Barbara R Grubb

UNCCH, School of Medicine, Medicine

Scopus Publication Detail

The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in Scopus. This abstract is what is used to create the fingerprint of the publication.

Calcium exchange in isolated cutaneous epithelium of toad Bufo marinus.

B.R. Grubb; P.J. Bentley (Profiled Author: Barbara R Grubb)

The American journal of physiology. 1985;249(2 Pt 2):R172-178.

The Ca content of isolated cutaneous epithelium of toads (Bufo marinus) was 5 mmol/kg wet wt (compared with approximately 300 mmol/kg wet wt for intact skin), of which approximately 1.7 mM is not readily exchangeable with external 45Ca. After incubation in a solution containing 45Ca, loss of the accumulated isotope in an isotope-free medium is almost complete in 2 h. This efflux or washout is reduced by the presence of external Ca- and Na-free media and by La. Loss of Ca from the epithelium may thus reflect the presence of several mechanisms including a Ca-Ca exchange and a Ca-Na exchange. The effect of La (2 mM) was greater than that of a Na- and Ca-free medium, possibly reflecting the presence of an uncoupled Ca extrusion or extrusion by a Ca-ATPase (pump) mechanism. Drugs (ouabain and amiloride) that, respectively, increase or decrease levels of internal Na had no significant effects on efflux or accumulation of Ca. Vasopressin was also without such effects on Ca.

PMID: 3927750    

Scientific Context

This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.