Scopus Publication Detail
The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in Scopus. This abstract is what is used to create the fingerprint of the publication.
Combined immunomodulating properties of 3,4-methylenedioxymethamphetamine (MDMA) and cannabis in humans
Roberta Pacifici; Piergiorgio Zuccaro; Magí Farré; Sandra Poudevida; Sergio Abanades; Simona Pichini; Klaus Langohr; Jordi Segura; Rafael De La Torre (Profiled Author: Magí Farré Albaladejo)
Aims: Cell-mediated immune function and the occurrence of mild infectious diseases was investigated. Participants: Polydrug consumers of 3,4-methylenedioxymethamphetamine (MDMA) and cannabis (n = 37) compared to cannabis users only (n = 23) and control group (n = 34). Design: A longitudinal prospective study with three cross-sectional evaluations at time 0 and at 6 months and 1 year was performed. Findings: At baseline, a significant decrease in interleukin (IL)-2 and an increase in anti-inflammatory transforming growth factor (TGF)-β1, together with a decrease in the number of total lymphocytes, CD4 and natural killer (NK) cells were observed in the MDMA-cannabis group, with intermediate alterations in the cannabis group. Immune alterations observed at baseline were sustained over time. No differences were found between regular and occasional MDMA users. A significantly higher rate of mild infections in regular MDMA-cannabis users compared with occasional MDMA-cannabis users and the remaining groups was observed. Conclusions: The present data confirm that long-term alterations in immunological homeostasis may result in general health status impairment and subsequent increased susceptibility to infection and immune-related disorders. © 2007 The Authors.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
S. De Sola Llopis; M. Miguelez-Pan; J. Peña-Casanova; S. Poudevida; M. Farré; R. Pacifici; P. Böhm; S. Abanades; A. Verdejo García; K. Langohr; et al.Journal of Psychopharmacology. 2008;22(5):498-510.
R. Pacifici; P. Zuccaro; M. Farré; S. Pichini; S. Di Carlo; P.N. Roset; I. Palmi; J. Ortuño; E. Menoyo; et al.Annals of the New York Academy of Sciences. 2002;965:421-433.
R. Pacifici; P. Zuccaro; M. Farré; S. Pichini; S. Di Carlo; P.N. Roset; J. Ortuño; J. Segura; R. De La TorreLife Sciences. 1999;65(26):PL-309-PL-316.
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