Richard J Samulski

UNCCH, School of Medicine, Pharmacology

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Richard J Samulski

• Organizations
  University of North Carolina at Chapel Hill
  
  School of Medicine
  
  Pharmacology
  
  

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This is a list of publications by this researcher, listed chronologically starting with the most recent first. New publications appear in this list weekly. The source of publications and 'cited by' data for this application is Scopus.

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• 1.

  2013

  S.J. Gray; S. Nagabhushan Kalburgi; T.J. McCown; R. Jude Samulski

  Global CNS gene delivery and evasion of anti-AAV-neutralizing antibodies by intrathecal AAV administration in non-human primates

  Gene Therapy. 2013;20(4):450-459.
  0

• 2.

  2013

  A-M Lompré; L Hadri; E Merlet; Z Keuylian; N Mougenot; I Karakikes; J Chen; F Atassi; A Marchand; R Blaise; et al.

  Efficient transduction of vascular smooth muscle cells with a translational AAV2.5 vector: a new perspective for in-stent restenosis gene therapy

  Gene Therapy. 2013.
  0

• 3.

  2013

  J.R. Ferreira; M.L. Hirsch; L. Zhang; Y. Park; R.J. Samulski; W.-S. Hu; C.-C. Ko

  Three-dimensional multipotent progenitor cell aggregates for expansion, osteogenic differentiation and 'in vivo' tracing with AAV vector serotype 6

  Gene Therapy. 2013;20(2):158-168.
  1

• 4.

  2013

  Kamal Ke Gadalla; Mark Es Bailey; Rosemary C Spike; Paul D Ross; Kenton T Woodard; Sahana Nagabhushan Kalburgi; Lavanya Bachaboina; Jie V Deng; Anne E West; R Jude Samulski; et al.

  Improved survival and reduced phenotypic severity following AAV9/MECP2 gene transfer to neonatal and juvenile male Mecp2 knockout mice

  Molecular Therapy. 2013;21(1):18-30.
  0

• 5.

  2013

  B.L. Ellis; M.L. Hirsch; S.N. Porter; R.J. Samulski; M.H. Porteus

  Zinc-finger nuclease-mediated gene correction using single AAV vector transduction and enhancement by Food and Drug Administration-approved drugs

  Gene Therapy. 2013;20(1):35-42.
  5

• 6.

  2012

  Paola Leone; David Shera; Scott W. J. McPhee; Jeremy S. Francis; Edwin H. Kolodny; Larissa T. Bilaniuk; Dah-Jyuu Wang; Mitra Assadi; Olga Goldfarb; H. Warren Goldman; et al.

  Long-term follow-up after gene therapy for canavan disease

  Science Translational Medicine. 2012;4(165).
  1

• 7.

  2012

  Thomas B. Lentz; Steven J. Gray; R. Jude Samulski

  Viral vectors for gene delivery to the central nervous system

  Neurobiology of Disease. 2012;48(2):179-188.
  4

• 8.

  2012

  C.-M. Lai; M.J. Estcourt; R.P. Himbeck; S.-Y. Lee; I. Yew-San Yeo; C. Luu; B.K. Loh; M.W. Lee; A. Barathi; J. Villano; et al.

  Preclinical safety evaluation of subretinal AAV2.sFlt-1 in non-human primates

  Gene Therapy. 2012;19(10):999-1009.
  2

• 9.

  2012

  Ping-Jie Xiao; R. Jude Samulski

  Cytoplasmic trafficking, endosomal escape, and perinuclear accumulation of adeno-associated virus type 2 particles are facilitated by microtubule network

  Journal of Virology. 2012;86(19):10462-10473.
  2

• 10.

  2012

  T. Federici; J.S. Taub; G.R. Baum; S.J. Gray; J.C. Grieger; K.A. Matthews; C.R. Handy; M.A. Passini; R.J. Samulski; N.M. Boulis

  Robust spinal motor neuron transduction following intrathecal delivery of AAV9 in pigs

  Gene Therapy. 2012;19(8):852-859.
  6

• 11.

  2012

  Ping-Jie Xiao; Thomas B. Lentz; R. Jude Samulski

  Recombinant adeno-associated virus: Clinical application and development as a gene-therapy vector

  Therapeutic Delivery. 2012;3(7):835-856.
  0

• 12.

  2012

  Jerome Denard; Cyriaque Beley; Robert Kotin; René Lai-Kuen; Stéphane Blot; Hervé Leh; Aravind Asokan; R. Jude Samulski; Philippe Moullier; Thomas Voit; et al.

  Human galectin 3 binding protein interacts with recombinant adeno-associated virus type 6

  Journal of Virology. 2012;86(12):6620-6631.
  4

• 13.

  2012

  Olivier Bockstael; Catherine Melas; Catherine Pythoud; Marc Levivier; Douglas McCarty; R. Jude Samulski; Olivier De Witte; Liliane Tenenbaum

  Rapid transgene expression in multiple precursor cell types of adult rat subventricular zone mediated by adeno-associated type 1 vectors

  Human Gene Therapy. 2012;23(7):742-753.
  1

• 14.

  2012

  Valentino Piacentino; Carmelo A. Milano; Michael Bolanos; Jacob Schroder; Emily Messina; Adam S. Cockrell; Edward Jones; Ava Krol; Nenad Bursac; Lan Mao; et al.

  X-linked inhibitor of apoptosis protein-mediated attenuation of apoptosis, using a novel cardiac-enhanced adeno-associated viral vector

  Human Gene Therapy. 2012;23(6):635-646.
  1

• 15.

  2012

  Aravind Asokan; David V. Schaffer; R. Jude Samulski

  The AAV vector toolkit: Poised at the clinical crossroads

  Molecular Therapy. 2012;20(4):699-708.
  9

• 16.

  2012

  C. Li; N. Narkbunnam; R.J. Samulski; A. Asokan; G. Hu; L.J. Jacobson; M.J. Manco-Johnson; P.E. Monahan; Marilyn J. Manco-Johnson; Brenda Riske; et al.

  Neutralizing antibodies against adeno-associated virus examined prospectively in pediatric patients with hemophilia

  Gene Therapy. 2012;19(3):288-294.
  7

• 17.

  2012

  Dawn E. Bowles; Scott W.J. McPhee; Chengwen Li; Steven J. Gray; Jade J. Samulski; Angelique S. Camp; Juan Li; Bing Wang; Paul E. Monahan; Joseph E. Rabinowitz; et al.

  Phase 1 gene therapy for duchenne muscular dystrophy using a translational optimized AAV vector

  Molecular Therapy. 2012;20(2):443-455.
  16

• 18.

  2012

  Ping-Jie Xiao; Chengwen Li; Aaron Neumann; R. Jude Samulski

  Quantitative 3D tracing of gene-delivery viral vectors in human cells and animal tissues

  Molecular Therapy. 2012;20(2):317-328.
  4

• 19.

  2012

  Joshua C. Grieger; R. Jude Samulski

  Adeno-associated virus vectorology, manufacturing, and clinical applications

  Methods in Enzymology. 2012;507:229-254.
  9

• 20.

  2012

  Chengwen Li; Nina Diprimio; Dawn E. Bowles; Matthew L. Hirsch; Paul E. Monahan; Aravind Asokan; Joseph Rabinowitz; Mavis Agbandje-McKenna; R. Jude Samulski

  Single amino acid modification of adeno-associated virus capsid changes transduction and humoral immune profiles

  Journal of Virology. 2012;86(15):7752-7759.
  2

• 21.

  2011

  Steven J Gray; Vivian W Choi; Aravind Asokan; Rebecca A Haberman; Thomas J McCown; Richard Jude Samulski

  Production of recombinant adeno-associated viral vectors and use in in vitro and in vivo administration.

  Current protocols in neuroscience / editorial board, Jacqueline N. Crawley ... [et al.]. 2011;Chapter 4:Unit 4.17.
  0

• 22.

  2011

  Shinichi Usui; Brian C. Oveson; Takeshi Iwase; Lili Lu; Sun Young Lee; Young-Joon Jo; Zhihao Wu; Eun-Young Choi; Richard J. Samulski; Peter A. Campochiaro

  Overexpression of SOD in retina: Need for increase in H ₂O ₂-detoxifying enzyme in same cellular compartment

  Free Radical Biology and Medicine. 2011;51(7):1347-1354.
  7

• 23.

  2011

  M.S. Weinberg; B.L. Blake; R.J. Samulski; T.J. McCown

  The influence of epileptic neuropathology and prior peripheral immunity on CNS transduction by rAAV2 and rAAV5

  Gene Therapy. 2011;18(10):961-968.
  3

• 24.

  2011

  Steven J. Gray; Vivian W. Choi; Aravind Asokan; Rebecca A. Haberman; Thomas J. McCown; Richard Jude Samulski

  Production of recombinant adeno-associated viral vectors and use in in vitro and in vivo administration

  Current Protocols in Neuroscience. 2011;(SUPPL.57).
  1

• 25.

  2011

  Steven J. Gray; Stacey B. Foti; Joel W. Schwartz; Lavanya Bachaboina; Bonnie Taylor-Blake; Jennifer Coleman; Michael D. Ehlers; Mark J. Zylka; Thomas J. McCown; R. Jude Samulski

  Optimizing promoters for recombinant adeno-associated virus-mediated gene expression in the peripheral and central nervous system using self-complementary vectors

  Human Gene Therapy. 2011;22(9):1143-1153.
  13

• 26.

