Young E Whang

UNCCH, School of Medicine, Medicine

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Young E Whang

• Organizations
  University of North Carolina at Chapel Hill
  
  School of Medicine
  
  Medicine
  
  

Help us refine your profile

This is a list of publications by this researcher, listed chronologically starting with the most recent first. New publications appear in this list weekly. The source of publications and 'cited by' data for this application is Scopus.

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• 1.

  2013

  Sarah A. Gallagher; Angela B. Smith; Jonathan E. Matthews; Clarence W. Potter; Michael E. Woods; Mathew Raynor; Eric M. Wallen; W. Kimryn Rathmell; Young E. Whang; William Y. Kim; et al.

  Roadmap for the development of the University of North Carolina at Chapel Hill Genitourinary OncoLogy Database-UNC GOLD

  Urologic Oncology: Seminars and Original Investigations. 2013.
  0

• 2.

  2013

  Young E. Whang; Andrew J. Armstrong; W. Kimryn Rathmell; Paul A. Godley; William Y. Kim; Raj S. Pruthi; Eric M. Wallen; Jeffrey M. Crane; Dominic T. Moore; Gayle Grigson; et al.

  A phase II study of lapatinib, a dual EGFR and HER-2 tyrosine kinase inhibitor, in patients with castration-resistant prostate cancer

  Urologic Oncology: Seminars and Original Investigations. 2013;31(1):82-86.
  0

• 3.

  2012

  Gary Hudes; Scott T. Tagawa; Young E. Whang; Ming Qi; Xiang Qin; Thomas A. Puchalski; Manjula Reddy; Mark Cornfeld; Mario Eisenberger

  A phase 1 study of a chimeric monoclonal antibody against interleukin-6, siltuximab, combined with docetaxel in patients with metastatic castration-resistant prostate cancer

  Investigational New Drugs. 2012:1-8.
  2

• 4.

  2012

  Ronald C. Chen; Julian G. Rosenman; Leroy G. Hoffman; Wing-Keung Chiu; Andrew Z. Wang; Raj S. Pruthi; Eric M. Wallen; Jeffrey M. Crane; William Y. Kim; W. Kimryn Rathmell; et al.

  Phase I study of concurrent weekly docetaxel, high-dose intensity-modulated radiation therapy (IMRT) and androgen-deprivation therapy (ADT) for high-risk prostate cancer

  BJU International. 2012.
  0

• 5.

  2011

  William Y. Kim; Young E. Whang; Raj S. Pruthi; Maria Q. Baggstrom; W. Kimryn Rathmell; Julian G. Rosenman; Eric M. Wallen; Lav K. Goyal; Gayle Grigson; Catharine Watkins; et al.

  Neoadjuvant docetaxel/estramustine prior to radical prostatectomy or external beam radiotherapy in high risk localized prostate cancer: A phase II trial

  Urologic Oncology: Seminars and Original Investigations. 2011;29(6):608-613.
  2

• 6.

  2011

  Raj Kurpad; William Kim; W. Kim Rathmell; Paul Godley; Young Whang; Julia Fielding; LuAnn Smith; Ava Pettiford; Heather Schultz; Matthew Nielsen; et al.

  A multidisciplinary approach to the management of urologic malignancies: Does it influence diagnostic and treatment decisions?

  Urologic Oncology: Seminars and Original Investigations. 2011;29(4):378-382.
  2

• 7.

  2011

  Ryan S. Raddin; Christine M. Walko; Young E. Whang

  Response to degarelix after resistance to luteinizing hormone-releasing hormone agonist therapy for metastatic prostate cancer

  Anti-Cancer Drugs. 2011;22(3):299-302.
  2

• 8.

  2011

  Joel Picus; Susan Halabi; W. Kevin Kelly; Nicholas J. Vogelzang; Young E. Whang; Ellen B. Kaplan; Walter M. Stadler; Eric J. Small

  A phase 2 study of estramustine, docetaxel, and bevacizumab in men with castrate-resistant prostate cancer

  Cancer. 2011;117(3):526-533.
  33

• 9.

