This is a chronological listing of grants held by this department, with the most recent listed first. New grants appear in this list weekly and contribute related to the department's Research Profile. The source of grants for this application comes directly from your institution.
p53-Dependent Responses to Toxicants in Parous and Nulliparous Breast
Melissa Troester6/1/2008 - 5/31/2011
|Sponsoring Organization:||University of Massachusetts|
|Awarding Organization Is:||University of North Carolina at Chapel Hill|
Melissa A Troester (Lead Principal Investigator)
This project investigates the hypothesis that responsiveness of the p53 pathway is enhanced in parous breast tissue, rendering the epithelium resistant to carcinogenic effects of environmental contaminants. Specific aims will define the interactions between environmental exposures and tissue responses in nulliparous and parous breast. Comparative studies in rodent models, human cell line models, and primary patient samples will be used to define molecular pathways of environmental susceptibility. Melissa Troester will facilite microarray processing, will oversee the microarray analysis for human explant tissue, cell lines, and mouse models. She will also oversee the comparative cross-species analyses. She will supervise one analyst whose primary responsibility will be data management, facilitating sample processing at UNC.