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Immune function in female B6C3F1 mice is modulated by DE-71, a commercial polybrominated diphenyl ether mixture
Patricia A. Fair; Hui-Chen Stavros; Meagan A.M. Mollenhauer; Jamie C. Dewitt; Natasha Henry; Kurunthachalam Kannan; Se Hun Yun; Gregory D. Bossart; Deborah E. Keil; Margie M. Peden-Adams (Profiled Author: Jamie C DeWitt)
Journal of Immunotoxicology. 2012;9(1):96-107.Abstract
Polybrominated diphenyl ethers (PBDEs) are an important class of flame-retardants that are environmentally persistent and bioaccumulative. Toxicity of these compounds has become a concern because detectable levels of PBDEs are present in humans and wildlife and they are structurally similar to polychlorinated biphenyls (PCBs). This study examined the effects of the commercial penta-BDE mixture, DE-71, in adult female B6C3F1 mice on hematology, serum clinical chemistry, thyroid hormones, tissue histology, and several immunotoxicity end-points (lymphocyte proliferation, NK cell activity, splenic immunophenotypes, and SRBC-specific-IgM production). Mice were exposed via oral gavage for 28 days to achieve total administered doses (TAD) of 0, 0.5, 5, 50, or 100mg/kg. No changes in histology, clinical chemistry, body or organ weights were observed. Serum total T3 and T4 levels were not altered by any of the DE-71 treatments. Peripheral blood monocyte numbers were decreased by the 0.5, 5, and 50mg/kg treatments, but not by the 100mg/kg TAD concentration. Compared to controls, mitogen-stimulated T- and B-cell proliferation was increased by the 100mg/kg TAD concentration (ED50=60mg/kg TAD [2.14mg/kg/day] and 58mg/kg TAD [2.57mg/kg/day], respectively). NK cell activity was decreased compared to controls by the 100mg/kg TAD concentration (ED50=20mg/kg TAD [0.7mg/kg/day]). No alterations were noted in thymic T-cell populations or in SRBC-specific-IgM production. Numbers of CD19 +CD21 -, CD19 +CD21 +, CD4 +CD8 -, CD4 -CD8 +, CD4 -CD8 -, and MHC-II + cells in the spleen were not affected. However, the numbers of splenic CD4 +CD8 + cells were decreased compared to the controls by 0.5, 5, and 100mg/kg TAD. This study provides an assessment of the systemic toxicity and immunotoxicity of DE-71, and indicates that immune parameters are modulated at exposure concentrations lower than previously reported. © 2012 Informa Healthcare USA, Inc.
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