Scopus Publication Detail
The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in Scopus. This abstract is what is used to create the fingerprint of the publication.
An automated method for nonparametric kinetic analysis of clinical DCE-MRI data: Application to glioblastoma treated with bevacizumab
Gregory Z. Ferl; Lu Xu; Michel Friesenhahn; Lisa J. Bernstein; Daniel P. Barboriak; Ruediger E. Port (Profiled Author: Daniel P. Barboriak)
Magnetic Resonance in Medicine. 2010;63(5):1366-1375.Abstract
Here, we describe an automated nonparametric method for evaluating gadolinium-diethylene triamine pentaacetic acid (Gd-DTPA) kinetics, based on dynamic contrast-enhanced-MRI scans of glioblastoma patients taken before and after treatment with bevacizumab; no specific model or equation structure is assumed or used. Tumor and venous blood concentration-time profiles are smoothed, using a robust algorithm that removes artifacts due to patient motion, and then deconvolved, yielding an impulse response function. In addition to smoothing, robustness of the deconvolution operation is assured by excluding data that occur prior to the plasma peak; an exhaustive analysis was performed to demonstrate that exclusion of the prepeak plasma data does not significantly affect results. All analysis steps are executed by a single R script that requires blood and tumor curves as the sole input. Statistical moment analysis of the Impulse response function yields the area under the curve (AUC) and mean residence time (MRT). Comparison of deconvolution results to fitted Tofts model parameters suggests that AUC/MRT and AUC of the Impulse response function closely approximate fractional clearance from plasma to tissue (K
trans) and fractional interstitial volume (v
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
Ruediger E. Port; Lisa J. Bernstein; Daniel P. Barboriak; Lu Xu; Timothy P. L. Roberts; Nicholas Van BruggenMagnetic Resonance in Medicine. 2010;64(2):408-417.
Evangelia I. Zacharaki; Cosmina S. Hogea; Dinggang Shen; George Biros; Christos DavatzikosNeuroImage. 2009;46(3):762-774.
Ashraf Mohamed; Evangelia I. Zacharaki; Dinggang Shen; Christos DavatzikosMedical Image Analysis. 2006;10(5):752-763.
Appears in this Document