  2010

  Victoria L. Bae-Jump; Chunxiao Zhou; John F. Boggess; Young E. Whang; Lisa Barroilhet; Paola A. Gehrig

  Rapamycin inhibits cell proliferation in type i and type II endometrial carcinomas: A search for biomarkers of sensitivity to treatment

  Gynecologic Oncology. 2010;119(3):579-585.
  5

• 10.

  2010

  Raj S. Pruthi; Matthew Nielsen; Samuel Heathcote; Eric M. Wallen; W. Kim Rathmell; Paul Godley; Young Whang; Julia Fielding; Heather Schultz; Gayle Grigson; et al.

  A phase II trial of neoadjuvant erlotinib in patients with muscle-invasive bladder cancer undergoing radical cystectomy: Clinical and pathological results

  BJU International. 2010;106(3):349-356.
  23

• 11.

  2010

  Y. Liu; M. Karaca; Z. Zhang; D. Gioeli; H.S. Earp; Y.E. Whang

  Dasatinib inhibits site-specific tyrosine phosphorylation of androgen receptor by Ack1 and Src kinases

  Oncogene. 2010;29(22):3208-3216.
  11

• 12.

  2010

  C. Lance Cowey; Chirag Amin; Raj S. Pruthi; Eric M. Wallen; Matthew E. Nielsen; Gayle Grigson; Cathy Watkins; Keith V. Nance; Jeffrey Crane; Mark Jalkut; et al.

  Neoadjuvant clinical trial with sorafenib for patients with stage II or higher renal cell carcinoma

  Journal of Clinical Oncology. 2010;28(9):1502-1507.
  65

• 13.

  2007

  Nupam P. Mahajan; Yuanbo Liu; Samarpan Majumder; Maria R. Warren; Carol E. Parker; James L. Mohler; H. Shelton Earp; Young E. Whang

  Activated Cdc42-associated kinase Ack1 promotes prostate cancer progression via androgen receptor tyrosine phosphorylation

  Proceedings of the National Academy of Sciences of the United States of America. 2007;104(20):8438-8443.
  69

• 14.

  2006

  John F. Boggess; Chunxiao Zhou; Victoria L. Bae-Jump; Paola A. Gehrig; Young E. Whang

  Estrogen-receptor-dependent regulation of telomerase activity in human endometrial cancer cell lines

  Gynecologic Oncology. 2006;103(2):417-424.
  11

• 15.

  2006

  Chin-Hui Hsiang; Toshiyuki Tunoda; Young E. Whang; Darren R. Tyson; David K. Ornstein

  The impact of altered annexin I protein levels on apoptosis and signal transduction pathways in prostate cancer cells

  Prostate. 2006;66(13):1413-1424.
  29

• 16.

  2006

  Samarpan Majumder; Yuanbo Liu; O. Harris Ford III; James L. Mohler; Young E. Whang

  Involvement of arginine methyltransferase CARM1 in androgen receptor function and prostate cancer cell viability

  Prostate. 2006;66(12):1292-1301.
  63

• 17.

  2006

  Chunxiao Zhou; Victoria L. Bae-Jump; Young E. Whang; Paola A. Gehrig; John F. Boggess

  The PTEN tumor suppressor inhibits telomerase activity in endometrial cancer cells by decreasing hTERT mRNA levels

  Gynecologic Oncology. 2006;101(2):305-310.
  22

• 18.

  2006

  Victoria L. Bae-Jump; Chunxiao Zhou; Paola A. Gehrig; Young E. Whang; John F. Boggess

  Rapamycin inhibits hTERT telomerase mRNA expression, independent of cell cycle arrest

  Gynecologic Oncology. 2006;100(3):487-494.
  17

• 19.

  2005

  Nupam P. Mahajan; Young E. Whang; James L. Mohler; H. Shelton Earp

  Activated tyrosine kinase Ack1 promotes prostate tumorigenesis: Role of Ack1 in polyubiquitination of tumor suppressor Wwox

  Cancer Research. 2005;65(22):10514-10523.
  63

• 20.

