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Kyoko Nakagawa-Goto; Po-Cheng Chang; Chin-Yu Lai; Hsin-Yi Hung; Tzu-Hsuan Chen; Pei-Chi Wu; Hao Zhu; Alexander Sedykh; Kenneth F. Bastow; Kuo-Hsiung Lee (Profiled Authors: Kenneth F Bastow; Kuo-Hsiung Lee; Kyoko Nakagawa-Goto)
Journal of Medicinal Chemistry. 2010;53(18):6699-6705.Abstract
6,6,8-Triethyldesmosdumotin B (2) was discovered as a MDR-selective flavonoid with significant in vitro anticancer activity against a multidrug resistant (MDR) cell line (KB-VIN) but without activity against the parent cells (KB). Additional 2 analogues were synthesized and evaluated to determine the effect of B-ring modifications on MDR-selectivity. Analogues with a B-ring Me (3) or Et (4) group had substantially increased MDR selectivity. Three new disubstituted analogues, 35, 37, and 49, also had high collateral sensitivity (CS) indices of 273, 250, and 100, respectively. Furthermore, 2-4 also displayed MDR selectivity in an MDR hepatoma-cell system. While 2-4 showed either no or very weak inhibition of cellular P-glycoprotein (P-gp) activity, they either activated or inhibited the actions of the first generation P-gp inhibitors verapamil or cyclosporin, respectively. © 2010 American Chemical Society.
PMID: 20735140 PMCID: PMC2945214
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
Kyoko Nakagawa-Goto; Kenneth F. Bastow; Tzu-Hsuan Chen; Susan L. Morris-Natschke; Kuo-Hsiung LeeJournal of Medicinal Chemistry. 2008;51(11):3297-3303.
Ting Zhou; Qian Shi; Kenneth F. Bastow; Kuo-Hsiung Lee
Antitumor agents 286. Design, synthesis, and structure-activity relationships of 3'R,4'R -disubstituted-2',2'-dimethyldihydropyrano[2,3- f ]chromone (DSP) analogues as potent chemosensitizers to overcome multidrug resistanceJournal of Medicinal Chemistry. 2010;53(24):8700-8708.
Kyoko Nakagawa-Goto; Kenneth F. Bastow; Jiu-Hong Wu; Harukuni Tokuda; Kuo-Hsiung LeeBioorganic and Medicinal Chemistry Letters. 2005;15(12):3016-3019.
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