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Mcl-1 rescues a glitch in the matrix

Joshua L. Andersen; Sally Kornbluth (Profiled Author: Sally A. Kornbluth)

Nature Cell Biology. 2012;14(6):563-565.

Bcl-2 family proteins are known to control cell death and influence mitochondrial function. The function of Mcl-1, an anti-apoptotic Bcl-2 protein, is now shown to depend on its subcellular localization. Mcl-1 at the mitochondrial outer membrane inhibits mitochondrial permeabilization to block apoptosis. However, a cleaved form of Mcl-1 localizes to the mitochondrial matrix and controls inner mitochondrial morphology and oxidative phosphorylation, without directly modulating apoptosis. © 2012 Macmillan Publishers Limited. All rights reserved.

PMID: 22643875    

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