Stacey Maurice Heath

DUKE, School of Medicine, Obstetrics and Gynecology, Harris & Smith OB-GYN

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Distribution of tin in brain subcellular fractions following the administration of trimethyl tin and triethyl tin to the rat

L.L. Cook; S.M. Heath; J.P. O'Callaghan (Profiled Authors: Larry Leon Cook; Stacey Maurice Heath)

Toxicology and Applied Pharmacology. 1984;73(3):564-568.

The time course of tin distribution in homogenates and subcellular fractions of rat brain was determined following the acute administration of trimethyl tin (TMT) and triethyl tin (TET) to the rat. Exposure to TMT resulted in lower concentrations but greater persistence of tin in subcellular fractions compared to exposure to TET. A delayed accumulation of tin in the mitochondrial fraction was observed following the administration of TMT but not TET. Analysis of total protein and mitochondrial markers did not reveal differences between the compositions of mitochondrial fractions prepared from control and TMT-treated subjects.

PMID: 6719471    

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