Frederic J. Seidler

DUKE, School of Medicine, Pharmacology & Cancer Biology

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Effect of transient hypoxia on oxygenation of the developing rat brain: Relationships among haemoglobin saturation, autoregulation of blood flow and mitochondrial redox state

A.L. Sylvia; F.J. Seidler; T.A. Slotkin (Profiled Authors: Frederic J. Seidler; Theodore Alan Slotkin)

Journal of Developmental Physiology. 1989;12(5):287-292.

Multi-wavelength, differential spectroscopy was used to examine the effects of transient hypoxia on oxygen delivery and intracellular utilization in the brain of developing rats. The in vivo redox status of cytochrome a,a3 was compared simultaneously with changes in relative haemoglobin saturation and blood volume in the cerebral cortex during lowered F(i)O2. During hypoxia, neonates maintained their intracellular cytochrome a,a3 redox state as well as did adults, but did so through unusual characteristics, including: (1) maintenance of haemoglobin oxygenaion at lower F(i)O2; (2) regulation of cerebral blood volume at blood pressures below the point at which autoregulation would fail in the adult; and (3) the capacity to tolerate a greater reduction of cytochrome a,a3 relative to haemoglobin desaturation at lowered F(i)O2. These data suggest that mechanisms which protect the neonate from hypoxic insult involve preservation of oxygen delivery, increased respiratory compensation for metabolic acidosis, and maintenance of cellular energy requirements predominantly through anaerobic metabolism.

PMID: 2634069    

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