  2011

  Brooke R. Snyder; Steven J. Gray; Eric T. Quach; Jeremiah W. Huang; Cary H. Leung; R. Jude Samulski; Nicholas M. Boulis; Thais Federici

  Comparison of adeno-associated viral vector serotypes for spinal cord and motor neuron gene delivery

  Human Gene Therapy. 2011;22(9):1129-1135.
  15

• 27.

  2011

  Wuping Li; Liqun Zhang; Zhijian Wu; Raymond J. Pickles; R. Jude Samulski

  AAV-6 mediated efficient transduction of mouse lower airways

  Virology. 2011;417(2):327-333.
  1

• 28.

  2011

  Chengwen Li; Pingjie Xiao; Steven James Gray; Marc Scott Weinberg; R. Jude Samulski

  Combination therapy utilizing shRNA knockdown and an optimized resistant transgene for rescue of diseases caused by misfolded proteins

  Proceedings of the National Academy of Sciences of the United States of America. 2011;108(34):14258-14263.
  9

• 29.

  2011

  Cemal Yazici; Masahiko Takahata; David G. Reynolds; Chao Xie; R. Jude Samulski; Jade Samulski; E. Jeffrey Beecham; Arthur A. Gertzman; Mark Spilker; Xinping Zhang; et al.

  Self-complementary AAV2.5-BMP2-coated femoral allografts mediated superior bone healing versus live autografts in mice with equivalent biomechanics to unfractured femur

  Molecular Therapy. 2011;19(8):1416-1425.
  12

• 30.

  2011

  Steven J. Gray; Valerie Matagne; Lavanya Bachaboina; Swati Yadav; Sergio R. Ojeda; R. Jude Samulski

  Preclinical differences of intravascular aav9 delivery to neurons and glia: A comparative study of adult mice and nonhuman primates

  Molecular Therapy. 2011;19(6):1058-1069.
  34

• 31.

  2011

  Jarrod S. Johnson; Martina Gentzsch; Liqun Zhang; Carla M. P. Ribeiro; Boris Kantor; Tal Kafri; Raymond J. Pickles; R. Jude Samulski

  AAV exploits subcellular stress associated with inflammation, endoplasmic reticulum expansion, and misfolded proteins in models of cystic fibrosis

  PLoS Pathogens. 2011;7(5).
  7

• 32.

  2011

  Kevin S. Goudy; Mark C. Johnson; Alaina Garland; Chengwen Li; Richard J. Samulski; Bo Wang; Roland Tisch

  Reduced IL-2 expression in NOD mice leads to a temporal increase in CD62L^loFoxP3⁺CD4⁺ T cells with limited suppressor activity

  European Journal of Immunology. 2011;41(5):1480-1490.
  5

• 33.

  2011

  Kevin S. Goudy; Mark C. Johnson; Alaina Garland; Chengwen Li; R. Jude Samulski; Bo Wang; Roland Tisch

  Inducible adeno-associated virus-mediated IL-2 gene therapy prevents autoimmune diabetes

  Journal of Immunology. 2011;186(6):3779-3786.
  8

• 34.

  2011

  Boris Kantor; Matthew Bayer; Hong Ma; Jude Samulski; Chengwen Li; Thomas McCown; Tal Kafri

  Notable reduction in illegitimate integration mediated by a PPT-deleted, nonintegrating lentiviral vector

  Molecular Therapy. 2011;19(3):547-556.
  3

• 35.

  2011

  Jana L Phillips; Julia Hegge; Jon A Wolff; R Jude Samulski; Aravind Asokan

  Systemic gene transfer to skeletal muscle using reengineered AAV vectors.

  Methods in molecular biology (Clifton, N.J.). 2011;709:141-151.
  2

• 36.

  2011

  Matthew L. Hirsch; B. Matthew Fagan; Raluca Dumitru; Jacquelyn J. Bower; Swati Yadav; Matthew H. Porteus; Larysa H. Pevny; R. Jude Samulski

  Viral Single-Strand DNA Induces p53-Dependent Apoptosis in Human Embryonic Stem Cells

  PLoS ONE. 2011;6(11).
  3

• 37.

  2010

  Robert Ng; Lakshmanan Govindasamy; Brittney L. Gurda; Robert McKenna; Olga G. Kozyreva; R. Jude Samulski; Kristin N. Parent; Timothy S. Baker; Mavis Agbandje-McKenna

  Structural characterization of the dual glycan binding adeno-associated virus serotype 6

  Journal of Virology. 2010;84(24):12945-12957.
  24

• 38.

  2010

  Paul E. Monahan; Clinton D. Lothrop; Junjiang Sun; Matthew L. Hirsch; Tal Kafri; Boris Kantor; Rita Sarkar; D. Michael Tillson; Joseph R. Elia; et al.

  Proteasome inhibitors enhance gene delivery by AAV virus vectors expressing large genomes in hemophilia mouse and dog models: A strategy for broad clinical application

  Molecular Therapy. 2010;18(11):1907-1916.
  15

• 39.

  2010

  Jerry R. Mendell; Katherine Campbell; Louise Rodino-Klapac; Zarife Sahenk; Chris Shilling; Sarah Lewis; Dawn Bowles; Steven Gray; Chengwen Li; Gloria Galloway; et al.

  Dystrophin immunity in Duchenne's muscular dystrophy

  New England Journal of Medicine. 2010;363(15):1429-1437.
  79

• 40.

  2010

  Nina Diprimio; Scott W.J. McPhee; R. Jude Samulski

  Adeno-associated virus for the treatment of muscle diseases: Toward clinical trials

  Current Opinion in Molecular Therapeutics. 2010;12(5):553-560.
  7

• 41.

  2010

  Martin Lock; Susan McGorray; Alberto Auricchio; Eduard Ayuso; E. Jeffrey Beecham; Véronique Blouin-Tavel; Fatima Bosch; Mahuya Bose; Barry J. Byrne; Tina Caton; et al.

  Characterization of a recombinant adeno-associated virus type 2 reference standard material

  Human Gene Therapy. 2010;21(10):1273-1285.
  21

• 42.

  2010

  Steven J Gray; Kenton T Woodard; R Jude Samulski

  Viral vectors and delivery strategies for CNS gene therapy

  Therapeutic Delivery. 2010;1(4):517-534.
  6

• 43.

  2010

  M.L. Hirsch; L. Green; M.H. Porteus; R.J. Samulski

  Self-complementary AAV mediates gene targeting and enhances endonuclease delivery for double-strand break repair

  Gene Therapy. 2010;17(9):1175-1180.
  11

• 44.

  2010

  Jarrod S. Johnson; Chengwen Li; Nina DiPrimio; Marc S. Weinberg; Thomas J. McCown; R. Jude Samulski

  Mutagenesis of adeno-associated virus type 2 capsid protein VP1 uncovers new roles for basic amino acids in trafficking and cell-specific transduction

  Journal of Virology. 2010;84(17):8888-8902.
  14

• 45.

  2010

  Edmund R. Hollis; Pouya Jamshidi; Ariana O. Lorenzana; Jae K. Lee; Steven J. Gray; Richard J. Samulski; Binhai Zheng; Mark H. Tuszynski

  Transient demyelination increases the efficiency of retrograde AAV transduction

  Molecular Therapy. 2010;18(8):1496-1500.
  5

• 46.

  2010

  Steven J. Gray; Bonita L. Blake; Hugh E. Criswell; Sarah C. Nicolson; R. Jude Samulski; Thomas J. McCown

  Erratum: Corrigendum to "Directed Evolution of a Novel Adeno-associated Virus (AAV) Vector That Crosses the Seizure-compromised Blood-Brain Barrier (BBB)" (Molecular Therapy (2010) 18 (570-578) 10.1038/mt.2009.292)

  Molecular Therapy. 2010;18(5):1054.
  0

• 47.

  2010

  Eleni A. Markakis; Kenneth P. Vives; Jeremy Bober; Stefan Leichtle; Csaba Leranth; Jeff Beecham; John D. Elsworth; Robert H. Roth; R. Jude Samulski; D. Eugene Redmond Jr.

  Comparative transduction efficiency of AAV vector serotypes 1-6 in the substantia nigra and striatum of the primate brain

  Molecular Therapy. 2010;18(3):588-593.
  17

• 48.

  2010

  Steven J. Gray; Bonita L. Blake; Hugh E. Criswell; Sarah C. Nicolson; R. Jude Samulski; Thomas J. McCown

  Directed evolution of a novel adeno-associated virus (AAV) vector that crosses the seizure-compromised blood-brain barrier (BBB)

  Molecular Therapy. 2010;18(3):570-578.
  38

• 49.

  2010

  Shufen Chen; Christie A. Sanford; Junjiang Sun; Vivian Choi; Terry Van Dyke; R. Jude Samulski; W. Kimryn Rathmell

  VHL and PTEN loss coordinate to promote mouse liver vascular lesions

  Angiogenesis. 2010;13(1):59-69.
  3

• 50.

  2010

  Curtis F. Hewitt; Jude R. Samulski

  Creating a novel origin of replication through modulating DNA-protein interfaces

  PLoS ONE. 2010;5(1).
  0

• 51.

  2010

  LaKisha K. Buie; Carol A. Rasmussen; Eric C. Porterfield; Vinod S. Ramgolam; Vivian W. Choi; Silva Markovic-Plese; Richard J. Samulski; Paul L. Kaufman; Teresa Borrás

  Self-complementary AAV virus (scAAV) safe and long-term gene transfer in the trabecular meshwork of living rats and monkeys

  Investigative Ophthalmology and Visual Science. 2010;51(1):236-248.
  17

• 52.

