 1956;177(4518):1033.
  25

• 325.

  1956

  O. Smithies; Norma Ford Walker

  Notation for serum-protein groups and the genes controlling their inheritance [11]

  Nature. 1956;178(4535):694-695.
  15

• 326.

  1955

  O. SMITHIES

  Zone electrophoresis in starch gels: group variations in the serum proteins of normal human adults.

  The Biochemical journal. 1955;61(4):629-641.
  211

• 327.

  1955

  O. Smithies; Norma Ford Walker

  Genetic control of some serum proteins in normal humans [9]

  Nature. 1955;176(4496):1265-1266.
  24

• 328.

  1955

  O. Smithies

  Grouped variations in the occurrence of new protein components in normal human serum [13]

  Nature. 1955;175(4450):307-308.
  8

• 329.

  1954

  O. SMITHIES

  The application of four methods for assessing protein homogeneity to

  The Biochemical journal. 1954;58(1):31-38.
  3

• 330.

  1953

  O. SMITHIES

  A dynamic osmometer for accurate measurements on small quantities of

  The Biochemical journal. 1953;55(1):57-67.
  3