Kenneth F Bastow

UNCCH, Eshelman School of Pharmacy, Pharmacy

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Filiasparosides A-D, cytotoxic steroidal saponins from the roots of Asparagus filicinus

Li-Bo Zhou; Tzu-Hsuan Chen; Kenneth F. Bastow; Makio Shibano; Kuo-Hsiung Lee; Dao-Feng Chen (Profiled Authors: Kenneth F Bastow; Kuo-Hsiung Lee)

Journal of Natural Products. 2007;70(8):1263-1267.

Four new steroidal saponins, filiasparosides A-D (1-4), together with known aspafiliosides A (5) and B (6) were isolated from the roots of Asparagus filicinus. The structures of these new compounds were elucidated by detailed spectroscopic study and chemical analysis. Compounds 1-6 were cytotoxic against human lung carcinoma (A549) and breast adenocarcinoma (MCF-7) tumor cell lines with EC 50 values of 2.3-16.8 μg/mL. Compound 3 showed the most potent cytotoxicity, with EC 50 values of 2.3 and 3.0 μg/mL toward A549 and MCF-7 cell lines, respectively. © 2007 American Chemical Society and American Society of Pharmacognosy.

PMID: 17629328    

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