  2010

  Aravind Asokan; Julia C. Conway; Jana L. Phillips; Chengwen Li; Julia Hegge; Rebecca Sinnott; Swati Yadav; Nina Diprimio; Hyun-Joo Nam; Mavis Agbandje-Mckenna; et al.

  Reengineering a receptor footprint of adeno-associated virus enables selective and systemic gene transfer to muscle

  Nature Biotechnology. 2010;28(1):79-82.
  40

• 53.

  2010

  Matthew L. Hirsch; Mavis Agbandje-Mckenna; R.Jude Samulski

  Little vector, big gene transduction: Fragmented genome reassembly of adeno-associated virus

  Molecular Therapy. 2010;18(1):6-8.
  17

• 54.

  2010

  F Curtis Hewitt; R Jude Samulski

  Creating a novel origin of replication through modulating DNA-protein interfaces.

  PloS one. 2010;5(1):e8850.
  2

• 55.

  2010

  Angela M. Mitchell; Sarah C. Nicolson; Jayme K. Warischalk; R. Jude Samulski

  AAV's Anatomy: Roadmap for Optimizing Vectors for Translational Success

  Current Gene Therapy. 2010;10(5):319-340.
  20

• 56.

  2010

  Chengwen Li; Matthew L. Hirsch; R. Jude Samulski

  Development of AAV vectors for the therapy of autoimmune and inflammatory diseases

  Milestones in Drug Therapy. 2010:161-180.
  0

• 57.

  2009

  L.R. Goodrich; V.W. Choi; B.A. Duda Carbone; C.W. McIlwraith; R.J. Samulski

  Ex vivo serotype-specific transduction of equine joint tissue by self-complementary adeno-associated viral vectors

  Human Gene Therapy. 2009;20(12):1697-1702.
  11

• 58.

  2009

  Wuping Li; Liqun Zhang; Jarrod S. Johnson; Wu Zhijian; Joshua C. Grieger; Xiao Ping-Jie; Lauren M. Drouin; Mavis Agbandje-Mckenna; Raymond J. Pickles; et al.

  Generation of novel aav variants by directed evolution for improved cftr delivery to human ciliated airway epithelium

  Molecular Therapy. 2009;17(12):2067-2077.
  30

• 59.

  2009

  Matthew L. Hirsch; Francesca Storici; Chengwen Li; Vivian W. Choi; R. Jude Samulski

  AAV recombineering with single strand oligonucleotides

  PLoS ONE. 2009;4(11).
  4

• 60.

  2009

  Karen M. Frank; D. Kyle Hogarth; Jonathan L. Miller; Saptarshi Mandal; Philip J. Mease; R. Jude Samulski; Glen A. Weisgerber; John Hart

  Investigation of the cause of death in a gene-therapy trial

  New England Journal of Medicine. 2009;361(2):161-169.
  34

• 61.

  2009

  D. Eugene Redmond Jr.; J.D. Elsworth; R.H. Roth; C. Leranth; T.J. Collier; B. Blanchard; K.B. Bjugstad; R.J. Samulski; P. Aebischer; et al.

  Embryonic substantia nigra grafts in the mesencephalon send neurites to the host striatum in non-human primate after overexpression of GDNF

  Journal of Comparative Neurology. 2009;515(1):31-40.
  14

• 62.

  2009

  Chengwen Li; Matt Hirsch; Nina DiPrimio; Aravind Asokan; Kevin Goudy; Roland Tisch; R. Jude Samulski

  Cytotoxic-T-lymphocyte-mediated elimination of target cells transduced with engineered adeno-associated virus type 2 vector in vivo

  Journal of Virology. 2009;83(13):6817-6824.
  13

• 63.

  2009

  Chengwen Li; Kevin Goudy; Matt Hirsch; Aravind Asokan; Yun Fan; Jeff Alexander; Junjiang Sun; Paul Monahan; David Seiber; et al.

  Cellular immune response to cryptic epitopes during therapeutic gene transfer

  Proceedings of the National Academy of Sciences of the United States of America. 2009;106(26):10770-10774.
  20

• 64.

  2009

  F. Curtis Hewitt; Chengwen Li; Steven J. Gray; Shelley Cockrell; Michael Washburn; R. Jude Samulski

  Reducing the risk of Adeno-Associated Virus (AAV) vector mobilization with AAV type 5 vectors

  Journal of Virology. 2009;83(8):3919-3929.
  6

• 65.

  2009

  Jarrod S. Johnson; R. Jude Samulski

  Enhancement of adeno-associated virus infection by mobilizing capsids into and out of the nucleolus

  Journal of Virology. 2009;83(6):2632-2644.
  39

• 66.

  2009

  S.W.J. McPhee; R.J. Samulski

  Gene therapy for cardiomyocytes, a heart beat away

  Gene Therapy. 2009;16(6):707-708.
  5

• 67.

  2009

  S.B. Foti; R.J. Samulski; T.J. McCown

  Delivering multiple gene products in the brain from a single adeno-associated virus vector

  Gene Therapy. 2009;16(11):1314-1319.
  4

• 68.

  2009

  C. Li; M. Hirsch; P. Carter; A. Asokan; X. Zhou; Z. Wu; R.J. Samulski

  A small regulatory element from chromosome 19 enhances liver-specific gene expression

  Gene Therapy. 2009;16(1):43-51.
  7

• 69.

  2008

  Junjiang Sun; Narine Hakobyan; Leonard A. Valentino; Brian L. Feldman; R. Jude Samulski; Paul E. Monahan

  Intraarticular factor IX protein or gene replacement protects against development of hemophilic synovitis in the absence of circulating factor IX

  Blood. 2008;112(12):4532-4541.
  21

• 70.

  2008

  Cemal Yazici; Laura Yanoso; Chao Xie; David G. Reynolds; R. Jude Samulski; Jade Samulski; Judith Yannariello-Brown; Arthur A. Gertzman; Xinping Zhang; et al.

  The effect of surface demineralization of cortical bone allograft on the properties of recombinant adeno-associated virus coatings

  Biomaterials. 2008;29(28):3882-3887.
  8

• 71.

  2008

  Wuping Li; Aravind Asokan; Zhijian Wu; Terry Van Dyke; Nina DiPrimio; Johnson S. Jarrod; Lakshmanan Govindaswamy; Mavis Agbandje-McKenna; Stefan Leichtle; Eugene D. Redmond Jr.; et al.

  Engineering and selection of shuffled AAV genomes: A new strategy for producing targeted biological nanoparticles

  Molecular Therapy. 2008;16(7):1252-1260.
  74

• 72.

  2008

  Steven J. Gray; R. Jude Samulski

  Optimizing gene delivery vectors for the treatment of heart disease

  Expert Opinion on Biological Therapy. 2008;8(7):911-922.
  30

• 73.

  2008

  Nina DiPrimio; Aravind Asokan; Lakshmanan Govindasamy; Mavis Agbandje-McKenna; R. Jude Samulski

  Surface loop dynamics in adeno-associated virus capsid assembly

  Journal of Virology. 2008;82(11):5178-5189.
  21

• 74.

  2008

  J.D. Elsworth; D.E. Redmond Jr.; C. Leranth; K.B. Bjugstad; J.R. Sladek Jr.; T.J. Collier; S.B. Foti; R.J. Samulski; K.P. Vives; R.H. Roth

  AAV2-mediated gene transfer of GDNF to the striatum of MPTP monkeys enhances the survival and outgrowth of co-implanted fetal dopamine neurons

  Experimental Neurology. 2008;211(1):252-258.
  12

• 75.

  2008

  Xiaohuai Zhou; Xinghua Zeng; Zhenghong Fan; Chengwen Li; Thomas McCown; R. Jude Samulski; Xiao Xiao

  Adeno-associated virus of a single-polarity DNA genome is capable of transduction in vivo

  Molecular Therapy. 2008;16(3):494-499.
  8

• 76.

  2008

  Li Zhong; Xiaohuai Zhou; Yanjun Li; Keyun Qing; Xiao Xiao; Richard Jude Samulski; Arun Srivastava

  Single-polarity recombinant adeno-associated virus 2 vector-mediated transgene expression In vitro and In vivo: Mechanism of transduction

  Molecular Therapy. 2008;16(2):290-295.
  15

• 77.

  2008

  Edmund R. Hollis II; Ken Kadoya; Matthew Hirsch; Richard J. Samulski; Mark H. Tuszynski

  Efficient retrograde neuronal transduction utilizing self-complementary AAV1

  Molecular Therapy. 2008;16(2):296-301.
  39

• 78.

  2008

  Zhijian Wu; Junjiang Sun; Taiping Zhang; Chaoying Yin; Fang Yin; Terry Van Dyke; Richard J. Samulski; Paul E. Monahan

  Optimization of self-complementary AAV vectors for liver-directed expression results in sustained correction of hemophilia B at low vector dose

  Molecular Therapy. 2008;16(2):280-289.
  52

• 79.

  2008

  Alexander R. Lyon; M. Sato; R.J. Hajjar; R.J. Samulski; S.E. Harding

  Gene therapy: Targeting the myocardium

  Heart. 2008;94(1):89-99.
  47

• 80.

  2008

  A. Asokan; J.S. Johnson; C. Li; R.J. Samulski

  Bioluminescent virion shells: New tools for quantitation of AAV vector dynamics in cells and live animals

  Gene Therapy. 2008;15(24):1618-1622.
  13

• 81.

