Jacqueline L Johnson

UNCCH, School of Medicine, Psychiatry

Scopus Publication Detail

The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in Scopus. This abstract is what is used to create the fingerprint of the publication.

Genomewide association for schizophrenia in the CATIE study: Results of stage 1

P.F. Sullivan; D. Lin; J.-Y. Tzeng; E. Van Den Oord; D. Perkins; T.S. Stroup; M. Wagner; S. Lee; F.A. Wright; F. Zou; et al. (Profiled Authors: Jung-Ying Tzeng; Diana O Perkins; Danyu Lin; Fei Zou; Fred A Wright; Patrick F Sullivan; Thomas S Stroup)

Molecular Psychiatry. 2008;13(6):570-584.

Little is known for certain about the genetics of schizophrenia. The advent of genomewide association has been widely anticipated as a promising means to identify reproducible DNA sequence variation associated with this important and debilitating disorder. A total of 738 cases with DSM-IV schizophrenia (all participants in the CATIE study) and 733 group-matched controls were genotyped for 492 900 single-nucleotide polymorphisms (SNPs) using the Affymetrix 500K two-chip genotyping platform plus a custom 164K fill-in chip. Following multiple quality control steps for both subjects and SNPs, logistic regression analyses were used to assess the evidence for association of all SNPs with schizophrenia. We identified a number of promising SNPs for follow-up studies, although no SNP or multimarker combination of SNPs achieved genomewide statistical significance. Although a few signals coincided with genomic regions previously implicated in schizophrenia, chance could not be excluded. These data do not provide evidence for the involvement of any genomic region with schizophrenia detectable with moderate sample size. However, a planned genomewide association study for response phenotypes and inclusion of individual phenotype and genotype data from this study in meta-analyses hold promise for eventual identification of susceptibility and protective variants. © 2008 Nature Publishing Group All rights reserved.

PMID: 18347602    

Scientific Context

This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.