  2005

  Weidong Wu; Robert A. Silbajoris; Young E. Whang; Lee M. Graves; Philip A. Bromberg; James M. Samet

  p38 and EGF receptor kinase-mediated activation of the phosphatidylinositol 3-kinase/Akt pathway is required for Zn²⁺-induced cyclooxygenase-2 expression

  American Journal of Physiology - Lung Cellular and Molecular Physiology. 2005;289(5 33-5):L883-L889.
  31

• 21.

  2005

  Yuanbo Liu; Samarpan Majumder; Wesley McCall; Carolyn I. Sartor; James L. Mohler; Christopher W. Gregory; H. Shelton Earp; Young E. Whang

  Inhibition of HER-2/neu kinase impairs androgen receptor recruitment to the androgen responsive enhancer

  Cancer Research. 2005;65(8):3404-3409.
  58

• 22.

  2005

  Christopher W. Gregory; Young E. Whang; Wesley McCall; Xiaoyin Fei; Yuanbo Liu; Liliana A. Ponguta; Frank S. French; Elizabeth M. Wilson; H. Shelton Earp III

  Heregulin-induced activation of HER2 and HER3 increases androgen receptor transactivation and CWR-R1 human recurrent prostate cancer cell growth

  Clinical Cancer Research. 2005;11(5):1704-1712.
  69

• 23.

  2004

  Young E Whang; Xiu-Juan Yuan; Yuanbo Liu; Samarpan Majumder; Terrence D Lewis

  Regulation of Sensitivity to TRAIL by the PTEN Tumor Suppressor

  Vitamins and Hormones. 2004;67:409-426.
  20

• 24.

  2003

  B. Nan; T. Snabboon; E. Unni; X.-J. Yuan; Y.E. Whang; M. Marcelli

  The PTEN tumor suppressor is a negative modulator of androgen receptor transcriptional activity

  Journal of Molecular Endocrinology. 2003;31(1):169-183.
  41

• 25.

  2003

  Chunxiao Zhou; Paola A Gehrig; Young E Whang; John F Boggess

  Rapamycin inhibits telomerase activity by decreasing the hTERT mRNA level in endometrial cancer cells.

  Molecular cancer therapeutics. 2003;2(8):789-795.
  40

• 26.

  2003

  Weidong Wu; Xinchao Wang; Wenli Zhang; William Reed; James M. Samet; Young E. Whang; Andrew J. Ghio

  Zinc-induced PTEN protein degradation through the proteasome pathway in human airway epithelial cells

  Journal of Biological Chemistry. 2003;278(30):28258-28263.
  76

• 27.

  2003

  Young E. Whang; Paul A. Godley

  Renal cell carcinoma

  Current Opinion in Oncology. 2003;15(3):213-216.
  20

• 28.

  2003

  Benjamin F. Calvo; Aaron M. Levine; Mavie Marcos; Qu F. Collins; Mary V. Iacocca; Laura S. Caskey; Christopher W. Gregory; Yuhua Lin; Young E. Whang; H. Shelton Earp; et al.

  Human epidermal receptor-2 expression in prostate cancer

  Clinical Cancer Research. 2003;9(3):1087-1097.
  41

• 29.

  2002

  Marty W. Mayo; Lee V. Madrid; Sandy D. Westerheide; David R. Jones; Xiu-Juan Yuan; Albert S. Baldwin; Young E. Whang

  PTEN blocks tumor necrosis factor-induced NF-κB-dependent transcription by inhibiting the transactivation potential of the p65 subunit

  Journal of Biological Chemistry. 2002;277(13):11116-11125.
  84

• 30.

  2002

  Xiu-Juan Yuan; Young E. Whang

  PTEN sensitizes prostate cancer cells to death receptor-mediated and drug-induced apoptosis through a FADD-dependent pathway

  Oncogene. 2002;21(2):319-327.
  79

• 31.