  2007

  S. Foti; R.P. Haberman; R.J. Samulski; T.J. McCown

  Adeno-associated virus-mediated expression and constitutive secretion of NPY or NPY13-36 suppresses seizure activity in vivo

  Gene Therapy. 2007;14(21):1534-1536.
  32

• 82.

  2007

  Jinhui Wang; Jing Xie; Hui Lu; Lingxia Chen; Bernd Hauck; Richard Jude Samulski; Weidong Xiao

  Existence of transient functional double-stranded DNA intermediates during recombinant AAV transduction

  Proceedings of the National Academy of Sciences of the United States of America. 2007;104(32):13104-13109.
  33

• 83.

  2007

  Joshua C. Grieger; Jarrod S. Johnson; Brittney Gurda-Whitaker; Mavis Agbandje-McKenna; R. Jude Samulski

  Surface-exposed adeno-associated virus Vp1-NLS capsid fusion protein rescues infectivity of noninfectious wild-type Vp2/Vp3 and Vp3-only capsids but not that of fivefold pore mutant virions

  Journal of Virology. 2007;81(15):7833-7843.
  23

• 84.

  2007

  Katsutoshi Yokoi; Shu Kachi; H. Steve Zhang; Philip D. Gregory; S. Kaye Spratt; R. Jude Samulski; Peter A. Campochiaro

  Ocular gene transfer with self-complementary AAV vectors

  Investigative Ophthalmology and Visual Science. 2007;48(7):3324-3328.
  23

• 85.

  2007

  Chengwen Li; Matthew Hirsch; Aravind Asokan; Brian Zeithaml; Hong Ma; Tal Kafri; R. Jude Samulski

  Adeno-associated virus type 2 (AAV2) capsid-specific cytotoxic T lymphocytes eliminate only vector-transduced cells coexpressing the AAV2 capsid in vivo

  Journal of Virology. 2007;81(14):7540-7547.
  44

• 86.

  2007

  Benjamin W. Maynor; Isaac LaRue; Zhaokang Hu; Jason P. Rolland; Ashish Pandya; Qiang Fu; Jie Liu; Richard J. Spontak; Sergei S. Sheiko; Richard J. Samulski; et al.

  Supramolecular nanomimetics: Replication of micelles, viruses, and other naturally occurring nanoscale objects

  Small. 2007;3(5):845-849.
  30

• 87.

  2007

  Vivian W Choi; Aravind Asokan; Rebecca A Haberman; Richard Jude Samulski

  Production of recombinant adeno-associated viral vectors for in vitro and in vivo use.

  Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.]. 2007;Chapter 16:Unit 16.25.
  1

• 88.

  2007

  Vivian W Choi; Aravind Asokan; Rebecca A Haberman; Richard Jude Samulski

  Production of recombinant adeno-associated viral vectors.

  Current protocols in human genetics / editorial board, Jonathan L. Haines ... [et al.]. 2007;Chapter 12:Unit 12.9.
  0

• 89.

  2006

  Vivian W. Choi; Douglas M. McCarty; R. Jude Samulski

  Host cell DNA repair pathways in adeno-associated viral genome processing

  Journal of Virology. 2006;80(21):10346-10356.
  35

• 90.

  2006

  Zhijian Wu; Aravind Asokan; Joshua C. Grieger; Lakshmanan Govindasamy; Mavis Agbandje-McKenna; R. Jude Samulski

  Single amino acid changes can influence titer, heparin binding, and tissue tropism in different adeno-associated virus serotypes

  Journal of Virology. 2006;80(22):11393-11397.
  66

• 91.

  2006

  Zhijian Wu; Aravind Asokan; R. Jude Samulski

  Adeno-associated Virus Serotypes: Vector Toolkit for Human Gene Therapy

  Molecular Therapy. 2006;14(3):316-327.
  261

• 92.

  2006

  Aravind Asokan; Julie B. Hamra; Lakshmanan Govindasamy; Mavis Agbandje-McKenna; Richard J. Samulski

  Adeno-associated virus type 2 contains an integrin α5β1 binding domain essential for viral cell entry

  Journal of Virology. 2006;80(18):8961-8969.
  63

• 93.

  2006

  Zhijian Wu; Edward Miller; Mavis Agbandje-McKenna; Richard Jude Samulski

  α2,3 and α2,6 N-linked sialic acids facilitate efficient binding and transduction by adeno-associated virus types 1 and 6

  Journal of Virology. 2006;80(18):9093-9103.
  84

• 94.

  2006

  Joshua C. Grieger; Vivian W. Choi; R. Jude Samulski

  Production and characterization of adeno-associated viral vectors

  Nature Protocols. 2006;1(3):1412-1428.
  94

• 95.

  2006

  R.J. Hajjar; R.J. Samulski

  Heart failure: A silver bullet to treat heart failure

  Gene Therapy. 2006;13(13):997.
  6

• 96.

  2006

  R.M. Tjin Tham Sjin; J. Naspinski; A.E. Birsner; C. Li; R. Chan; K.-M. Lo; S. Gillies; D. Zurakowski; J. Folkman; J. Samulski; et al.

  Endostatin therapy reveals a U-shaped curve for antitumor activity

  Cancer Gene Therapy. 2006;13(6):619-627.
  30

• 97.

  2006

  Joshua C. Grieger; Stephen Snowdy; Richard J. Samulski

  Separate basic region motifs within the adeno-associated virus capsid proteins are essential for infectivity and assembly

  Journal of Virology. 2006;80(11):5199-5210.
  34

• 98.

  2006

  Teresa Borrás; Wei Xue; Vivian W. Choi; Jeffrey S. Bartlett; Guorong Li; Richard J. Samulski; Sarah S. Chisolm

  Mechanisms of AAV transduction in glaucoma-associated human trabecular meshwork cells

  Journal of Gene Medicine. 2006;8(5):589-602.
  16

• 99.

  2006

  S.W.J. McPhee; C.G. Janson; C. Li; R.J. Samulski; A.S. Camp; J. Francis; D. Shera; L. Lioutermann; M. Feely; A. Freese; et al.

  Immune responses to AAV in a phase I study for Canavan disease

  Journal of Gene Medicine. 2006;8(5):577-588.
  91

• 100.

  2006

  Vivian W Choi; Aravind Asokan; Rebecca A Haberman; Thomas J McCown; Richard Jude Samulski

  Production of recombinant adeno-associated viral vectors and use for in vitro and in vivo administration.

  Current protocols in neuroscience / editorial board, Jacqueline N. Crawley ... [et al.]. 2006;Chapter 4:Unit 4.17.
  0

• 101.

  2006

  Thorsten G. Lehmann; Tom Luedde; Robert F. Schwabe; Hartwig Bunzendahl; R. Jude Samulski; John J. Lemasters; David A. Brenner

  Minimizing oxidative stress by gene delivery of superoxide dismutase accelerates regeneration after transplantation of reduced-size livers in the rat

  Liver Transplantation. 2006;12(4):550-559.
  9

• 102.

  2006

  Aravind Asokan; R. Jude Samulski

  AAV does the shuffle

  Nature Biotechnology. 2006;24(2):158-160.
  4

• 103.

  2005

  Chengwen Li; Dawn E. Bowles; Terry Van Dyke; Richard Jude Samulski

  Adeno-associated virus vectors: Potential applications for cancer gene therapy

  Cancer Gene Therapy. 2005;12(12):913-925.
  66

• 104.

  2005

  Joshua C. Grieger; Richard J. Samulski

  Adeno-associated virus as a gene therapy vector: Vector development, production and clinical applications

  Advances in Biochemical Engineering/Biotechnology. 2005;99:119-145.
  61

• 105.

  2005

  Ulrich.T. Hacker; Lisa Wingenfeld; David M. Kofler; Natascha K. Schuhmann; Sandra Lutz; Tobias Herold; Susan B.S. King; Franz M. Gerner; Luca Perabo; et al.

  Adeno-associated virus serotypes 1 to 5 mediated tumor cell directed gene transfer and improvement of transduction efficiency

  Journal of Gene Medicine. 2005;7(11):1429-1438.
  29

• 106.

  2005

  Joshua C. Grieger; Richard J. Samulski

  Packaging capacity of adeno-associated virus serotypes: Impact of larger genomes on infectivity and postentry steps

  Journal of Virology. 2005;79(15):9933-9944.
  74

• 107.

  2005

  Vivian W. Choi; R. Jude Samulski; Douglas M. McCarty

  Effects of adeno-associated virus DNA hairpin structure on recombination

  Journal of Virology. 2005;79(11):6801-6807.
  19

• 108.

  2005

  Vivian W. Choi; Douglas M. McCarty; R. Jude Samulski

  AAV hybrid serotypes: Improved vectors for gene delivery

  Current Gene Therapy. 2005;5(3):299-310.
  79

• 109.

  2005

  Aravind Asokan; Richard J. Samulski

  From crystal structure to clinic: Highlights of the Tenth International Parvovirus Workshop

  Molecular Therapy. 2005;11(5):656-660.
  1

• 110.

  2005

  Chengwen Li; R. Jude Samulski

  Serotype-specific replicating AAV helper constructs increase recombinant AAV type 2 vector production

  Virology. 2005;335(1):10-21.
  8

• 111.

