Kenneth F Bastow

UNCCH, Eshelman School of Pharmacy, Pharmacy

Scopus Publication Detail

The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in Scopus. This abstract is what is used to create the fingerprint of the publication.

Antitumor agents. 271: Total synthesis and evaluation of brazilein and analogs as anti-inflammatory and cytotoxic agents

Chiao-Ting Yen; Kyoko Nakagawa-Goto; Tsong-Long Hwang; Pei-Chi Wu; Susan L. Morris-Natschke; Wan-Chun Lai; Kenneth F. Bastow; Fang-Rong Chang; Yang-Chang Wu; Kuo-Hsiung Lee (Profiled Authors: Susan L Morris-Natschke; Kenneth F Bastow; Kuo-Hsiung Lee; Kyoko Nakagawa-Goto)

Bioorganic and Medicinal Chemistry Letters. 2010;20(3):1037-1039.

The first total synthesis of the naturally occurring tetracyclic homoisoflavonoid brazilein (1) and 14 new analogs (1a-n) is reported. Target compounds and intermediates were assayed for anti-inflammatory effects on superoxide anion generation and elastase release by human neutrophils in response to fMLP/CB, and for cytotoxic activity against nasopharyngeal (KB), vincristine-resistant nasopharyngeal (KBvin), lung (A549) and prostate (DU-145) human cancer cell lines. The most active compound 1b showed potent effects on superoxide anion generation and elastase release with IC50 values of 1.2 and 1.9 μM, respectively, and was 65 times more potent than phenylmethylsulfonyl fluoride (PMSF), the positive control, in the latter assay. Additionally, 1b exhibited broad spectrum in vitro anticancer activity with IC50 values of 6-11 μM against the four tested cancer cell lines. © 2009 Elsevier Ltd. All rights reserved.

PMID: 20036537     PMCID: PMC2831747

Scientific Context

This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.