Scopus Publication Detail
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Xavier Matias-Guiu; Jaime Prat (Profiled Author: Jaume Prat Díaz de Losada)
Virchows Archiv. 1998;433(2):103-111.Abstract
There is evidence that ovarian cancer may be derived from the progressive transformation of benign and/or borderline tumours. Mutations involving different oncogenes and tumour suppressor genes accumulate during the process of malignant transformation, and the alterations of genes involved in the pathogenesis of familial ovarian cancer are probably early events in ovarian tumorigenesis. BRCA-1 and BRCA-2 act as classical tumour suppressor genes in hereditary tumours, but their role in sporadic tumours remains controversial; however, a high frequency of allele losses in BRCA-1 (17q) and BRCA-2 (13q) loci has been observed in both familial and sporadic tumours. The possible role of mismatch repair genes and microsatellite instability is also controversial, but a role for them has been proposed in borderline tumours. Mutations in K-ras are specific for mucinous tumours and may be related to mucinous differentiation. Finally, a role in tumour progression has been proposed for both c-erb B-2 and p53, but their practical value in prognosis remains questionable.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
Esther Gras; Joan Cortes; Orland Diez; Carmen Alonso; Xavier Matias-Guiu; Montserrat Baiget; Jaime PratCancer. 2001;92(4):787-795.
Cheng-Han Lee; Subbaya Subramanian; Andrew H. Beck; Inigo Espinosa; Janine Senz; Shirley X. Zhu; David Huntsman; Matt van de Rijn; C. Blake GilksPLoS ONE. 2009;4(10).
N.L. Sieben; G.M.J.M. Roemen; J. Oosting; G.J. Fleuren; M. van Engeland; J. PratJournal of Pathology. 2006;210(4):405-411.
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