  2005

  Dong Xu; Doug McCarty; Alda Fernandes; Michael Fisher; R.J. Samulski; R.L. Juliano

  Delivery of MDR1 small interfering RNA by self-complementary recombinant adeno-associated virus vector

  Molecular Therapy. 2005;11(4):523-530.
  60

• 112.

  2005

  A. Flierl; Y. Chen; P.E. Coskun; R.J. Samulski; D.C. Wallace

  Adeno-associated virus-mediated gene transfer of the heart/muscle adenine nucleotide translocator (ANT) in mouse

  Gene Therapy. 2005;12(7):570-578.
  18

• 113.

  2005

  Hiromu Ito; Mette Koefoed; Prarop Tiyapatanaputi; Kirill Gromov; J. Jeffrey Goater; Jonathan Carmouche; Xinping Zhang; Paul T. Rubery; Joseph Rabinowitz; et al.

  Remodeling of cortical bone allografts mediated by adherent rAAV-RANKL and VEGF gene therapy

  Nature Medicine. 2005;11(3):291-297.
  128

• 114.

  2005

  Sifeng Chen; Matthias Kapturczak; Scott A. Loiler; Sergei Zolotukhin; Olena Y. Glushakova; Kirsten M. Madsen; Richard J. Samulski; William W. Hauswirth; Martha Campbell-Thompson; et al.

  Efficient transduction of vascular endothelial cells with recombinant adeno-associated virus serotype 1 and 5 vectors

  Human Gene Therapy. 2005;16(2):235-247.
  38

• 115.

  2004

  Atsuko Negishi; Jinghua Chen; Douglas M. McCarty; R. Jude Samulski; Jian Liu; Richard Superfine

  Analysis of the interaction between adeno-associated virus and heparan sulfate using atomic force microscopy

  Glycobiology. 2004;14(11):969-977.
  15

• 116.

  2004

  Lingling Du; Masakuni Kido; Darwin V. Lee; Joseph E. Rabinowitz; R. Jude Samulski; Stuart W. Jamieson; Matthew D. Weitzman; Patricia A. Thistlethwaite

  Differential myocardial gene delivery by recombinant serotype-specific adeno-associated viral vectors

  Molecular Therapy. 2004;10(3):604-608.
  47

• 117.

  2004

  Joseph E. Rabinowitz; Dawn E. Bowles; Susan M. Faust; Julie G. Ledford; Scott E. Cunningham; R. Jude Samulski

  Cross-Dressing the Virion: The Transcapsidation of Adeno- Associated Virus Serotypes Functionally Defines Subgroups

  Journal of Virology. 2004;78(9):4421-4432.
  94

• 118.

  2004

  Pierre Chenuaud; Thibaut Larcher; Joseph E. Rabinowitz; Nathalie Provost; Yan Cherel; Nicole Casadevall; Richard J. Samulski; Philippe Moullier

  Autoimmune anemia in macaques following erythropoietin gene therapy

  Blood. 2004;103(9):3303-3304.
  77

• 119.

  2004

  Pierre Chenuaud; Thibaut Larcher; Joseph E. Rabinowitz; Nathalie Provost; Béatrice Joussemet; Hermann Bujard; Richard J.S. Samulski; David Favre; Philippe Moullier

  Optimal design of a single recombinant adeno-associated virus derived from serotypes 1 and 2 to achieve more tightly regulated transgene expression from nonhuman primate muscle

  Molecular Therapy. 2004;9(3):410-418.
  38

• 120.

  2004

  Jackie L. Stilwell; Richard Jude Samulski

  Role of viral vectors and virion shells in cellular gene expression

  Molecular Therapy. 2004;9(3):337-346.
  41

• 121.

  2004

  Nathan A. Allen; R. Jude Samulski

  The pros and cons of using the mechanism of AAV site-specific recombination in gene delivery

  Gene Therapy and Regulation. 2004;2(2):121-138.
  3

• 122.

  2004

  Douglas M. McCarty; Samuel M. Young Jr.; R. Jude Samulski

  Integration of adeno-associated virus (AAV) and recombinant AAV vectors

  Annual Review of Genetics. 2004;38:819-845.
  169

• 123.

  2003

  D.M. McCarty; H. Fu; P.E. Monahan; C.E. Toulson; P. Naik; R.J. Samulski

  Adeno-associated virus terminal repeat (TR) mutant generates self-complementary vectors to overcome the rate-limiting step to transduction in vivo

  Gene Therapy. 2003;10(26):2112-2118.
  188

• 124.

  2003

  Haiyan Fu; Joseph Muenzer; Richard J. Samulski; George Breese; Jerillyn Sifford; Xinhua Zeng; Douglas M. McCarty

  Self-complementary adeno-associated virus serotype 2 vector: Global distribution and broad dispersion of AAV-mediated transgene expression in mouse brain

  Molecular Therapy. 2003;8(6):911-917.
  75

• 125.

  2003

  Jackie L. Stilwell; Douglas M. McCarty; Atsuko Negishi; Richard Superfine; R. Jude Samulski

  Development and Characterization of Novel Empty Adenovirus Capsids and Their Impact on Cellular Gene Expression

  Journal of Virology. 2003;77(23):12881-12885.
  38

• 126.

  2003

  Michael D. Wheeler; Olivia M. Smutney; R. Jude Samulski

  Secretion of Extracellular Superoxide Dismutase From Muscle Transduced With Recombinant Adenovirus Inhibits the Growth of B16 Melanomas in Mice

  Molecular Cancer Research. 2003;1(12):871-881.
  27

• 127.

  2003

  Rebecca P. Haberman; R. Jude Samulski; Thomas J. McCown

  Attenuation of seizures and neuronal death by adeno-associated virus vector galanin expression and secretion

  Nature Medicine. 2003;9(8):1076-1080.
  97

• 128.

  2003

  Thorsten G. Lehmann; Michael D. Wheeler; Matthias Froh; Robert F. Schwabe; Hartwig Bunzendahl; R. Jude Samulski; John J. Lemasters; David A. Brenner; Ronald G. Thurman

  Effects of three superoxide dismutase genes delivered with an adenovirus on graft function after transplantation of fatty livers in the rat

  Transplantation. 2003;76(1):28-37.
  38

• 129.

  2003

  Michel Weber; Joseph Rabinowitz; Nathalie Provost; Hervé Conrath; Sébastien Folliot; Delphine Briot; Yan Chérel; Pierre Chenuaud; Jude Samulski; Philippe Moullier; et al.

  Recombinant adeno-associated virus serotype 4 mediates unique and exclusive long-term transduction of retinal pigmented epithelium in rat, dog, and nonhuman primate after subretinal delivery

  Molecular Therapy. 2003;7(6):774-781.
  97

• 130.

  2003

  Terry J. Amiss; Doug M. McCarty; Anna Skulimowski; R. Jude Samulski

  Identification and characterization of an adeno-associated virus integration site in CV-1 cells from the African green monkey

  Journal of Virology. 2003;77(3):1904-1915.
  11

• 131.

  2003

  Dawn E. Bowles; Joseph E. Rabinowitz; R. Jude Samulski

  Marker rescue of adeno-associated virus (AAV) capsid mutants: A novel approach for chimeric AAV production

  Journal of Virology. 2003;77(1):423-432.
  38

• 132.

  2003

  Jackie L. Stilwell; R. Jude Samulski

  Adeno-associated virus vectors for therapeutic gene transfer

  BioTechniques. 2003;34(1):148-159.
  33

• 133.

  2003

  Matthew D Weitzman; Samuel M Young Jr.; Toni Cathomen; Richard Jude Samulski

  Targeted integration by adeno-associated virus.

  Methods in molecular medicine. 2003;76:201-219.
  5

• 134.

  2002

  Karen McAllister; Peter Sazani; Mirielle Adam; Moo J. Cho; Michael Rubinstein; Richard Jude Samulski; Joseph M. DeSimone

  Polymeric nanogels produced via inverse microemulsion polymerization as potential gene and antisense delivery agents

  Journal of the American Chemical Society. 2002;124(51):15198-15207.
  118

• 135.

  2002

  Joseph E. Rabinowitz; R. Jude Samulski

  Crystal-clear view

  Gene Therapy. 2002;9(21):1413-1414.
  2

• 136.

  2002

  Rebecca P. Haberman; Hugh E. Criswell; Stephen Snowdy; Zhen Ming; George R. Breese; R.Jude Samulski; Thomas J. McCown

  Therapeutic liabilities of in vivo viral vector tropism: Adeno-associated virus vectors, NMDAR1 antisense, and focal seizure sensitivity

  Molecular Therapy. 2002;6(4):495-500.
  31

• 137.

  2002

  Joseph E. Rabinowitz; R.Jude Samulski

  The adeno-associated virus crystal: Impact inversely proportional to size

  Molecular Therapy. 2002;6(4):443-445.
  6

• 138.

  2002

  J.E. Rabinowitz; F. Rolling; C. Li; H. Conrath; W. Xiao; X. Xiao; R.J. Samulski

  Cross-packaging of a single adeno-associated virus (AAV) type 2 vector genome into multiple AAV serotypes enables transduction with broad specificity

  Journal of Virology. 2002;76(2):791-801.
  412

• 139.

  2002

  Haiyan Fu; Richard J. Samulski; Thomas J. McCown; Yoana J. Picornell; David Fletcher; Joseph Muenzer

  Neurological correction of lysosomal storage in a mucopolysaccharidosis IIIB mouse model by adeno-associated virus-mediated gene delivery

  Molecular Therapy. 2002;5(1):42-49.
  59

• 140.

