William Elwood Garrett

DUKE, School of Medicine, Orthopaedics

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The role of mechanical loading in the onset and progression of osteoarthritis

Timothy M. Griffin; Farshid Guilak (Profiled Author: Farshid Guilak)

Exercise and Sport Sciences Reviews. 2005;33(4):195-200.

Osteoarthritis is a progressive joint disease characterised by an imbalance of articular cartilage biosynthesis and degradation attributed to both inflammatory and biomechanical factors. Whereas moderate mechanical loading appears necessary for maintaining healthy cartilage, abnormal joint loading increases the risk of osteoarthritis. Obesity-induced osteoarthritis and the benefits of physical activity may be mediated by systemic levels of proinflammatory mediators as well as local biomechanical factors in the joint. Copyright © 2005 by the American College of Sports Medicine.

PMID: 16239837    

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