Bastiaan Driehuys

DUKE, School of Medicine, Radiology, Radiology

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Relaxation of hyperpolarized ¹²⁹Xe in a deflating polymer bag

Harald E. Möller; Zackary I. Cleveland; Bastiaan Driehuys (Profiled Author: Bastiaan Driehuys)

Journal of Magnetic Resonance. 2011;212(1):109-115.

In magnetic resonance imaging with hyperpolarized (HP) noble gases, data is often acquired during prolonged gas delivery from a storage reservoir. However, little is known about the extent to which relaxation within the reservoir will limit the useful acquisition time. For quantitative characterization, ¹²⁹Xe relaxation was studied in a bag made of polyvinyl fluoride (Tedlar). Particular emphasis was on wall relaxation, as this mechanism is expected to dominate. The HP ¹²⁹Xe magnetization dynamics in the deflating bag were accurately described by a model assuming dissolution of Xe in the polymer matrix and dipolar relaxation with neighboring nuclear spins. In particular, the wall relaxation rate changed linearly with the surface-to-volume ratio and exhibited a relaxivity of κ = 0.392 ± 0.008 cm/h, which is in reasonable agreement with κ = 0.331 ± 0.051 cm/h measured in a static Tedlar bag. Estimates for the bulk gas-phase ¹²⁹Xe relaxation yielded T 1^bulk = 2:55 ± 0:22h, which is dominated by intrinsic Xe-Xe relaxation, with small additional contributions from magnetic field inhomogeneities and oxygen-induced relaxation. Calculations based on these findings indicate that relaxation may limit HP ¹²⁹Xe experiments when slow gas delivery rates are employed as, for example, in mouse imaging or vascular infusion experiments. © 2011 Elsevier Inc. All rights reserved.

PMID: 21752680     PMCID: PMC3163736

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