  2002

  Joseph E. Rabinowitz; Jude Samulski

  Looking into the eclipse

  Molecular Therapy. 2002;5(3):215-216.
  0

• 141.

  2002

  Christopher Janson; Joan Rupin; Elizabeth Saslow; Olga Goldfarb; Michael Goldberg; Ghassem Larijani; William Sharrar; Larisa Liouterman; Angelique Camp; Edwin Kolodny; et al.

  Gene therapy of Canavan disease: AAV-2 vector for neurosurgical delivery of aspartoacylase gene (ASPA) to the human brain

  Human Gene Therapy. 2002;13(11):1391-1412.
  112

• 142.

  2001

  Michael D. Wheeler; Hiroshi Kono; Ming Yin; Mikio Nakagami; Takehiko Uesugi; Gavin E. Arteel; Erwin Gäbele; Ivan Rusyn; Shunhei Yamashina; Matthias Froh; et al.

  The role of kupffer cell oxidant production in early ethanol-induced liver disease

  Free Radical Biology and Medicine. 2001;31(12):1544-1549.
  118

• 143.

  2001

  Samuel M. Young Jr.; Richard Jude Samulski

  Adeno-associated virus (AAV) site-specific recombination does not require a Rep-dependent origin of replication within the AAV terminal repeat

  Proceedings of the National Academy of Sciences of the United States of America. 2001;98(24):13525-13530.
  48

• 144.

  2001

  Hengjun Chao; Paul E. Monahan; Yuanbo Liu; R.Jude Samulski; Christopher E. Walsh

  Sustained and complete phenotype correction of hemophilia B mice following intramuscular injection of AAV1 serotype vectors

  Molecular Therapy. 2001;4(3):217-222.
  93

• 145.

  2001

  D.M. McCarty; P.E. Monahan; R.J. Samulski

  Self-complementary recombinant adeno-associated virus (scAAV) vectors promote efficient transduction independently of DNA synthesis

  Gene Therapy. 2001;8(16):1248-1254.
  206

• 146.

  2001

  Michael D. Wheeler; Hiroshi Kono; Ming Yin; Ivan Rusyn; Matthias Froh; Henry D. Connor; Ronald P. Mason; R.J. Samulski; Ronald G. Thurman

  Delivery of the Cu/Zn-superoxide dismutase gene with adenovirus reduces early alcohol-induced liver injury in rats

  Gastroenterology. 2001;120(5):1241-1250.
  73

• 147.

  2001

  M. Yin; M.D. Wheeler; H.D. Connor; Z. Zhong; H. Bunzendahl; A. Dikalova; R.J. Samulski; R. Schoonhoven; R.P. Mason; J.A. Swenberg; et al.

  Cu/Zn-superoxide dismutase gene attenuates ischemia-reperfusion injury in the rat kidney

  Journal of the American Society of Nephrology. 2001;12(12):2691-2700.
  46

• 148.

  2001

  T.J. Amiss; R.J. Samulski

  Methods for adeno-associated virus-mediated gene transfer into muscle.

  Methods in molecular biology (Clifton, N.J.). 2001;175:455-469.
  6

• 149.

  2001

  Michael D. Wheeler; Michelle Katuna; Olivia M. Smutney; Matthias Froh; Anna Dikalova; Ronald P. Mason; Richard J. Samulski; Ronald G. Thurman

  Comparison of the effect of adenoviral delivery of three superoxide dismutase genes against hepatic ischemia-reperfusion injury

  Human Gene Therapy. 2001;12(18):2167-2177.
  48

• 150.

  2000

  Hengjun Chao; Yuanbo Liu; Joseph Rabinowitz; Chengwen Li; Richard Jude Samulski; Christopher E. Walsh

  Several log increase in therapeutic transgene delivery by distinct adeno-associated viral serotype vectors

  Molecular Therapy. 2000;2(6):619-623.
  247

• 151.

  2000

  P.J. Carter; R.J. Samulski

  Adeno-associated viral vectors as gene delivery vehicles.

  International journal of molecular medicine. 2000;6(1):17-27.
  94

• 152.

  2000

  R.J. Samulski

  Expanding the AAV package.

  Nature biotechnology. 2000;18(5):497-498.
  13

• 153.

  2000

  Thorsten G. Lehmann; Michael D. Wheeler; Robert Schoonhoven; Hartwig Bunzendahl; R.J. Samulski; Ronald G. Thurman

  Delivery of Cu/Zn-superoxide dismutase genes with a viral vector minimizes liver injury and improves survival after liver transplantation in the rat

  Transplantation. 2000;69(6):1051-1057.
  38

• 154.

  2000

  D.K. Gavin; Jr. Young S.M.; W. Xiao; B. Temple; C.R. Abernathy; D.J. Pereira; N. Muzyczka; R.J. Samulski

  Erratum: Charge-to-alanine mutagenesis of the adeno-associated virus type 2 Rep78/68 proteins yields temperature-sensitive and magnesium-dependent variants (Journal of Virology (1999) 73:11 (9433-9445))

  Journal of Virology. 2000;74(1):591.
  0

• 155.

  2000

  S.M. Young Jr.; W. Xiao; R.J. Samulski

  Site-specific targeting of DNA plasmids to chromosome 19 using AAV cis and trans sequences.

  Methods in molecular biology (Clifton, N.J.). 2000;133:111-126.
  8

• 156.

  2000

  Jeffrey S. Bartlett; Rose Wilcher; R. Jude Samulski

  Infectious entry pathway of adeno-associated virus and adeno-associated virus vectors

  Journal of Virology. 2000;74(6):2777-2785.
  245

• 157.

  2000

  Ryan Pruchnic; Baohong Cao; Zhuqing Qu Peterson; Xiao Xiao; Juan Li; Richard Jude Samulski; Mike Epperly; Johnny Huard

  The use of adeno-associated virus to circumvent the maturation-dependent viral transduction of muscle fibers

  Human Gene Therapy. 2000;11(4):521-536.
  65

• 158.

  2000

  Ajay K. Malik; Paul E. Monahan; David L. Allen; Bing-Guan Chen; R. Jude Samulski; Kotoku Kurachi

  Kinetics of recombinant adeno-associated virus-mediated gene transfer

  Journal of Virology. 2000;74(8):3555-3565.
  32

• 159.

  2000

  Joseph E. Rabinowitz; R.Jude Samulski

  Building a better vector: The manipulation of AAV virions

  Virology. 2000;278(2):301-308.
  71

• 160.

  2000

  Thorsten G. Lehmann; Michael D. Wheeler; Robert F. Schwabe; Henry D. Connor; Robert Schoonhoven; Hartwig Bunzendahl; David A. Brenner; R.Jude Samulski; Zhi Zhong; et al.

  Gene delivery of Cu/Zn-superoxide dismutase improves graft function after transplantation of fatty livers in the rat

  Hepatology. 2000;32(6):1255-1264.
  55

• 161.

  2000

  Paul E. Monahan; R.Jude Samulski

  Adeno-associated virus vectors for gene therapy: More pros than cons?

  Molecular Medicine Today. 2000;6(11):433-440.
  155

• 162.

  2000

  Michael D. Wheeler; Hiroshi Kono; Ivan Rusyn; Gavin E. Arteel; Douglas McCarty; Richard Jude Samulski; Ronald G. Thurman

  Chronic ethanol increases adeno-associated viral transgene expression in rat liver via oxidant and NFκB-dependent mechanisms

  Hepatology. 2000;32(5):1050-1059.
  22

• 163.

  2000

  R.P. Haberman; T.J. McCown; R.J. Samulski

  Novel transcriptional regulatory signals in the adeno-associated virus terminal repeat A/D junction element

  Journal of Virology. 2000;74(18):8732-8739.
  53

• 164.

  2000

  P.E. Monahan; R.J. Samulski

  AAV vectors: Is clinical success on the horizon?

  Gene Therapy. 2000;7(1):24-30.
  227

• 165.

  2000

  Samuel M. Young Jr.; Douglas M. Mccarty; Natalya Degtyareva; Richard Jude Samulski

  Roles of adeno-associated virus Rep protein and human chromosome 19 in site-specific recombination

  Journal of Virology. 2000;74(9):3953-3966.
  81

• 166.

  1999

  Joseph E. Rabinowitz; Weidong Xiao; R. Jude Samulski

  Insertional mutagenesis of AAV2 capsid and the production of recombinant virus

  Virology. 1999;265(2):274-285.
  81

• 167.

  1999

  H. Chao; R.J. Samulski; D.A. Bellinger; P.E. Monahan; T.C. Nichols; C.E. Walsh

  Persistent expression of canine factor IX in hemophilia B canines

  Gene Therapy. 1999;6(10):1695-1704.
  76

• 168.

  1999

  D. Grimm; A. Kern; M. Pawlita; F.K Ferrari; R.J. Samulski; J.A. Kleinschmidt

  Titration of AAV-2 particles via a novel capsid ELISA: Packaging of genomes can limit production of recombinant AAV-2

  Gene Therapy. 1999;6(7):1322-1330.
  89

• 169.

  1999

  S. Zolotukhin; B.J. Byrne; E. Mason; I. Zolotukhin; M. Potter; K. Chesnut; C. Summerford; R.J. Samulski; N. Muzyczka

  Recombinant adeno-associated virus purification using novel methods improves infectious titer and yield

  Gene Therapy. 1999;6(6):973-985.
  577

• 170.

  1999

  Candace Summerford; Richard Jude Samulski

  Viral receptors and vector purification: New approaches for generating clinical-grade reagents

  Nature Medicine. 1999;5(5):587-58.
  41

• 171.

