Scopus Publication Detail
The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in Scopus. This abstract is what is used to create the fingerprint of the publication.
Julia K.L. Walker; Alan M. Fong; Barbara L. Lawson; Jordan D. Savov; Dhavalkumar D. Patel; David A. Schwartz; Robert J. Lefkowitz (Profiled Authors: Robert J. Lefkowitz; Julia K.L. Walker; Dhavalkumar D Patel)
Journal of Clinical Investigation. 2003;112(4):566-574.Abstract
Asthma is a chronic inflammatory disorder of the airways that is coordinated by Th2 cells in both human asthmatics and animal models of allergic asthma. Migration of Th2 cells to the lung is key to their inflammatory function and is regulated in large part by chemokine receptors, members of the seven-membrane-spanning receptor family. It has been reported recently that T cells lacking β-arrestin-2, a G protein-coupled receptor regulatory protein, demonstrate impaired migration in vitro. Here we show that allergen-sensitized mice having a targeted deletion of the β-arrestin-2 gene do not accumulate T lymphocytes in their airways, nor do they demonstrate other physiological and inflammatory features characteristic of asthma. In contrast, the airway inflammatory response to LPS, an event not coordinated by Th2 cells, is fully functional in mice lacking β-arrestin-2. β-arrestin-2-deficient mice demonstrate OVA-specific IgE responses, but have defective macrophage-derived chemokine-mediated CD4+ T cell migration to the lung. This report provides the first evidence that β-arrestin-2 is required for the manifestation of allergic asthma. Because β-arrestin-2 regulates the development of allergic inflammation at a proximal step in the inflammatory cascade, novel therapies focused on this protein may prove useful in the treatment of asthma.
PMID: 12925697 PMCID: PMC171386
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
Samir N. P. Kelada; Mark S. Wilson; Urraca Tavarez; Kari Kubalanza; Bhavesh Borate; Greg S. Whitehead; Shuichiro Maruoka; Michelle G. Roy; Michelle Olive; Danielle E. Carpenter; et al.American Journal of Respiratory Cell and Molecular Biology. 2011;45(4):817-824.
Rahul Sharma; Poonam R. Sharma; Young-Chul Kim; Norbert Leitinger; Jae K. Lee; Shu Man Fu; Shyr-Te Ju
IL-2-controlled expression of multiple T cell trafficking genes and Th2 cytokines in the regulatory T cell-deficient scurfy mice: Implication to multiorgan inflammation and control of skin and lung inflammationJournal of Immunology. 2011;186(2):1268-1278.
Michael R. Van Scott; Jerry L. Hooker; David Ehrmann; Yoshimi Shibata; Cynthia Kukoly; Kenneth Salleng; Greg Westergaard; Anthony Sandrasagra; Jonathan NyceJournal of Applied Physiology. 2004;96(4):1433-1444.
Appears in this Document