  2002

  Eric L. Olson; Young E. Whang

  Hypertriglyceridemia and pancreatitis associated with estramustine phosphate

  American Journal of Clinical Oncology: Cancer Clinical Trials. 2002;25(4):342-343.
  3

• 32.

  2001

  S. Gupta; S. Stuffrein; R. Plattner; M. Tencati; C. Gray; Y.E. Whang; E.J. Stanbridge

  Role of phosphoinositide 3-kinase in the aggressive tumor growth of HT1080 human fibrosarcoma cells

  Molecular and Cellular Biology. 2001;21(17):5846-5856.
  16

• 33.

  2000

  Young E. Whang; Chris Tran; Cailin Henderson; Randi G. Syljuasen; Nora Rozengurt; William H. McBride; Charles L. Sawyers

  c-Abl is required for development and optimal cell proliferation in the context of p53 deficiency

  Proceedings of the National Academy of Sciences of the United States of America. 2000;97(10):5486-5491.
  18

• 34.

  2000

  S. Kharbanda; V. Kumar; S. Dhar; P. Pandey; C. Chen; P. Majumder; Z.-M. Yuan; Y. Whang; W. Strauss; T.K. Pandita; et al.

  Regulation of the hTERT telomerase catalytic subunit by the c-Abl tyrosine kinase

  Current Biology. 2000;10(10):568-575.
  94

• 35.

  2000

  Xinyi Wu; Karin Hepner; Shobha Castelino-Prabhu; Duc Do; Marc B. Kaye; Xiu-Juan Yuan; Jonathan Wood; Christopher Ross; Charles L. Sawyers; Young E. Whang

  Evidence for regulation of the PTEN tumor suppressor by a membrane- localized multi-PDZ domain containing scaffold protein MAGI-2

  Proceedings of the National Academy of Sciences of the United States of America. 2000;97(8):4233-4238.
  213

• 36.

  1999

  C. Henderson; Y. Whang; C. Tran; C. Chhor; C. Sawyers

  Genetic interactions between c-Abl and p53: The role of c-Abl in viability and cell growth

  Journal of Investigative Medicine. 1999;47(2):60A.
  0

• 37.

  1998

  Xinyi Wu; Kristen Senechal; Mehran S. Neshat; Young E. Whang; Charles L. Sawyers

  The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway

  Proceedings of the National Academy of Sciences of the United States of America. 1998;95(26):15587-15591.
  451

• 38.

  1998

  Y.E. Whang; X. Wu; C.L. Sawyers

  Identification of a pseudogene that can masquerade as a mutant allele of the PTEN/MMAC1 tumor suppressor gene

  Journal of the National Cancer Institute. 1998;90(11):859-861.
  16

• 39.

  1998

  Young E. Whang; Xinyi Wu; Hiroyoshi Suzuki; Robert E. Reiter; Chris Tran; Robert L. Vessella; Jonathan W. Said; William B. Isaacs; Charles L. Sawyers

  Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression

  Proceedings of the National Academy of Sciences of the United States of America. 1998;95(9):5246-5250.
  440

• 40.

  1998

  Surender Kharbanda; Pramod Pandey; Patricia L. Morris; Young Whang; Yuhui Xu; Satin Sawant; Li-Ji Zhu; Narender Kumar; Zhi-Min Yuan; Ralph Weichselbaum; et al.

  Functional role for the c-Abl tyrosine kinase in meiosis I

  Oncogene. 1998;16(14):1773-1777.
  30

• 41.

  1997

  Arthur B. Raitano; Young E. Whang; Charles L. Sawyers

  Signal transduction by wild-type and leukemogenic Abl proteins

  Biochimica et Biophysica Acta - Reviews on Cancer. 1997;1333(3):F201-F216.
  92

• 42.

  1996

  Z.-M. Yuan; Y. Huang; Y. Whang; C. Sawyers; R. Weichselbaum; S. Kharbanda; D. Kufe

  Role for c-Abl tyrosine kinase in growth arrest response to DNA damage

  Nature. 1996;382(6588):272-274.
  179