  1999

  Jeffrey S. Bartlett; Jurgen Kleinschmidt; Richard C. Boucher; R. Jude Samulski

  Targeted adeno-associated virus vector transduction of nonpermissive cells mediated by a bispecific f(ab'γ)₂ antibody

  Nature Biotechnology. 1999;17(2):181-186.
  134

• 172.

  1999

  Candace Summerford; Jeffrey S. Bartlett; Richard Jude Samulski

  αVβ5 integrin: A co-receptor for adeno-associated virus type 2 infection

  Nature Medicine. 1999;5(1):78-82.
  443

• 173.

  1999

  Denise K. Gavin; Samuel M. Young Jr.; Weidong Xiao; Brenda Temple; Corinne R. Abernathy; Daniel J. Pereira; Nicholas Muzyczka; Richard Jude Samulski

  Charge-to-alanine mutagenesis of the adeno-associated virus type 2 Rep78/68 proteins yields temperature-sensitive and magnesium-dependent variants

  Journal of Virology. 1999;73(11):9433-9445.
  7

• 174.

  1999

  J.S. Bartlett; J. Kleinschmidt; R.C. Boucher; R.J. Samulski

  Erratum: Targeted adeno-associated virus vector transduction of nonpermissive cells mediated cells by a bispecific F(ab'γ)₂ antibody (Nature Biotechnology (1999))

  Nature Biotechnology. 1999;17(4):393.
  1

• 175.

  1999

  J. Qiu; H. Mizukami; K.E. Brown; K. Qing; J. Hansen; A. Srivastava; R.J. Samulski; J.S. Bartlett; C. Summerford

  Adeno-associated virus 2 co-receptors? [2] (multiple letters)

  Nature Medicine. 1999;5(5):467-468.
  19

• 176.

  1998

  S. Teramoto; J.S. Bartlett; D. Mccarty; X. Xiao; R.J. Samulski; R.C. Boucher

  Factors influencing adeno-associated virus-mediated gene transfer to human cystic fibrosis airway epithelial cells: Comparison with adenovirus vectors

  Journal of Virology. 1998;72(11):8904-8912.
  62

• 177.

  1998

  Joseph E Rabinowitz; Jude Samulski

  Adeno-associated virus expression systems for gene transfer

  Current Opinion in Biotechnology. 1998;9(5):470-475.
  109

• 178.

  1998

  Jeffrey S. Bartlett; R. Jude Samulski; Thomas J. McCown

  Selective and rapid uptake of adeno-associated virus type 2 in brain

  Human Gene Therapy. 1998;9(8):1181-1186.
  165

• 179.

  1998

  Jeffrey S. Bartlett; R. Jude Samulski

  Fluorescent viral vectors: A new technique for the pharmacological analysis of gene therapy

  Nature Medicine. 1998;4(5):635-637.
  20

• 180.

  1998

  Xiao Xiao; L.I. Juan; Richard Jude Samulski

  Production of high-titer recombinant adeno-associated virus vectors in the absence of helper adenovirus

  Journal of Virology. 1998;72(3):2224-2232.
  707

• 181.

  1998

  Candace Summerford; Richard Jude Samulski

  Membrane-associated heparan sulfate proteoglycan is a receptor for adeno-associated virus type 2 virions

  Journal of Virology. 1998;72(2):1438-1445.
  746

• 182.

  1998

  P.E. Monahan; R.J. Samulski; J. Tazelaar; X. Xiao; T.C. Nichols; D.A. Bellinger; M.S. Read; C.E. Walsh

  Direct intramuscular injection with recombinant AAV vectors results in sustained expression in a dog model of hemophilia

  Gene Therapy. 1998;5(1):40-49.
  147

• 183.

  1998

  R.P. Haberman; T.J. McCown; R.J. Samulski

  Inducible long-term gene expression in brain with adeno-associated virus gene transfer

  Gene Therapy. 1998;5(12):1604-1611.
  68

• 184.

  1998

  M.J. During; R.J. Samulski; J.D. Elsworth; M.G. Kaplitt; P. Leone; X. Xiao; J. Li; A. Freese; J.R. Taylor; R.H. Roth; et al.

  In vivo expression of therapeutic human genes for dopamine production in the caudates of MPTP-treated monkeys using an AAV vector

  Gene Therapy. 1998;5(6):820-827.
  118

• 185.

  1998

  C. Summerford; R.J. Samulski

  Adeno-associated viral vectors for gene therapy

  Biogenic Amines. 1998;14(5):451-475.
  1

• 186.

  1997

  C.C. Yang; X. Xiao; X. Zhu; D.C. Ansardi; N.D. Epstein; M.R. Frey; A.G. Matera; R.J. Samulski

  Cellular recombination pathways and viral terminal repeat hairpin structures are sufficient for adeno-associated virus integration in vivo and in vitro

  Journal of Virology. 1997;71(12):9231-9247.
  111

• 187.

  1997

  F.K. Ferrari; X. Xiao; D. McCarty; R.J. Samulski

  New developments in the generation of Ad-free, high-titer rAAV gene therapy vectors.

  Nature medicine. 1997;3(11):1295-1297.
  74

• 188.

  1997

  Stuart D. Keir; Jeffrey Miller; Gang Yu; Rebecca Hamilton; Richard J. Samulski; Xiao Xiao; Carlo Tornatore

  Efficient gene transfer into primary and immortalized human fetal glial cells using adeno-associated virus vectors: Establishment of a glial cell line with a functional CD4 receptor

  Journal of NeuroVirology. 1997;3(5):322-330.
  19

• 189.

  1997

  Juan Li; Richard Jude Samulski; Xiao Xiao

  Role for highly regulated rep gene expression in adeno-associated virus vector production

  Journal of Virology. 1997;71(7):5236-5243.
  131

• 190.

  1997

  Xiao Xiao; Thomas J. McCown; Juan Li; George R. Breese; A. Leslie Morrow; R. Jude Samulski

  Adeno-associated virus (AAV) vector antisense gene transfer in vivo decreases GABA(A) α₁ containing receptors and increases inferior collicular seizure sensitivity

  Brain Research. 1997;756(1-2):76-83.
  55

• 191.

  1997

  Xiao Xiao; Juan Li; Thomas J. McCown; R. Jude Samulski

  Gene transfer by adeno-associated virus vectors into the central nervous system

  Experimental Neurology. 1997;144(1):113-124.
  138

• 192.

  1997

  Xiao Xiao; Weidong Xiao; Juan Li; R. Jude Samulski

  A novel 165-base-pair terminal repeat sequence is the sole cis requirement for the adeno-associated virus life cycle

  Journal of Virology. 1997;71(2):941-948.
  81

• 193.

  1997

  R.J. Samulski; M.J. During; M.G. Kaplitt; X. Xiao; G. Redman; T. McCown

  Adeno-associated virus vectors yield long-term expression and delivery of potentially therapeutic genes into non-dividing neuronal cells

  Journal of NeuroVirology. 1997;3(SUPPL. 1):S72.
  3

• 194.

  1996

  Michael G. Kaplitt; Xiao Xiao; Richard J. Samulski; Juan Li; Kaie Ojamaa; Irwin L. Klein; Hideo Makimura; Martin J. Kaplitt; Robert K. Strumpf; Edward B. Diethrich

  Long-term gene transfer in porcine myocardium after coronary infusion of an adeno-associated virus vector

  Annals of Thoracic Surgery. 1996;62(6):1669-1676.
  77

• 195.

  1996

  Xiao Xiao; Juan Li; Richard Jude Samulski

  Efficient long-term gene transfer into muscle tissue of immunocompetent mice by adeno-associated virus vector

  Journal of Virology. 1996;70(11):8098-8108.
  620

• 196.

  1996

  Gail Ross; Robert Erickson; Debra Knorr; Arno G. Motulsky; Robertson Parkman; Jude Samulski; Stephen E. Straus; Brian R. Smith

  Gene therapy in the United States: A five-year status report

  Human Gene Therapy. 1996;7(14):1781-1790.
  99

• 197.

  1996

  Jeffrey S. Bartlett; Manjiri Sethna; Lakshman Ramamurthy; Sally A. Gowen; R. Jude Samulski; William F. Marzluff

  Efficient expression of protein coding genes from the murine U1 small nuclear RNA promoters

  Proceedings of the National Academy of Sciences of the United States of America. 1996;93(17):8852-8857.
  15

• 198.

  1996

  Catherine McKeon; Richard Jude Samulski

  NIDDK Workshop on AAV Vectors: Gene transfer into quiescent cells

  Human Gene Therapy. 1996;7(13):1615-1619.
  13

• 199.

  1996

  Thomas J. McCown; Xiao Xiao; Juan Li; George R. Breese; R. Jude Samulski

  Differential and persistent expression patterns of CNS gene transfer by an adeno-associated virus (AAV) vector

  Brain Research. 1996;713(1-2):99-107.
  294

• 200.

  1996

  D.M. McCarty; R.J. Samulski

  Adeno-associated virus vectors for gene transfer into erythroid cells

  Current Topics in Microbiology and Immunology. 1996;218:75-91.
  0

• 201.

  1996

  Forrest K. Ferrari; Thaddeus Samulski; Thomas Shenk; Richard Jude Samulski

  Second-strand synthesis is a rate-limiting step for efficient transduction by recombinant adeno-associated virus vectors

  Journal of Virology. 1996;70(5):3227-3234.
  435

• 202.

