Frederic J. Seidler

DUKE, School of Medicine, Pharmacology & Cancer Biology

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Non-neurogenic stimulation of adrenomedullary secretion during endotoxicosis in the one day old rat

F.J. Seidler; E. Mills (Profiled Author: Frederic J. Seidler)

Life Sciences. 1989;45(5):379-381.

In both newborn and twenty day old rats, bacterial (S. enteritidis) endotoxin caused a marked decrease in adrenal epinephrine and norepinephrine. Catecholamine release was prevented by ganglionic blockade in 20 day old, but not 1 day old animals, indicating that the release in the neonatal rat is 'non-neurogenic'. The amount released was physiologically significant: equivalent to 20 μg/kg by i.v. administration. Two possible mechanisms known to promote non-neurogenic secretion are hypoxia or histamine release, both of which can occur during endotoxicosis.

PMID: 2671564    

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