Jamie C DeWitt

ECU, Brody School of Medicine, Pharmacology

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Developmental immunotoxicity (DIT): the why, when, and how of DIT testing.

Rodney R Dietert; Jamie Dewitt (Profiled Author: Jamie C DeWitt)

Methods in molecular biology (Clifton, N.J.). 2010;598:17-25.

Developmental immunotoxicity (DIT) has emerged as a serious health consideration given the increases in the prevalence of many immune-based childhood diseases and conditions, including allergic diseases and asthma, recurrent otitis media, pediatric celiac disease, and type 1 diabetes. As a result, the use of DIT testing to identify potential environmental risk factors contributing to these and other diseases has become a higher priority. This introductory chapter considers: (1) the basis for an increased and earlier use of DIT testing in safety evaluations and (2) the general features of DIT testing strategies designed to reduce health risks.

PMID: 19967503    

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