  1995

  Fabienne Rolling; Richard Jude Samulski

  AAV as a viral vector for human gene therapy - Generation of recombinant virus

  Molecular Biotechnology. 1995;3(1):9-15.
  39

• 203.

  1995

  J.L. Miller; R.E. Donahue; S.E. Sellers; J.L. Samulski; N.S. Young; A.W. Nienhuis

  Erratum: Recombinant adeno-associated virus (rAAV)-mediated expression of a human γ-globin gene in human progenitor-derived erythroid cells (Proceedings of the National Academy of Science of the United States of America (October 1, 1994) 91:21 (10183-10187))

  Proceedings of the National Academy of Sciences of the United States of America. 1995;92(2):645.
  0

• 204.

  1995

  L.B. Walters; N.A. Wivel; A.M. Capron; G.A. Chase; P.A. DeLeon; R.H. Doi; K.R. Dronamraju; R.P. Erickson; D. Ginsburg; A.S. Meyers; et al.

  Recombinant DNA Advisory Committee. Minutes of meeting September 12-13, 1994

  Human Gene Therapy. 1995;6(4):481-525.
  1

• 205.

  1995

  C.E. Brinckerhoff; A.M. Capron; G.A. Chase; P.A. DeLeon; R.H. Doi; R.P. Erickson; J.C. Glorioso; R. Haselkorn; A.S. Meyers; A.D. Miller; et al.

  Department of Health and Human Services, National Institutes of Health, Recombinant DNA Advisory Committee. Minutes of Meeting, December 1-2, 1994

  Human Gene Therapy. 1995;6(8):1065-1124.
  2

• 206.

  1995

  A.W. Skulimowski; R.J. Samulski

  [1] Adeno-associated virus: Integrating vectors for human gene therapy

  Methods in Molecular Genetics. 1995;7(C):3-12.
  5

• 207.

  1994

  Jeffery L. Miller; Robert E. Donahue; Stephanie E. Sellers; Richard Jude Samulski; Neal S. Young; Arthur W. Nienhuis

  Recombinant adeno-associated virus (rAAV)-mediated expression of a human γ-globin gene in human progenitor-derived erythroid cells

  Proceedings of the National Academy of Sciences of the United States of America. 1994;91(21):10183-10187.
  82

• 208.

  1994

  Christopher E. Walsh; Arthur W. Nienhuis; Richard Jude Samulski; Michael G. Brown; Jeffery L. Miller; Neal S. Young; Johnson M. Liu

  Phenotypic correction of Fanconi anemia in human hematopoietic cells with a recombinant adeno-associated virus vector

  Journal of Clinical Investigation. 1994;94(4):1440-1448.
  109

• 209.

  1994

  Michael G. Kaplitt; Paola Leone; Richard J. Samulski; Xiao Xiao; Donald W. Pfaff; Karen L. O'Malley; Matthew J. During

  Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brain

  Nature Genetics. 1994;8(2):148-154.
  718

• 210.

  1994

  Stacey Goodman; Xiao Xiao; Robert E. Donahue; Austine Moulton; Jeffrey Miller; Christopher Walsh; Neal S. Young; Richard J. Samulski; Arthur W. Nienhuis

  Recombinant adeno-associated virus-mediated gene transfer into hematopoietic progenitor cells

  Blood. 1994;84(5):1492-1500.
  123

• 211.

  1994

  Jing-Fang Wei; Fu-Sheng Wei; R. Jude Samulski; John A. Barranger

  Expression of the human glucocerebrosidase and arylsulfatase A genes in murine and patient primary fibroblasts transduced by an adeno-associated virus vector

  Gene Therapy. 1994;1(4):261-268.
  21

• 212.

  1993

  R.O. Snyder; D.-S. Im; T. Ni; X. Xiao; R.J. Samulski; N. Muzyczka

  Features of the adeno-associated virus origin involved in substrate recognition by the viral Rep protein

  Journal of Virology. 1993;67(10):6096-6104.
  80

• 213.

  1993

  J.L. Miller; C.E. Walsh; P.A. Ney; R.J. Samulski; A.W. Nienhuis

  Single-copy transduction and expression of human γ-globin in K562 erythroleukemia cells using recombinant adeno-associated virus vectors: The effect of mutations in NF-E2 and GATA-1 binding motifs within the hypersensitivity site 2 enhancer

  Blood. 1993;82(6):1900-1906.
  25

• 214.

  1993

  R.J. Samulski

  Adeno-associated virus: Integration at a specific chromosomal locus

  Current Opinion in Genetics and Development. 1993;3(1):74-80.
  94

• 215.

  1993

  C.E. Walsh; J.M. Liu; J.L. Miller; A.W. Nienhuis; R.J. Samulski

  Gene therapy for human hemoglobinopathies

  Proceedings of the Society for Experimental Biology and Medicine. 1993;204(3):289-300.
  21

• 216.

  1992

  C.E. Walsh; J.M. Liu; X. Xiao; N.S. Young; A.W. Nienhuis; R.J. Samulski

  Regulated high level expression of a human γ-globin gene introduced into erythroid cells by an adeno-associated virus vector

  Proceedings of the National Academy of Sciences of the United States of America. 1992;89(15):7257-7261.
  85

• 217.

  1992

  C.A. Muro-Cacho; R.J. Samulski; D. Kaplan

  Gene transfer in human lymphocytes using a vector based on adeno- associated virus

  Journal of Immunotherapy. 1992;11(4):231-237.
  26

• 218.

  1992

  R.J. Samulski; X. Zhu; X. Xiao; J.D. Brook; D.E. Housman; N. Epstein; L.A. Hunter

  Corrigendum: Targeted integration of adeno-associated virus (AAV) into human chromosome 19 (The EMBO Journal (1991) 10 (3941-3950))

  EMBO Journal. 1992;11(3):1228.
  2

• 219.

  1992

  L.A. Hunter; R.J. Samulski

  Colocalization of adeno-associated virus rep and capsid proteins in the nuclei of infected cells

  Journal of Virology. 1992;66(1):317-324.
  44

• 220.

  1991

  R.J. Samulski; X. Zhu; X. Xiao; J.D. Brook; D.E. Housman; N. Epstein; L.A. Hunter

  Targeted integration of adeno-associated virus (AAV) into human chromosome 19

  EMBO Journal. 1991;10(12):3941-3950.
  396

• 221.

  1990

  R.O. Snyder; R.J. Samulski; N. Muzyczka

  In vitro resolution of covalently joined AAV chromosome ends

  Cell. 1990;60(1):105-113.
  83

• 222.

  1990

  R.M. Kotin; M. Siniscalco; R.J. Samulski; X. Zhu; L. Hunter; C.A. Laughlin; S. McLaughlin; N. Muzyczka; M. Rocchi; K.I. Berns

  Site-specific integration by adeno-associated virus

  Proceedings of the National Academy of Sciences of the United States of America. 1990;87(6):2211-2215.
  484

• 223.

  1989

  R.J. Samulski; L.-S. Chang; T. Shenk

  Helper-free stocks of recombinant adeno-associated viruses: Normal integration does not require viral gene expression

  Journal of Virology. 1989;63(9):3822-3828.
  426

• 224.

  1989

  C.H. Srivastava; R.J. Samulski; L. Lu; S.H. Larsen; A. Srivastava

  Construction of a recombinant human parvovirus B19: Adeno-associated virus 2 (AAV) DNA inverted terminal repeats are functional in a AAV-B19 hybrid virus

  Proceedings of the National Academy of Sciences of the United States of America. 1989;86(20):8078-8082.
  24

• 225.

  1988

  R.J. Samulski; T. Shenk

  Adenovirus E1B 55-M(r) polypeptide facilitates timely cytoplasmic accumulation of adeno-associated virus mRNAs

  Journal of Virology. 1988;62(1):206-210.
  41

• 226.

  1987

  R.J. Samulski; L.-S. Chang; T. Shenk

  A recombinant plasmid from which an infectious adeno-associated virus genome can be excised in vitro and its use to study viral replication

  Journal of Virology. 1987;61(10):3096-3101.
  212

• 227.

  1987

  P. Hearing; R.J. Samulski; W.L. Wishart; T. Shenk

  Identification of a repeated sequence element required for efficient encapsidation of the adenovirus type 5 chromosome

  Journal of Virology. 1987;61(8):2555-2558.
  65

• 228.

  1984

  N. Muzyczka; R.J. Samulski; P. Hermonat; A. Srivastava; K.I. Berns

  The genetics of adeno-associated virus.

  Advances in Experimental Medicine and Biology. 1984;179:151-161.
  18

• 229.

  1983

  R.J. Samulski; A. Strivastava; K.I. Berns; N. Muzyczka

  Rescue of adeno-associated virus with recombinant plasmids: Gene correction within the terminal repeats of AAV

  Cell. 1983;33(1):135-143.
  96

• 230.

  1982

  R.J. Samulski; K.I. Berns; M. Tan; N. Muzyczka

  Cloning of adeno-associated virus into pBR322: Rescue of intact virus from the recombinant plasmid in human cells

  Proceedings of the National Academy of Sciences of the United States of America. 1982;79(6 I):2077-2081.
  160

• 231.

  1980

  G.K. McMaster; R.J. Samulski; J.L. Stein; G.S. Stein

  Rapid purification of covalently closed circular DNAs of bacterial plasmids and animal tumor viruses

  Analytical Biochemistry. 1980;109(1):47-54.
  1