Barbara R Grubb

UNCCH, School of Medicine, Medicine

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Effect of in vivo corticosteroids on Na⁺ transport across airway epithelia

B.R. Grubb; R.C. Boucher (Profiled Authors: Barbara R Grubb; Richard C Boucher)

American Journal of Physiology - Cell Physiology. 1998;275(1 44-1):C303-C308.

We have investigated the role in vivo of mineralocorticoid and glucocorticoid hormones in regulating the rate of electrogenic amiloride- sensitive Na⁺ absorption across murine airway tissue studied in vivo (nasal potential difference) and in vitro (Ussing chambers). We found that elevating the plasma aldosterone concentration 10-fold (low-Na⁺ diet) had no significant effect on amiloride-sensitive Na⁺ absorption across tracheal or nasal epithelia. High doses of dexamethasone for I wk likewise did not change the rate of amiloride-sensitive Na⁺ absorption across airway epithelia. In contrast, both hormonal manipulations elevated the rate of colonic Na⁺ absorption. Furthermore, adrenalectomy (both normal and cystic fibrosis mice) also failed to alter Na⁺ absorption across airway epithelia. We conclude that, in vivo, neither the mineralocorticoid nor the glucocorticoid hormones significantly regulate the rates of amiloride-sensitive electrogenic Na⁺ absorption across airway epithelia in the adult mouse.

PMID: 9688862    

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