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Synthesis and bioactivity of 4,10-dimethyl-pyridino[2,3-h]quinolin-2(1H)-one-9-carboxylic acid and its esters
Qian Zhang; Ying Chen; Yun Qing Zheng; Peng Xia; Yi Xia; Zheng Yu Yang; Kenneth F. Bastow; Susan L. Morris-Natschke; Kuo-Hsiung Lee (Profiled Authors: Susan L Morris-Natschke; Kenneth F Bastow; Kuo-Hsiung Lee)
Bioorganic and Medicinal Chemistry. 2003;11(6):1031-1034.Abstract
4,10-Dimethyl-pyridino[2,3-h]quinolin-2(1H)-one-9-carboxylic acid (1) was synthesized by a new approach via the key intermediate 7-[1-aza-2-(dimethylamino)vinyl]-4-methylquinolin-2(1H)-one (4). Compound 1 and its esters were evaluated in cytotoxicity and anti_HIV assays. The 9-carboxyl (1s)-endo-(-)-borneol ester (9) showed marginal cytotoxic activity in CAK1-1, HOS, KB, and HCT-8 cells. © 2003 Elsevier Science Ltd. All rights reserved.
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